P168 : Split-face comparison study of new hyaluronic acid filler for efficacy and safety of HA-IDF versus Restylane® for correction of nasolabial folds

( Jie Hyun Jeon ),( Joo Ha Kim ),( Jung Woo Lee ),( Kui Young Park ),( Seong Jun Seo ),( Hae Jun Song ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: After successive trials and failures of various injectable materials such as bovine collagen, polyacryamide, calcium hydroxylapatite, etc., hyaluronic acid (HA) has become the most popular filling material. Many new HA fillers are being produced for the purpose of correcting wrinkles and augmentation of soft tissue. Objectives: This study aimed to test the efficacy, tolerability, and safety of a new HA filler, HA-IDF (Yvoire Classic s touch-up, LG Life Sciences, Inc., Seoul, South Korea) and compare HA-IDF with Restylane (Q-Med, Uppsala, Sweden). Methods: Fifty-eight subjects with visible nasolabial folds (NLFs) were enrolled in a randomized, multi-center, single-blind, active-controlled, matched-pair clinical study. Each subject was injected with HA-IDF in one NLF and Restylane in the other. All participants were assessed for cosmetic change at 2, 10, 18, and 26 weeks. Results: At screening, the average Wrinkle Severity Rating Scale (WSRS) for both right and left NLFs was 3.24±0.43. After 26 weeks, the results were 2.56±0.09 for both groups. There was no significant difference in WSRS scores for wrinkle improvement and in incidence of adverse events for both HA filler treatments. Conclusion: The new HA filler HA-IDF is effective and safe for correcting NLFs.

연구논문 : 만성 바이러스간질환에서 간섬유화의 다양한 비침습 혈청표지자검사의 비교

김선민 ( Sun Min Kim ),손주현 ( Joo Hyun Sohn ),김태엽 ( Tae Yeob Kim ),노영욱 ( Young Wook Roh ),은창수 ( Chang Soo Eun ),전용철 ( Yong Cheol Jeon ),한동수 ( Dong Soo Han ),오영하 ( Young Ha Oh ) 대한간학회 2009 Clinical and Molecular Hepatology(대한간학회지) Vol.15 No.4

목적: 만성 바이러스간질환에서 병의 경과와 예후를 평가하고 치료반응을 예측함에 있어 간섬유화의 진단은 중요하다. 최근 간섬유화 평가에 표준방법이지만 침습적 간생검을 대신하여 여러 가지 비침습적 진단법이 이용되고 있고, 또한 새로운 검사법들이 개발되고 있다. 저자들은 만성 B형 및 C형간염 환자를 대상으로 임상에서 광범위하게 흔히 시행하는 혈액검사와 임상 소견을 이용한 아래와 같은 진단법들만으로 간섬유화를 얼마나 정확하게 평가할 수 있는지 알아보고, 단일 검사로 간섬유화를 평가하는 데 유용하다고 알려져 있는 hyaluronic acid(HA)와 IV형 콜라겐 농도와 비교하여 그 임상적 유용성을 평가하였다. 대상과 방법: 2002년 3월부터 2007년 2월까지 만성 바이러스간 질환으로 간생검을 시행받은 225명의 환자(HBV 180명, HCV 43명, HBV+HCV 2명)를 대상으로 분석하였다. 간생검을 시행하는 날에 말초혈액검사, 혈액응고검사, 혈청생화학검사를 시행하고, 혈중 HA, IV형 콜라겐 농도를 측정하였다. 간섬유화의 정도는 F0(섬유화가 없음), F1(문맥역 섬유화), F2(문맥주변부 섬유화), F3(섬유성 격막) 및 F4(간경변증)의 4단계로 구분하였다. 대상 환자를 F0-1, F2-4 혹은 F0-2, F3-4의 두 집단으로 분류하여 두 집단을 구분하고자 할 때 AAR(AST/ALT ratio), API(age-platelet index), APRI(AST to platelet index), CDS(cirrhosis discriminant score), platelet count, HA, IV형 콜라겐의 예측능을 area under the receiver operating characteristic curve (AUROC)값을 이용하여 비교하였다. 결과: 대상환자의 섬유화의 단계는 F0 집단은 17명, F1 집단은 40명, F2 집단은 61명, F3 집단은 74명, F4 집단은 33명이었다. 의미 있는 간섬유화를 F2 이상으로 판단할 때, 의미 있는 섬유화의 예측에 대한 AUROC 값은 APRI=0.822, CDS=0.776, platelet count=0.773, API=0.756, HA=0.749, IV형 콜라겐=0.718, AAR=0.642 순이었고, F3 이상의 광범위한 섬유화 예측에 대한 AUROC값은 CDS=0.835, platelet count=0.795, API=0.794, HA=0.766, AAR=0.711, IV형 콜라겐=0.697, APRI=0.691 순으로 관찰되었다. 결론: 만성 바이러스간질환에서 간섬유화를 평가하는 데 임상 소견 및 혈액검사를 이용한 방법들이 비침습적 진단법 중 단독 검사로도 유용한 것으로 알려져 있는 혈중 HA와 IV형 콜라겐 농도와 비교하여 우월하거나 대등하였다. 특히 APRI는 다른 인자들에 비해 F2 이상의 의미 있는 섬유화를 예측하는 데 가장 유용하였고, CDS는 F3 이상의 광범위한 섬유화를 예측하는 데 가장 유용하였다. Background/Aims: The aim of this study was to determine the clinical performances of noninvasive serum markers for the prediction of liver fibrosis in chronic viral liver diseases. Methods: We analyzed a total of 225 patients with chronic viral liver diseases (180 with hepatitis B virus, 43 with hepatitis C virus, and 2 with hepatitis B+C virus) who underwent a liver biopsy procedure at the Hanyang University Guri Hospital between March 2002 and February 2007. Serum was also obtained at the time of liver biopsy. Liver fibrosis was staged according to the scoring system proposed by the Korean Study Group for the Pathology of Digestive Diseases. Various noninvasive serum markers were evaluated, including the aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AAR), age-platelet (AP) index, AST/platelet ratio index (APRI), cirrhosis discriminant score (CDS), platelet count, hyaluronic acid (HA), and type IV collagen. Results: There were 17, 40, 61, 74, and 33 patients at stages F0, F1, F2, F3, and F4, respectively. The overall diagnostic accuracies of each marker, as determined by the area under receiver operating characteristics curves, were APRI=0.822, CDS=0.776, platelet count=0.773, AP index=0.756, HA=0.749, type IV collagen=0.718, and AAR=0.642 for predicting significant fibrosis (≥F2); and CDS=0.835, platelet count=0.795, AP index=0.794, HA=0.766, AAR=0.711, type IV collagen=0.697, and APRI=0.691 for predicting extensive fibrosis (≥F3). Conclusions: Conclusions: All noninvasive serum markers evaluated in this study were useful for predicting significant or extensive liver fibrosis in chronic viral liver diseases. In particular, APRI was most useful for the prediction of significant fibrosis, and CDS was most useful for the prediction of extensive fibrosis. (Korean J Hepatol 2009;15:454-463)

