전경대원에서 발생한 결핵의 임상 양상

문창기,박상준,조민구,김영중,김소연,김윤권,정준오,안석진,김은실,서승오,김지훈,최원제,이윤영,박형기,최규영,김현근 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

Background: The purpose of this study was to document the incidence and clinical characteristics of patients with tuberculosis (TB) in combat and auxiliary police, living in a group, in Korea where the incidence rate of active TB in a general population is higher than in Western countries. Materials and Methods:We retrospectively reviewed the medical records of all tuberculosis patients diagnosed at National Police Hospital from January 2002 through December 2004. Results:In 2002-2004, a total of 156 cases of tuberculosis were identified with the mean (Standard deviation) age of 20.6 (±1.0) years. Of these, 134 (85.9%) patients were registered as new cases, 11 (7.1%) as relapse, 2 (1.3%) as failure, 5 (3.1%) as treatment-after-default cases whereas 4 (2.6 %) patients were not included in any categories. Average annual new TB rate and smear-positive TB rate were 86.5/10^(5) and 17.4/10^(5) person-years, respectively. In 12 of 31 smear-positive cases, time from onset of symptoms to diagnosis was more than 30 days. Two multidrug-resistance TB cases were identified and two suspected outbreak episodes of TB had occurred during 3 years. Conclusion:There was no statistically significant difference in the incidence rate of new cases of TB between the general population aged 20 to 29 years and combat and auxiliary police in Korea. 배경 : 국내 결핵의 발생은 감소 추세에 있으나 여전히 후진국형 발생양상을 보이고 있다. 특히 집단생활을 하는 젊은이들에서 발생하는 결핵의 유행이 간헐적으로 알려지고 있어 우려를 낳고 있다. 이에 저자들은 최근 전경대원의 결핵 발병 양상에 대해 알아보고자 본 연구를 시행하였다. 재료 및 방법 : 2002년 1월부터 2004년 12월까지 3년간 경찰병원에서 결핵 진료를 받은 전경대원의 의무기록을 후향적으로 분석하여 연도별 결핵 신환발생률, 도말양성결핵 신환율, 진단 지연, 집단발병, 다제내성결핵을 조사하였다. 결과 : 연도별 결핵 신환자 수(10만명당 발생추정치)는 2002년 50명(83.6명), 2003년 42명(83.7명), 2004년 42명(93.5명)이었고 도말양성 폐결핵 신환자 수는 2002년 10명(16.7명), 2003년 11명(21.9명), 2004년 6명(13.4명)이었다. 3년간 도말양성 폐결핵 환자는 31명이 있었고 그 중 12명은 호흡기 증상 발생 30일이 지나서 진단을 받았다. 다제내성 결핵은 2명이 있었으며 결핵의 집단발병이 의심되는 사례는 2차례 있었다. 결론 : 전경대원과 20-29세 연령군 일반인의 결핵 신환발생률, 도말양성 폐결핵 발생률의 통계적으로 유의한 차이는 없었다.

히스토아크릴을 이용한 십이지장 궤양 출혈의 지혈 후 발생한 급성췌장염

유재훈,문원,노지훈,구동영,조영화,김기수,윤준모 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.1

Upper gastrointestinal bleeding is common and potentially life threatening medical emergency. Emergency endoscopy is the first choice of diagnostic and treatment measure for patients with active upper gastrointestinal bleeding. Histoacryl should be considered a second-line treatment modality when conventional treatments were failed. However, it might cause several complications. Herein, we report a case of acute pancreatitis developed after histoacryl injection therapy for active duodenal ulcer bleeding. A 71-year-old man was admitted with melena and hematemesis. On emergency endoscopy, a 2 cm sized active ulcer with bleeding from an exposedvessel was seen at the duodenal bulb. Attempts to arrest the bleeding with hemoclipping and submucosal epinephrine injection were tried, but failed. We changed the method to endoscopic histoacryl injection, and obtained hemostasis immediately. A few hourslater, after successful hemostasis, patient complained diffuse abdominal pain. Ultrasonography revealed hyperechoic heterogenous diffuse pancreatic enlargement and right pararenal space fluid collection, this ultrasonographic findings and elevated serum pancreatic enzymes are compatible with acute pancreatitis.

