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Kim, Shin-Hyun,Park, Hyo Sung,Choi, Jae Hoon,Shim, Jae Won,Yang, Seung-Man WILEY-VCH Verlag 2010 Advanced materials Vol.22 No.9
<B>Graphic Abstract</B> <P>The cover shows a schematic illustration of patterned colloidal photonic crystals with different bandgap positions. When an unknown light source impinges on the patterned photonic crystals, the light information can be identified from the reflection intensity profile of the constituent photonic crystals. The two optical microscopy images and background image display integrated photonic crystals with 20 different bandgaps spanning the entire visible range, and the SEM image shows the cross-section of the photonic crystal stripes, as reported by Shin-Hyun Kim, Seung-Man Yang, and co-workers on p. 946. <img src='wiley_img_2010/09359648-2010-22-9-ADMA201090022-content.gif' alt='wiley_img_2010/09359648-2010-22-9-ADMA201090022-content'> </P>
( Hyun Su Baek ),( Hye Sung Lee ),( Bok Joo Kim ),( In Kyo Chung ),( Chul Hoon Kim ),( Sun Mi Jin ),( Hie Sung Hwang ),( Sang Hun Shin2 ) 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.6
The objective of this study was to evaluate platelet-rich fibrin (PRF)’s effectiveness in repairing articular disc defect in the temporomandibular joint (TMJ) of rabbits. Eight rabbits were divided into four groups of two rabbits each, corresponding to groups A, B, C, and D. Both TMJs of all of the rabbits were used in the experiments: the right joints comprised the experimental groups, and the left ones, the control groups. The disc defect was circular and 2 mm in diameter. In the experimental groups, the PRF was compressed into the defect, whereas the control group defects were left untreated. A, B, C, and D groups were sacrificed at the 1st, 2nd, 4th and 6th weeks, respectively. The defects of each control group exhibited no specific changes. Contrastingly, in each experimental group, there was an increased number of chondroblasts at the margins of the defects, along with accelerated cell differentiation and a columnar cell arrangement observable at the time of cell differentiation. The experimental groups showed inflammatory cell infiltrations and fibrosis by the 1st week, maturation of chondrocytes by the 2nd week, and proliferation by the 4th week, after which the defects began to be filled with chondrocytes, a process that was complete after the 6th week. In the histological evaluation (H-E), the experimental groups showed significant increases of chondroblasts after the 2nd and 4th weeks, as well as regular columns of chondrocyte arrays observable during cell division. After 6 weeks, the defects were filled with chondrocytes.
( Sang Heon Kim ),( Sang Hoon Kim ),( Jang Won Sohn ),( Ho Joo Yoon ),( Dong Ho Shin ),( Sung Soo Park ),( Jae Hyung Lee ),( Byoung Hoon Lee ),( Youn Seup Kim ),( Jae Seuk Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Maculopapular eruption is the most common adverse reactions to antituberculosis drugs (ATD), often leading to discontinuation of the medication. While the mechanisms of ATD-induced MPE are not well understood, oxidative stress induced by the ATD metabolites could play a role in drug-induced MPE. We aimed to examine if the genetic polymorphisms in superoxide dismutase genes (SOD1, SOD2 and SOD3) were associated with MPE induced by ATD. Methods: We enrolled 75 patients with ATD-induced MPE and 237 ATD-tolerant control by regular monitoring of adverse reactions to ATD. Genotyping was performed 4 single nucleotide polymorphisms (SNP) in SOD1 (rs2070424), SOD2 (rs4880) and SOD3 (rs2536512 and rs1799895) in patients with ATD-induced MPE and patients tolerant to ATD. Genotype-phenotype association was examined by logistic regression analysis adjusting for gender and age. Results: In SOD1, there was signifi cant association between rs2070424 (Ivs3-251A/G) and ATD-induced MPE (P = 0.019, OR = 2.42, 95% CI 1.16-5.05), with higher frequency of genotype, GA + GG, in patients with ATD-induced MPE compared with ATD-tolerant controls. The other polymorphisms in SOD2 and SOD3 did not show signifi cant difference of genotypes between case and control group. Conclusions: Intron SNP rs2070424 of SOD1 (Ivs3-251A/G) showed signifi cant association with ATD-induced MPE. These fi ndings suggest that this genetic variant may increase the risk of ATD-induced MPE.
