Effect of simultaneous therapy of arthrocentesis and occlusal splints on temporomandibular disorders: anterior disc displacement without reduction

Hye-Sung Lee,Hyun-Su Baek,Dong-Suk Song,Hee-Chul Kim,Hyo-Geun Kim,Bok-Joo Kim,Myung-Soo Kim,Sang-Hoon Shin,Sung-Hee Jung,Chul-Hoon Kim 대한구강악안면외과학회 2013 대한구강악안면외과학회지 Vol.39 No.1

Objectives: This study sought to evaluate the effect of simultaneous application of arthrocentesis and occlusal splint. Materials and Methods: A retrospective study of 43 patients (3 males, 40 females) whose symptoms had improved was conducted at the Department of Oral and Maxillofacial Surgery, Dong-A University Hospital between 2008 and 2010. Subjects were divided into three groups: Group A (17 patients with arthrocentesis and occlusal splints simultaneously applied), Group B (13 patients whose symptoms did not improve with occlusal splints, undergoing arthrocentesis after occlusal splint use for 8 weeks), and Group C (13 patients that only used occlusal splints). We compared these groups in maximum comfortable opening (MCO) and the visual analogue scale of pain and noise. Follow-up was performed at 1 week, 1 month, 3 months, and 6 months. Results: The improvement of symptoms was noted in all three groups, but Group A had a quicker improvement than the other groups, in terms of pain reduction and MCO increases. Conclusion: The simultaneous application of arthrocentesis and occlusal splints can reduce patient discomfort more quickly.

표정인식을 위한 PCA와 템플릿 정합을 사용한 얼굴 요소 추출

우효정, 이슬기, 김동우, 류성필, 안재형 충북대학교 산업과학기술연구소 2013 산업과학기술연구 논문집 Vol.27 No.2

This paper proposed an extracting algorithm of human facial components for the recognition of facial expressions. First face image is acquired using the Haar-like feature mask from an input image. The face image is divided into two images. One is the upper image including eye and eyebrow. The other is the lower image including mouth and jaw. The extraction of facial components, such as eye and mouth, begins getting eye image and mouth image. Then eigenfaces are produced by the PCA training process with learning images. An eigeneye and an eigenmouth are produced from eigenfaces. Result eye image is obtained by template matching the upper image with the eigeneye, and the mouth image is obtained by template matching the lower image with the eigenmouth. The simulation results show that the proposed method has superior extraction ratio than previous method.

말초염증에 의한 등족뿌리신경절의 brain-derived neurotrophic factor 합성의 변화

김상열,김정기,김효신,이상지,하선옥,홍해숙,김동선 대한해부학회 1998 Anatomy & Cell Biology Vol.31 No.3

유아 로타바이러스 설사증에 대한 IgY 난황 항체의 효과시험

정동혁, 박효선, 김경미, 정규항, 김강영, 정후길, 윤숭섭, 전호남, 강신영 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.2