Valuation of ecosystem services in the organic carbon of the Pinus densiflora forest at Mt. Namsan, Seoul Metropolitan City

Lee, Eung-Pill,Lee, Soo-In,Jeong, Heon-Mo,Han, Young-Sub,Lee, Seung-Yeon,Park, Jae-Hoon,Jang, Rae-Ha,Hong, Youg-Sik,Jung, Young-Ho,Kim, Eui-Joo,Lee, Sang-Hun,You, Young-Han The Ecological Society of Korea 2019 Journal of Ecology and Environment Vol.43 No.4

Background: Standing biomass, litter production, rate of litter decomposition, amount of litter on forest floor, and amount of soil organic carbon distribution were investigated from March 2016 to November 2018 in order to evaluate the ecosystem value through organic carbon distribution in the Pinus densiflora forest at Namsan, Seoul Metropolitan City. Results: The amount of organic carbon in the Pinus densiflora forest was 261.09 ton C ha^-1 during the research period, and fixed organic carbon in plant through net photosynthesis was 3.2 ton C ha^-1 year^-1. The organic carbon in plant was 62.77 ton C ha^-1 (24.04%), in litter on the forest floor was 3.65 ton C ha^-1 (1.40%), and in soil was 194.67 ton C ha^-1 (74.56%). The value of plant, litter on forest floor, and soil organic carbon distribution were each 6,277,000 won ha^-1, 365, 000 won ha^-1, and 19,467,000 won ha^-1. The value per ton of fixed organic carbon in plant through net photosynthesis was 320,000 won ha^-1 year^-1 and the value of ecosystem services stored in carbon in the Namsan forest ecosystem was about 26.1 million won ha^-1 for 3 years. Conclusions: The results of this study suggest that the pine forests of Namsan rapidly decompose leaves due to the high atmospheric temperature and accumulate a large amount of organic carbon in the soil to provide climate control regulatory service function.

Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

에러가 없는 제곱근기와 대역제한필터를 사용한 SECAM Video Decoder를 위한 색상 및 밝기 신호의 복원장치

하주영,김주현,강봉순 東亞大學校附設情報技術硏究所 2005 情報技術硏究所論文誌 Vol.12 No.2

In this paper, we propose the SECAM video decoder system using error-free square root and band pass filter (BPF). SECAM uses frequency modulation (FM) to transmit the Db and Dr color difference information, with each component having its own subcarrier, so input signal of decoder, CVBS, has various frequencies whose bandwidth is 6.0 MHz. The proposed SECAM decoder uses two differentiators, trigonometric functions and as error-free square root to demodulate color information in chrominance processing. The BPF in decoder is used for removing color noise in chrominance and dividing CVBS into chrominance and luminance. The proposed system is experimentally demonstrated with Altera FPGA APEX20K1000EBC652-3 and TV-card available for SCEAM.

