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      • KCI등재후보

        조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

        김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

        Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

      • KCI등재후보

        여성영화에 나타난 역사의 "소외"

        최석희 한국독일어문학회 2003 독일어문학 Vol.21 No.-

        In dieser Arbeit werden vier Frauenfilme untersucht, die Ende der 70er bzw. Anfang der 80er Jahre gedreht wurden: Deutschland, bleiche Mutter von Sanders-Brahms, Das Bildnis der Trinkerin von Ulrike Ottinger , Die Reise nach Lyon von Claudia von Alemann und Die bleierne Zeit von Margarethe von Trotta . Frauen stellen andere Inhalte aus einer anderen Perspektive dar, weil sie als Frauen die Welt grundsa¨tzlich anders erfahren. Obgleich die Frage einer weiblichen A¨sthetik in Bezug auf das Filmschaffen von Frauen wiederholt aufgeworfen wurde, haben viele Regisseurinnen den Begiff abgelehnt. In den oben ero¨rterten Filmen wurden die Erfahrungen von Frauen in den Vordergrund gestellt, aber bei allen liegt ein entscheidendes Merkmal darin, wie sie die Realita¨t verfremden. Wenn man eine vertikale Untersuchung daruber durchfuhrt, wie sich eine spezielle Situation anfu¨hlt, kann u¨ber jeden der vier oben ero¨rterten Filme gesagt werden, dass er eine verfremdende Wirkung hat. Deutschland bleiche Mutter verfremdet die Art, auf die wir den Zweiten Weltkrieg als eine Zeit des Todes und der Zersto¨rung und die 50er Jahre als eine Zeit des Wohlstandes in Deutschland wahrzunehmen gelernt haben. Das Bildnis der Trinkerin zeigt West-Berlin im Gegensatz dazu, dass es in der O¨ffentlichkeit als Symbol fur die Freiheit des Westens angesehen wurde, als isolierte Insel. Die Reise nach Lyon zeigt, dass Geschichte nicht etwas da draußen ist und einfach dokumentiert werden kann, wa¨hrend Die bleierne Zeit von Trotta das vorherrschende Bild von deutschen Terroristen verfremdet. Von jedem dieser Filme kann man sagen, dass er mit Schklowskys Forderung ubereinstimmt, dass Kunst die Empfindung von Dingen vermitteln solle, wie sie wahrgenommen werden, und nicht, wie sie bekannt sind. So kann man den Standpunkt vertreten, dass das Konzept der Verfremdung und die Idee einer weiblichen A¨sthetik zwei Mo¨glichkeiten sind, u¨ber dasselbe Pha¨nomen zu sprechen.

      • KCI등재
      • KCI등재

        그림 Grimm동화에 나타난 여성상과 남성상

        최석희 한국독일어문학회 2000 독일어문학 Vol.11 No.-

        Von insgesamt 211 Texten der Grimmschen Ma¨rchen ist die Zahl der Ma¨rchen mit den ma¨nnlichen Helden uberwiegend gro¨βer als die mit weiblichen Helden. Die weiblichen Helden fallen jedoch im Ma¨rchen mehr auf als die ma¨nnlichen, weil die bekanntesten Ma¨rchen fast alle weibliche Helden haben. In dieser Arbeit wird das Frauen- und Ma¨nnerbild der Grimmschen Ma¨rchen untersucht. Das Zustandekommen der Grimmschen Ma¨rchen und vor allem ihre weltweite Rezeption ist im ho¨chsten Maβe von und durch Frauen bestimmt. Das Bild der Frau in den KHM ist weithin abha¨ngig vom Weltbild der Erza¨hler. die die Gewa¨hrsleute der Grimms waren. Auβerdem entsprechen diese Figuren weitgehend dem Frauenbild des 19. Jahrhunderts. Der weibliche Held ist eine Frau. die ein unglu¨ckliches Schicksal hat. geduldig und tu¨chtig arbeitet. Fleiβ, Ordnung. Reinlichkeit. Demut. Tu¨chtigkeit, Passivita¨t. Schweigsamkeit und Keuschheit sind hervorstechende Eigenschaften der Heldinnen. Aber es gibt auch einige weibliche Helden. die sehr eigensta¨ndig sind. Die Heidin ist in den Grimmschen Marchen an die moralischen Lehren der Zeit gebunden. Von ihr wird verlangt. ein Idealbild in der realen Welt zu sein. Andererseits ist der ma¨nnliche Held arm. faul. arbeitsunfa¨hig und unbeku¨mmert. Er tritt als Abenteurer, Du¨mmling und Retter auf, und hat mit der Hilfe von Zauber oder einem Erlo¨ser Glu¨ck. wenn er nur Mut hat. Er ist nicht eigentlich ein Vorbild. dem man nacheifert. sondern ein Traumbild, das man bewundert. Man mo¨chte so sein wie er und ist sich zugleich bewuβt. dass man nicht so ist und wohl auch niemals so sein wird. und gerade deshalb wu¨nscht man sich so zu sein wie er. Er ist also kein Idealbild fur die reale Welt. sondern ein Wunschbild in der Traumwelt des Ma¨rchens. Der weibliche Held ist zwar sehr bekannt, aber nicht frei von den Forderungen der Wirklichkeit.