본문참고

쑥 추출물의 항돌연변이 활성효과

이성,권동진,유진영,정동효 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.1

한국산 쑥으로부터 얻어진 ethanol 추출물과 각 용매획분에 대하여 in vitro로서 Salmonella typhimurium reversion assay 시험을 하여 자체 변이원성 유무와 4가지 양성 변이원 물질(3㎍/plate 2NF, 2㎍/plate AFB_1, 1㎍/plate Trp-P-1 그리고 1㎍/plate Trp-P-2)에 대한 항돌연변이 활성에 대한 쑥의영향을 고찰하였다. 쑥의 ethanol 추출물은 2NF, AFB_1, Trp-P-1 그리고 Trp-P-2 등으로 유도한 돌연변이 시험(Ames test)에서 변이원성을 보여주지 않았다. 돌연변이 억제시험에서는 frameshift type인 Sal. typhimurium TA 98에 대하여 직접 변이원인 2-NF에서는 19.7~22.9%, 간접 변이원인 AFB_1, Trp-P-1과 Trp-P-2에서는 각각 47.9~61.2%, 64.1~70.7% 그리고 67.4~78.7%의 억제효과를 나타내었다. 또한 쑥의 ethanol 추출물을 n-hexane, chloroform, ethyl acetate 그리고 water로 각각 분획하여 직접변이 원인 2-NF와 간접변이원인 AFB_1을 사용하여 변이원성과 항돌연변이원성 시험을 하였다. 돌연변이 시험에서 변이원성은 4가지 획분에서 모두 나타나지 않았다. 직접 변이원인 2-NF로 유도된 돌연변이에 대하여 n-hexane 획분은 9.4~33.7%, chloroform 획분은 21.6~26.5% 그리고 ethytl acetate 획분은 2.4~21.9%를 나타내었다. 간접 변이원인 AFB_1로 유도된 돌연변이에 대하여 n-hexane 획분, chloroform 획분 그리고 ethytl acetate 획분들은 각각 63.0~80.0%, 77.5~82.1%, 68.5~83.1%로 높은 억제 효과를 보여주었다. Mugwort has been know as a traditional substitutive foodstuff and as showing a physiologically beneficial function to a human being. Therefore, effect of mugwort extract in terms of mutagenicity and desmutagenicity was investigated to verify its function. Ethanol extract from mugwort did not exhibit any mutagenicity. On the contrary, inhibitory effects of the ethanol extract were observed on mutagenicity induced by aflatoxin B_1(AFB_1), 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole(Trp-P-1), 3-amino-1-methyl-5H-pyrido[4,3]indole(Trp-P-2) and 2-nitroflourene(2NF) using Salmonella typhimurium reversion assay. On direct-acting mutagen(2NF, 3 ㎍/plate), ethanol extract showed a slight inhibitory effect of 19.7%~22.9%, however on indirect-acting mutagen such as AFB1(2 ㎍/plate), Trp-P-1(1 ㎍/plate) and Trp-P-2(1 ㎍/plate), we observed higher inhibitory effect of 47.9~61.2%, 64.1~70.7%, 67.4~78.7%, respectively. Step-wise fractionation of the ethanol extract was done by using hexane, chlorofractions showed high inhibition of 63.0~80.0%, 77.5~82.1%, and 68.5~83.1%, respectively on the mutagenicity of AFB_1 in Sal. typhimurium TA98. Consequently, these results indicated that mugwort extract contains some compound(s) which may show desmutagenicity.

메조기공의 실리카-티타니아 코겔의 제조와 자율적 조습 및 광촉매 특성

이상화,곽중협,서태수,김효중,김동표 한국공업화학회 2003 공업화학 Vol.14 No.3

수용액상의 졸겔반응에 의해 메조기공의 실리카-티타니아 코겔을 제조하고 이들의 자율적 조습력과 광촉매 특성에 대해 검토하였다. 실리카-티타니아 코겔에 있어 조습력과 관계되는 세공크기와 용적은 본 연구에서 고안된역적정법에 의해 Ph 7부근 및 SiO_2/TiO_2 비가 상대적으로 큰 9/1인 경우에 가장 큰 생성물이 얻어졌다. 폐놀 분해율에 의한 광촉매 특성은 동일조건에서 SiO_2/TiO_2 비가 감소함에 따라 증가하였고, SiO_2/TiO_2 비가 9/1에서 세공크기 4.0~6.0 nm 및 세공용적 0.6~0.8 mL/g 범위로 제어된 코겔의 경우 환경습도 40~70% 범위에서 흡습량 25%, 방습량 45%로서 종래 조습재료 보다 자율조습력이 큰 것을 볼 수 있었고, 같은 조성의 실리카-티타니아 혼합 산화물과의 폐놀 분해율에 의한 광촉매 특성 비교에서도 우수한 물성을 보이고 있었는데 이것은 Ti-O-Si 결합형성으로 인해 코겔 구조내에 음전하 과잉으로 인한 활성점(브렌스테드 산점) 발현에 기인된 것으로 고찰된다. Silica-titania cogel materials have been prepared by aqueous sol-gel process using a back titration technique designed for this study. The humidity self-control and photocatalytic properties of the materials have been also investigated. In these silica-titania cogel materials, relatively large pore size and pore volume than can give a good humidity control ability are desired, and they were synthesized under the reaction condition at pH of 7 and SiO_2/TiO_2 ratio of 9/1. The photocatalytic property, which was measured by the decomposition ratio of phenol, increased with the decrease of SiO_2/TiO_2 ratio in the composition. The cogel at the SiO_2/TiO_2 ratio of 9/1, resulted in the pore size of 4.0~6.0 nm and the pore volume of 0.6~0.8mL/g. At the relative humidity range of 40~70%, the amounts of moisture absorption and desorption were 25% 45%, respectively, and these had a better humidity control ability than conventional ones. In addition, the cogel showed a superior photocatalytic property compared to that of silica and titania mixture with the same composition. This enhancement is probably due to the revelation of active sites by the excess negative charges that were induced by Ti-O-Si bond formation in the cogel structure.

