Acriflavine-Guanosine 복합제 (AG60)의 조직내 분포에 대한 형광현미경적 연구

고정식,임수재,안의태,김진국,김상건,이경영,강종구,홍은경,정영신,유보림,한영복 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.1

장상피화생과 Helicobactor pylori와의 상관 관계에 관한 연구

이복희,김대수,이현숙,진영주,윤세진,송형근,성노현,정현용,이동호 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

In 1965 Lauren divided advanced gastric carcinoma into two main types-namely, "intestinal" and "diffuse" type carcinoma, which differ not only morphologically but also in their clinical and epidemiological characteristics. Moreover, a different histogenetic process has been postulated by many authors that intestinal type gastric carcinoma might arise from areas with intestinal metaplasia. Since Warren and Marshall reported the presence of Helicobacter pylori in the stomach in 1983, strong evidence has been obtained that there is a close relationship between Helicobacter pylori and chronic gastritis, atrophic gastritis, intestinal metaplasia, and intestinal type gastric carcinoma. To study the relationship between intestinal metaplasia and Helicobacter pylori infection, we performed gastroscopic biopsies and CLO tests taken from patients with epigastric pain. Only 87 patients with macroscopically suspected antral gastritis were included. The prevalence of intestinal metaplasia in gastric antral biopsies increased from 33.3% in the age group<30 years to 63.6% in the age group 60 years. When all patients were divided into two age groups-namely, (i)<50 years(n=41) and (ii)≥ 50 years(n-=46), intestinal metaplasia was found significantly more often in patients ≥ 50 years. ((i) 39.2%, (ii) 54.3%, p<0.0001). The prevalence of Helicobacter pylori in gastric antral biopsies decreased from 66.7% in the age group<30 years to 62.5%, in the age group in the age group 50 to 59 years. When all patients were divided into the same two age groups-namely(i)<50 years and (ii)≥50 years, the prevalence of Helicobacter pylori did not differ between two groups in a statistically significant way. The mean age of intestinal metaplasia positive patients who were also Helicobacter pylori positive was 48±11.0(mean±S.D.)years, whereas the mean age of intestinal metaplasia positive patients who were Helicobacter pylori negative was 52±9.7(mean±S.D.)years. In conclusion. although our data do not prove a causal relationship between Helicobacter pylori infection and the histogenesis of intestinal metaplasia, we suggest that Helicobacter pylori plays an important role in the development of intestinal metaplasia in the gastric mucosa. Whether Helicobacter pylori has to be present at all times during this process or is only necessary as a 'trigger', needs further research.

Poly(perfluoroalkyl acrylate)/Silica 나노복합체의 표면이행성 연구

범정철,하종욱,이광원,박인준,소원욱,이수복 한국공업화학회 2003 응용화학 Vol.7 No.2

Surface migration of Poly(perfluoroalkylethyl acrylate)(PFA)/silica nanocomposites added in poly(methylmethacrylate()(PMMA) was investigated by comparing before and after annealing. In this study, surface migration characterizations of PFA/silica composites were measured by SEM(Scanning Electron Microscopy) and contact angle measurement. Their surface free energies were calculated with contact angle data by geometric mean approximation. The contact angles were increased and the surface free energies were decreased, according to increasing the graft density of nanocomposites and decreasing the concentration of PMMA, respectively. It was confirmed that PFA/silica nanocomposites were successfully migrated toward the surface of the PMMA film.

