Lidocaine 이 흰쥐 해마박편에서 CA 1 추체세포의 활성에 미치는 영향

김형룡,민승기,김대업,오상천,유형근,김은철,고건일,원진숙 원광대학교 생명공학연구소 1995 생명공학연구소보 Vol.3 No.1

비만세포주에서 Histamine 유리에 관한 연구

김형룡,국윤아,신민,이홍수,원진숙,김형민,이영미,정헌택,이혜숙,안녕형 원광대학교 생명공학연구소 1995 생명공학연구소보 Vol.3 No.1

水泳一스트레스에 의한 血裝 Corticosterone 증가에 미치는 水溫, Clonidine 및 Bromazepam의 영향

金炯健,申炅浩,金庚旭,全普權,千然淑 고려대학교 의과대학 1989 고려대 의대 잡지 Vol.26 No.2

Recently, many reports suggested that warm water swim-stress induces an opioid-analgesia, while cold water swim-stress produces a nonopioid form of analgesia. And Hong et. al. reported that the increase of plasma corticosterone (p-CS) in response to swim-stress at 20℃(20-SS) was significantly attenuated by swim-stress at 4℃ (4-SS) was affected by CL but markedly suppressed by BA. In this paper, the influences of CL-500㎍/㎏ and BA-5㎎/㎏ on the change of p-CS in response to 20-SS or 4-SS were studied in male mice comparing with those of morphine and naloxone. The 20-SS induced increase of p-CS was significantly inhibited by CL and BA, respectively, while the 4-SS induced increase was not affected by CL but markedly inhibited by BA. And the 20-SS or 4-SS induced increase of p-CS was slightly inhibited by naloxone,2mg/kg but not affected by morphine, 2㎎/㎏. The increase of p-SS in response to three times repeated 20-SS or 4-SS with one hour interval was little affected by B-pretreatment, but CL-pretreatment slightly attenuated the 4-SS induced increase of p-CS and significantly inhibited the 20-SS induced increase. The increase of p-CS induced by the repeated SS was little affected by the treatment of BA 30 minutes before the last SS, but the such treatment of CL slightly attenuated the p-CS increase induced by the repeated 20-SS but significantly enhanced the p-CS increase by the repeated the repeated 4-SS. And during the experiment of repeated 4-SS, 55.6% of mice pretreated with BA were drowned. The results demonstrate that there are some pharmacological differences between the mechanisms of hypothalamo-adenohypophysial responses to 20-SS and 4-SS, respectively.

로버스트 능형회귀 추정법

김부용,박형숙 숙명여자대학교 자연과학연구소 1999 자연과학논문집 Vol.- No.10

회귀분석을 위한 자료에는 회귀이상점이 포함되어 있으며, 동시에 다중공선성이 존재하는 경우가 있다. 이상점들만 포함되어 있는 경우에는 로버스트 추정법을 적용할 수 있으며, 다중공선성만 존재하는 경우에는 능형회귀 추정법을 적용할 수 있다. 그러나 회귀이상점과 다중공선성은 상호 관련을 가지므로 어느 한 문제만을 해결하는 것은 완전한 것일 수가 없다. 따라서 회귀이상점과 다중공선성이 동시에 존재하는 상황에서의 효과적인 추정 방법을 제안하고자 한다. Statisticians have suggested many methods for the problems of multicollinearity and outliers seperately. However, we usually encounter many data sets which have both problems. Thus, we propose a procedure that is called the robust ridge estimation and is very effective to deal with the problems simultaneously. The proposed procedure employs the LMS estimate to determine the bias parameter of ridge regression. In addition, it is verified by simulation studies that the proposed iterative method is more effective, in terms of the stability of estimates and squared distances, than the existing procedure based on the least squares estimates.