하악골에 발생한 다발성 중심성 골종 : 증례보고 REPORT OF A CASE

전효상,이문희,정해송,이동근,김성곤,조병욱 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.4

Osteomas are benign tumor composed of mature compact or cancellous bone. Generally, they are classified as peripheral(periosteal) osteoma and central(endosteal) osteoma by origin. Osteomas are essentially restricted to the craniofacial skeleton and are rarely diagnosed in other bones. Most jaw osteomas are detected in young adults and are generally asymptomatic, solitary lesion. The authors present a case of a endosteal osteoma of the mandible. The lesion was located beneath both the mandibular first premolars, about 2.5㎝×1.5㎝ size. Surgical excision of the lesion was performed and we obtained good result after operation.

진동법을 이용한 케이블의 장력측정기법과 계측환경의 영향분석

김상효,최수일,여동훈,이상호 연세대학교 산업기술연구소 1997 논문집 Vol.29 No.2

Recently, cable-supported long-span bridges are widely constructed due to the quality improvement of cables and the development of design and construction techniques. Cable is an important and essential element in cable-supported bridges and the tensile force of cable is an important factor to evaluate the load carrying capability, current state of bridge, and structural safety. In this study, cable tensions of bridge are measured using vibration method, and the variation of cable tensions due to the temperature change and moving vehicles is analyzed. Experimental results show that the cable tensions are a little higher in day times rather than early morning, however the difference can be negligible. The variation of cable tensions due to moving vehicles is also very small. The result of this study shows that, in the maintenance point of view, the acceleration of cable measured under any daily circumstances such as day time and/or uncontrolled moving vehicles does little affect to the evaluation of the cable tensions.

중학교 남녀학생별 가정교과에 대한 인식 및 학습효과 : 경남지역을 중심으로

신동순,김상희,오화자,정효숙,정혜경 한국 가정과 교육 학회 1997 한국가정과교육학회지 Vol.9 No.1

The aims of this research study is to clear the differences of the learning effects and the cognition of Home Economics by sex in the middle school and to collect the future-oriented educational datas, after implementing the 6th education curriculum. The results of the study are as follows ; 1. Most of students had the cognition that Home Economics is a subject matter of a needful knowledge and skill for the family life, half students a cultural subject matter for the modern life. The former was supported by female students, the latter by male students. 2. Most of students were interested in actual training fields of cooking and hand-sewing, had a strong interest about a field of physical and social-psychological growth. The differences by sex were statistically significant in these fields. 3. Most of students had positive responses in the learning effects of Home Economics. The most useful field was cooking and the worst was the structure and method of sewing machine. 4. The shortage and the dissatisfaction in the learning of Home Economics were lacking of the actual training hours, the old-fashioned teaching methods and the shortage of teaching materials etc.

백서 혈관평활근 세포에서 α-Lipoic acid가 PAI-1 발현, 세포의 증식, 주유능 및 신생내막 형성억제에 미치는 효과

신동우,이동욱,이상준,김혜순,강효경,안종덕,이인규 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.25 No.6

