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식품중 중금속 규격 과학화를 위한 조사연구(Ⅲ) : 음료수의 중금속 향량에 대하여 Heavy metal contents beverages
김명철,김미혜,권기성,정소영,박성국,이윤동,이승훈,김은정,강민철,박효정 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-
본 연구는 국내에 유통되고 있는 음료류중 중금속 함량을 파악하여 식품공전 제 ·개정시 과학적 기초자료로 활용하고자 수행하였다. 출 2☞7여건의 음료류에 대하여 유도결합플라스마 분광기(ICP), 원자홉광광도 계(AAS) 및 수은분석기 등을 치용하여 납, 카드윰 등 중금속함량을 측정하였으며 그 결과는 다음과 같다 [단위 : min-ma)t(irran) ; mrk3 ; f : 0.0001-0.0025(0.0003), As :불검출곰.OB45(0.0003), Pb : 불검출-0.0893(0.0041),Cd ' 불검출곤.0064(0.0011), Cfl : 불검출.(i9(0.05), Mn : 불검출글.찌(0.16), Zn : 불검출-12.85(0.뽀), Sn :불검출-45.36(1.97). 본 조사결과 우리나라에서 유통되고 있는 음료류 중 납 등 중금속 함량은 외국의 모니터랑 결과와 유사하였다. 또한 우리나라 국민이 음료류를 통한 중금속 섭취량은 FAO/UTfO에서 설정한 잠 정주간섭취처용량의 약 0.OleO.06% 이하로 매우 낮았다. 편 연구조사에서 먼어진 결과는 음료류 중 납 기준 설정을 위한 중요한 기초자료로 활용할 수 있는 것으로 사료된다. This study was conducted to estimate the cantents of heavy netals in beverages and to fIFovide a scientific basis for heav)· meta3 standardizatior of Korea Food Code. The contents of rriercur17(Hg), lead(Pb), cadmium(Cd), arsenic(As), manganese(Mn),ziac(Zn), tin(Sn) and topper(Cu) were determined in a total of 20? samples of beverages usinga mercury anal!'zer, aromic absorption spectrophotometer(AAS) and inductiuety coupled plasmaspectrometer(fcpl. The vatues of heavy metals In beverages were as fellows (min-max (mean) , mg/krl , Hg : 0.DOOI-0.0095(0.0004), As : ND-0.0245(0.0003), Pb ND-0.0893(0.0041), Cd : ND-0.0064(0.0011),Cu : ND-1.69(0.03), Mn : ND-3.94(0.16), Zn ND-12.85(0.28), Sn : ND-45.36(1,97). Our results weresimilar to thofe reported by other countries. It is thought that our results could be utilizedimportant references toT es?ablish the standard of lead in beverages.
Outcomes of patients treated with Sengstaken-Blakemore tube for uncontrolled variceal hemorrhage
( Ja Yun Choi ),( Yun Won Jo ),( Sang Soo Lee ),( Wan Soo Kim ),( Hye Won Oh ),( Cha Young Kim ),( Eun Young Yun ),( Jin Joo Kim ),( Jae Min Lee ),( Hong Jun Kim ),( Hyun Jin Kim ),( Tae Hyo Kim ),( W 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.4
Background/Aims: The aim of this study was to investigate the mortality, bleeding control rate, and their associated predictors in patients treated with Sengstaken-Blakemore (SB) tube for uncontrolled variceal hemorrhage associated with hemodynamic instability or failure of endoscopic treatment. Methods: The clinical data of 66 consecutive patients with uncontrolled variceal hemorrhage treated with SB tube at Gyeongsang National University Hospital from October 2010 to October 2015 were retrospectively analyzed. Results: The overall success rate of initial hemostasis with SB tube was 75.8%, and the independent factors associated with hemostasis were non-intubated state before SB tube (odds ratio, 8.50; p = 0.007) and Child-Pugh score < 11 (odds ratio, 15.65; p = 0.022). Rebleeding rate after successful initial hemostasis with SB tube was 22.0%, and esophageal rupture occurred in 6.1%. Mortality within 30 days was 42.4%, and the related independent factors with mortality were failure of initial hemostasis with SB tube (hazard ratio, 6.24; p < 0.001) and endotracheal intubation before SB tube (hazard ratio, 2.81; p = 0.018). Conclusions: Since the era of endoscopic band ligation, SB tube might be a beneficial option as a temporary salvage treatment for uncontrolled variceal hemorrhage. However, rescue therapy had a high incidence of fatal complication and rebleeding.
