활동혈압에 의한 Cicletanine의 강압효과 판정

정태기,김현대,류재춘,최석구,유원상 인제대학교 1993 仁濟醫學 Vol.14 No.4

Prostaglandin 합성을 촉진하는 새로운 강압약인 cicletanine의 강압효과를 진료실 혈압과 24시간 활동혈압으로 평가했을 때 상당한 차이를 보여 그 이유를 검토해 보았다. To evaluate antihypertensive effect of cicletanine with both clinic and ambulatory blood pressure monitoring, 10 male hypertensive patients were administered cicletanine, a new antihypertensive stimulating prostaglandin synthesis, in 100∼200 mg daily for 12 weeks. The following were the results. 1.Mean of clinic BP decreased from 161/98 mmHg to 153/98 mmHg. 2.Mean of ambulatory BP changed from 140/91 mmHg to 153/99 mmHg. 3.Side reactions were mild, namely indigestion and constipation. 4.Discrepancy between clinic and ambulatory BP were discussed. In conclusion cicletanine revealed slight antihypertensive effect with clinic blood pressure, but failed to confirm it with ambulatory blood pressure.

特用作物 利用에 關한 硏究(第1報) : 韓國産枸杞子와 木瓜의 化學的 成分과 그 製品에 關하여 On the Chemical composition of Lycium chinense MILL and Chaenomeles sinensis KOEHNE and their products

鄭址炘,김 관,裵顯錫 全南大學校 農漁村開發硏究所 1980 農業科學技術硏究 Vol.15 No.-

韓國産구기자와 모과의 化學的 成分과 그 製品에 關한 結果는 다음과 같다. 1. 구기자의 一般成分에 있어서 진도산-1이 粗蛋白質 12.7%로 가장 적은 含有量을 제외하면 一般的으로 진도산이 공주산보다 成分含量이 많았다. 2. 구기자의 特殊成分中 Vitam A 含量은 試料間 1.4∼55.1mg%으로 差異가 基하였는데 그 原因은 保存中의 條件에 따라 달라진다고 思料된다. 3. 구기자중의 Fe含量은 공주산 6.6mg%보다 진도산 11.2∼11.9mg%으로 진도산에 많다. 4. 구기자의 試料와 焙燥한 試料를 比較하여 볼 때 Vit. A는 1.7mg%에서 0.5mg%으로, 휘발산은 0.24mg%에서 0.01mg%으로 total ester은 3.9mg%에서 1.2mg%으로 減少하지만 alkaloid와 mineral은 變動이 없다. 5. 모과試料間에 있어서 실생은 mineral中, 燐酸 18mg% 以外의 各 成分含量이 他試料보다 많았다. 6. 구기차의 官能檢査結果는 試料間의 맛에 對한 有意性을 認定하여 抽出粉末茶가 가장 좋았다. 7. 구지주에 關하여는 試料間에 맛, 香氣, 色에 對한 有意性을 認定할 수 없다. 8. 모과차에 對한 官能檢査結果는 試料에 대하여 맛과 香氣에 관한 有意性이 認定되며 모과의 生果磨碎설탕졸임 茶가 가장 좋았다. 끝으로 本 硏究는 전남도 농촌진흥청 작물과의 '80共同硏究課題로 遂行되었으며 進行하는데 있어서 本 大學院生 金龍斗君의 勞苦에 對하여 感射하는 바이다. The results obtained from the experiments about the chemical compositions and the product quality of Lycium Chinense M?? and Chaenomels Sinensis K??? in Korea are summarized as follows: 1. The concents of proximate components of Lycium Chinense M?? were hgiher in the Jindo-products than that of the Kongju-products, except the content of crude protein of Jindo-products which was the least one(12.7%). 2. The content of Vitamine A, one of the special components of Lycium Chinense M???, was varied from 1.4mg% to 55.1mg%. It was thought because that samples were affected by the several factors during storage. 3. The Fe content of Lycium Chinense M??? of Jindo-products(11.2∼11.9mg%) was higher than that of Kong-ju-product.(6.6mg%) 4. Comparing the parched Lycium Chinense M??? with dried one, the contents of Vitamine A, volatile acid and total ester were decreased from 1.7 to 0.5mg%, 0.24 to 0.01mg% and 3.9mg% to 1.2mg%, respectively. But it was found that the contents of alkoloid and mineral were not changed. 5. In ungrafted seedling, the contents of the tested minerals except for phosphorous(18mg%) were higher than those of the other species. 6. The extracted powder tea was best according to the panel test. 7. There was no significant difference among the Lycium Chinense M??? liguors in taste, flavor and color. 8. By means of panel test on Chaenomeles Sinensis Koehne tea, the significant difference about taste and flavor of each sample was recognized and grinding fresh fruit sugared tea was the best.

