http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
사람 비만세포주에서 Clozapine과 Fluoxetine에 의한 케모카인 및 케모카인 수용체의 상이한 발현
유영민,김종우,조정제,임강현 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2
Objectives : It has been suggested that the immune system has a role in the pathophsiology of neuropsychiatric diseases. There are some reports that clozapine and fluoxetine affect on cytokine networks. Recently, it has been known that chemokines have chemotactic effect, and modulate a number of biological responses including the process of inflammation and the maintenance of CNS homeostasis. In the present study, we investigated the effect of clozapine or fluoxetine on the expression of chemokines and their receptors. Methods : Human mast cells(HMC-1) was incubated with phorbol myristate acetate(PMA, 100ng/㎖) and calcium ionophore A23187(350ng/㎖) for 3 hours. Colzapine(10^-7M) or fluoxetine(10^-7M) were pretreated for 1 hour. RT-PCR was performed for the detection of expression of various chemokines and chemokine receptors. Results : after treatment of clozapine, the expression of MCP-1, MIP-1β, CCR3,CXCR2, CXCR3 and CXCR4 were lower than the PMA/Ca ionophore-treated group, while the expression of MIP-1α, RANTES and IL-8 were not changed. However, fluoxetine was not affected the changes of expression of various chemokines and chemokine receptors. Conclusion : This result indicates that clozapine may affect on the expression of chemokines and chemokine receptors. Therefore, this study could, in part, provide the important basic data on the explanation of side effects of clozapine, such as fever and pancreatitis.
9-12%Cr강의 첨가원소 및 열처리에 따른 미세조직거동과 경도변화
주성욱,유정훈,신기삼,허성강,이재현,석진익,김병훈,김정태 국립7개대학공동논문집간행위원회 2004 공업기술연구 Vol.4 No.-
9-12%Cr steel are getting increasing attention for expanded application as high temperature materials applicable for gas turbine compressors, steam turbine rotors, blade and casing. For efficient and extensive application of 9-12%Cr steel, the data in addition to the improvement of mechanical properties on the correlation of microstructural evolution and mechanical properties are inevitable and thus the investigation in this study is performed for the determination for the specimens heat-treated at 600, 650 and 700℃ for 1000, 3000 and 5000hrs. The microstructure of as-received specimen was tempered martensite, with a high dislocation density and secondary phases. Upon high temperature heat-treatment, the martensite lath got larger and dislocation density decreased resulting the reduction of the strength. In addition, sharp growth of secondary phases was observed in the specimen heat-treated at 700℃ for 5000hrs. A specimen aged at 600℃ and 650℃ Laves phase was observed. The hardness showed close relationship with the secondary phase particle and dislocation density.
麻黃의 사람 비점막 섬유아세포 monocyte chemotactic protein 중 MCP - 1 , MCP - 2 , 및 MCP - 3 분비에 대한 효과
김현미,이향숙,김정선,조정제,유영천,안현종,최훈,임강현 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1
Recent reports have proposed that Ephedrae Herba may modulate the immune response on allergy or asthma. Human nasal mucosal fibroblasts are a rich source cytokines, inflammatory mediators, and chemokines. Chemokines are important for the recruitment of leukocytes to sites of infection, which is essential in host defense. Objectives : The objective of this study was to investigate the effect of Ephedrae Herba on the release of the chemokines such as monocyte chemotactic protein(MCP)-1, MCP-2, and MCP-3 in human nasal mucosal fibroblasts after stimulation with cytokines like tumor necrosis factor -α(TNF-α), interferon-γ(IFN-γ), and interleukin -1β(IL-1β).
