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김정일,김병권,김정원,채창호,이철호,강동묵,김지홍,김진하,김영욱,이영하,이지호,김정호,윤형렬,유철인,정백근,장태원,김운규,윤동영,강진욱,김종은,안진홍,이동준,장준호,이광영,송혜란,최영희,이용환,조병만,최홍렬,고상백,김은아,이유진,홍영습,정갑열,김정만,김준연 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.1
Objective: Occupational medicine specialists in the Busan, Ulsan and Kyung-Nam areas established an area-based occupational disease surveillance system and used this system to collected case information for the purpose of preventing occupational diseases Methods: l l hospital participated in this system. The authors selected five main diseases, which were hand-arm vibration syndrome (HAVS), work-related musculoskeletal disorder (WRMSD), occupational asthma, occupational skin disease and occupational and occupational lung cancer and established their case definitions. All cases were reported on the web, and real time analysis was conducted. Results: Between April 2001 and April 2003, 192 cases of HAVS, 118 cases of WRMSD, 33 cases of occupational asthma, 17 cases of occupational skin disease and 17 cases of occupational lung cancer (for a total of 377 cases of these five main diseases) were reported. most of the HAVS cases came from shipbuilding, and 172 of them (92.7%) were associated with grinding. Of the four main types of WRMSD, carpal tunnel syndrome (CTS) was the most prevalent with 46 cases and shipbuilding was also the main industry involved (83.9%). The ergonomic risk factors involved mainly associated with the hand. In 19 (57.6%) and 4 (12.1%) cases of occupational asthma, the agents involved. The causative agents of occupational lung cancer included Cr, welding fume, PAH, Ni, etc. 10(58.8%) of the cases were diagnosed as squamous cell carcinoma and 5(29.4%) as adenoma. Conclusion: This result showed that an area-based occupational disease surveillance system might provide an effective method of evaluating the prevalence of such diseases, however the Busan, Ulsan and Kyung-Nam provinces are too large to be treated as individual areas. Therefore, the authors suggest that each province should establish its own surveillance system.
Loss-of-function screens of druggable targetome against cancer stem–like cells
Song, Mee,Lee, Hani,Nam, Myung-Hee,Jeong, Euna,Kim, Somin,Hong, Yourae,Kim, Nayoung,Yim, Hwa Young,Yoo, Young-Ji,Kim, Jung Seok,Kim, Jin-Seok,Cho, Yong-Yeon,Mills, Gordon B.,Kim, Woo-Young,Yoon, Sukjo Federation of American Societies for Experimental 2017 The FASEB Journal Vol.31 No.2
<P>Cancer stem–like cells (CSLCs) contribute to the initiation and recurrence of tumors and to their resistance to conventional therapies. In this study, small interfering RNA (siRNA)-based screening of ∼4800 druggable genes in 3-dimensional CSLC cultures in comparison to 2-dimensional bulk cultures of U87 glioma cells revealed 3 groups of genes essential for the following: survival of the CSLC population only, bulk-cultured population only, or both populations. While diverse biologic processes were associated with siRNAs reducing the bulk-cultured population, CSLC-eliminating siRNAs were enriched in a few functional categories, such as lipid metabolism, protein metabolism, and gene expression. Interestingly, siRNAs that selectively reduced CSLC only were found to target genes for cholesterol and unsaturated fatty acid synthesis. The lipidomic profile of CSLCs revealed increased levels of monounsaturated lipids. Pharmacologic blockage of these target pathways reduced CSLCs, and this effect was eliminated by addition of downstream metabolite products. The present CSLC-sensitive target categories provide a useful resource that can be exploited for the selective elimination of CSLCs.—Song, M., Lee, H., Nam, M.-H., Jeong, E., Kim, S., Hong, Y., Kim, N., Yim, H. Y., Yoo, Y.-J., Kim, J. S., Kim, J.-S., Cho, Y.-Y., Mills, G. B., Kim, W.-Y., Yoon, S. Loss-of-function screens of druggable targetome against cancer stem–like cells.</P>
Synthesis and Potent Anti-leukemic Activity of Novel 5'-Norcarbocyclic C-nucleoside Phosphonic Acids
Kim, Seyeon,Kim, Eunae,Oh, Chang-Hyun,Yoo, Kyung Ho,Hong, Joon Hee Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.12
The first synthetic route to 5'-norcarbocyclic C-nucleoside [7-oxa-7,9-dideazadenosine (furo[3,2-d]pyrimidine) and 9-deazaadenosine (pyrrolo[3,2-d]pyrimidine)] phosphonic acids from commercially available 1,3-dihydroxy cyclopentane was described. The key C-C bond formation from sugar to base precursor was performed using Knoevenagel-type condensation from a ketone derivative. Synthesized C-nucleoside phosphonic acids were tested for anti-HIV activity as well as anti-leukemic activity. Compound 26 showed significant anti-leukemic activity.
Sensorial Property Evaluation of Scoured Silk Fabrics Using Quad Analysis
Kim, Jeong-Jin,Yoo, Shinjung,Kim, Eunae Sage Publications 2005 Textile Research Journal Vol.75 No.5
<P>The importance and usefulness of a subjective evaluation of the sensorial properties of scoured silk fabrics is discussed. Silk fabric was treated with 12 different scouring rates and the scoured fabrics were used as specimens. Seven trained subjects, using paired comparisons, evaluated seven subjective sensorial properties. A quad experimental design was adopted for a more effective and reliable evaluation. Objective sensorial properties were assessed by using the Kawabata Evaluation System (KES), and objective measurement and subjective evaluation of sensorial properties were correlated to the scouring rate. The results show that subjects did not recognize the differences in smoothness of the samples, even though the objective measurements demonstrated differences between them. Softness or stiffness, drapability, and luster were closely correlated to the scouring rate, implying that these subjective properties can be effectively manipulated by the scouring process of silk fabrics.</P>
Kim, Seyeon,Kim, Eunae,Yoo, Jin Cheol,Hong, Joon Hee Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.9
Novel 4'-trifluoromethyl-5'-norcarbocyclic purine phosphonic acid analogs were efficiently synthesized from commercially available 1,3-dihydroxy cyclopentane (5). Trifluoromethylation was successfully performed by using the Ruppert-Prakash reaction. The purine nucleosidic bases were efficiently coupled by using the Mitsunobu reaction. The synthesized adenosine phosphonic acids analogs 13 and 16 were screened for antiviral activity against human immunodeficiency virus-1 (HIV-1). Adenine derivative 13 exhibited significant anti-HIV-1 activity.