진공플라즈마 용사법에 의한 Nickel Aluminides의 기계적 성질에 관한 연구

정용기,박수정,이현규 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.10

Nickel aluminides are a family of materials which offer the potential of improved high temperature performance over conventional nickel based superalloys. The synthesized material has been characterized by x-ray diffraction, scanning electron microscopy, energy dispersive spectroscopy and selected area image analysis. The mechanical properties of the Ni₃Al/NiAl alloy have been determined as a function of temperature through compressive and four point flexural tests. The lamellar aluminide provides synergistic properties of each of the monolithic aluminides resulting in appreciable room temperature tensile ductility, reasonable room and elevated temperature fracture toughness and higher compressive yield strength than those of obtained in monolithic NiAl.

Risperidone이 백서의 Schedule-Induced Polydipsia에 미치는 영향

이기철,이정호,윤도준,최영민,전성일,김태수,정홍경,하준명,정재현 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.3

연구목적 : 강박장애의 원인론중 세로토닌-도파민 가설에 기초하여 강박장애 동물모형으로 고려되는 고정된 시간 간격으로 평소의 먹이섭취량보다 작은 양의 음식물을 백서에게 장기간 공급하여 다음중(schedule-induced polydipsia : SIP)을 유발시켰다. SIP모형에 강박장애에 효과적이라고 알려진 선택적 세로토닌 재흡수 차단제로서 fluoxetine을 장기 투여하고, 신경절후 5-HT²와 도파민 D² 수용체를 동시에 차단하는 risperidone을 투여하고, 신경절후 도파민 수용체 차단제인 haloperidol을 투여하였다. 그결과로서 risperidone이 강박장애 동물모형으로 고려되는 SIP에서 어떤 영향을 미치는지 알아보았다. 방 법 : SIP를 유발하기 위해 각각의 사육상자에 1정당 90㎎의 사료를 자동급이장치 (automatic dispenser)에서 60초당 1정씩 고정된 시간 간격으로 하루에 150분씩 공급하였다. 4주간 고정된 시간 간격으로 머기를 공급하고 매주 음수량과 체중을 측정한 실험 동물과 동등한 사료의 양을 한번에 덩어리로 공급받은 통제 집단의 체중과 음수량을 비교하였다. SIP 행동변화를 보인 실험 동물들을 fluoxetine 5㎎/㎏(N=8), risperidone 0.1㎎/㎏(N=8), haloperidol 0.1㎎/㎏(N=8), 그리고 vehicle 대조군 1㏄/㎏(N=8)으로 나누고 각각의 실험 동물군에서 3주간에 걸쳐서 실험 약물을 매일 복강내 주사하였다. 매주 실험 동물의 음수량과 체중을 측정, 비교하였다. 결 과 : 1) 고정된 시간 간격으로 제한된 먹이를 공급한 실험 동물군은 1주부터 4주에 걸쳐서 기저치보다 유의한 음수량의 증가를 보였다. 반면 통제 집단은 2주째 음수량이 일시적으로 증가한 소견 이외에 4주간의 실험 기간중 유의한 변화는 보이지 않았다. 실험 동물과 통제 집단간의 음수량에서 3주와 4주째에 실험 동물이 통제 집단보다 유의하게 높은 음수량을 보였지만 양군간에 체중의 차이는 보이지 않았다. 2) 각각의 실험 동물군 내에서 risperidone 0.1㎎ 투여군은 약물 투여 2주부터 3주까지 기저치 음수량과 비교하여 유의한 저하를 보였다. Risperidone 0.5㎎ 투여군은 약물터여 3주에서 기저치의 음수량과 비교하여 유의한 저하를 보였다. Fluoxetine 투여군은 약물 투여 시작 1주부터 3주에서 기저치의 음수량과 비교하여 유의한 저하를 보였다. 한편, haloperidol 투여군과, vehicle은 3주간에 걸친 약물 투여에서 각각의 기저치 음수량과 비교하여 차이를 보이지 않았다. 3) 실험 동물 각 군간에 약물 투여 시간 경과에 따른 음수량을 비교한 바, 약물투여 1주에서 각 군간에 유의한 차이는 없었다. 약물 토여 2주에서 fluoxetine 투여군, risperidone 0.1㎎ 투여군, 그리고 risperidone 0.5㎎투여군이 haloperidol 투여군과 비교하여 유의한 차이를 보였다. 약물투여 3주째에 fluoxetine투여군, risperidone 0.1㎎ 투여군, 그리고 risperidone 0.5㎎투여군이 haloperidol 투여군, vehicle과 비교하여 유의한 음수량의 저하를 보였다. 결 론 : 백서의 강박 행동은 fluoxetine, risperidone에 의해 효과적으로 억제되었으나 haloperidol에는 반응이 없었으므로, 임상에서 난치성 강박장애의 치료에 비정형 항정신병 약물 투여를 고려해 볼 수 있다고 제안한다. Objectives : This study was designed to evaluate the effects of risperidone on the schedule-induced polydipsia(SIP) which is one of animal model of obsessive-compulsive disorder in rats. We administered risperidone as a serotonin and dopamine blocking agent, fluoxetine as a selective serotonin reuptake inhibitor, and haloperidol as a dopamine antagonist to rats which showed schedule-induced polydipsic behaviour. Methods : Sprage-Dawley rats weighing 200∼250gm were individually housed and maintained and