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      • SCOPUSKCI등재

        Original Articles : Clinical significance of occult hepatitis B virus infection in chronic hepatitis C patients

        ( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3

        Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)

      • 국내 레미콘사의 부순모래 사용실태 조사

        김기훈,金虎林,金光華,윤기원,한천구 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

        Crushed sand is made by crushing the rock artificially. With the wide shortage of natural fine aggregates at all regions in Korea. crushed sand has been increasingly consumed as a alternative aggreagtes of natural sand. But there is insufficient information related to the actual situation on the produce. quality and manufacturing company of crushed sand. In this paper. survey is performed in order to know actual consumption situation of crushed sand through ready mixed concrete company in domestic. The remicon companies using crushed sand were estimated with 55%. According to the using method of crushed sand. most remicon company used fine aggregates by mixing natural sand and crushed sand. It is found that natural sand is replaced by crushed sand by about 20~50%. For quality problems in using crushed sand. grain shape. grade and fine particles shall be improved to meet the quality requirement of remicon and wide application. Therefore. it is found that quality improvement of crushed sand is required.

      • KCI등재

        한국인 알코올 의존 자녀들과 도파민 D2, D4 수용체, GABAΑ 수용체 β Subunit 및 세로토닌 운반체 유전자 다형성 사이의 연관성에 대한 예비적 연구

        천근아,김재원,전진용,이준영,남궁기 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.1

        Objectives : The studies on the genetic risk factors of the children of alcoholics (COAs) are still in an early stage. The A 1 allele of the dopamine receptor 2 gene (DRD2) may be associated with the negative affect and positive alcohol expectancy of the COAs. In addition, several researchers reported that COAs might be associated with the GABA_(A) receptor β subunit gene (GABRB3) and serotonin transporter gene (5-HTTLPR). In this study, we investigated the association of polymorphism of the DRD2, Dopamine D4 receptor gene (DRD4), GABRB3, 5-HTTLPR with COAs to examine the genetic risk factors of COAs. Methods : Twenty-two COAs and 23 control children (children of non-Alcoholics ; Non-COAs) were included for the genetic study. All COAs aged 6 to 18 were recruited and selected from families of alcoholic patients in alcohol clinics of three university and mental hospital. Alcoholism of parents was classified as type I (non-antisocial, late onset) and type II (antisocial, early onset) by Cloninger's classification. The genotyping of the DRD2, DRD4, GABRB3, 5-HTTLPR was carried out. Chi-square method was used for evaluating the associations between genetic polymorphism and the COAs Results : The frequency of A1 + allele of DRD2 in COAs were significantly higher than Non-COAs (χ²=4.45, df= 1, p=0.035). Significant association between the genotype of DRD4 and COAs was found (χ²=8.32, df= 1, p=0.004). Gl- alleles of GABRB3 in COAs were significantly higher than in Non-COAs (χ²=6.622, df= 1, p=0.022). We found no association of the polymorphic alleles of 5-HTTLPR with the COAs (χ²=0.021, df= 1, p=0.884). There were significant associations between the type of parental alcoholism and depression of COAs. Conclusion : We found that the children of alcoholics had significantly increased genetic risk of alcohol drinking expectancy. This study provides some preliminary information on the risk and protective factors associated with the COAs, which can be usedas a foundation for prevention and intervention of future psychopathology.

      • KCI등재
      • 국산 및 수입 Luncheon Meat의 품질비교에 관한 연구

        김천제,최수일,한의수,이효진,고원식 건국대학교 동물자원연구센터 1991 動物資源硏究誌 Vol.16 No.-

        본 연구는 국내에서 생산되고 있는 돈육 luncheon meat과 수입 luncheon meat의 성분조성 및 품질을 비교 평가하기 위하여 실시하였다. 그 결과를 요약하면 다음과 같다. 1) 국산돈육 luncheon meat의 수분함량은 57.2%로 수입품(53.1%)보다 높았으며 조지방 함량은 수입품(53.1%)보다 높았으며 조지방 함량은 수입품이 26.6%로 국산품(20.6%)보다 높았다. 그러나 조단백질 함량은 거의 같았다. 2) 국산돈육 luncheon meat와 수입품 모두 대장균이 검출되지 않으며, 타르색소(tar colors)도 사용하지 않은 것으로 나타났다. 3) 국산돈육 luncheon meat의 NO₂의 함량은 4 ∼ 35ppm으로 돈육수입 luncheon meat(1.7∼6ppm)보다 높았다. 4) 국산돈육 luncheon meat의 TBA가는 0.09∼0.13로 비교적 낮았으나, 유통기간이 긴 수입돈육 luncheon meat는 0.09∼0.39로 국내제품에 비하여 상대적으로 높은 값을 나타내었다. 5) 국산돈육 luncheon meat의 VBN(12.3∼18.4mg%)은 수입품(15.7∼18.2mg%)보다 낮았다. 6) 수입 luncheon meat는 국산 luncheon meat보다 jelly loss가 약2배 높았다. 7) 경도는 국산돈육 luncheon meat통조림이 수입품보다 높은 것으로 나타났으나, 탄력성과 응집성은 큰 차이가 나지 않았다. The aim of this study was to assay and compare the ingredient or composition and quality of imported pork luncheon meat with those of domestic's. The results obtained were as follows. 1. The amount of water in domestic pork luncheon meat products(57.2%0 was higher than that of imported products(52.2%0, and the content of crude fat in imported products(26.6%) was higher than that of domestic products(20.6%). The amount of crude protein, however, both domestic and imported products was approximately the same. 2. E.coli was not found in both domestic and imported products. No tar-colors were detected in both samples. 3. The amount of NO₂in domestic pork luncheon meat products(4 to 35ppm) was higher than that of imported products(1.7 to 6ppm). 4. The TBA-value of domestic pork luncheon meat products(0.09 to 0.13) was relatively low, whereas the value of imported products was higher than that of domestic products(0.09 to 0.39). 5. The VBN-value of domestic luncheon meat products(12.3∼18.4mg%) was lower than that of imported products(15.7∼18.2mg%). 6. The jelly loss of imported pork luncheon meat products was approximately 2 times higher than that domestic's . 7. The hardness of imported pork luncheon meat products was lower than that of domestic products. Elasticity and coheshiveness in both products were not significantly different.

