Flavobacterium meningosepticum에 의한 균혈증 1예

장성원,유진홍,진승원,김선우,김연식,박순민,이대훈,최민호,최주연,신완식,강문원,강지민 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.1

1996년 6월 카톨릭대학교 부천성가병원에 뇌경색으로 입원했던 61세 남자 환자의 혈액에서 Flavobacterium meningosepticum을 분리하였다. 환자는 폐렴을 동반한 패혈증의 예로 ceftriaxone과 metronidazole을 투여하였으나 입원 48시간만에 사망하였다. Flabovacterium meningosepticum is a rae cause of nosocomial infection which shows multi-drug resistance. It mainly invades patients with impaired immunity. Recently, we experienced a case of F. meningosepticum bacteremia in a patient with chronic debilitated state owing to stroke. The clinical progress was so rapid that he died within 48 hours. Blood culture revealed F. meningosepticum which showed characteristic yellow colony in blood agar plate.

인진쑥 배지에서 배양한 노루궁뎅이버섯 균사체 추출물(HEAC)의 알코올 대사촉진 활성

최원식(Choi, Won-Sik),장도연(Jang, Do-Yoen),차경민(Cha, Kyung-Min),박천규(Park, Chun-Kyu) 한국산학기술학회 2008 한국산학기술학회논문지 Vol.9 No.1

인진쑥 배지에서 배양한 노루궁뎅이버섯(HEAC), 노루궁뎅이버섯과 인진쑥 추출물들의 음주 후 체내 알코올 농도의 감소 효과를 확인하였으며, 또한 혈중 알코올 탈수소효소 및 아세트알데히드 탈수소효소의 활성을 조사하여 알코올 분해 활성을 조사하였다. 체내 알코올 농도 측정결과 HEAC의 경우 170분, 노루궁뎅이 버섯 추출물은 210 분후에 혈중 알코올이 검출되지 않았다. 또한, HEAC는 알코올 탈수소효소 활성에서 대조군 보다 시간에 따라 154%, 노루궁뎅이버섯 추출물은 148%로 비교적 높은 활성을 나타내었다. 아세트알데히드 탈수소활성에서는 HEAC와 노루궁뎅이버섯 추출붙이 대조구에 비해 104~111%이상의 효소활성이 유지되는 것을 확인하였으며 이들 추출물들은 알코올 분해 촉진작용이 매우 우수함을 알았다. Alcohol concentration in the blood was effectively decreased by extracts from Hericium erinaceum hypha cultivated with Artermisia capillaris medium(HEAC), Hericium erinaceum hypha and Artermisia capillaris after dirnking. Also, the activities of alcohol dehydrogenase and acetaldehyde dehydrogenase in the blood was studied. As a result of testing an alcohol concentration in the blood, the alcohol in the blood was not detected after 170 min. in case of HEAC and after 210 min. in case of Hericium erinaceum. Compared to control, each activities of alcohol dehydrogenase of HEAC and Hericium erinaceum hypha was showed up to 154% and 148% respectively. The activities of the acetaldehyde dehydrogenase of both extracts from HEAC and Hericium erinaceum was maintained in the range of 104 to 110% compared to control. In conclusion, such extracts represent significant effect to facilitate decomposition of alcohol.

태양광 발전 시스템 적용을 위한 관공서 전력 에너지 소비량 분석

장민호,김현진,홍원화 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

The purpose of this study was to gather and categorize the data of electrical energy sources for public office buildings in Taegu, South Korea. The fossil energy sources are not enough for all of us, as we know, to use. In a few days, it will be hard to utilize or find them neither under the earth nor the sea or around the world. New energy sources should be recommended and solar energy has been referred to substitute these limited sources. Prior to studying solar energy sources applied to public office buildings, necessary data should be systematically surveyed and lined up. This research ,therefore, will be a very important foundation for studying next thesis, solar energy project.

환자안전 인식 향상을 위한 의과대학생 대상 환자안전 역할극 교육의 효과

이원,표지희,장승경,최은영,옥민수,조민우,이상일 건강보험심사평가원 2021 HIRA RESEARCH Vol.1 No.1

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정신병리적 언어행위의 형식적 특징규명을 위한 기초연구