allowed free access to water. The rats were placed on a restricted diet. To induce polydipsia, rats were placed in the cage where a pellet dispenser automatically dispensed 90㎎ pellets on a fixed-time 60 seconds(FT 60s) feeding schedule over 150 minute test session per day. Water was available at all times in the cage. After 4 weeks of daily exposure to the FT 60s feeding schedule, experimental rats met a predetermined criterion for polydipsic behavior(greater than 3 times of water per session on average). 5 groups of rats were administered risperidone(0.1㎎/㎏, i.p), risperidone(0.5㎎/㎏, i.p), fluoxetine(5㎎/㎏, i.p), haloperidol(0.1㎎/㎏, i.p), and vehicle(1㏄/㎏, i.p) for 3 weeks. The rats were tested once a week to access schedule induced polydipsic behavior. Water bottles were weighed before and after the 150-minute test session. The chronic effects of administration of experimental drugs on schedule induced polydipsic behavior were analyzed with ANOVA and Scheffe test as a post-hoc comparison. In order to measure water consumption in non-polydipsic food-deprived rats, a separate group of rats(N=8) was individually housed and given a single bolus(14.5gm) of food per day which maintained them at their average body weight. Results : The results were as follows ; 1) After 4 weeks of scheduled feeding procedure, the experimental group showed significant differences than the bolus control in the amount of water consumption as compared with their average water intakes for 4 weeks. At the same periods, there were no differences between the experimental group and the bolus control in the body weight. 2) The fluoxetine group showed significant decrease in the amount of water intake at 1st, 2nd, and 3rd weeks of drug treatment as compared with their average amount of polydipsic water intakes. The risperidone 0.1㎎ group and the risperidone 0.5㎎ group showed significant decrease in the amount of water intake at the 3rd weeks of drug treatment as compared with their baseline of polydipsic water intakes. However, the haloperidol group and the vehicle control group showed no changes of amounts of water intake for 3 weeks of treatment as compared with their baseline of polydipsic water intakes. 3) The fluoxetine group(22.5±10.4ml) showed significantly lower amounts of water intake than haloperidol group(41.3±7.1ml) at 2nd weeks of drug treatment. And also the fluoxetine group(18.8±3.5ml) showed significantly lower amounts of water intake than the haloperidol group(35.0±11.7ml) and the vehicle control(34.4±6.8ml) at 3rd weeks of drug treatment. The risperidone 0.1㎎ group and the risperidone 0.5㎎ group showed significantly lower amounts of water intake than the haloperidol group(35±11.7ml) at 2nd weeks and the vehicle control(37.5±12.5, 34.4±6.8ml) at 2nd and 3rd weeks of drug treatment. Conclusions : Above findings suggest that the fixed time feeding procedure for schedule induced polydipsia could be applied as an effective animal model of obsessive compulsive disorder for the evaluation of pharmacological challenge study. We confirmed that chronic treatment with risperidone revealed antipolydipsic effect as effective as fluoxetine on the schedule-induced polydipsic behaviour but the onset of effect was later than fluoxetine.

