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김정일,김병권,김정원,채창호,이철호,강동묵,김지홍,김진하,김영욱,이영하,이지호,김정호,윤형렬,유철인,정백근,장태원,김운규,윤동영,강진욱,김종은,안진홍,이동준,장준호,이광영,송혜란,최영희,이용환,조병만,최홍렬,고상백,김은아,이유진,홍영습,정갑열,김정만,김준연 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.1
Objective: Occupational medicine specialists in the Busan, Ulsan and Kyung-Nam areas established an area-based occupational disease surveillance system and used this system to collected case information for the purpose of preventing occupational diseases Methods: l l hospital participated in this system. The authors selected five main diseases, which were hand-arm vibration syndrome (HAVS), work-related musculoskeletal disorder (WRMSD), occupational asthma, occupational skin disease and occupational and occupational lung cancer and established their case definitions. All cases were reported on the web, and real time analysis was conducted. Results: Between April 2001 and April 2003, 192 cases of HAVS, 118 cases of WRMSD, 33 cases of occupational asthma, 17 cases of occupational skin disease and 17 cases of occupational lung cancer (for a total of 377 cases of these five main diseases) were reported. most of the HAVS cases came from shipbuilding, and 172 of them (92.7%) were associated with grinding. Of the four main types of WRMSD, carpal tunnel syndrome (CTS) was the most prevalent with 46 cases and shipbuilding was also the main industry involved (83.9%). The ergonomic risk factors involved mainly associated with the hand. In 19 (57.6%) and 4 (12.1%) cases of occupational asthma, the agents involved. The causative agents of occupational lung cancer included Cr, welding fume, PAH, Ni, etc. 10(58.8%) of the cases were diagnosed as squamous cell carcinoma and 5(29.4%) as adenoma. Conclusion: This result showed that an area-based occupational disease surveillance system might provide an effective method of evaluating the prevalence of such diseases, however the Busan, Ulsan and Kyung-Nam provinces are too large to be treated as individual areas. Therefore, the authors suggest that each province should establish its own surveillance system.
Loss-of-function screens of druggable targetome against cancer stem–like cells
Song, Mee,Lee, Hani,Nam, Myung-Hee,Jeong, Euna,Kim, Somin,Hong, Yourae,Kim, Nayoung,Yim, Hwa Young,Yoo, Young-Ji,Kim, Jung Seok,Kim, Jin-Seok,Cho, Yong-Yeon,Mills, Gordon B.,Kim, Woo-Young,Yoon, Sukjo Federation of American Societies for Experimental 2017 The FASEB Journal Vol.31 No.2
<P>Cancer stem–like cells (CSLCs) contribute to the initiation and recurrence of tumors and to their resistance to conventional therapies. In this study, small interfering RNA (siRNA)-based screening of ∼4800 druggable genes in 3-dimensional CSLC cultures in comparison to 2-dimensional bulk cultures of U87 glioma cells revealed 3 groups of genes essential for the following: survival of the CSLC population only, bulk-cultured population only, or both populations. While diverse biologic processes were associated with siRNAs reducing the bulk-cultured population, CSLC-eliminating siRNAs were enriched in a few functional categories, such as lipid metabolism, protein metabolism, and gene expression. Interestingly, siRNAs that selectively reduced CSLC only were found to target genes for cholesterol and unsaturated fatty acid synthesis. The lipidomic profile of CSLCs revealed increased levels of monounsaturated lipids. Pharmacologic blockage of these target pathways reduced CSLCs, and this effect was eliminated by addition of downstream metabolite products. The present CSLC-sensitive target categories provide a useful resource that can be exploited for the selective elimination of CSLCs.—Song, M., Lee, H., Nam, M.-H., Jeong, E., Kim, S., Hong, Y., Kim, N., Yim, H. Y., Yoo, Y.-J., Kim, J. S., Kim, J.-S., Cho, Y.-Y., Mills, G. B., Kim, W.-Y., Yoon, S. Loss-of-function screens of druggable targetome against cancer stem–like cells.</P>
Kim, Jun Young,Cho, Eunae,Kim, Jaehoon,Shin, Hyeonwoo,Roh, Jeongkyun,Thambidurai, Mariyappan,Kang, Chan-Mo,Song, Hyung-Jun,Kim, SeongMin,Kim, Hyeok,Lee, Changhee Optical Society of America 2015 Optics express Vol.23 No.19