      • KCI등재후보

        조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험

        최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

        Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.

      • Aspergillus oryzae를 이용한 캡슐형 메주의 품질특성

        최재훈,권선화,이상원,남상해,최상도,박석규 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2003 한국식품저장유통학회지 Vol.10 No.3

        전통메주의 표면에서 발행하는 야생곰팡이 착생, 유해곰팡이에 대한 mycotoxin 생성 및 메주 표면의 과도한 건조 등을 해결하기 위하여 메주 외층에 Aspergillus oryzae로 만든 쌀 종국(0.3%, w/w)을 혼합시킨 증자 검정콩으로 얇게 코팅한 후, 25℃, 상대습도 80%에서 14일간 발효시킨 캡슐형 메주를 개발하였다. 캡슐형 메주의 표면에서 야생곰팡이의 오염은 발견되지 않았으나, 대조구 메주는 12일 이후에 푸른곰팡이가 많이 관찰되었다. 메주의 수분 함량은 평균 32.7%로서 34.7~29.4%의 범위를 나타내었다. 적정산도는 캡슐형 메주가 대조구 메주보다 높게 나타났으며, 대두 캡슐형 메주와 검정콩 캡슐형 메주는 비슷하게 나타났다. 유리당의 함량은 검정콩 캡슐형 메주가 123.98㎎%로 대조구 메주 15.02㎎%와 대두 캡슐형 메주 59.85㎎%보다 각각 10배, 2.1배, 높게 나타났다. 아미노산성 질소의 함량은 대조구 메주에서 147.00㎎%였으며, 검정콩 캡슐형 메주는 255.50㎎%로서 대두 캡슐형 메주 187.25㎎%보다 약 1.37배 높은 함량을 나타내었다. 총 유기산의 함량은 캡슐형 메주(대두 119.98㎎%, 검정콩 95.94㎎%)가 대조두 메주(26.44㎎%)보다 함량이 높게 나타났으며, 캡슐화에 따라 lactic acid와 malic acid 가 가장 큰 변화를 나타내었다. 색차계 색도는 검정콩 캡슐형 메주가 대두 캡슐형 메주보다 명도값(L)이 크게 나타났으며 지방산 조성은 메주의 종류에 따라 큰 차이를 나타내지 않았다. 총 유리 아미노산의 함량은 검정콩 캡슐형 메주(1039.70㎎%)가 대두 캡슐형 메주 (556.07㎎%)와 대조구 메주(236.45㎎%) 비하여 각각 2.4배, 4.4배 높았다. In order to improve some problems such as contamination of undersirable mold, mycotoxin production and excessive drying on the surface of traditional meju, we developed a capsule type-meju(CM) coated with steamed black bean and Aspergillus oryzae - rice koji(0.3%, w/w) mixture to surface of traditional meju and fermented at 25℃ for 14 days under 80% relative hunmidity. Contamination of undersirable mold on the surface of CM was not detected within 2 weeks and some genus Penicillium molds on control meju without koji were found naturally after 12 days of fermentation. The moisture content of meju was showed to be in the range of 34.7 - 29.4% being 32.7(w/w) of mean value. Titratable acidities in CMs prepared with black bean(BCM) and soybean(SCM) were much higher than that in control meju, and BCM was similar to SCM. Free sugar content in BCM(123.98 ㎎%) was 10 times and 2.1 times higher than that in control meju(15.02 ㎎%) and SCM(59.85㎎%), respectively. Amino type nitrogen content in control meju was 147.00 ㎎% and its content in BCM(255.50㎎%) was 1.37 times higher than that in SCM(187.25 mg%). Total organic acid content in BCM(95.98㎎%) and SCM(119.98㎎%) were much higher than that in control meju(26.44 ㎎%), and then latic and malic acid contents were markedly changed according to capsulation of meju. Lightness value(l) of Hunter color index was much higher in BCM than in SCM. Fatty acid composition of CM was not different as compared to control meju. Total free amino acid content in BCM(1039.70 ㎎%) was 4.4 times and 2.4 times higher than that in control meju(236.45 ㎎%) and SCM(556.07 ㎎%), respectively.