해방공간의 한국미술 : 서구문화 수용과 민족정체성 구현의 문제

김형숙 서울대학교 미술대학 2001 造形 FORM Vol.- No.24

Following the Korean War and Independence in 1945, South Koreans attempted to establish a modem Korean government and to construct a new society. This reconstruction called for the adoption of Western culture and embodiment of Korean identity at the same time. This was reflected in Korean art of the 1950s, which combined Japanese influence during colonization and Western influence after the Korean War. This paper will examine modem Korean art by asking the question, How was Korean traditional art reinterpreted when modern Korean artists accepted the influence of Western culture? The relationships between artists, the art world, and art education are investigated, in order to understand the 50's cultural environment. Previous studies have looked at art or the art world, or art education in isolation from one another, and therefore they could not explain the big picture of art, the art world, art education within the context of the 50's Korea. During the 50s, when Korean artists accepted the Western art world, they reconstructed modern Korean art, was organized during this time and exhibited the academic style of artworks by Ko Heedong, Lee Jong-woo, and Do Sang-bong, all influenced by Impressionism in Japanese art. Additionally, with the publication of the first art journal in 1956 and the opening of the modem structure of galleries at the center of Seoul, Korean artists had more diverse opportunities to exhibit their works of art. Artists in the 50s interpreted the Korean tradition newly and formed a Korean identity by accepting the Western artistic style and methods in Expressionism, Informel, and Abstract Expressionism. Park Soo-keun painted people struggling to survive after the Korean War, reflecting the atmosphere in Korean at the time. He made the thick matre of white, black, and gray oil paint like Korean granite on canvas made of cardboard and veneer board. Lee Joong-seup was interested in Korean traditional motifs such as cows and children, experimenting with improvisational and expressive brushstrokes as seen in Expressionism of 20th-Century Western Art. Kim Hwan-ki's artworks established a modern picture of the calligraphic school with the use of materials of Western art and Korean traditional motifs such as mountains, moon, trees, and so on. When the first generation of Korean artists in the 50s received modem art education, they were much more positive and open to accepting Western art. Young artists of the and the attacked the ward-heeling politics of and searched for a universal visual language that could keep step with the International world, particularly Western culture. Having been exposed to modern Japanese art and art books, Korean artists were interested in the trends of Informel in Europe and Abstract Expressionism in the United States. Like Jackson Pollock's action painting, Korean Informel artists dripped the paints on the surface of canvases and created Korea's own calligraphy. After Independence in 1945, the art world of Korean traditional painting and sculpture also tried new ways to modernize traditional Korean art by overcoming Japanese influence. Lee Sang-bum, Byun Kwan-sik, and Park Ryae-hyun maintained the style of Korean traditional painting while also adopting the style and materials of Western art. Park kept the materials of Korean painting such as Hanji and Korean paints; however, she also positively adopted the style of Cubism and Abstract Expressionism. Before the 50s, Korean sculptors remained in Japan and learned modern sculpture from modern Japanese artists. However, following Independence, Korean sculptors came to a turning point in practicing modern sculpture. Kim Jong-young in the 50s produced abstract sculpture, which seemed to be influenced by Constantin Brancusi in Western art. Additionally, modern art education also opened after Independence when Korea accepted the system of Western art education. From 1945 to 1956, Ewha Women's University, Seoul National University, and Hong Ik University shaped the modern structure of art education and produced new young artists. Japanese influence on Korean art education was a serious problem that had to be overcome in the 50s. Additionally, art textbooks 'Do Hwa ° § Gong Jack' in Japanese Colonization had been transformed to Mi Sool.' Instead of Japanese art education, ‘New Education,’ based on the 'Creative-Self Expressionism' of 'Progressive Education' of the early 20th century, was emphasized in the field of modern education. When the UN and the United States offered economic and political help to reconstruct Korean society after the war, went to Korea and introduced and experimented with John Dewey's philosophy of Education. For Koreans, Dewey's theories and practices of Progressive Education from the United States provided a hope to overcome old Japanese structures and thoughts in Korean education. The 1950s' Korean art, art world, and art education went through the Korean War, and are considered to be a stepping stone between modem Korean art under Japanese influence and modem art of universal international language.