<P>We demonstrate that nanocrystalline Al-doped zinc oxide (n-AZO) thin film used as an electron-extraction layer can significantly enhance the performance of inverted polymer solar cells based on the bulk heterojunction of poly[[9-(1-octylnonyl)-9H-carbazole-2,7-diyl]-2,5-thiophenediyl-2,1,3-benzothiadiazole-4,7-diyl-2,5-thiophenediyl] (PCDTBT) and [6,6]-phenyl C<sub>71</sub>-butyric acid methyl ester (PC<sub>70</sub>BM). A synergistic study with both simulation and experiment on n-AZO was carried out to offer a rational guidance for the efficiency improvement. As a result, An n-AZO film with an average grain size of 13 to 22 nm was prepared by a sol-gel spin-coating method, and a minimum resistivity of 2.1 ?? 10<sup>-3</sup> 곽·cm was obtained for an Al-doping concentration of 5.83 at.%. When an n-AZO film with a 5.83 at.% Al concentration was inserted between the ITO electrode and the active layer (PCDTBT:PC<sub>70</sub>BM), the power conversion efficiency increased from 3.7 to 5.6%.</P>
Eunae Kim,Junheon Kim,Seon-Mi Seo,Hwa-Jeong Yeom,Hye-Mi Park,Il-Kwon Park,Sang-Chul Shin 한국응용곤충학회 2010 한국응용곤충학회 학술대회논문집 Vol.2010 No.10
In this study, we investigated the nematicidal activities of 102 Korean domestic plant extracts which have not been tested before against B. xylophilus. Nematicidal activity of plant extracts were varied according to plant species and extraction part. Among 102 plant extracts, 42 plant extracts in 22 families showed >50% nematicidal activity against pine wood nematode at 10 mg/mL concentration. Among 31 wood extracts, very strong nematicidal activity (100%) was produced from extract of Neolitsea aciculate, Prunus sargentii and Rhus chinensis at 10 mg/mL concentration. Extracts from Camellia japonica, Carpinus cordata, Daphniphyllum macropodum, Eucommia ulmoides, Ilex cornuta, Myrica rubra, Vaccinium bracteatum, and Zelkova serrata showed strong nematicidal activities (80-99%). The other samples exhibited activities <80%. In a test with leaf extracts, strong neamticidal activity was observed in extract of Machius japonica (100%) followed by Picea koraiensis (99.4%), Meliosma oldhamii (82.7%), and Zelkova serrata (81%). The other 37 plant species revealed <80% mortality. Strong nematicidal activity (>80%) was observed from bark extract of Carpinus cordata, Comus kousa, Cryptomeria japonica, Machius japonica, Quercus glauca and Zelkova serrata. Nematicidal activity of other 19 bark extracts was less than 80%. Twig extract of Smilax china and fruit extract of Forsythia koreana showed 86.6 and 81.4% nematicidal activity at 10 mg/mL concentration, respectively.
종합병원 입원 환자의 간호대학생 실습허용에 대한 견해 및 인식
김영진 ( Kim Youngjin ),김지선 ( Kim Jeesun ),김혜림 ( Kim Hyerim ),박수비 ( Park Subi ),소샛별 ( So Saetbyul ),정보성 ( Jung Bosung ),조은애 ( Choh Eunae ),이선영 ( Lee Seonyoung ),김정은 ( Kim Jeongeun ) 서울대학교 간호과학연구소 2017 간호학의 지평 Vol.14 No.1
Purpose: The aim of this study was to explore the patients` perspectives on nursing students` clinical practices in the wards, and to investigate their willingness for allowing students to practice on them. Methods: This was a descriptive study. 116 inpatients were recruited from the S University Hospital. A 60-item questionnaire was applied to collect the data. The participants were 19 years and older with sound judgement, and were not in special or intensive care units. Data analysis was done in SPSS/WIN 22.0 using descriptive statistics, Fishers exact test, and the ANOVA test. the participant answered to questionnaire from April 29th 2016 to May 10th. Results: 40 participants (34.5%) stated they would allow students` practice, while 72 (61.2%) said they would allow only under staff supervision. 5 participants (4.3%) stated they would not allow whatsoever. The 3 most allowed were emotional support, oral care, and vital signs measurement while the 3 least allowed were gastric feeding, intravenous catheterization, and urinary catheterization. Conclusion: Patients were more inclined to allow students to practice on them when a member of the medical team was present. A fair number of participants said they would be more inclined to allow students` practice if they felt the student was competent; hence, reinforcing simulation sessions is vital in enhancing students` competency and ultimately practice allowance.
