중독한 추체로 증상을 보인 cyclosporine에 의한 뇌증 1예

강정현,곽승근,신현영,김성은,이정호,이정찬,곽상혁,윤환중,조덕연,김삼용,김제,송창준 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.1

The use of cyclosporine(CsA), a potent immunosuppressive agent, is associated with numerous side effects. Neurotoxicity was earlier less well known, but with growing experience central nervous system side effects are now reported up to 40% of patients. Among various CsA-induced neurotoxicities, tremor is most common and posterior leukoencephalopathy is well characterized. An encephalopathy presenting with pyramidal weakness, however, seems to be rare and poorly documented. We report here a case of encephalopathy presenting with multiple generalized seizures followed by fluctuating quadriparesis developed a few days after starting CsA and resolved spontaneously after withdrawal of the drug . A 48-year-old woman with aplastic anemia was placed upon immmunosuppressive treatment consisting of antithymocyte globulin(ATG), CsA, and methylprednisolone. Two days after starting the therapy, she developed a generalized seizure. The next day she developed 2 more episodes of seizure and the therapy was stopped. Computed tomogram of the brain was normal. Six days after starting therapy, she developed mild motor weakness and paresthesia of both lower extremities, which progressed to a definite quariparesis confining her to a bed in 3 days. Magnetic resonance imaging(MRI) of the brain revealed asymmetric, bilateral high-signal abnormalites in the subcortical white matter of fronto-temporal areas. After reaching to a maximum with some fluactuation(14 days after starting the therapy) the motor weakness started to be resolved. She was discharged with a almost complete resolution of the weakness 45 days after starting the therapy. Five months later she did well and brain MRI was negative.

비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

Single Median Maxillary Central Incisor(SMMCI) 환아의 증례보고

신윤경,김영재,김정욱,장기택,이상훈,한세현,김종철 大韓小兒齒科學會 2007 大韓小兒齒科學會誌 Vol.34 No.4

Anatomic abnormalities of teeth development include the presence of a single maxillary central incisor at midline instead of two central incisors. The incidence of cases with a single maxillary central incisor is approximately 1 in every 50,000 live births. single median maxillary central incisor(SMMCI) may be a integral manifestation of anyone of a number of syndromes. It has been reported an association with several midline disorders which have varied in severity. A SMMCI has also been reported as an isolated finding. But in some cases, it has been considered as an incomplete expression of autosomal dominant holoprosencephaly. So any patient who appears for treatment with a SMMCI should be referred for a detailed medical examination to exclude other associated systemic abnormalities and for mutation analysis to facilitate correct diagnosis and the provision of appropriate genetic counseling. Early orthodontic treatment is needed to minimalize emotional trauma of child. This case report was about three patients with a SMMCI as isolated finding. The purpose of these case reports was to present cases of single maxillary central incisor not associated with other disorders. Single Median Maxillary Central Incisor(SMMCI)는 상악 중절치 형성부전으로 하나의 상악 중절치가 정중앙에 위치하는 치아 발달의 해부학적 이상을 의미한다. 50,000명 중에 1명 꼴로 발생할 정도로 아주 드물며 각종 증후군 및 정중선 이형성을 보이는 발달장애와 연관되어 나타나는 것으로 보고되고 있다. SMMCI는 다른 이상과 연계되지 않고 독립적으로 나타날 수도 있으나 상염색체 우성유전인 전전뇌증(holoprosencephaly)의 경미한 발현일 가능성이 있으므로 유전자 상담이 필요하다. 또 특징적인 안모 및 구강 상태를 보이므로 환아의 바람직한 신체적,정서적 발달을 위해 조기에 교정적 접근이 필요하다. 본 증례는 다른 이상 소견을 보이지 않는 세 명의 SMMCI 환아의 증례를 보고하는 바 이다.

어린이에서 함치성 낭과 연관된 매복 소구치와 대구치의 치료

신차욱,김영재,김정욱,장기택,이상훈,김종철,한세현 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.4