( Sung Bae Kim ),( Won Seok Kang ),( Seung Hwan Shin ),( Hee Seung Lee ),( Sang Hoon Lee ),( Gi Hong Choi ),( Jun Yong Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
We report a case of a 57-year-old male who underwent a curative resection for hepatocellular carcinoma (HCC) with histological confi rmation of spontaneously necrotized tumor. Initial serum AFP level was 4,778ng/mL. Ultrasonography demonstrated a 3. 7cm hyperechoic mass in segment 6 of the liver and dynamic contrast-enhanced liver magnetic resonance imaging showed 3. 7×3. 1cm sized HCC. He was scheduled for curative surgical resection under the clinical diagnosis of an early stage HCC (Barcelona Clinic Liver Cancer stage A). Without any intervention, the serum AFP level rapidly declined to 50 ng/mL over three weeks. He underwent curative wedge resection of segment 6 of the liver. Histology revealed a complete necrosis of the mass rimmed by infi amed fi brous capsule on a background of HBV-related cirrhosis with infi ltration of lymphoplasma cells. Exact pathophysiology underlying this event remains unknown. Among the proposed mechanisms of spontaneous neoplastic remission of HCC, circulatory disturbance and activation of host immune response offer the most scientifi c explanation for the complete histologic necrosis of HCC in the resected mass seen in our patient.
Preparation of YSZ Electrolyte for SOFC by Electron Beam PVD
Shin, Tae Ho,Yu, Ji Heang,Lee, Shi Woo,Han, In Sub,Woo, Sang Kuk,Jang, Byung Koog,Hyun, Sang Hoon Trans Tech Publications, Ltd. 2006 Key Engineering Materials Vol.317 No.-
<P>Yttria stabilized zirconia (YSZ) films with the thickness of up to 12 μm were prepared on alumina and NiO-YSZ substrates by electron beam physical vapor deposition (EB-PVD). The films showed nano-scaled columnar structures depending on the substrate temperature. Electrical conductivity of the YSZ films on alumina was also investigated at the temperature between 700 and 1000oC in oxidizing atmosphere. High activation energy of the conductivity (>1.03eV) indicated that the conduction via grain boundary controlled the ionic conduction in the films prepared by EB-PVD. La0.6Sr0.4CoO3-δ as a cathode was applied on the YSZ/NiO-YSZ in order to evaluate the performance of the YSZ electrolyte.</P>
Clinical Experiences of Transforaminal Balloon Decompression for Patients with Spinal Stenosis
( Sung Hoon Kim ),( Won Uk Koh ),( Soo Jin Park ),( Woo Jong Choi ),( Jeong Hun Suh ),( Jeong Gil Leem ),( Pyung Hwan Park ),( Jin Woo Shin ) 대한통증학회 2012 The Korean Journal of Pain Vol.25 No.1
Lumbar spinal stenosis is a commonly treated with epidural injections of local anesthetics and corticosteroids, however, these therapies may relieve Leg pain for weeks to months but do not influence functional status. Furthermore, the majority of patients report no substantial symptom change over the repeated treatment. Utilizing balloon catheters, we successfully treated with three patients who complained persistent symptoms despite repeated conventional steroid injections. Our results suggest that transforaminal decompression using a balloon catheter may have potential in the nonsurgical treatment of spinal stenosis by modifying the underlying pathophysiology. (Korean J Pain 2012; 25: 55-59)
Shin, Dong Hoon,Kang, Min-Ju,Kim, Jin Wook,Shin, Dong-Jin,Park, Hyeon-Mi,Sung, Young Hee,Kim, Eung Yeop S. Karger AG 2017 Cerebrovascular diseases Vol.44 No.5