CIE1931좌표상에서 경계선과 S-모양 변환 곡선을 사용하여 푸른색과 붉은색을 선명하게 하기 위한 색상 변환 시스템의 구현 및 설계

하주영,강봉순 東亞大學校 大學院 2004 大學院論文集 Vol.29 No.-

In this paper, we propose the color conversion system on the CIE1931 chromaticity-coordinate diagram by using boundary lines and S-Shaped curves to emphasize blue and red colors. The proposed system prevents specific colors, such as human skins, from changing by using boundary lines that divide non-conversion areas from conversion areas. The colors in the conversion areas vary along quadratic curves with S-shaped conversion curves based on conversion ratios. The loci of the quadratic curves are very similar to the arc of the white-point line, known as the Planckian locus. Furthermore, they are relatively easy for hardware implementation. The S-shaped curves are selected to change the bluish (or reddish) color to more bluish (or more reddish), while the areas around white color are not changing. The left side of the quadratic curves represents the blue color and the right represents the red color. Thus, the proposed system changes the colors into more bluish and reddish by moving positions of the colors toward left or right on the curves. The proposed system is also experimentally demonstrated with Xilinx Virtex FPGA XCV2000E-6BG560 and the TV set.

최적 디지탈 서보계의 설계에 관한 연구

하영원,강정호,정주수 慶南專門大學 1995 論文集 Vol.23 No.1

출산의례의 변용(變容)과 근대적 변화(變換) : 1940~1990

주영하 경희대학교 민속학연구소 2003 한국의 민속과 문화 Vol.7 No.-

This is a historical folklorismic approach to the transfiguration and recent transformation of the childbirth rituals taken in Kyunggi-do province of Korean from the year of 1940 to 1990. In general, childbirth rituals are the ceremonies starting from new baby born. In other words it can be called the birth-ceremonies or birth-customs. But I understand that these two words are not good to be used in this paper because the birth-ceremony is strongly related to the situation of the baby just born, and the birth-custom includes the word of 'custom' which is too unofficial and oriented to the viewpoint of the ruling class. So I will use the word of 'childbirth' instead of 'birth-ceremony' or 'birth-custom' and the word of 'ritual' instead of 'custom' in my paper. As a result of this study, I found the facts as follows; Firstly, I ascertained the fact in this site investigation that the trend of preferring a son to a daughter is more distinguished even today. And also I ascertained this trend affects each stage of child birth-rituals enormously. As a very well known fact, today more remarkable trend of the notion of preferring a son to a daughter which was derived from the paternal family system that was a basis of whole Lee-dynasty ascertains that a premodern way of perception is rather strengthening in the modernized Korean society passed the modernized period already. Secondly, the continuos urbanization of Korean society since 20th century changes the style of living space; the changing the conception of the living space disfigured out of all traditional recognitions. The urbanized life promoted by division of work takes it as a matter of course to have a baby in the hospital rather than each house, and this phenomenon let eliminate the space oriented folk-deed in the traditional taboo of childbirth. But the tendency of the food-taboo during the period of pregnancy is rather remarkable and maintained. This shows the possibility of that the Korean recognition of childbirth doesn't follow up the changing of the materialistic dimension. Thirdly, it was founded as a result of this study that a group of relatives scattered due to urbanization take advantage of an opportunity of the ceremony of the hundredth day of the newborn baby or the ceremony given on a baby's first birthday to contact with each other actually. It is the case that especially the parents' colleagues at work and religious organization are deeply evolved in the rituals often the childbirth. It is a general trend that the rituals are finally taken by the specialized enterprise out of the home, so the traditional rituals are generalized from the special form based on each family or locality. This can be called as a new style of folklorism being formed in the urban area. I disclosed in this paper that it is not right to apply the urbanized folklorismic argument raised in western Europe and japan as same as to the Korean society whose social and cultural system is quiet different from them. I confirmed that the changing process of the modern age from the premodern age in the Korean folklorism is the more essential issue than the dichotomy of the rural and urban district.

김치문화의 기원과 변화 연구

周永河 漢陽大學校 民族學硏究所 1993 民族과文化 Vol.1 No.-

문화체계로서의 기술(technology) : 중국 이족의 옻칠기술을 중심으로 The Case of Lacquering Technology among the Lolo in Southwest China

周永河 서울대학교 사회과학연구원 비교문화연구소 1999 비교문화연구 Vol.- No.5