치아 매복은 어린이 환자 진료시에 자주 관찰되는 맹출 장애이다. 어린 환자에서 매복된 치아가 존재하는 경우,함치성 낭과 연관이 있을 가능성이 높다. 함치성 낭은 제3대구치를 제외하고는 상악 견치,하악 소구치 부위에서 가장 호발하며,점진적인 증식으로 악골이 팽윤되어 안모를 변화시키며,주위 악골의 파괴와 치근의 흡수를 야기하거나 침범된 치아의 변위를 유발할 수 있으므로,조기 진단과 적절한 치료가 무엇보다도 중요하다. 함치성 낭과 연관된 치아가 과잉치나 지치라면,치아의 발거를 포함한 완전한 낭종 적출술이 적절한 치료라 할 수 있지만,그렇지 않은 경우에는 환자의 심리적,정선적 외상을 예방하기 위해 원인 치아의 보존이 고려되어야 할 것이다. 이뿐만 아니라,치아의 변위 정도,골 파괴 정도,치근의 성숙도,주위 치아와의 관계,환자의 교합과 구강 악안면 영역의 성장 양상 등도 같이 고려되어야 할 것으로 생각된다. 본 증례에서는 위와 같은 사항들을 고려하여,함치성 낭과 연관된 매복 소구치와 대구치블 낭종 적출술 후 공간 유지,외과적 수술과 교정적 견인,외과작 발거 후 교정적 배열 등의 방법을 통해 양호한 치료 결과를 얻었기에 보고하는 바이다. Tooth impaction is a frequently observed eruption anomaly in pediatric dental practice. Young patients with impacted or unerupted teeth have more prediction for dentigerous cyst formation. Dentigerous cyst presents radiographic features. unilocular or multilocular radioluscency. Cysts occur most frequently in the premolar region except third molar. Dentigerous cysts can grow to a considerable size, and large cysts may be associated with a painless expansion of the bone in the involved area. Extensive lesions may result in facial asymmetry, osseous destruction, root resorption of proximal teeth and displacement of associated tooth. The nature of the causative tooth influences the type of surgical treatrnent required for the dentigerous cyst. If the cyst is associated with a supernumerary or wisdom tooth. complete enucleation of the cyst along with extraction of tooth may be the first treatment choice. Otherwise. preservation of the associated teeth should be considered to prevent a young patient from psychological and mental trauma because of the loss of tooth. We should consider the degree of tooth displacement. osseous destruction and growth pattern of oromaxillofacial area when planning treatment. Thus a proper and logical treatment planning can help a proper growth and development of oromaxillofacial area and can save the patient from a psychological and mental trauma. This report describes 4 cases of the management of impacted premolars and molars associated with dentigerous cysts in children.

고등학교 영어 교과서 정책의 문제점

신정현 서울대학교 어학연구소 1998 語學硏究 Vol.34 No.1

Concerning education, "What knowledge is of most worth" and "How to teach it" are the most important question. It is regrettable, however, that our curriculum workers haven't taken much pains to answer these questions. The fact is that they are unawarely participating in making wise people foolish. G. C. Lichtenberg's aphorism that "A clever child brought up with a foolish one can itself become foolish" is true of our present textbook policy. No research papers concerned with our recent educational reform movement show their deep concern with these classic educational questions. Even "Textbook Organizational Skills in Other Countries"("교과서 정책과 내용구성 방식: 국제비교연구"), the formost study on curriculum reform in Korea, does not say of what knowledge should be most valuable to us here and now. It tells nothing but some organizing principles of textbook; it tells nothing about the philosophy on which its content should be based. The "Guideline" for the highschool English textbook writing is a prime example of the serious lack of philosophy in Korean textbook policy. It is full of many nonsensical restrictions such as the limitation of the number of the usable words in the textbook, the kind of situations, the allowed idioms and phrases, and the forth. However, it doesn't say anything about what kind of English knowledge we need to survice in this globalized world. How can our ambassadors perform their task perfectly with his 3,000 English vocabulary? In our present situation, the most important knowledge is the one capable of increasing autonomy in a wide range of decisions, not just inside the high school classroom but far beyond. And it is impossible to deny that English knowledge is closely related to reaching such autonomy. The problem is how to help students to reach autonomy in every sphere of our lives through English. First of all, we have to decide what kind of English we will teach students who vary in their wishes and objectives and produce various kinds of textbooks which can satisfy their wishes and objectives. Secondly, we have to re-establish educational systems on which our English education can be functioned well. And finally, English teachers should be trained hard against the difficult task of teaching so vast knowledge of English.

박막 크로멜-알루멜 열전퇴형 교류-직류 변환기

정인식,김호운,김진섭,이정희,이종현,신장규,박세일,권성원 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

A planar chromel-alumel multijunction ac-dc converter was fabricated on a LPCVD Si_(3)N_(4)/SiO_(2)/Si_(3)N_(4)-diaphragm, prepared by silicon bulk micromachining, which thermally isolated a bifilar evanohm-heater and the hot junctions of a chromel-alumel thermopile from the silicon substrate. The voltage responsivity, the ac-dc transfer error, and the fluctuation of the output thermoelectric voltage of the converter were investigated. The respective voltage responsivities in air and in a vacuum of the converter were about 3.16 mV/mW and 9.41 mV/mW. The ac-dc voltage and the current transfer errors in air were about ±1.5 ppm and ±0.7 ppm in a frequency range from 10 Hz to 10 kHz, respectively. The fluctuation of the output thermoelectric voltage from 5 seconds to 120 seconds after preheating in air for 5 seconds was about 0.06 % for a heater input of dc 1 V.