      • 막스 프리쉬의『학교수업을 위한 빌헬름 텔』(Wilhelm Tell fu¨r die Schule)에 나타난 텔신화의 파괴

        최석희 대구효성가톨릭대학교 외국어문학연구소 1990 語文學硏究 Vol.3 No.-

        Max Frisch Vero¨ffentlichte 1971 seine Variante der Tellgeschichte "Wilhelm Tell fu¨r die Schule", die mit der Absicht verfaβt worden ist, den schweizerischen Nationalmythos zu zersto¨ren. In dieser Arbeit wird anhand von Max Frischs Wilhelm Tell die Zersto¨rung des schweizerischen Mythos aufgezeigt. Zuerst wird die Intention in Max Frischs Wilhelm Tell behandelt. Frisch zersto¨rt den Nationalmythos, um dadurch die Schweizer zu kritisieren, die Tell als ihr Nationalhelden ansehen. Max Frisch zersto¨rt die Legende des Wilhelm Tell durch die Psychologisierung der Personen.: In Geβler wird beim Leser das Feinbild zersto¨rt. Und aus dem Ra¨cher Tell wird ein ganz banaler Mo¨rder. Eine treibende Kraft der Handlung sind Miβversta¨ndnisse. Die Dinge bedingen sich nicht zwangsla¨ufig aus einer Ordung heraus, sondern die Handlung wird eher zufa¨llig vorangetrieben. Der Apfelschuβ kommt nur zustande, weil ein Witz falsch verstanden wurde. Die Wortwahl ist banal und getragen von Kleinigkeiten. Wo¨rter wie "Ka¨se", "Kopfschmerzen", "Schieβfliegen", "Langeweile" und "Kuhglocke" pra¨gen die Erza¨hlung. Durch das Wortmaterial und durch den Sprachstil gelingt dem Autor die Ironie, die den ganzen Text durchzieht. Die Schweizer sind stolz und Fremden gegenu¨ber sehr unfreundlich. Frisch gibt zu bedenken, daβ dies noch heute in der Schweiz weit verbreitet sei. Die erhabenen Berge und das harmonische La¨uten der Kuhglocken in Schillers Drama werden in Frischs Erza¨hlung eher zu bedrohenden Elementen. Als letztes Beispiel fu¨r die Zersto¨rung der Legende bei Frisch mo¨chte ich auf die Anmerkungen eingehen, die den gesamten Text durchziehen. Frisch benutzt die Anmerkungen, um den Tellmythos in Frage zu stellen, aber auch, um die Geschichte zu aktualisieren. Ein genauer Vergleich zwischen Schillers "Wilhelm Tell" und dem "Wilhelm Tell fu¨r die Schule" von Max Frisch ist kaum mo¨glich, da die Intentionen der beiden Autoren grundverschieden waren. Schiller wollte ein Drama scheiben, welches einen Mythos verherrlichen sollte, wa¨hrend Max Frisch die Tell-Legende zersto¨ren wollte. Ob heute in der Schweiz Schillers Tell gegenwa¨rting ist oder Frischs Tell aktuell ist, wollte Frisch wissen. Auf jeden Fall hat Frisch dazu beigetragen, daβ die Tell-Legende heute etwas kritischer gesehen wird und den Platz eingenommen hat, der ihr gebu¨hrt.

      • 鬱金이 Angiogenesis 抑制機轉에 미치는 影響

        崔昇勳,安圭錫,成熙根 慶熙大學校韓醫科大學韓醫學硏究所 1999 慶熙韓醫大論文集 Vol.22 No.1

        This experimental study was carried out to evaluate the effects of Curcuma on angiogenic inhibition mechanism. In order to investigate the effects of Curcuma on angiogenic inhibition mechanism evaluate cell survival rate by MTT assay, cell adhesive inhibition effect, DNA fragmantaion analysis. Nuclear Condensation assay FACScan analysis, angiogenesis inhibition assay. Immunocytochemistry analysis, RT-PCR for mRNA expression. Western Blot analysis. The results were summarized as follows : 1. The IC50 was 10㎍/ml to ECV 304 cell. 2. The cell adhesive inhibition ability was strong from 5㎍/ml. 3. The G0/G₁arrest peak was existed on ECV304 cell-line. 4. The cells on Collagen plate were inhibition of proliferation and inducement of apoptosis by Cur water extract. 5. Lumen formation was inhibited by Cur water extract. 6. LFA-1 and ELAM-1's expression were inhibited by Cur water extract, they are commenly participation on inflammation and tumor regeneration. 7. The expression of MMP-9 and uPA were inhibited by Cur water extract. 8. The expression of integrin αvβ₃ was inhibited by Cur water extract. 9. The expression of intracellular molecule were successively inhibited by Cur water extract therefore the proliferation of ECV304 cell line was stopped and apoptosis was induced. According to the results Curcuma has been shown to be a key antagonist of intergrin αvβ₃and which seems to be apoptosis by P53 through Flow cytometry. This report demonstrated that expression of MMP-9 and uPA blocked to under angiogenesis model. Thus, we suggested that Curcuma water block angiogenesis by inducing unscheduled apoptosis in ECV304 and ECVPAR cell lines and another orient herbal medicine that treat Qi-stagnation and Blood-stasis type also have angiogenic inhibition effects.

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