時變磁界 測定用 센서에 관한 硏究

이복희,백용현,박형기,정승수,전덕규 경북대학교 센서기술연구소 1992 센서技術學術大會論文集 Vol.3 No.1

소그룹 신체활동이 치매노인의 인지기능에 미치는 영향

김정기,김한수,정복희 고령자.치매작업치료학회 2008 고령자.치매작업치료학회지 Vol.2 No.2

목적 : 본 연구는 치매노인의 신체활동프로그램을 만들어 소그룹에서 규칙적으로 시행하여 신체활동이 치매노인의 인지기능과 삶의 질 향상에 미치는 영향을 알아보고자 한다. 연구방법 : 최경도-경도치매 노인 6명을 대상으로 2007년 9월부터 11월까지 12주간, 주 3회 40분씩 자체에서 만들어진 10가지 신체활동프로그램으로 시행하였다. 치매 노인에서 신체활동 시행 전후에 간이정신 상태평가(MMSE-K), 인지기능검사(LOTCA-G)와 삶의질척도검사를 평가하였다. 연구결과 : 신체활동 시행 후 MMSE-K의 총점에서 유의적인 변화를 보였으며(P<0.05), LOTCA-G의 경우 도형인식, 신체지적인식에 변화가 없으며 다른 항목들에서 신체활동 시행 후에 증가하였다. 삶의 질에 경우 전체총점에서 시행 후에 유의적인 변화가 있었으며(P<0.05), 세부항목에서 만족도의 질적인 변화를 보였다. 결론 : 치매 노인에 대한 신체 활동프로그램을 통해 신체기능의 개선과 인지기능의 증가로 일상생활활동의 독립성을 증가시키고 노인들의 삶의 질 향상에 유용한 치료적 접근방법이라는 것을 알 수 있었다. Objective : The present study purposed to make a physical activity program for demented elderly people, execute the program regularly in small group, and examine the effects of physical activities on improvement in demented elderly's cognitive functions and quality of life. Method : For six elderly persons with very mild or mild dementia, we executed 10 kinds of self-devel-oped physical activities for 12 weeks from September to November, 2007, 3 times per week, and 40 minutes each time. Before and after the physical activities, the old adults were tested with Mini-mental State Examination for Koreans (MMSE-K), Lowenstein Occupational Therapy Cognitive Assessment (LOTCA-G), and quality-of-life scale. Result : After the physical activities, the subjects showed significant changes in the total score of MMSE-K (P<0.05). In case of LOTCA-G, visual identification of shapes(VS) and direction in front(DF) did not change, but other items increased after the physical activities. For quality of life scale, a significant change was observed in the total score after the physical activities (P<0.05), and qualitative changes were observed in subcategory satisfaction. Conclusion : The reesults of this study show that a physical activity program for demented elderly people is a useful therapeutic approach by enhancing the edlerly's independence in activities of daily living and their quality of life through improving their physical and cognitive functions.

건드릴가공의 절삭성에 대한 연구〔Ⅰ〕

李守鍾,鄭英得,朴相福 釜山工業大學校 1990 論文集 Vol.32 No.-

Gundrilling is a key process in deep hole machining which for example, occupye 20~30 percentage on the mild die machining. Recently, according to popularization of NC machine and machining center, Gundrilling's high efficient processing is powerfully required. This paper deal with enperimental research on the machinahility of gundrilling. We obsersed on the cutting power and variety of machined hole diameter in case various materials such as SM20C SM45C SUS304 and gundrill's configurations and cutting oil. The main results are obtained as follows : 1. Machining torque and thrust are well approached MILTON C, SHAW'S theorectical eq. at feed range 0.015~0.02mm/rev. 2. Total machining condition is good at feed range 0.015~0.02mm/rev. 3. Mean hump ratio is founded 1.47~16 in torque 1.03~2.27 in thrust. 4. When gundrill's cutting angle is near 30。-20。removal chip is normally formed.

표면중합을 이용한 초발수 복합입자의 제조 및 표면특성 : 중합시간의 영향 The Effect of Polymerization Time

범정철,하종욱,박인준,김정훈,이수복,ShiYuan, Cheng 한국공업화학회 2003 응용화학 Vol.7 No.2

This study investigates the preparation of poly(perfluoroalkyl acrylate)[PTA]/silica composite particles by surface polymerization and their characteristics according to surface polymerization time. The particles were prepared by "grafting-from" technique by immobilizing self-assembled initiator and surface radical polymerization from silica particle surface. Characterization was done by contact angle and sliding angle measurements, surface roughness measurement and surface free energy estimation Contact angle were inversely proportion to sliding angle. Graft density(GD) and contact angle of composites increased according to polymerization time. On the other hand, surface free energy and sliding angle were decreased according to increment of polymerization time.

