내시경적 점막절제술로 치험한 식도 과립상 세포종 1례

강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.

Investigation of the April 2000 forest fire damage in Kang-won Province, Korea, using RADARSAT data

Kang, Sung Chul,Seo, Jin Won,Lee, Tae Hee,Park, Sang Eun,Hong, Suk Young,Moon, Wooil M. 대한원격탐사학회 2000 International Symposium on Remote Sensing Vol.16 No.1

The series of forest Fires in Kangwon Province in April, 2000, were one of the mast serious ones in the Kang-won Province in recent years. The fire damaged areas are extensive and this paper investigates the utility of the satellite image data, particularly the RADARSAT SAR data. One of the main objectives of this study included evaluation of potential usefulness of the C-band RADARSAT data in the detection of forest fires in mountainous areas. Among several fire damaged sites, the area near Samchuk (city) was selected as the main study area and mufti-temporal RADARSAT(raw) data were acquired and the processed results were comparatively investigated with the IRS-1c data acquired shortly after the fire. To identify the burnt area from the undamaged background in the optical imagery, supervised classification and NDVI processing were carried out and tested with the IRS-1C data. For this experiment, several sets of raw RADARSAT standard and Fine mode (S4, F3, ascending orbit) data were processed and the final image was formed. In addition to the final image, sigma nought (σ°) was catnputed and compared for the burnt area against the undamaged areas. Because of the steep slopes in the study area and subsequent deviation from the flat surface scattering models, the fire scars in the sigma nought (σ°) image were not apparent. However, fire scars are slightly detected in the difference and ratio images obtained from the signal intensity data acquired at different dates (bath before and after fire). Texture analysis of the image data including the burnt areas were carried out using the Multiplicative Markov Random-Field (MMRF) algorithm. The detection of the fire damaged area from both standard mode and fine mode RADARSAT was not as straightforward as in optical data. However, Previous studies with ERS-1 S_AR and RADARSAT data in Indonesia and in the North American Plains indicate that C-band SAR data provide us with an effective tool for studying the forest fire damages. However, the application of C-band SAR data to the analysis of the forest fire areas requires careful processing of the data with realistic scattering models.

A New Sesame Variety, “Kangbaek” with Disease Resistance, Lodging Tolerence and High Yield

Kang-Bo Shim,Churl-Whan Kang,Suk-Bok Pae,Si-Kyu Lim,Yu-Young Lee,Duck-Yong Suh,Jae-Whan Rho,Jin Song,Dong-Whi Kim,Ho-Young Kim 한국육종학회 2005 한국육종학회지 Vol.37 No.5

A new sesame variety Kangbaek was developed from Yeongnam Agricultural Research Institute in 2004. Cros wasmade by lodging resistant SP9003-3 line to the F1with high yielding capacity, folowed by pedigree selection, yield test and RYT by the sesame breeding team at the National Insti-tute of Crop Science up to 2003. The variety showed higher disease resistance, especially phytophothra disease, and lodging resis-respectively. It's 1000 grains weight was about 2.54 g indicating 0.03 g heavier than that of Yangbaekkae, and it's oil content wasabout 52%. Kangbaek also contained total 7.65mg/g of such lignans as sesamin and sesamolin. The average yield of Kang-baek was 82 kg per 10a at the national-wide regional performance.

Toluene, Xylene, Trichloroethylene 투여가 흰쥐의 시상하부와 뇌하수체의 GnRH, GnRH Receptor, Pit-1 유전자 발현에 미치는 영향

기노석,이종태,강대성,김대환,이채관,이헌,전진호,김정호,이채언 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.2

The workplace exposure of chemicals has steadily increased, therefore the concern for subsequent effect on reproductive outcome has been an important issue in occupational medicine. In previous studies, higher rates of spontaneous abortion, reduced fertility and menstrual disorder among women, and an impairement of sperm quantity and quality among men have been associated with a wide variety of chemical agents. This study was conducted to evaluate the effects of toluene, xylene and trichloroethylene(TCE) injection on the mRNA levels of GnRH, GnRH receptor and Pit-1 genes in male rats hypothalamus and pituitary and the effects on the plasma levels of FSH, LH, prolactin and testosterone. Sprague-Dawley male rats were divided into five groups of five each according to concentration of toluene, xylene and TCE. The rats were injected subcutaneously to 0, 50, 100, 200, 400 mg/kg body weight/day of toluene, xylene and TCE, respectively for 6 days. Rat brains were excised and hypothalamus and pituitary were separated. Reverse transcription-polymerase chain reaction (RT-PCR) and RNase protection assay(RPA) were used to evaluate the GnRH, GnRH receptor and Pit-1 mRNA levels. Plasma concentrations of FSH, LH, prolactin and testosterone were assayed by radioimmunoassay(RIA). The results were as follows; 1. GnRH, GnRH receptor and Pit-1 mRNA levels in toluene and xylene injected groups, and GnRH receptor mRNA levels in TCE injected group were lowered dose-dependently. Especially, GnRH receptor and Pit-1 mRNA levels in 200mg/kg of toluene injected group, and GnRH, GnRH receptor and Pit-1 mRNA levels in 400mg/kg of toluene injected group were significantly lower than control group (p<0.05). GnRH receptor and Pit-1 mRNA levels in 400mg/kg of xylene injected group, and GnRH receptor mRNA levels in 400mg/kg of TCE injected group were significantly lower than control group(p<0.05). 2. The plasma levels of prolactin and testosterone in 400mg/kg of toluene injected group, and LH in 100, 200 and 400mg/kg of xylene injected group, and testosterone in 400 mg/kg of TCE injected group were significantly lower than control group(p<0.05). In conclusion, we speculated that toluene and xylene affected reproductive system secondarily through hypothalamus-pituitary axis, and TCE affected directly through steroidogenesis. And we recommended that further study for assessment of the reproductive toxicity of mixed organic solvent exposures should be conducted.