연구배경:당뇨병의 혈관 합병증의 발생에 있어서 산화스트레스는 중요한 역할을 하는 것으로 알려져 있다. 혈관 평활근세포에서 고혈당은 안지오텐신Ⅱ와 더불어 활성산소족(ROS)을 증가시키며, 산화스트레스에 민감한 전사인자들을 활성화시켜 동맥경화증을 유발하는 것으로 알려져 있다. 이에 저자들은 항산화제로 알려진 알파­리포산이 혈관 평활근세포의 증식속도와 이주에 미치는 영향과 PAI­1발현에 미치는 영향을 조사하였고 이와 동시에 백서의 혈관 손상 모델을 이용하여 알파­리포산이 신생내막 증식을 억제시킬 수 있는지를 알아보았다. 방법:In vitro 실험은 백서의 대동맥 평활근세포를 고농도의 포도당(22mM)과 100nM의 안지오텐신Ⅱ로 4시간 배양하였다. 알파­리포산을 처리 후, PAI­1 mRNA의 발현을 보기 위해 노던 블롯을 시행하였고 평활근세포의 유주능과 증식속도에 미치는 영향을 보기 위해 성장속도의 유주능 분석을 시행하였다. 또한 평활근세포의 유주능에 NF­μB 경로가 미치는 영향을 보기 위해 겔 지연 분석과 NF­μB 보고 유전자 분석을 시행하였다. In vivo 실험으로 백서의 혈관손상 모델을 이용하여 알파­리포산 처리 후 혈관의 신생내막 두께를 비교하였다. 결과:In vitro 실험에서 고농도 포도당과 안지오텐신Ⅱ에 의해 유도된 PAI­1 mRNA 발현증가는 알파­리포산 처리에 의하여 용량에 비례하여 억제되었다(p<0.05). 알파­리포산 처리로 혈관 평활근세포의 유주능은 유의하게 억제되었으나(p<0.01),증식속도는 유의하게 억제되지 않았다. 또한 알파­리포산 처리로 NF­μB 발현도 유의하게 억제되었다(p<0.01). In vivo 실험에서 알파­리포산을 주입한 군에서 혈관손상에 의한 신생내막의 증식이 유의하게 억제되는 것을 보여주었다(p<0.01). 결론:알파­리포산은 백서의 대동맥 평활근 세포의 증식속도는 억제하지 못했으나 유주능은 유의하게 억제하였으며, 혈관 손상 모델에서 신생 내막 증식도 유의하게 억제함을 확인할 수 있었다. 이러한 작용은 알파­리포산에 의한 NF­μB 경로의 억제와 연관이 있는 것으로 사료된다. Background : Exposure to large amounts of glucose causes a characteristic dysfunction and morphologic changes of the endothelium by an increased production of reactive oxygen species(ROS) in diabetes. The plasminogen activator inhibitor-1(PAI-1), which modulates fibrinolysis and cell migration may influence proteolysis and neointimal formation in vascular smooth muscle cells(VSMC). Antioxidants have been proposed to inhibit multiple proatherogenic events. This study investigated the effect of α-lipoic acid on PAI-1 expression and VSMC proliferation and migration both in vivo and in vitro. Methods : In the in vitro study, cultured rat aortic smooth muscle cells(RASMC) were incubated in a medium containing high glucose (22 mM) and 100 nM angiotensin Ⅱ for 4 hour. After α-lipoic acidtreatment, a -migration and growth assay of the RASMC, and a gelmobility shift assay and reportergene analysis for nuclear factor- иB(NF- иB) and northern blot analysis for PAI-1 were performed. In the in vivo study, the effect of α-lipoic acid on neointimal hyperplasia in a rat carotid balloon injury model was evaluated. Results : RASMC migration was inhibited significantly by α-lipoic acid (p<0.01), but their prolife ration was not inhibited. The NF-иB DNA binding activity and NF-иB promoter activity was inhibited by α-lipoic acid significantly (p<0.01). α-lipoic acid inhibited PAI-1 mRNA expression by high glucose and angiotensin Ⅱ in dose dependent manner (p<0.05). In the rat carotid artery balloon injury model, neointimal formation was reduced by α-lipoic acid treatment in a dose dependent manner significantly (p<0.01). Conclusion : α-lipoic acid suppresses migration, but not prolife ration in RASMC. α-lipoic acid also reduce neointima formation in a rat carotid balloon injured model. This effect might be related to the blocking of NF-иB which increase the expression of the genes associated with atherosclerosis including TNF-α, IL-1, IL-6, endothelin-1, MCP-1, VCAM-1, ICAM-1, E-selectin, tissue factor(J Kor Diabetes Asso 25:446~459, 2001).