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RISS 인기검색어
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- 저자 : 은창수 ( Chang Soo Eun ) (검색결과 75 건)
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HT-29 세포주에서 Peroxisome Proliferator Activated Receptor γ 활성화를 통한 프로바이오틱스의 염증 억제 효과
은창수 ( Chang Soo Eun ),한동수 ( Dong Soo Han ),이승현 ( Seung Hyun Lee ),전용철 ( Yong Cheol Jeon ),손주현 ( Joo Hyun Sohn ),김용석 ( Yong Seok Kim ),이진 ( Jin Lee ) 대한소화기학회 2007 대한소화기학회지 Vol.49 No.3
Background/Aims: The peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor highly expressed in the colon which plays an anti-inflammatory role through the inhibition of nuclear factor-κB (NF-κB) pathway. Probiotics have been shown to exert beneficial effects on inflammatory bowel diseases. However, the exact mechanism by which probiotics exert protection against intestinal inflammation is not well understood. The aims of this study were to evaluate the attenuation of inflammatory response by probiotics in intestinal epithelial cells and to study the association between probiotics and PPARγ. Methods: HT-29 human epithelial cells were stimulated with LPS (20μg/mL) and probiotics, Lactobacillus casei (L. casei) (10(5)-10(7) cfu/mL), or with LPS (20μg/mL) alone for 24 hours. Interleukin-8 (IL-8), cyclooxygenase-2 (COX-2), toll-like receptor-4 (TLR-4) and PPARγ mRNA expressions were assessed by RT-PCR. IL-8 protein secretion was measured by ELISA. HT-29 cells were transfected with tk promoter-luciferase plasmid containing a peroxisome proliferator response element (PPRE). After stimulation with L. casei or PPARγ agonist (15d-PGJ2 or ciglitazone), luciferase activities were measured. Results: LPS induced IL-8, COX-2, TLR-4 mRNA expression, and IL-8 protein secretion in HT-29 cells. Treatment with LPS and L. casei in comparison with LPS stimulation alone lowered IL-8, COX-2, TLR-4 mRNA expression, and IL-8 protein secretion. L. casei increased PPARγ mRNA expression in dose-dependent manner. L. casei activated PPRE in HT-29 cells transfected with PPRE3-tk-luciferase construct. Conclusions: Probiotics, L. casei, suppresses the expression of inflammatory mediators in intestinal epithelial cells. The anti-inflammatory action of L. casei might be partially related to PPARγ activation. (Korean J Gastroenterol 2007;49:139-146)
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소화성 궤양 환자의 Helicobacter pylori 항생제 내성률 변화
방소영 ( So Young Bang ),한동수 ( Dong Soo Han ),은창수 ( Chang Soo Eun ),김지은 ( Ji Eun Kim ),안상봉 ( Sang Bong Ahn ),손주현 ( Joo Hyun Sohn ),전영철 ( Yong Cheol Jeon ),강정옥 ( Jung Oak Kang ) 대한소화기학회 2007 대한소화기학회지 Vol.50 No.6
Background/Aims: Antibiotic resistance of Helicobacter pylori (H. pylori) is a significant clinical problem because it reduces the efficacy of eradication therapy. The aims of this study were to assess the changing patterns of antibiotic resistance of H. pylori in patients with peptic ulcer diseases and to evaluate the eradication rate in antibiotic resistant H. pylori strains. Methods: One hundred forty four H. pylori isolates obtained from 466 patients with peptic ulcer disease between June 2001 and December 2005 were examined for antimicrobial resistance. The minimum inhibitory concentration (MIC) of metronidazole was determined by modified broth microdilution method (mBMD) and E test. MICs of clarithromycin and amoxicillin were determined by mBMD, E test, and disc diffusion test. The breakpoints for metronidazole, clarithromycin, and amoxicillin resistance were defined as >8μg/mL, >1μg/mL, and ≥1μg/mL, respectively. Results: Resistance to metronidazole and clarithromycin was detected in 34.7% and 16.7% of H. pylori isolates, respectively. During the recent 5-year study period, amoxicillin-resistant rate of H. pylori was 11.8%, and multi-drug resistance rate of H. pylori was 16.7%. The eradication rate of clarithromycin containing triple therapies was low (7.8%) in clarithromycin-resistant H. pylori strains. Conclusions: The proportions of clarithromycin-resistant H. pylori strains have increased significantly over the last 5-years. There is an increasing tendency for the emergence of strains with multi-drug resistance. The increase in clarithromycin-resistant strains results in a decrease in eradication rate for H. pylori. In areas with high clarithromycin resistance, new alternative first-line treatment combination should be considered. (Korean J Gastroenterol 2007;50:356-362)
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은창수,함준수,김기찬,조윤주,전용철,이오영,한동수,손주현,최호순,윤병철,이민호,이동후,기춘석,박경남 (Chang Soo Eun,Joon Soo Hahm,Ki Chan Kim,Yoon Joo Cho,Yong Chul Jun,Oh Young Lee,Dong Soo Han,Joo Hyun Sohn,Ho Soon Choi,Byoeng Chul Yoon,Min Ho 대한소화기학회 1999 대한소화기학회지 Vol.33 No.6