국가 위성항법 시스템의 활용과 관련된 이용서비스

이기칠,정중식,서상현 東亞大學校 建設技術硏究所 2008 硏究論文集 Vol.31 No.2

This study is intended to describe and suggest the future available services by using the ability of estimating position with submeter error, which is provided by National Differential Global Positioning System(NDGPS). Such countries as Japan, Australia, Europe, and the United States have reviewed various applications for DGPS services with high accuracy of submeter level. In Korea, many researchers have found applications usable by NDGPS. Korea government is also seeking for applications to efficiently utilize NDGPS services as a national infrastructure. We suggest Global Navigation Satellite Services(GNSS) position services with high accuracy by investigating technologies with relation to a national R&D strategy in the field of Information Technology(IT) and Marine Technology(MT). The suggested services would help expand the future applications for NDGPS.

슬래브의 영향을 고려한 보-기둥 접합부에서 보의 인장철근 배치에 관한 수치해석적 연구

洪起燮,朴正鉉 홍익대학교환경개발연구원 2000 환경개발연구논문집 Vol.5 No.-

Due to the congestion of the reinforcement, it is difficult to arrange properly 2-layer tension reinforcement at the beam-column joint. In ACI and Eurocode, it is recommended to distribute the tension reinforcement within the effective width of flange uniformly to control flexural cracks. In this study, it is conducted a nonlinear analysis of beam-to-column joints using ANSYS to evaluate the ultimate strength and the general behavior of the joints. It is compare to arrange 2-layer tension reinforcement within rectangular section with single-layered tension reinforcement at the beam flange. Based on the results of this analysis, the following conclusion can be drawn : 1. The load-displacement curves of the models were very similar to below 3㎜. That is, the ultimate strength of the model is no difference between arranging 2-layer tension reinforcement within rectangular section and single-layered tension reinforcement at the beam flange at the below 85% of ultimate strength. 2. For the single-layered tension reinforcement it is recommended to provide additional reinforcement at the beam-column joint to attain ultimate load capacity equal to the 2-layered case.

Dunaliella salina의 성장에 미치는 탄소원 및 빛의 영향

이지현,이정석,조만기 동서대학교부설연구소 1998 연구소 논문집 Vol.3 No.-

The marine microalga Dunaliella salina was studied to optimize its growth conditions in batch cultrue. Various culture conditions were studied by adding glucose and NaHCO??. Another culture methods like photoautotrophic, photoheterotrophic and heterotrophic conditions were studied. The adding 0.5% glucose in the medium made the growth rate increased more than 2 times, but the adding NaHCO?? had no effect on the growth rate of Dunaliella salina. Dunaliella salina did not grow in heterotrophic condition but grew rapidly in photoheterotrophic condition with light and glucose.