통조림용 가다랑어육의 식품성분

오광수,김정균,김인수,이응호,김복규 國立統營水産專門大學 附設 水産科學硏究所 1990 수산과학연구소보고 Vol.2 No.-

가다랑어 혈합육을 보다 효율적으로 이용하기 위한 일련의 기초연구로서, 가다랑어 혈합육의 지질성분, 함질소엑스분 및 구성아미노산 등을 보통 육과 함께 분석하여 비교, 검토하였다. 보통육은 혈합육에 비해 수분, 조단백질 함량은 약간 많은 반면, 조지방과 회분 함량은 혈합육이 약간 많았다. 휘발성염기질소량은 보토육이 22.7mg/100g, 혈합육이 46.9mg/100ㅎ으로 혈합육이 보통육에 비해 선도저하가 훨씬 빨랐다. 보통육과 혈합육의 총지질 조성은 각각 중성지질 79.7%, 71.9%, 당지질, 6.8%, 9.5%, 인지질13.5%, 18.6%로 이루어져 있었다. 중성지질의 성분은 free fatty acid ac triglyceride, 인지질은 phosphatidyl ethanolamine, phosphatidyl, 인지질은 phosphatidyl choline이 주성분이었고, lysogud 인지질의축적도 확인되었다. 총지지르 중성, 당 및 인지질의 축적도 확인되었다. 종지질, 중성, 당 및 인지질의 지반산 조성에서 보통육은 16:0 및 18:1을 주체로 한 포화산 및 모노엔산의 조성비가 혈합육보다 높았으며, 혈합육은 폴리엔산, 특히 22:6의 비율이 월등히 높았다. 16:0. 18:0, 18:1, 20:5 및 22:6 등이 주요 구성지방산이었다. 유리아미노산의 조성은 총함량에서 보통육 쪽이 많았고, 보통육에는 histidine, 혈합육에는 tauring의 보통육에서는 680.9mg.100g 정도 전존해 있었으나, 혈합육에서는 IMP의 분해가 급속히 진행되어 73.1mg/100g에 지나지 않았다. TMAO 및 TMA는 보통육에 비해 혈합육에 휠씬 많이 함유되어 있었고, total creatinine은 보통육 쪽이 많았다. 구성아미노산의 조성은 양시료 간에 별차이가 없었고, glutamic acid, aspartic acid, lysine, leucine, alanine, isoleucine 및 arginine 등이 주요 구성아니노산이었다. The lipid components, nitrogenous extracts and amino acids of dark muscle(DM) of skipjack (Katsuwonus pelamis) were analyzed and compared with those of white muscle(WM). WM was higher in moisture and crude protein content, and lower in crude lipid and ash content than those of DM. Contents of volatile basic nitrogen in WM and DM were 22.7mg/100g and 46.9mg/100g. Total lipid(TL) of WM and DM consisted of 79.7%, 71.9% neutral lipid(NL), 6.8%, 9.5% glycolipid(GL), and 13.5%, 18.6% phospholipid(PL), respectively. NL was mainly composed of free fatty acid, triglyceride, and PL was mainly occupied by phosphatidyl ethanolamine, phosphatidyl choline. Also lysophosphatidyl choline and lysophosphatidyl ethanolamine were identified in PL. In fatty acid composition of TL, NL, GL and PL, WM revealed higher contents in saturates and monoenes such as 16 : 0, 18 : 1, while DM showed higher contents in polyenes such as 22 : 6 especially. The major fatty acids of these samples were generally 16 : 0, 18 : 0, 18 : 1, 20 : 5 and 22 : 6. Contents of total free amino acids from WM and DM were 5,982.3mg/100g and 4,450.7mg/100g (dry base). Of free amino acids, Tau concentration was much higher in DM than in WM, Ala, Gly, Met, Arg, Thr were also high in DM. But His was much higher in concentration in WM. Content of inosinic acid(IMP) in WM(680.9mg/100g) was higher than that of DM(73.1mg/100g). The degradations of IMP proceeded very rapidly in DM. DM contained much higher trimethylamine oxide and trimethylamine than those of WM. The profile of combined amino acids in these samples were very similar, and main amino acids were Glu, Asp, Lys, Ala, Ile and Arg.

PFA / Silica 유-무기 복합체의 제조 및 표면특성

범정철,하종욱,박인준,이수복 한국공업화학회 2003 응용화학 Vol.7 No.1

Poly(perfluoroalkyl acrylate)(PFA) / silica composites having different silica size were prepared by surface polymerization. In this study, surface characterizations of PFA/silica composites were done by HR-TEM(High Resolution Transmission Microscopy), contact angle measurement, sliding angle measurement, surface roughness measurement, and the relationships between the sliding angle and the contact angle were investigated. In the highly hydrophobic region, the sliding angles of water droplets decreased with increasing contact angle. Their surface free energies were calculated with contact angle data by geometric mean approximation. The composites with super water repellent and sliding could be obtained with contact angle of above 150。and sliding angle of below 10。to water droplets. The ultimate value of surface free energies of the composites reached below ca. ldyn/cm.

불소함유 지문방지제 합성

차미선,범정철,하종욱,박인준,소원욱,이수복 한국공업화학회 2004 응용화학 Vol.8 No.2

The anti-fingerprint coating agents, consist of a fluorinated macromer(F-macromer) were prepared by marcromonomer technique and hydrosilation reaction. The products were characterized by ¹H-NMR, differential scanning calorimetry. The surface properties of the anti-fingerprint coating agents were investigated by the contact and sliding angle measurement. The modified surface with the anti-fingerprint coating agents showed the extremely low surface free energy of a 10.09 dyn/cm and the sliding angle was smaller than that of commercial products. That is, The synthesised coating agents can be the good candidate for the water and oil repellent, soil release and anti -fingerprint application coating agent.