Junheon Kim,Seon-Mi Seo,Eunae Kim,Hwa-Jeong,Yeom, Il-Kwon Park,Sang-Chul Shin 한국응용곤충학회 2010 한국응용곤충학회 학술대회논문집 Vol.2010 No.05
Plant essential oils from 26 plant species were tested for their insecticidal activities against the Japanese termite, Reticulitermes speratus Kolbe, using a fumigation bioassay. Responses varied with source, exposure time, and concentration. Among the essential oils tested, strong insecticidal activity was observed with the essential oils of ajowan (Trachyspermum ammi), allspice (Pimenta dioica), caraway (Carum carvi), dill (Anethum graveolens), geranium (Pelargonium graveolens), and litsea (Litsea cubeba). The composition of six essential oils was identified by using gas chromatography-mass spectrometry. The compounds thus identified were tested individually for their insecticidal activities against Japanese termites. Responses varied in a dose-dependent manner for each compound. Phenol compounds exhibited the strongest insecticidal activity among the test compounds further, alcohol and aldehyde groups were more toxic than hydrocarbons. The essential oils and compounds described herein merit further study as potential fumigants for termite control.
Thirteen-week Repeated Dose Toxicity Studies of Processed Genkwa flos Extract in F344 Rats
Seung-Hyun Kim,Ji-Ran You,Euna Kwon,Eun-Young Cho,Jung-Hee Yoon,Chang-Gil Kang,Hye-Jeong Jeong,Jung Ki Kim,In Ae Park,Hee-Chan Kim,Young-Tae Kim,Byeong-Cheol Kang,Jeong-Hwan Che 한국실험동물학회 2007 한국실험동물학회 학술발표대회 논문집 Vol.2007 No.-
Zhou, Ying,Kim, Ji Whan,Nandhakumar, Raju,Kim, Min Jung,Cho, Eunae,Kim, Youn Soo,Jang, Yoon Hee,Lee, Chongmok,Han, Seungwu,Kim, Kwan Mook,Kim, Jang-Joo,Yoon, Juyoung Royal Society of Chemistry 2010 Chemical communications Vol.46 No.35
<P>OLEDs employing <B>CMB1</B>, a novel binaphthyl-containing bi-nuclear boron complex, as the emitter exhibited bright yellow emission with a luminous efficiency of 2.1 cd A<SUP>−1</SUP>.</P> <P>Graphic Abstract</P><P>OLEDs employing <B>CMB1</B>, a novel binaphthyl-containing bi-nuclear boron complex, as the emitter exhibited bright yellow emission with a luminous efficiency of 2.1 cd A<SUP>−1</SUP>. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0cc01715a'> </P>
Sung-Woong Kim,Hwa-Jung Yeom,Eunae Kim,Seon-Mi Seo,Il-Kwon Park 한국응용곤충학회 2012 한국응용곤충학회 학술대회논문집 Vol.2012 No.05
We evaluated insecticidal activity of 11 Apiaceae plant essential oils and their constituents against rice weevil, Sitophilus oryzae.. Of 11 Apiaceae plant essential oils tested, dill (Anethum graveolens), carvi (Carum carvi), caraway seed (Carum carvi) and cumin (Cuminum cyminum) essential oils demonstrated strong fumigant toxicity against adults of rice weevil. Components of 4 active compounds were analyzed by GC and GC-MS, and fumigant toxicity of individual compound was also tested. Among test compounds, carvone, dihydrocarvone, carveol, linalool oxide, neral, cuminaldehyde, and anethole demonstrated the strong insecticidal activity. The toxicity of blends of constituents identified in 4 active oils indicated that carvone, and cuminaldehyde were major contributors to the fumigant toxicity of the artificial blend.