제주마의 번식과정에 있어서 혈중 Steroid Hormone수준변화에 관한 연구 Ⅲ : Ⅲ. PGF_(2)α처리에 의한 무발정 제주마의 치료효과

장덕기,양기천,김중계,서문현 제주대학교 농과대학 제주도축산문제연구소 1991 畜産論叢 Vol.6 No.1

The effects of PGF_(2α) on the conception rate and the plasma levels of estradiol- 17β and progesterone of anestrus Cheju mares were investigated at the breeding and non-breeding seasons. The results obtained from this studies are as follows; 1. The durations of the estrus and diestrus after PGF_(2α) treatment persisted shorter than control cycle (p<O.05), but ovulation time was fast. 2. The levels of estradiol-17β and progesteron before PGF_(2α) treatment showed 103.8pg/ml, 8.Ong/ml in breeding season and 72.8pg/ml, 4.7ng/ml in non-breeding season, respectively. 3. The levels of estradiol-17β rose to 115.4-154.Opg/ml. and 90.8-127.Opg/ml from 2nd to 6th day after the treatment of PGF_(2α), in breeding and non-breeding seasons, respectively, while progesterone level dropped to Ing/ml with the sign of estrus and at 8th day rose in breeding season (p<O.05) 4. Of thirty anestrus mares investigated for PGF_(2α) administration, 87.5% showed estrus on an average of 3.8 days after treatment and the conception rate was 62.5% in breeding season, but the estrus and conception rates dropped 40%, and 20% in non-breeding season, respectively.

In situ hybridization과 염색체 미세해부에 의한 특정 염색체 띠에 대한 유전자 발굴

홍기정,김현수,전용혁,김현,박선화 고려대학교 의과대학 1996 고려대 의대 잡지 Vol.33 No.1

Recently surmountable amounts of genes are being cloned but it is hard to define the chromosomal location and functions of these genes. In this study, a new technique was developed for cloning genes expressed in the developing human brain with confirmed chromosomal location. The mRNAs were extracted from 18 week old human fetal brain, cDNAs were made by reverse transcription from these mRNAs and Uni-amp cDNAs having Uni-amp adapters a t both ends were made for subsequent PCR. To observe the distribution of the Uni-amp cDNAs on the chromosome, fluorescent in situ hybridization was performed with biotin labeled Uni-amp cDNAs. Among the chromosome bands showing strong hybridization with the cDNAs, lq21, lq25, lq32 and lq42 were microdissected from the chromosome hybridized with unlabeled Uni-amp cDNAs and amplified by PCR with Uni-amp primers. These amplified cDNA fragments were subcloned to plasmid vectors and the nucleic acid sequences were analysed. As a result 18 different clones were confirmed the chromosomal localization. They were categorized as 4 clones of well characterized genes, 3 clones showing low homology with known genes, 5 clones of simply registered uncharacterized human cDNAs, and 6 clones of unknown genes. The evidence suggests that the technique is very useful to clone the genes that express in the developing human brain, with confirmed chromosomal location. In addition, this cloning technique can be used to discover the new genes related with neuronal development in combination with functional screening method.

자산감액 손실 현황과 회계규정의 개선방안

박기석,이태정,현수룡 한국세무회계학회 2004 세무회계연구 Vol.14 No.-

본 연구는 우리나라 기업회계기준과 해석 등에 산재된 자산감액손실 관련 회계규정을 검토하고 상장기업의 자산감액손실의 현황과 특징을 살펴봄으로써 문제점과 해결방안을 제시하고자 하였다. 연구결과 자산감액회계는 일부 특정 기업의 재무상태와 일부 계정과목에 중대한 영향을 미치고 있으며, 자산감액손실을 계상하는 기업이 증가추세에 있는 것으로 나타났다. 그러나 현행 회계기준은 감액손실의 인식과 환입에 대하여 재법적인 내용만 담고 있을 뿐이며 실무 적용에 있어서의 구체적인 지침은 마련되어 있지 않은 것으로 나타났으며, 토론서 제16호는 현행 기업회계기준의 문제점을 상당히 개선하고 있는 것으로 보이지만 실무 적용을 위한 구체적인 지침을 제시하지 못하고 있다. 따라서, 향후 자산감액손실에 대한 회계처리기준을 정립하기 위해서는 첫째, 자산의 구분과 적용범위, 사용가치의 추정방법, 감액손실의 추정방법 등에 대한 구체적인 실무지침을 제시하여야 할 것이며, 둘째, 자산감액손실의 엄격한 인식기준과 상장기업의 감액손실 공시의 적시성을 확보, 이익관리의 수단으로 악용 가능성 방지를 위한 관련 법규 등의 개정 등이 검토되어야 할 것이다.