Choo, Eun Jeong,Rhee, Yun-Hee,Jeong, Soo-Jin,Lee, Hyo-Jung,Kim, Hyun Seok,Ko, Hyun Suk,Kim, Ji-Hyun,Kwon, Tae-Rin,Jung, Ji Hoon,Kim, Jin Hyoung,Lee, Hyo-Jeong,Lee, Eun-Ok,Kim, Dae Keun,Chen, Chang-Yan Pharmaceutical Society of Japan 2011 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.34 No.1
<P>Anethole is known to possess anti-inflammatory and anti-tumor activities and to be a main constituent of fennel, anise, and camphor. In the present study, we evaluated anti-metastatic and apoptotic effects of anethole on highly-metastatic HT-1080 human fibrosarcoma tumor cells. Despite weak cytotoxicity against HT-1080 cells, anethole inhibited the adhesion to Matrigel and invasion of HT-1080 cells in a dose-dependent manner. Anethole was also able to down-regulate the expression of matrix metalloproteinase (MMP)-2 and -9 and up-regulate the gene expression of tissue inhibitor of metalloproteinase (TIMP)-1. The similar inhibitory effect of anethole on MMP-2 and -9 activities was confirmed by zymography assay. Furthermore, anethole significantly decreased mRNA expression of urokinase plasminogen activator (uPA), but not uPA receptor (uPAR). In addition, anethole suppressed the phosphorylation of AKT, extracellular signal-regulated kinase (ERK), p38 and nuclear transcription factor kappa B (NF-κB) in HT-1080 cells. Taken together, our findings indicate that anethole is a potent anti-metastatic drug that functions through inhibiting MMP-2/9 and AKT/mitogen-activated protein kinase (MAPK)/NF-κB signal transducers.</P>
김효정 ( Hyo Jeong Kim ),윤성훈 ( Seong Hoon Yun ),김미현 ( Mi Hyun Kim ),설희윤 ( Hee Yun Seol ),조우현 ( Woo Hyun Cho ),김지은 ( Ji Eun Kim ),김기욱 ( Ki Uk Kim ),박혜경 ( Hye Kyung Park ),전두수 ( Doo Soo Jeon ),김윤성 ( Yun Se 대한천식알레르기학회 2010 천식 및 알레르기 Vol.30 No.2
Ranitidine is a widely used H2 receptor antagonist that is usually well tolerated by patients. An anaphylactic reaction to ranitidine is rare. Here, we report a case of ranitidine- induced anaphylaxis. A 56-year-old man with a history of asthma and allergic rhinitis presented with generalized hives, facial edema, dizziness and abdominal pain that developed 20 minutes after taking one tablet of ranitidine 2 weeks earlier. The skin prick test with ranitidine was positive. The oral challenge test with ranitidine resulted in hive, angioedema and hypotension 5 minutes after taking ranitidine 150 mg. Skin prick tests and intradermal tests with famotidine and pantoprazole were negative. Although the incidence of anaphylactic reaction induced by ranitidine is rare, clinicians should be aware of this adverse reaction. (Korean J Asthma Allergy Clin Immunol 2010;30: 140-143)
( Yun-mi Kang ),( Eun-jin Jeon ),( Kyung-sook Chung ),( Se-yun Cheon ),( Jong Hyuk Park ),( Yoo-chang Han ),( Hyo-jin An ) 대한본초학회 2017 大韓本草學會誌 Vol.32 No.2
Objectives : This study was conducted to investigate candidate materials as anti-inflammatory agent from extracts of Korean medicinal plants in Hwaak mountain. Ligustrum obtusifolium (LO) is a Korea medicinal plants that commonly used for robustness and hemostasis. It has been reported that LO has exhibited anti-ischemic, anti-oxidative, antihypolipidemic, anti-tumor and hypoglycemic effects. However, LO has not been previously reported to have an antiinflammatory effect. Therefore, we have evaluated the anti-inflammatory effects of LO and its underlying molecular mechanisms in LPS-induced RAW 264.7 macrophages. Methods : Cell viability was determined by MTT assay in RAW 264.7 macrophages. Nitric Oxide (NO) was measured with Griess reagent and pro-inflammatory cytokines were detected by ELISA in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Protein expressions of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and p65 subunit of nuclear factor-κB (NF-κB) were determined by Western blot analysis. Results : Among 15 extracts of Korean medicinal plants tested, Ligustrum obtusifolium (LO) showed the inhibition of NO production without cytotoxicity. LO reduced the expression levels of iNOS and COX-2 proteins in LPS-simulated RAW 264.7 macrophages in dose-dependent manner. Consistent with these data, LO inhibited the productions of TNF-α, IL-6, and IL-1β in LPS-simulated RAW 264.7 macrophages. Furthermore, LO attenuated the LPS-induced nuclear translocation of p65 NF-κB in RAW 264.7 macrophages involving suppression of NF-κB activation. Conclusions : Taken together, these results suggest that the anti-inflammatory effects of LO is associated with regulation of inflammatory mediators via inhibition of NF-κB activation in LPS-treated RAW 264.7 macrophages.