민형원,홍성기,정승아,이장한,양병환 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 정신분열병집단과 정상집단의 사고형태의 차이를 언어철학적으로 접근하여 이해하고 이를 바탕으로 사고형태를 측정하는 도구를 개발하고자 한다. 방 법 : 1997년의 예비실험에서 얻은 결과를 중심으로 새로운 작품사진(具象, 抽象의 彫刻과 繪畵)을 약 50장을 선정한 후 반응의 용이성과 다양성을 기준으로 최종 10개의 작품을 실험도구로 결정하였다. 피검자는 1999년 2월부터 동년11월까지 대학병원 신경정신과에 입원한 24명(정신분열병)과 정상대조군으로 19명의 일반인들이 실험에 참가하였다. 피검자들은 제시되는 작품의 제목을 붙이도록 요구받았으며, 피검자의 세 가지 반응측면 즉 반응의 방식, 반응이 지칭하는 작품의 범위, 그리고 반응이 지칭하는 대상의 구체성 혹은 추상성 여부로 구분하여 전체 7가지 양상으로 기호화하였고 각 반응를 직접과 간접으로 구분하였다. 피검자에게 실험을 실시한 후 기호화하여 집단간 빈도분석을 실시하였다. 결 과 : 1) 정신분열병집단이 정상집단보다 직접속성, 단순기술의 반응이 많은 반면에, 정상집단의 경우 투사가 결합된 직접속성, 간접속성, 간접연상, 그리고 개념의 형성에 필요한 일반화가 많았다. 2) 제목과 이 제목이 지칭하는 작품의 범위관계에 대한 정신분열병집단과 정상집단의 반응빈도는 의미 있는 차이를 보이지 않았으나 두 집단 모두 작품의 부분보다는 전체를 보고 제목을 정하는 경향이 높았고, 비교적 정신분열병집단이 제목을 작품전체를 보고 단순하게 반응하는 경향이 있는 반면에 정상집단은 작품의 일부분을 보고 이를 일반화하는 경향이 많았다. 3) 정신분열병집단과 정상집단 모두 제목의 추상성보다는 구체성이 우세한 경향을 보였으나, 정신분열병집단(95.3%)이 정상집단(71.4%)에 비해서 보다 더 제목의 구체성이 두드러졌으며 정상집단(28.6%)은 정신분열병집단(4.7%)에 비해서 전체 반응빈도에서 제목의 추상성이 더 우세하였다. 4) 정신분열병집단이 정상집단보다 사고의 직접성이 더 높았고(73.5%), 정상집단은 사고의 간접성이 더 높았다.(58.7%). 결 론: 1) 정신분열병집단이 정상집단에 비하여 추론과정과 사고의 단계성이 없는 직접적이고 단순한 형태의 사고형태나 언어표현이 확연히 드러났다. 또한 정신분열병집단이 사물을 지각하고 이를 표현하는데 있어서도 사물의 전체를 보고 단순하게 반응하거나, 구체적이고 직접적인 표현이 많은 것으로 보인다. 2) 본 연구를 통해 개발된 실험도구를 좀 더 넓은 범위의 대상자에게도 반복 적용하여 연구함으로써 지속적인 신뢰도와 타당성을 높일 수 있을 것이다. 또한 개별적 차이에 대한 연구를 병행함으로써 개인간의 혹은 동일한 인물의 시간경과에 따른 사고방식의 차이를 검사할 수 있는 방법으로 정착될 필요가 있다. 3) 비록 양집단 사이의 확연한 차이에도 불구하고 실험도구의 신뢰성을 객관적으로 확보하기 위하여 사고형태 및 언어적 표현에 영향을 미치는 것으로 추정되는 지적능력, 교육연한, 그리고 문화적 경험을 좀 더 고려한 추가연구가 필요할 것으로 생각된다. Objective : The purpose of this study was to identify differences in thinking between schizophrenic patients and healthy subjects with linguistic-philosophical approach and to develop a tool to measure pathological thinking. Methods : Approximately 50 cards(pictures of either representational or abstract sculptures and paintings) from the previous experiment(1997) were carefully examined and 10 cards were selected based on their variety and promptness of the response. Twenty-four schizophrenic patients and 19 healthy subjects participated in this experiment. Participants were required to give a title to each picture. Their responses were analysed based on the forms of thinking, abstractness(or concreteness) and the category of the title. Each response was also coded either direct of indirect. Results : 1) Schizophrenic patients emitted more direct and simple descriptive responses whereas healthy subjects showed projection-related direct traits, indirect traits, indirect association and generalization. 2) Both groups tended to utilize the whole rather than parts. Schizophrenic group depended more on the whole pictures than healthy group. Healthy subjects showed more generalization tendency with parts. 3)Both groups preferred concrete titles to abstract ones. Schizophrenic group(95.3%) used more concrete titles than healthy group(71.4%) and healthy group(28.65%) used more abstract titles than schizophrenic group(4.7%). 4) Schizophrenic patients(73.5%) showed more directness in thinking than healthy subjects, whereas healthy subjects(58.7%) more indirectness. Conclusions : 1) Schizophrenic patients clearly showed direct and simple forms of thinking and expressive language, lacking reasoning, and systematic processing. Additionally, schizophrenic patients simply responded to the whole and used concrete and direct expression. 2) Replication study is warranted to improve reliability and validity of the tool we developed. Research on individual differences needs to be conducted to measure differences among individuals and change over time in an individual. 3) Further study on the factors which might be related to forms of thinking and language expressions, such as intelligence is warranted.