      • KCI등재후보

        주의력결핍 과잉행동장애 아동의 지적수준에 따른 정신병리와 실행기능의 차이

        천은진,서완석,이종범,김진성,구본훈,송창진,성형모,배준용,배대석 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.4

        To investigate psychopathoIogy and executive functions of attention deficit hyperactivity disorder (ADHD) children according to intelligence level, this study included 197 ADHD children who visited the outpatient department of neuropsychiatry of YeungNam University Medical Center, from July 2000 to June 2002. The children were divided into groups based on their intelligence levels. They were compared by the Personality Inventory for Children (PIC), Conncers' Continuous Performence Test (CPT), and Wisconsin Card Sorting Test (WCST). There were significant differences in PIC, on the subscales of verbal development, socialization and autism. In the CPT, there was no significant difference. In the WCST, there were significant differences in the total number of errors, the number of perseverative errors, the number of completed categories and the number of trials needed to complete the first category. Considering these results, the intelligence level of ADHD children is related to their disabilities and behavioral symptoms.Executive functions such as abstract thinking, categorization, working memory and flexibility had significant relationship to the intelligence levels of ADHD children. Therefore, the intelligence level of children with ADHD influences the higher executive functions of regulating attention and information processing rather than attentional functions and capacity alone.

      • KCI등재
      • 안정화제를 사용한 회수수의 고형분량 및 방치시간에 따른 시멘트 모르터의 특성

        金光華,김기정,이문환,이세현,한천구 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

        This study is intended to investigate the fundamental properties of cement mortar with solid content and leaving time of recycled water that stabilizing agent is added. According to the results, fluidity and air content does not make a big difference with variation of solid content. As the leaving time of recycled water is long, fluidity and air content increases. Setting time is shortened due to fine particle with an increase of solid content and leaving time. Compressive strength and flexural strength increase with an increase of solid content, and they increase at the leaving time of 1 day, but decrease after 2days. Length change by drying shrinkage is smaller than that of plain concrete, and is almost same with variation of solid content. And it is reduced at the leaving time of 1 day, but increases after that. Therefore, it analyzed that the effect of stabilizing agent is best under condition of adding ratio of 0.15%, solid content of 3% and leaving time of 1day, and it also works upto solid content of 5% and leaving time of 2days.

      • KCI등재

        백서 뇌의 정상 노화와 병적 노화 과정의 조직학적 차이 및 약물효과

        전진숙,한호성,장희경,길영기,김순옥 대한생물치료정신의학회 1997 생물치료정신의학 Vol.3 No.1

        Objectives : Besides of malnutrition and neurotoxic effect of alcohol on the prefrontal cortex or subcortical structures, premature aging may be involved in alcohol-induced cognitive disorders. The aims of this study were to evaluate the effect of alcohol on short-term memory function and histology, and to identify the drug responses and an association with aging process to understand a biological mechanism underlying alcoholic dementia. Methods: In experiment 1, T-maze tests were done in 5 aged controls and 5 atropine-treated rats. In experiment 2, T-maze tests were repeated on every week for a month in 5 normal adult and 5 ethanol-treated rats. In experiment 3, T-maze tests were repeated on every week for a month in seven groups of 5 ethanol-treated rats injected with normal saline, fluoxetine, bromocriptine, bethacholine, nimodipine, clonidine and ketamine. After completion of behavioral tests rats were sacrificed by the intracardiac perfusion with phosphate buffered 10% formaldehyde solution, and the brain specimen was stained with hematoxylin-eosin to count cells in prefrontal cortex and hippocampus. Results: 1) Cell numbers of hippocampus(CA1, CA3 and dentate gyrus) and prefrontal cortex were reduced in ethanol-treated rats(P<0.05) without significant changes on T-maze tests. 2)Cell numbers of hippocampus(CA1, CA3 and dentate gyrus) and prefrontal cortex were recovered by bethacholine(P<0.05), while those of hippocampus raised by bromocriptine and clonidine(P<0.05 respectively). There were no significant changes on T-maze tests. 3) Cell numbers of prefrontal cortex in ethanol-treated rats were correlated with those of atropine-treated(r=0.977,P<0.001), and of normal aged(r=0.448, P<0.05) rats. Conclusions : Alcohol-induced memory disorder might be mainly related with cholinergic system as well as adrenergic or dopaminergic ones. Pathological aging process could be involved in a mechanism underlying alcoholic dementia.

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