Background/Aims: It has been suggested that cholecystectomy can be related with the developmen of colon cancer and altered bile acid metabolism after cholecystectomy may be an important facto in the carcinogenesis. Thus, we have conducted a retrospective case-control study to clarify the relationship between cholecystectomy and subsequent development of colon cancer. Methods: We compared the incidence of previous cholecystectomy in 424 patients with colon cancer who had treated in our clinic during the period of 1983 to 1997 and in 424 age- and sex-matched controls Results: There was no significant difference in a prevalence of cholecystectomy and gallstones between colon cancer patients and controls (Cholecystectomy: odds ratio=1.17, 95% confidence interval=0.39-3.51; Gallstone: odds ratio=1.27, 95% confidence interval=0.73-2.21). The prevalence of cholecystectomy and gallstones was a little high in right-sided colon cancer group, but there was no statistically significant difference between right and left colon. Conclusions: The present study showed that there was no statistically significant association between cholecystectomy and colon cancer. To clarify whether colon cancer is associated with cholecystectomy or gallstones, further study with large sample size and a prospective study of the incidence of colon cancer afte cholecystectomy are proposed. (Kor J Gastroenterol 1999;33:823 - 830)
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위에서 발생한 선암과 미만성 거대 B세포 림프종의 동시성 중복암
박수역 ( Soo Yuck Park ),은창수 ( Chang Soo Eun ),변영상 ( Young Sang Byun ),윤지영 ( Ji Young Yoon ),전용철 ( Yong Cheol Jeon ),한동수 ( Dong Soo Han ),손주현 ( Joo Hyun Sohn ),오영하 ( Young Ha Oh ) 대한소화기학회 2011 대한소화기학회지 Vol.57 No.2
The simultaneous occurrence of primary gastric lymphoma and adenocarcinoma is rarely reported. We here report a case of synchronous double primary tumor of advanced gastric cancer and diffuse large B cell lymphoma. A 65-year-old woman underwent an esophagogastroduodenoscopy for the evaluation of abdominal discomfort of two months` duration. The endoscopic examination showed an ulcerating tumor in the gastric antrum and thickened folds in the fundus and the microscopic examination revealed an adenocarcinoma in the antrum and a diffuse large B-cell lymphoma in the fundus. She has had total gastrectomy and CHOP chemotherapy with rituximab. Since the cases of synchronous double primary gastric tumors have been increased on the recent medical advances, when a gastric tumor is detected for the endoscopic examination, an endoscopist has to make every endeavor not to miss another tumor in the stomach. (Korean J Gastroenterol 2011;57:115-119)
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간경변 환자에서 식도정맥류결찰술 유발 궤양 출혈에 대한 시아노아크릴레이트 주입 후 유발된 식도 공동 형성
김은경 ( Eun Kyoung Kim ),손주현 ( Joo Hyun Sohn ),김태엽 ( Tae Yeob Kim ),김배근 ( Bae Keun Kim ),유연화 ( Yeon Hwa Yu ),은창수 ( Chang Soo Eun ),전용철 ( Yong Cheol Jeon ),한동수 ( Dong Soo Han ) 대한소화기학회 2011 대한소화기학회지 Vol.57 No.3
Intravariceal injection of N-butyl-2-cyanoacrylate is widely used for the hemostasis of bleeding gastric varices, but not routinely for esophageal variceal hemorrhage because of various complications such as pyrexia, bacteremia, deep ulceration, and pulmonary embolization. We report a rare case of esophageal sinus formation after cyanoacrylate obliteration therapy for uncontrolled bleeding from post-endoscopic variceal ligation (EVL) ulcer. A 50-year-old man with alcoholic liver cirrhosis presented with hematemesis. Emergent esophagogastroscopy revealed bleeding from large esophageal varices with ruptured erosion, and bleeding was initially controlled by EVL, but rebleeding from the post-EVL ulcer occurred at 17th day later. Although we tried again EVL and the injections of 5% ethanolamine oleate at paraesophageal varices, bleeding was not controlled. Therefore, we administered 1 mL cyanoacrylate diluted with lipiodol and bleeding was controlled. Three months after the endoscopic therapy, follow-up endoscopy showed medium to large-sized esophageal varices and sinus at lower esophagus. Barium esophagography revealed an outpouching in esophageal wall and endoscopic ultrasonography demonstrated an ostium with sinus. It is noteworthy that esophageal sinus can be developed as a rare late complication of endoscopic cyanoacrylate obliteration therapy. (Korean J Gastroenterol 2011;57:180-183)
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