측백나무 추출물의 Monoamine Oxidase 저해활성

이문순,오지훈,이학수 忠北大學校 農業科學硏究所 2012 農業科學硏究 Vol.28 No.2

Monoamine oxidase (MAO) exists in the outer membrane of mitochondria and contained a flavin adenine dinucleotide (FAD). MAO is classified into two forms, A-type (MAO-A) and B-type (MAO-B) on the basis of their different specifications toward substrates and inhibitors. This study was carried out to identify inhibitory components on MAO from Thuja orientalis seed extract by bioassay- guided isolation. The seeds of Thuja orientalis was extracted with 80% MeOH, and the MeOH extract was fractionated with n-hexane, chloroform, ethylacetate and n-butanol successively. The n-hexane and chloroform fraction showed relatively high inhibitory activity on MAO. Among the fractions from n-hexane layer through silicagel column chromatography, the fractions 2, 3 and 4 showed strong inhibitory activity on MAO

소리쟁이 뿌리의 Monoamine Oxidase(Mao)활성 저해성분

오지훈,이문순 忠北大學校 農業科學硏究所 2012 農業科學硏究 Vol.28 No.2

The roots of Rumex crispus was extracted with 70% MeOH, and the MeOH extract was fractionated with dichloromethane, ethylacetate and n-butanol successively. The relatively active dichloromethane fraction was divided into several fractions with silicagel column chromatography using by MAO inhibition assay. A non-glycosidic anthraquinone, emodin was isolated from the active fraction. The structure of emodin (1,6,8-trihydroxy-3-methyl anthraquinone) was determined based on NMR and MS spectroscopic data and other chemical evidence.

응축형 복합레진의 기계적 성질에 관한 비교연구

정지아,문주훈,고영곤 대한치과보존학회 2001 Restorative Dentistry & Endodontics Vol.26 No.6

The purpose of this study was to compare the mechanical properties of three condensable composite resins and one hybrid composite resin. The compressive strength, diametral tensile strength, Vicker's microhardness were tested for mechanical properties of condensable composite resins (SureFil, Ariston pHc, Synergy compact), and hybrid composite resin (Z 100). The tested materials were divided into four groups : control group - Z 100 (3M Co, USA), experimental group I- Ariston pHc, (Vivadent, Co., Liechtenstein) , experimental group II - SureFil (Dentsply, Co., U.S.A.) , experimental group III- Synergy Compact (Coltene, Co., Swiss) . According to the above classification, we made samples of SureFil, Ariston pHc, Synergy Compact, Z 100 with separable cylindrical metal mold. And then, we measured and compared the value of compressive strength, diametral tensile strength and Vicker's microhardness of each sample. The results were as follows : 1. In compressive strength, control group (Z 100) revealed the highest value (398.85±19.61MPa), and followed by SureFil (381.65±31.24MPa), Synergy compact (354.85±12.22MPa), Ariston pHc (308.60±36.88MPa). There were no significant differences between SureFil group and Z 100 group, whereas there were significant differences between SureFil group and Ariston pHc group (P<0.05) . 2. In diametral tensile strength, Synergy compact revealed the highest value (86.54±3.44MPa) and followed by SureFil (84.54±3.53MPa), Z100 (76.91±1.63MPa), Ariston pHc(60.34±6.95MPa). There were no significant differences between SureFil group and Synergy compact group 3. In microhardness, control group (Z 100)revealed the highest value (223.7 ±58.0Hv), and followed by SureFil (117.5±10.2Hv), Ariston pHc (116.2±11.9Hv), Synergy Compact (101.9±10.8Hv). There were no significant differences between Ariston pHc group and Synergy compact group Key words : Condensable composite resin, Compressive strength Diametral tensile strength, Vicker's microhardness