<P><B><I>Background:</I></B> An accurate measurement of patient weight is important in determining the dosage for intravenous alteplase thrombolysis. In most emergency rooms, however, weight is not measured. We investigated the difference between stated and measured weight and its effect on hemorrhagic transformation and clinical outcomes. <B><I>Methods:</I></B> We enrolled 128 consecutive patients who had hyperacute stroke and were treated by alteplase. Alteplase dose was calculated using the weight provided by patient or guardian/caregiver, and the actual weight was measured after administration. Patients were classified into 2 groups: overused group (stated weight >measured weight) and underused group (measured weight ≥stated weight). The prevalence of hemorrhagic transformation on follow-up, determined by gradient-recalled echo MRI or non-enhanced CT, was compared between the 2 groups. The predictors for hemorrhage with progression, defined as an increase in the National Institutes of Health Stroke Scale (NIHSS) by a value of 4 or more accompanied by hemorrhage, were determined using multivariable logistic regression analysis and included the overused or underused alteplase and baseline clinical and laboratory findings. <B><I>Results:</I></B> Sixty-six (51.6%) of 128 patients were in the underused group and 62 patients (48.4%) in the overused group. The median difference between the stated and measured weights was 1.5 (interquartile range 0.56-3.81) kg, with the largest difference being 25.6 kg. Although there were no significant difference in baseline clinical and laboratory findings between the 2 groups, the overused group showed a significantly higher prevalence of hemorrhagic transformation (<I>p</I> = 0.012) and hemorrhage with progression (<I>p</I> = 0.025). The multivariable logistic regression analysis demonstrated that overused alteplase (OR 7.26; 95% CI 1.24-42.45; <I>p</I> = 0.028), baseline glucose (>144 mg/dL; OR 5.03; 95% CI 1.00-25.26; <I>p</I> = 0.050), and initial NIHSS (OR 1.13 per 1-point NIHSS increase; 95% CI 1.00-1.27; <I>p</I> = 0.047) in model 1 that use alteplase overdose as a categorical variable and overused alteplase (OR 1.67 1-mg increase; 95% CI 1.05-2.66; <I>p</I> = 0.027) in model 2 that use an overused alteplase dose as numerical variable were significant predictors for hemorrhage with progression. <B><I>Conclusion:</I></B> More alteplase usage than actual weight led to higher hemorrhagic transformation. As one of the predictors for clinical deterioration, it is important to administrate alteplase based on an accurately measured weight.</P>
Sung, Hwa Jung,Hong, Soon Cheol,Yoo, Ji Hyun,Oh, Jee Hyun,Shin, Hye Jin,Choi, In Young,Ahn, Ki Hoon,Kim, Sun Haeng,Park, Yong,Kim, Byung Soo The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.10
<P>This study was done to evaluate the stemness of human mesenchymal stem cells (hMSCs) derived from placenta according to the development stage and to compare the results to those from adult bone marrow (BM). Based on the source of hMSCs, three groups were defined: group I included term placentas, group II included first-trimester placentas, and group III included adult BM samples. The stemness was evaluated by the proliferation capacity, immunophenotypic expression, mesoderm differentiation, expression of pluripotency markers including telomerase activity. The cumulative population doubling, indicating the proliferation capacity, was significantly higher in group II (<I>P</I><0.001, 31.7±5.8 vs. 15.7±6.2 with group I, 9.2±4.9 with group III). The pattern of immunophenotypic expression and mesoderm differentiation into adipocytes and osteocytes were similar in all three groups. The expression of pluripotency markers including ALP, SSEA-4, TRA-1-60, TRA-1-81, Oct-4, and telomerase were strongly positive in group II, but very faint positive in the other groups. In conclusions, hMSCs from placentas have different characteristics according to their developmental stage and express mesenchymal stemness potentials similar to those from adult human BMs.</P>