p-Anisaldehyde가 조골세포 분화에 미치는 영향

김경민 ․ 이도원 ․ 김현준 ․ 김아랑 ․ 장원구 대구대학교 산업기술연구소 2018 産業技術硏究 Vol.29 No.2

p-Anisaldehyde is a natural fragrance extracted from Pimpinella anisum L., and used as a preservative. This study examined the effect of p-anisaldehyde on osteoblast differentiation. First, cytotoxicity tests were carried out after examining the concentrations that did not show toxicity to the cells. The expression of osteoblast differentiation marker gene was confirmed by RT-PCR and was not effective in the treatment with p-anisaldehyde alone. However, p-anisaldehyde decreased the expression levels of inhibitor of differentiation-1 (Id1), distalless related homeobox (Dlx5), and runt-related transcription factor 2 (Runx2), which are osteogenic differentiation marker genes, which are increased in osteogenic condition. alkaline phosphatase (ALP) activity was also confirmed by ALP staining that p-anisaldehyde reduced ALP activity. These results show that p-anisaldehyde is effective in reducing osteoblast differentiation.

中學 科學敎育의 探究學習에 대한 評價問項 開發 (Ⅱ)

閔庚德,楊洪準,李善行,鄭遠佑,이병교,金裕漢,羅長薰 경북대학교 과학교육연구소 1985 科學敎育硏究誌 Vol.9 No.-

This study was accomplished to develope the evaluation items for inquiry learning in the 2nd grade Middle School Science for the consecutive study of the evaluation items for inquiry learning in the 1st grade Middle School Science(U-Hang Ki et al, 1984). In this study, paper and pencil test items and performance test items are made by analyzing the abilities of inquiry according to the contents and four basic experiments from each unit in the 2nd grade Middle school science. These evaluation items were applied to tke five classes of the 2nd grade of middle school to test their validity. It is desirable that performance test schuld be used for the evaluation for the abilities of inquiry which can not be evaluated by paper and pencil test. In the evaluation methods of performance test, tester evaluation, peer evaluation and self-evaluation can be applied to the science class in a multi-student class. In higher grade, however tester evaluation is more desirable than peer and self evaluation. It is found that peer evaluation and self-evaluation make possible the perfect study by feedback.

전류제어형 PWM컨버터를 이용한 동기발전기용 여자시스템에 관한 연구

장수진,류동균,서민성,김준호,원충연,이진국 성균관대학교 2003 학술회의지원논문목록집 Vol.2003 No.-

동기발전기 출력전압은 여자시스템의 계자전류 제어에 의해 일정하게 유지된다. 고주파 PWM 컨버터(전류제어모드 buck컨버더)형태의 여자시스템은 부하변동이 발생하였을 때 동기발전기의 계자전류를 제어하게 된다. 이 논문은 정상상태 및 과도상태에서의 안정화를 개선하기 위하여 여자시스템의 설계 및 실험에 대해 다루었다. 시뮬레이션 및 실험 결과는 제안된 여자시스템이 50kW 동기발전기의 DVR에 의해 응답시간이 개선되었음을 보여주었다. The output voltage of synchronous generator is regulated constantly by field current control in excitation system. High frequency PWM converter (current control mode buck conveter) type excitation system for synchronous generator is able to control exciter current when the load change happened. This paper deals with the design and evaluation of the excitation system for a synchronous generator to improve the steady state and transient stability. The simulation and experimental results show that the proposed excitation system is able to improve the response time by the DVR(digital voltage regulator) of 5O[kW] synchronous generator.

다발성 연조직 종괴를 동반한 급성 림프구성 백혈병의 증례 보고

장정용,허경회,이원진,허민석,이삼선,최순철 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.2

A 15-year-old patient, who had been diagnosed and treated as Burkitt cell type acute lymphoblastic leukemia (ALLL3) already, visited our department. He complained of gingival enlargement and loosening teeth 1 month ago. The clinical examination revealed anterior open bite, gingival enlargement, and nontender swelling particularly in molar regions of both jaws. Deep periodontal pockets and severe mobility was shown on most of the teeth. The panoramic radiographs showed severe bone destruction and extrusion of the molars. The contrast enhanced CT showed multiple enhanced mass and bone marrow obliteration in both jaws. Chemotherapy was done and the swelling was subsided at 1 month later. In conclusion, radiologic findings of leukemia with soft tissue mass, known as chloroma or granulocytic sarcoma, mimic those of lymphoma, so blood test may be needed for the final diagnosis.

고유함수전개법을 이용한 비대칭 유전체 원주공진기의 공진특성해석

류원열,민경호,장중호,전오곤,이창화,최현철 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

The resonant frequency of the dielectric rod resonator which is surrounded by cylindrical cavity can be calculated very exactly by using eigenfunction expansion method in the concept of electric and magnetic wall from the symmetry. But if the supporter is put in the cavity, the symmetry disappears. Thus this method has some errors. In this paper, the resonant frequency of the asymmetric dielectric rod resonator was calculated by using the eigenfunction expansion method. Also, the effect of the supporter was discussed. Then we found that the resonant frequency was more affected in the case of TM mode than TE or Hybrid modes as the length of the supporter was longer.