항암 치료를 받은 아동의 치아 발육 장애

김민정,이형숙,김신,정태성 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.4

The malignant tumor in childhood is one of the main causes of children s death due to disease. The traditional treatment for the malignancy is known for the radiation therapy and the chemical therapy or both. However, the treatments tend to induce intraoral complications. Different from adults, almost all children on cancer therapy are expected to have dental complications, because their permanent teeth are on the developmental stage. The degree of dental complication depends on the patient's age, type of chemical and other factors-radiation dose and frequency. In this report, 3 children who had experienced the anti-cancer therapy on their age between 1 and 4 years were selected and dental complications were examined. The children have chance for the various oral complications including the developmental problems such as agenesis, microdontia and hypoplasia of the teeth. Therefore, it's important to understand the side-effects of anticancer therapy during the permanent teeth had been developmental stage in young patients. Also, oral health care specialists, including pediatric and hospital dentist can support the oncology team by providing basic oral care, implementing oral care protocols, delivering emergency dental treatment undergoing anticancer treatment. 소아기의 악성 종양은 질병으로 인한 소아 사망의 가장 흔한 원인이다. 이에 대한 대표적인 치료 방법으로 항암 화학 요법과 방사선 요법의 단독 사용 혹은 이들의 병용을 들 수 있다. 그러나 이러한 치료 방법은 다양한 구강 내 합병증을 동반한다. 성인과 달리 소아 환자는 항암치료 시기에 일부 영구치가 활발한 발육단계에 있으므로 발육중인 치아에 치과적 합병증이 예상된다. 치과적 합병증의 정도는 화학약물의 종류, 용량 및 방사선 조사 빈도와 치료 당시 환자의 나이에 따라 달라진다. 본 증례들에서는 특정 영구치의 발육단계에 있는 만 1-4세경에 종양의 치료를 위해 항암 화학 요법과 방사선 치료를 받은 어린이 3명을 대상으로 치료 내용과 치아 발육 상황을 검토해 보았다. 이환된 치아의 수나 그 정도에 차이는 있으나, 각각의 환자에서 영구치 치배의 선천 결손, 왜소치, 치근 저형성 등 발육장애 관련 소견이 관찰되었다. 항암치료를 받은 병력이 있는 소아에 있어서 항암치료 이후에 나타날 수 있는 일반적인 구강 합병증 이외에 발육시기 동안 치아에 미치는 영향을 고려하여, 공간 문제를 포함하여 향후 발생 할 수 있는 다앙한 문제점 예방을 위한 장기적인 관찰과 관리가 필요할 것으로 생각된다.

栽培年數에 따르는 人蔘精油量

金愛子,金英順,李榮子(B),李明淑 梨花女子大學校 藥學硏究所 1961 梨花藥學硏究 Vol.- No.2

발효정도가 다른 동치미 국물을 첨가한 냉면 육수의 이화학적 특성

김형렬,김용식,장명숙 한국조리과학회 2004 한국식품조리과학회지 Vol.20 No.6

The application of Dongchimi liquid to Naengmyon broth to improve its eating quality was scientifically explored by reviewing the quality of the product properties. Primarily, the optimum fermentation conditions for Dongchimi from which the liquid portion was extracted were pursued and the optimum mixing ratio sought on the basis of the product physicochemical properties. The liquid portions, periodically extracted from Dongchimi at intervals of two or five days, during fermentation at 10℃, were added to Naengmyon broth. The treatments were prepared at three levels namely, basic broth only ('A') and with ratios of Dongchimi liquid to basic broth of 3:7 (v/v, 'B') and 5:5 (v/v, 'C'). As a typical phenomenon of kimchi fermentation, a gradual decrease in the pH with increasing total acidity was observed as the fermentation of the Dongchimi progressed. At 10V, the optimum ripening was obtained from day 8, and continued until day 15, when the pH was maintained at about 3.8 to 4.0. The total vitamin C and reducing sugar contents increased until the 13th-day of fermentation, but then decreased thereafter. The turbidity and solid content of the Dongchimi liquid increased with progression of the fermentation. With respect to the color values, the lighmess (L) decreased, with increases in the redness (a), yellowness (b) and total color difference (ΔE) during fermentation. Most of these observed phenomena for the Naengmyon broth substituted with 30% (Treatment 'A') and 50% (Treatment 'B') Dongchimi liquid, with different storage periods, confirmed the previous fermentation patterns of Dongchimi. A decrease in the pH with increasing total acidity, as well as gradual increases in the total vitamin C and reducing sugars (glucose and fructose) up to the 13th-day of fermentation were accompanied by subsequent declining patterns. The turbidity and solid content of the mixed broth also increased with increasing Dongchimi liquid fermentation period. With respect to the color of the tnixed broth, the lightness was decreased, while the redness, yellowness and total color difference increased with increasing Dongchimi liquid fermentation period. It was also proven that the addition of slightly over-ripened Dongchimi liquid to the Naengmyon broth was more preferable.