Epidermal Phytochrome B Inhibits Hypocotyl Negative Gravitropism Non-Cell-Autonomously
Kim, Jaewook,Song, Kijong,Park, Eunae,Kim, Keunhwa,Bae, Gabyong,Choi, Giltsu American Society of Plant Biologists 2016 The Plant cell Vol.28 No.11
<P>Seedling hypocotyls display negative gravitropism in the dark but agravitropism in the light. The Arabidopsis thaliana pif quadruple mutant (pifQ), which lacks four PHYTOCHROME-INTERACTING FACTORS (PIFs), is agravitropic in the dark. Endodermis-specific expression of PIF1 rescues gravitropism in pifQ mutant seedlings. Since phytochromes induce light responses by inhibiting PIFs and the COP1-SPA ubiquitin E3 ligase complex in the nucleus, we asked whether phyB can cell autonomously inhibit hypocotyl negative gravitropism in the endodermis. We found that while epidermis-specific expression of PHYB rescues hypocotyl negative gravitropism and all other phyB mutant phenotypes, endodermis-specific expression of PHYB does not. Epidermal phyB induces the phosphorylation and degradation of endodermal PIFs in response to red light. This induces a global gene expression pattern similar to that induced by red light treatment of seedlings expressing PHYB under the control of its own endogenous promoter. Our results imply that epidermal phyB generates an unidentified mobile signal that travels to the endodermis where it promotes PIF degradation and inhibits hypocotyl negative gravitropism.</P>
A novel discovery of a gaseous sH clathrate hydrate former
Kim, Eunae,Seo, Yongwon Elsevier 2019 CHEMICAL ENGINEERING JOURNAL -LAUSANNE- Vol.359 No.-
<P><B>Abstract</B></P> <P>No gaseous guests have ever been discovered that can form sH clathrate hydrates. Herein, we show that a large molecular fluorinated gas (octafluorocyclobutane, c-C<SUB>4</SUB>F<SUB>8</SUB>), can stabilize the crystal structure of sH clathrate hydrate by occupying large (5<SUP>12</SUP>6<SUP>8</SUP>) cages. The inclusion of c-C<SUB>4</SUB>F<SUB>8</SUB> molecules in sH clathrate hydrate in the presence of CH<SUB>4</SUB> molecules was clearly demonstrated through three-phase (clathrate hydrate (H) – liquid water (L<SUB>W</SUB>) – vapor (V)) equilibria, powder X-ray diffraction (PXRD) and <SUP>13</SUP>C NMR spectroscopy. The discovery of a gaseous sH former, c-C<SUB>4</SUB>F<SUB>8</SUB>, contributes to broadening clathrate hydrate science and engineering by expanding target components for sH clathrate hydrates, and also offers excellent potential in various applications of sH clathrate hydrates, especially in clathrate hydrate-based gas separation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We examine the enclathration of c-C<SUB>4</SUB>F<SUB>8</SUB> in clathrate hydrate lattices. </LI> <LI> c-C<SUB>4</SUB>F<SUB>8</SUB> forms sH hydrate in presence of CH<SUB>4</SUB> as a help gas. </LI> <LI> We demonstrate c-C<SUB>4</SUB>F<SUB>8</SUB> is gaseous sH hydrate former. </LI> <LI> c-C<SUB>4</SUB>F<SUB>8</SUB> is enclathrated in large (5<SUP>12</SUP>6<SUP>8</SUP>) cages of sH hydrate. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kim, Eunae,Ahn, Yo Han,Lee, Jung Won,Park, Eujin Korean Society of Pediatric Nephrology 2021 Childhood kidney diseases Vol.25 No.1
Purpose: The purpose of this study was to investigate the clinical outcomes of non-carbapenem treatment for urinary tract infections (UTIs) caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (E. coli) in young children. Methods: We retrospectively reviewed the medical records of children under 2 years of age who were diagnosed and treated for UTIs caused by ESBL-producing E. coli from September 2014 to March 2020. Results: Forty-three children under 2 years of age were treated with non-carbapenem antimicrobials for UTIs caused by ESBL-producing E. coli without bloodstream infections. The overall clinical and microbiological success rates for empirical antimicrobial treatment were 90.7% and 97.7%. Three of the patients (7.0%) experienced a relapse of UTI within a month. An in vitro susceptibility test showed that two patients were sensitive and one was resistant to the antimicrobial treatments. Furthermore, there were no significant differences in the time to defervescence, clinical success, microbiological success, and relapse rate between the susceptible (n=13) and non-susceptible groups (n=30). Conclusion: In this study, the overall relapse rate of patients treated with non-carbapenem antimicrobials was 7.0%. The patients showed high success rates in the clinical and microbiological responses to the non-carbapenems regardless of the results of the in vitro antimicrobial susceptibility test. These results provide evidence that non-carbapenems may be viable alternative treatments for UTIs caused by ESBL-producing E. coli.