젖소의 번식형질에 영향을 미치는 환경효과에 관한 연구

김경수,이광전,강민식,최윤석,강석형,이정규 한국낙농학회 1995 韓國酪農學會誌 Vol.17 No.3

진딧물의 경보페로몬인 (E)-β-Farnesene의 합성과 생물활성시험

강석구,정경운,이정운,고현관 성균관대학교 기초과학연구소 1986 論文集 Vol.37 No.1

(E)-β-Farnesene, the alarm pheromone of aphids was synthesized from nerolidol by reacting in a sealed tube at 150℃ for 24h with DMSO. Base(KOtBu/DMSO) catalized elimination of HCl from farnesyl chloride at 50℃ for 4h afforded (E)-β-farnesene as the major product. Farnesyl chloride was prepared from nerolidol or farnesol with SOCl_2 or HCl. Biological activity test of (E)-β-farnesene thus synthesized was conducted.

제2종 중도절단에 근거한 지수분포의 신뢰함수 추정

강석복,서영수,이광호 嶺南大學校 基礎科學硏究所 1997 基礎科學硏究 Vol.17 No.-

In this paper, we shall propose several reliability estimators in the two-parameter exponential distribution, and compare the proposed estimators in terms of the MSE through the Monte Carlo simulation.

청소년 하위문화로서의 스포츠활동을 통한 사회교육방안에 관한 연구

이강우,김석기 한국스포츠리서치 2001 한국 스포츠 리서치 Vol.12 No.4

The purpose of this study is to provide a suggestion that sports activities are useful for the social education of the young generation after having investigated and analysed the conditions of sports activities, a sector of the youth's cultural activities. In order to find out the usefulness of sports activities for the social education of the young generation, total 504 students, 227 Air and Correspondence High School students and 277 undergraduates both which belong to a same age group, were investigated through questionnaires in that questions were made concerning four sectors; the youth's leisure utilization and sports activities, the environment and conditions of their sports activities, the extent of their participation in sports activities, their requirements in sports activities Statistical data processing was done by % and X2-square, and conclusions were reached as follows: 1. It appeared that teenagers or adolescents are passive in their leisure activities including sports, inclined toward their one-sided reception of other cultural elements, and do not well utilize their spare time. 2. It appeared that the environment in that teenagers or adolescents can participate in sound sports activities is very insufficient. 3. It appeared that in a view of the youth's participation in the cultural and sports activities performing in general public, the working youth's participation in such activities in inactive. 4. It is deemed that the social sports activities for the youth is preponderant to the older generation. 5. It appeared that the requirements by teenagers or adolescents to society concerning their sports environment are their proper use of the popular sports space after their office hours or school hours, provision of sports facilities or places for their own use, the society's attachment and understanding of the youth, etc.

L-929 세포에 감염시킨 Rickettsia tsutsugamushi의 전자현미경적 연구

이종석,송호연,이강순 순천향대학교 1992 논문집 Vol.15 No.2

We observe the biological characteristics of R. tsutsugamushi infected in L-929 cells by electron microscopy. Especially, we examined the infection cycle of R. tsutsugamushi infected in L-cells according to time of infection. 1. In hematoxylin-eosin stain to show the morphology of monolayer cultured L-cells, glutaldehyde fixation is greater than alcohol fixation. 2. R.tsutsugamushi infected in L-cells were located mainly in cytoplasm surrounding the nucleus of L-cells. 3. R.tsutsugamushi infected in L-cells at 10min. after infection by electron microphotograph were showed various infection steps as attachment, phagocytosis, in-phagosome and incytoplasm steps. 4. R.tsutsugamushi infected in L-cells at 40 min. after infection were showed process of binary fission. 5. At 12 hours after infection, rickettsia surrounded by the host cell membrane were budding out of the L-cell surface.

(+)-Eldanolide의 합성에 관한 연구

강석구,이동하,이정민 성균관대학교 1990 論文集 Vol.41 No.2

출발물질로 D-타타르산 사용하여 (+)-eldanolide의 합성을 연구하였다. 이 합성에서의 중요반응은 온도를 -78℃→0℃로 하여 lithium diisopropylamide 사용하여 (2R, 3R)-1-chloro-2,3-isopropylidenedioxy-6-methy-5-heptene을 탈수소-제거반응시켜 중요한 반응 중간체인 (3R)-6-methyl-heptyn-5-en-3-ol을 합성하는 것이다. Synthetic approach to (+)-eldanolide from D-tartaric acid as starting material is described. They key reaction is the deprotonation-elemination reaction of (2R, 3R)-1-chloro-2, 3-isopropylidenedioxy-6-methyl-5-heptene with lithium diisopropylamide at -78℃→℃ and the key intermediate is (3R)-6-methyl-heptyn-5-en-3-ol.