냉면육수의 품질에 관한 연구 : 동치미 발효 정도와 첨가량에 따른 관능적 및 미생물학적 특성 Sensory and Microbiological properties by fermentation and addition of Dongchimi

김형렬,장명숙 한국조리과학회 2005 한국식품조리과학회지 Vol.21 No.1

The application of Dongchimi liquid into Naengmyon broth for the improved eating quality of Naengrmyon was scientifically explored by reviewing the quality properties of the product. Primarily, the optimum fermentation conditions for Dongchimi from which the liquid portion was extracted were pursued and the optimum mixing ratio was sought on the basis of sensory and microbiological properties of the product. The liquid portions which had been periodically extracted from Dongclimi at intervals of two or five days during fermentation at l0℃ were added to Naengmyon broth. The treatments were prepared with three levels, namely, basic broth only('A') and the ratios of 3:7(v/v, B') and 5:5(v/v, 'C') of Dongchinti liquid and basic broth, respectively. According to assessments of Dongchimi liquid on taste and intensity based on sensory analyses, the organoleptic factors such as color, smell, sour taste, carbonated taste, and overall acceptability were given higher values from day I1 to day 17 in all items. As for the assessment of Dongchinti liquid on intensity, color, sour odor, moldy odor, and carbonated taste have shown the increasing scores during with high intensities while those for clearness has stayed low. Most of the phenomena observed from the Naengnlvon broth substituted with 30%(Treatment 'A') and 50% (Treatment 'B') of Dongchirni liquids with different storage periods ensued much of the previous fermentation pattern of Dongchinti itself. Organoleptic assessment on taste and its intensity showed that better(the best) scores could be obtained at between day 16~25(17) and 13~20(15) for Treatments A and B, respectively, The intensity scores of taste for color, smell, carbonated taste, sour taste, and mouthfeel were increased while those for clearness, palatability, and meaty ones were decreased with lapse of fermentation. The numbers of total cell and lactic acid bacterial counts of Dongchimi has increased until day 13 and then decreased in the later stages. Total cell count and lactic acid bacterial counts of Naengmyon broth also increased until the 13th day and then they began to decrease. It was also proven that slightly over-ripened Dongchimi liquid was more preferable for adding into Naengmyon broth. Granting the optimum ripening period of Dongchimi liquid itself to be 13 days. both Treatment A and Treatment B were evenly favored using Dongchimi liquids slightly over-ripened at days 13 to 17. However, Treatment A was more favored than Treatment B when Dongchimi liquid over-ripened for 20 to 26 days was used.

소화성 궤양에서 삼제 병합 요법의 저용량에 의한 Helicobacter pylori 제균률과 궤양 치유효과

김예리,박봉안,이재동,이종혁,김인숙,박형석,진춘조,김상윤,박의우 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Helicobacter pylori is the major cause of histologic chronic gastritis and is strongly associated with peptic ulcer disease, gastric cancer and lymphoma. Several recommendations for the management of the Helicobacter pylori infection have been developed. However, there has been no clear therapeutic regimen for the optimal treatment of Helicobacter pylori infection. This study was desinged to evaluate the eradication rate and the ulcer healing rate of the triple regimen with low-dose clarithromycin(0.5g/day) in peptic ulcer patients. Forty three patients with gastric ulcer(n=15) and duodenal ulcer(n=28) were enrolled. The patients were treated either with omeprazole 20mg b.i.d. amoxicillin 0.5g b.i.d. and clarithromycin 250mg b.i.d. (low-dose regimen group, n=29) or with omeprazole 20mg b.i.d., amoxicillin 1.0g b.i.d. and clarithromycin 0.5g b.i.d.(high-dose regimen group, n= 14) for 2 weeks. After 4 weeks, the patients were evaluated for the eradication of Helicobacter pylori and the healing of ulcer. And gastritis scores according to the Sydney system were evaluated before and after 4 weeks from the end of the triple regimen. There was no significant difference in the eradication rate and the ulcer healing rate between the low-dose regimen group, group and the high-does regimen group. In the low-does regimen group, the mean initial scores of chronic inflammation and activity were decreased after the eradication of Helicobacter pylori. In conclusion, the low-dose triple regimen is as effective as the high-dose triple regimen on the eradication of Helicobacter pylori and the ulcer healing rate in peptic ulcer disease.