유명철,조윤제,김강일,전영수,고동오,이진웅 대한골절학회 2003 대한골절학회지 Vol.16 No.2
목 적 : 비구 골절 후 이차적으로 시행한 인공고관절 전치환술의 결과를 분석하고자 한다. 대상 및 방법 : 비구 골절의 치료로 보존적 치료 또는 관혈적 정복 후 이차적으로 고관절 전치환술을 시행한 20례를 대상으로 하였으며, 비구 골절 후 일차적으로 보존적 치료를 시행한 경우가 6례, 관혈적 정복 및 내고정술을 실시한 경우가 14례였다. 인공고관절 전치환술후 추시기간은 평균 5년 2개월이었다. 전치환술의 원인으로는 외상성 관절염 15례, 대퇴 골두 무혈성 괴사 5례였다. 사용된 기구로는 비구부에 무시멘트 비구컵 18례, 시멘트 비구컴 2례였고, 대퇴부는 무시멘스 스템 18례와 시멘트 스템 2례였다. 비구부의 결손은 13례에서 있었다. Harris 고관절 점수, 동통, 관절 운동범위와 양하지 부동 여부, 정기적인 방사선학적 분석을 하였다. 결 과 : Harris 고관절 점수는 술 전 평균 57점에서 91점으로 향상되었으며 술 전 13례에서 하지 부동을 보였으나 1례를 제외하고 모두 개선되었다. 최종 추시시 방사선적 검사상 골용해는 비구부 2례, 대퇴부 5례였고 삽입물의 해리는 비구부 2례, 대퇴부 1례 이었고 비구부 2례 모두 시멘트 컵을 사용하였던 경우였다. 재치환술은 비구컵 3례 (15%), 대퇴스템 2례(10%)에서 시행되었다. 결 론 : 비구 골절 후 시행된 인공고관절 전치환술은 비구의 해부학적 구조변형, 골결손 등으로 술 후 결과가 일반 고관절 전치환술보다는 만족스럽지 못하였으며, 따라서 비구부의 적절한 골 이식과 함께 비구컵 고정이 비구컵의 생존율을 연장하는데 중요한 요인으로 사료된다. Purpose: We evaluated the results of secondary total hip arthroplasty (THA) after acetabular fracture. Material & Methods: Twenty cases of THA were performed to treat acetabular fracture as secondary treatment after conservative management (6 cases) or internal fixation (14 cases). The mean follow up period was 5 years 2 months. The cause of secondary THA was post traumatic arthritis in 15 hips and osteonecrosis of the femoral of the femoral head in 5. Cementless acetabular cup was used in 18 cases and cemented in 2 cases. Cementless femoral componenet was used in 18 cases and cemeted in 2 cases. Serial Hariis hip score (HHS), pain, limb length discrepancy and radiographs were evaluated. Results: HHS improved from 57 points to 91 points. Osteolysis in the acetabular component occurred in 2 cases and 5 cases in the femoral component. Loosening occurred in 2 cases of cemented acetabular components and 1 case in the femoral component. In this study, 3 cases (15%) required revision of the acetabluar component and 2 cases(10%) of the femoral component. Conclusion: The clinical results of THA after acetabular fracture was inferior to that of conventional arthroplasty. The secure cementless acetabular fixation with proper bone grafting is mandatory to improve the survival of acetabular component.
Magnetic resonance imaging of the canine brain at 7 T.
Kang, Eong-Teck,Ko, Ki-Jin,Jang, Dong-Pyo,Han, Jae-Yong,Lim, Chae-Young,Park, Chul,Yoo, Jong-Hyun,Kim, Ju-Won,Jung, Dong-In,Kim, Young-Bo,Woo, Eung-Je,Cho, Zang-Hee,Park, Hee-Myung The College 2009 Veterinary Radiology and Ultrasound Vol.50 No.6
<P>The purpose of this study was to describe relevant canine brain structures as seen on T2-weighted images following magnetic resonance (MR) imaging at 7 T and to compare the results with imaging at 1.5 T. Imaging was performed on five healthy laboratory beagle dogs using 1.5 and 7 T clinical scanners. At 1.5 T, spin echo images were acquired, while gradient echo images were acquired at 3 T. Image quality and conspicuity of anatomic structures were evaluated qualitatively by direct comparison of the images obtained from the two different magnetic fields. The signal-to-nose ratio (SNR) and contrast-to-noise ratio (CNR) were calculated and compared between 1.5 and 7 T. The T2-weighted images at 7 T provided good spatial and contrast resolution for the identification of clinically relevant brain anatomy; these images provided better delineation and conspicuity of the brain stem and cerebellar structures, which were difficult to unequivocally identify at 1.5 T. However, frontal and parietal lobe and the trigeminal nerve were difficult to identify at 7 T due to susceptibility artifact. The SNR and CNR of the images at 7 T were significantly increased up to 318% and 715% compared with the 1.5 T images. If some disadvantages of 7 T imaging, such as susceptibility artifacts, technical difficulties, and high cost, can be improved, 7 T clinical MR imaging could provide a good experimental and diagnostic tool for the evaluation of canine brain disorders.</P>