공공스포츠센타 참가 주부의 레저만족과 생활만족의 관계

이승훈,배성민,문근석,유미진,이지훈 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.2

The purpose of this study was to define the relationship between housewife's practical physical education activity, leisure satisfaction and life satisfaction. For achieving the purpose, an analysis was made over the impact of attendance at public sports center on leisure satisfaction, the influence of attendance at public sports center on life satisfaction, the relationship of leisure satisfaction to life satisfaction for those who joined public sports center, and the impact of an experience of taking part in public sports center on life satisfaction. The instruments used in this study were Beard and Ragheb(1980)'s Leisure Satisfaction Scale(LSS) and Diener, Emmoson, Larsen, and Griffin(1985)'s Satisfaction with Life Scale(SWLS) adapted for this study. The statistical technique employed to analysis of variance and multiple regression analysis. The findings of this study were as below: First, the housewives who attended public sports center was significantly different in leisure satisfaction from one another according to personal characteristics. A significantly better leisure satisfaction was expressed by the group that was less educated, was older, had less than 3,000 thousand won of family income, was in very good health, chose golf, or responded to seeking more meaningful life. For job, the unemployed group was slightly higher in leisure satisfaction than the employed. Second, the personal characteristics also made a significant difference to the life satisfaction of the housewives who attended public sports center. Especially, a significantly higher life satisfaction was shown by the group that was older, had less than 3,000 thousand won of family income, was in very good health, chose golf was a little higher in life satisfaction than the unemployed. But education level generated no significant difference. Third, there appeared a close relationship between the housewives' leisure satisfaction and life satisfaction and life satisfaction who attended public sports center. Fourth, when the experience of attending public sports center was considered, the housewives with more than 3-year experience, who weren't expected to drop out in the practical physical education program, expressed significantly higher leisure satisfaction and life satisfaction. As this study found that the group that had participated in practical physical education program in public sports center for more than 3 years expressed better life satisfaction, it can be concluded that practical physical education can serve to raise housewife's leisure satisfaction and life satisfaction who joins public sports center.

폐렴 구균(Streptococcus pneumoniae)에 의한 척수 경막외 농양 1예

이지영,위유미,손경목,기현균,문치숙,오원섭,백경란,송재훈 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

폐렴구균은 보통 폐렴이나 뇌막염을 일으키는 균으로 척수 경막외 농양을 일으키는 경우는 매우 드물다. 본 저자들은 폐렴 구균에 의한 척수 경막 외 농양을 경험하여 보고하는 바이다. 과거 건강했던 36세 남자 환자로 사다리에서 낙상한 후 요통 및 고열, 신경학적 이상으로 내원하여 자기 공명 촬영 결과 척수 경막 외 농양으로 진단받고 항균제 투여와 함께 응급 수술을 시행하였다. 농 배양 결과 페니실린 감수성인 폐렴 구균이 분리 되었고, 수술 요법과 항생제 투여 후 농양은 치유되었으나 신경학적 이상은 호전 없는 상태로 타원으로 전원되었다. Pneumonia and meningitis are the most frequent manifestations of pneumococcal infections. Pneumococcal spinal epidural abscesses have been rarely reported. Spinal epidural abscess by Streptococcus pneumoniae has been diagnosed among the patients with diabetes mellitus, alcoholism, corticosteroid therapy, intravenous drug use, chronic renal failure, AIDS, and history of spinal surgery. Recently, we experienced a case of pneumococcal spinal epidural abscess after spinal trauma. A 36-year-old male patient was admitted with back pain, fever, and paraplegia which occurred 5 days after the trauma. Spine MRI revealed spinal epidural abscess at the level from T2 to T9. He was treated with antimicrobial agents and surgical exploration for spinal epidural abscess. Pus culture grew S. pneumoniae which was susceptible to penicillin. Despite early surgical treatment, neurologic sequelae remained. Considering the high mortality and morbidity of pneumococcal spinal epidural abscess, early diagnosis and aggressive treatment including surgical intervention and antibiotics therapy should be implemented immediately.