치아 맹출전 시행한 기관 삽관이 유치열기에 미치는 영향에 대한 증례보고

신윤경,Hyun, Hong-Keun,김영재,김정욱,장기택,이상훈,김종철,한세현 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.3

유치 맹출전에 치조융기에 가해진 외상은 유치의 맹출 지연 및 형태이상,치배의 변위 등을 일으킬 수 있으며 심한 경우 구개의 흠 형성,절치의 결함 및 후천성 구개열 등을 야기할 수 있다. 본 증례는 치아가 맹출하기 전에 수차례의 기관 삽관을 시행한 병력이 있는 심한 저체중아에서 맹출지연,형태이상,법랑질 저형성,영구치 치배 등의 변위가 관찰되어 이를 보고하는 바이다. Delayed eruption and abnormal morphology of the primary incisors following intubation may be due to follicular displacement and localized trauma caused by the process of intubation. Result of such damage included palatal groove formation, defective incisors and acquired clefts. This clinical report presents effect of intubation on the primary dentition of premature low-birth-weight children prior to tooth eruption.

초피나무 樹皮의 脂質成分에 관한 硏究

申秀澈,徐在信,鄭賢淑 順天大學校 1983 論文集 Vol.2 No.1

초피나무 樹皮에 含有된 一般成分과 脂質成分의 構成 및 脂肪酸의 組成을 分析한 結果를 要約하면 다음과 같다. 1. 一般分析値는 水分이 61.09%, 組蛋白質이 12.18%, 組脂質이 5.89%, 조섬유가 11.66%, 회분이 9.18%였다. 2. 脂肪質의 構成은 中性脂質이 64.77%, 糖脂質이 27.2%, 燐脂質이 7.58%였고, 中性脂質成分은 hydrocarbon, esterified sterol, triglyceride, free fatty acid, free sterol diglyceride 및 monoglyceride의 成分으로 分離 同定하였다. 3. GC에 의하여 7가지 脂肪酸이 檢出되었는데 주요 脂肪酸은 palmitoleic acid, oleic acid, linoleic acid, linolenic acid의 不飽和 脂肪酸이었고, myristic acid, palmitic acid, stearic acid의 飽和脂肪酸은 소량 含有되어 있었다. The lipid components and fatty acid composition of crude lipid in bark of Xanthoxylum piperitum were determined by the methods of thin layer chromatography and gas liquid chromatography. The results were summerized as follows: 1. Proximate components of the bark were shown to be 61.09% moisture, 12.18% crude protein 5.89% crude lipid, 11.66% crude fiber, 9.18% ash. 2. Lipid components were 64.77% neutral lipid, 27.2% glycolipid and 7.58% phospholipid The neutral lipids were fractionated and identified as hydrocarbons, esterified sterols, triglycerides free fatty acid, free sterols, diglycerides and monoglycerides. 3. Lipids of the bark of X. piperitum contained 7kinds of fatly acid as constituent by gas liquid chromatography anlysis. The main fatty acides in the lipids were unsaturated fatty acids(palmitoleic acid, oleic acid, linoleic acid, linolenic acid), and saturated fatty acids(myristic acid, palmitic acid, stearic acid) were as minor components.

敗醬草가 癌細胞柱에 미치는 影響

申大澈,權貞南,金瑩均,韓宗鉉,김재석,김재섭 동의대학교 한의학연구소 1997 동의한의연구 Vol.1 No.-

The purpose of this study was to investigate effect of water extract of Patriniae Herba on the poliferation of human cancer cell-lines. The effects of Patriniae Herba on the poliferation of A43l, HeLa, MOLT-4, K562 cells, Balb/c 3T3 cells, mouse thymocytes, splenocytes and human lymphocytes were estimated by MTT colorimetric assay, The results were as follows; 1. Patriniae Herbs did not effect A43l, HeLa, MOLT-4, K562 cells. 2. The cytotoxicity of mitomycin C on MOLT-4 cells was increased by the combination of Patriniae Herba. 3. Patriniae Herba inhibited the proliferation of Balb/c 3T3 cells. 4. Patriniae Herba stimulated the proliferation of thymocytes. 5. Patriniae Herba stimulated the proliferation of splenocytes. 6. Patriniae Herba stimulated the proliferation of human lymphocytes.

한반도 평화체제구축의 과제 : 신뢰구축 문제와 관련해서

신정현 조선대학교 통일문제연구소 2000 統一 問題 硏究 Vol.13 No.-