( Yun Bin Lee ),( Eun Ju Cho ),( Dong Hyeon Lee ),( Yuri Cho ),( Su Jong Yu ),( Jeong Hoon Lee ),( Yoon Jun Kim ),( Hyo Suk Lee ),( Chung Yong Kim ),( Jung Hwan Yoon ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background/Aim: Emodin, 1,3,8-trihydroxy-6-methyl-anthraquinone, is an anthraquinone derivative contained in the rhizome of Rheum palmatum L., which is traditionally used in Chinese medicine. It has been reported that Emodin possesses biological activities such as anti-inflammatory or hepatoprotective effects. Thus, we aimed to investigate if Emodin may attenuate hepatocyte apoptosis induced by bile acid or saturated fatty acid. Methods: We performed in vitro studies using human hepatocellular carcinoma cell line, SNU761, which contains bile acid transporter and thereby, susceptible to bile acid-induced apoptosis. Deoxycholate (DC) and palmitate were used to induce apoptosis. Endoplasmic reticulum (ER) stress was induced by tunicamycin or thapsigargin. Cell growth and apoptosis were assessed using MTS assay, and apoptotic and kinase signaling pathways were explored by immunoblot analysis. Results: Emodin diminished DC- and palmitate-induced JNK activation, which in turn lead to attenuation of caspase-dependent hepatocyte apoptosis. However, Emodin did not affect tumor necrosis factor-related apoptosis- inducing ligand (TRAIL)- induced and ER stress-induced apoptosis, indicating that it had no effects on death receptor- and ER stress-mediated pro-apoptotic signalings. Conclusions: Emodin attenuates bile acid-induced hepatocyte apoptosis and palmitate-induced hepatocyte lipoapoptosis by suppressing JNK activation. Therefore, Emodin may exhibit hepatoprotective activities against cholestatic liver injury and steatohepatitis.
( Eun Ju Cho ),( Hyo Cheol Kim ),( Jeong Hoon Lee ),( Jeong Ju Yoo ),( Won Mook Choi ),( Young Youn Cho ),( Min Jong Lee ),( Yuri Cho ),( Dong Hyeon Lee ),( Yun Bin Lee ),( Su Jong Yu ),( Yoon Jun Kim 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: Sorafenib is regarded as the standard treatment of care in Barcelona Clinic Liver Cancer (BCLC) stage C patients in the BCLC treatment algorithm. However, the modest survival warrants for a better treatment modality. This study aimed to investigate the feasibility of combined TACE and radiotherapy (TACE+RT) in comparison with sorafenib for locally advanced HCC. Methods: From 2007 to 2011, a total of 116 patients with locally advanced HCC without distant metastasis were retrospectively enrolled. 35 patients were treated with sorafenib and 67 patients underwent treatment with TACE+RT. Propensity score-matching generated a matched cohort composed of 54 patients. Overall survival was the primary endpoint for the analysis. Results: At baseline, the sorafenib treated group had a tendency for a tumor size ≥10 cm (74.3% vs. 59.7%, P<0.001), presence of lymph node metastasis (34.3% vs. 11.9%, P=0.007) and presence of main portal vein tumor thrombosis (45.7% vs. 25.4%, P=0.037). The overall survival in the TACE+RT group was significantly longer compared to the sorafenib group (3.3 months vs. 14.1 months, P<0.001). In the propensity scorematched cohort, baseline characteristic did not differ between the two groups. The TACE+RT group (n=27) showed prolonged overall survival compared to the sorafenib group (n=27) (6.7 months vs. 3.1 months, P<0.001). Multivariate analysis revealed that TACE+RT was the only independent prognostic factor associated with survival in the propensity score-matched cohort (HR=0.172, 95% CI 0.078-0.379; P<0.001). Conclusions: The overall survival of the combined treatment of TACE+RT was associated with a prolonged survival compared to the administration of sorafenib in locally advanced hepatocellular carcinoma patients.