Lesch-Nyhan 증후군 환아의 자해 예방 : A CASE REPORT

이지현,김지훈,김재문,정태성,김신 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.2

Lesch-Nyhan 증후군은 purine의 대사장애를 보이는 질환이다. 신생아에서 대략 1:100,000 정도의 이환율을 보이는 X염색체 열성 유전 질환으로 남자에서 흔하며, purine의 대사에 관여하는 효소인 hypoxanthine guanine phospho ribosyl transferase(HGPRT)의 결손 또는 활성 감소 결과, 과도한 요산 형성 및 과요산혈증(hyperuricemia)이 일어난다. 이 질환은 임상적으로 정신지체, 무도증(choreoathetosis), 경련성 뇌성 마비, 심각한 자해 행위가 특징이다. 이 중 자해행위는 입술과 혀, 손가락을 깨무는 경우가 흔하고, 혀와 손가락이 완전히 절단될 수도 있다. 이 경우 자해로 인한 통증뿐 아니라, 상처 부위로의 2차 감염 및 연조직 결손으로 인한 심미성이 문제가 된다. 본 증례는, 상하악 유전치의 입술 깨물기 습관에 의해 하순이 심하게 손상된 Lesch-Nyhan 증후군 환아로서, mouth guard를 이용한 보존적인 방법과 소아정신과와의 협진을 통한 신경학적 약물치료로 자해에 의 한 손상을 방지하여, 단기간에 비교적 만족할 만한 결과를 얻었기에 이를 보고하는 바이다. Lesch-Nyhan syndrome is a rare disorder of purine metabolism, first described in 1964. The incidence is estimated to be 1:100,000 birth. It is an X-linked recessive disorder in which affected males have a virtually complete deficiency of the enzyme hypoxanthine guanine phosphorybosyl transferase(HGPT) . This enzyme deficiency gives rise to excessive uric acid production and consequent hyperuricemia. Lesch-Nyhan syndrome is clinically characterized by mental retardation, choreoathetosis, spastic cerebral palsy, and severe self-mutilation behavior. Patient with Lesch-Nyhan syndrome mostly bite their lip, tongue and finger. In severe cases, partial or total amputation of the lip and tongue is common. Self-inflicted bites are often further complicated by secondary infection to injuried site as well as pain. And tissue loss by biting results in esthetic problems. This report presents a Lesch-Nyhan syndrome patient with self-mutilation, who have a destruction of perioral tissue, especially the lower lip. He was treated successfully with soft mouth guard, psychological and pharmacological method.

TV 스포츠프로그램에 관한 고찰

이승훈,배성민,문근석,유미진,이지훈 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.2

Nowadays, watching sports on TV is becoming a frame in the act of culture. Sports news, sports broadcast, and other programs that has relations with sports are developing not only with the quality of modern people but also with the relations of broadcasting company. This study aims at examining the way of studying TV sports programs and the influence of TV sports programs. It could be said that sports and television programs on sports have not been offered in-depth discussion and empirical exploration in the academic world so for, although their social influence is considerable. We firstly look over the meaning of mass media and then, we go into the study about mass media and sports. TV sports program takes social function, therefore, many theories is being used to study TV sports program. "Cultivation theory" and " Uses and gratification Approaches" are the main theories of the study on TV sports programs. At the first glance, the Cultivation Theory, which empirically analyzed the symbolic function of television as social ideological institution, and the Uses and Gratification Approaches, which contend the media audience are active rather than passive recipients, seem to be contradictory. However, if we look at the relationship between the mass media and audience not as one-way but as interactive process, it could be suggested that combining those two different theoretical worlds will be useful.

상아질 접착제의 중합 시간 조절에 따른 복합레진의 중합 수축 방향의 변화

배지현,오명환,김창근,손호현,엄정문,조병훈,권혁춘 대한치과보존학회 2001 Restorative Dentistry & Endodontics Vol.26 No.4

The purpose of this study was to evaluate the effect of adhesive curing timing on the direction of polymerization shrinkage of light-curing composite resin. In this study, the curing times of adhesive and composite resin were measured by differential scanning calorimeter(DSC). 28 extracted human molars were embedded in clear resin and box-type cavities were prepared. Based on DSC data. the experimental teeth were divided into 4 groups. Group 1: no bond: Group 2: late curing: Group 3: Intermediate curing: Group 4: Early curing. After treating with adhesive, the buccal cavities were filled with Z-100 hybrid composite resin and the lingual ones were filled with AEliteflo flowable composite resin. The depressions at the surface were measured by surface profilometer, then the specimens were embedded in clear resin and sectioned. Impressions were obtained and used to get epoxy resin replicas. The epoxy replicas were gold-coated and observed under SEM. Average Maximum Gap(AMG), Gap Proportion(GP), Average Marginal Index(AMI) were used to compare the shrinkage gap of each group. The results were statistically analyzed using the Kruskal-Wallis One Way ANOVA, Student-Newman-Keuls method. The results of this study were as follows. 1. Average Maximum Gap. Gap Proportion, Average Marginal Index and depression at the surface of Z-100 hybride composite resin were smailer than those of AEliteflo flowable composite resin(P(0.05) 2. When the bonding between composite resin and tooth structure was strong, the shrinkage gap was small, and depression at the surface was deep(P<0.05). 3. In the well-bonded group. light-curing composite resin shrank toward bonded cavity wall. not toward light source. The result suggested that the direction of polumerization shrinkage was affected by the quality of bonding in the dentin-resin interface. The strong was the bonding between composite resin and tooth structure, the smaller was the gap and the deeper was the depression at the surface. Then the flow to compensate the polymerization shrinkage proceeded from surface to bonded cavity wall.