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김태엽,임정진,이홍재,김현주,김중현,이재성,Kim, Tae-Yeob,Lim, Jung-Jin,Lee, Hong-Jae,Kim, Hyun-Joo,Kim, Joong-Hyun,Lee, Jae-Sung 대한핵의학기술학회 2011 핵의학 기술 Vol.15 No.1
Purpose: The SUV is a widely used semi-quantitative index in PET for the estimation of radio-tracer accumulation in VOI. In this study, SUVs from three different PET/CT scanners were assessed, and differences between SUVs were evaluated. Materials and Methods: The PET/CT scanners which were assessed in this study were GEMINI, GEMINI TF 64 (Philips) and Biograph True Point True V 40 (Siemens). The NEMA PET phantom (Data Spectrum Corp., USA) was used to evaluate SUVs. The NEMA PET phantom has6.8 kg weight and three hot inserts. Two different activity distributions for the background and inserts were tested. The activity ratio were 3.7:3.7:7.4:11.1 MBq (1:1:2:3) and 1.85:7.4:9.25:11.1MBq (1:4:5:6) for each of background, insert 1, insert 2 and insert 3. Acquisition time was 2 minutes per bed position and NEMA PET phantom could be covered by two bed positions for all PET/CT scanners. The SUVs from each PET/CT scanner were compared with calculated true value. Results: For both activity ratios, all scanners showed similar results. The differences between each scanner were insignificant. Each scanner showed 91.2%, 85.9% and 87.2% of true SUV for GEMINI, GEMINI TF 64, Biograph True Point TrueV, respectively. Conclusion: For all scanners, SUVs were slightly lower than true value. However, the difference between scanners was insignificant. The SUVs from these scanners would be clinically meaningful if their consistent underestimation is kept in mind.
김태엽 ( Tae Yeob Kim ),손누현 ( Joo Hyun Sohn ) 대한내과학회 2010 대한내과학회지 Vol.79 No.5
Recently, the prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing in Korean population. NAFLD includes a spectrum of hepatic pathology from simple steatosis in its most benign form, to nonalcoholic steatohepatitis (NASH) and/or cirrhosis. NAFLD has a strong association with type 2 diabetes and obesity, and thus it is now recognized to represent the hepatic manifestation of metabolic syndrome. The pathogenesis of simple steatosis occurrence and its progression to NASH is not entirely elucidated and multi-factorial. Liver fat accumulation is mainly induced by insulin resistance and increased free fatty acids, and then NASH is developed by oxidative stress, lipid peroxidation, mitochondrial dysfunction, gut-derived endotoxin, and cytokine/adipokine interplay. Genetic factors and environmental factors such as exercise and high fat and high fructose diet also participate in the development of NAFLD. This review is focused to summarize the up-to-date understanding of NAFLD pathogenesis. (Korean J Med 79:461-474, 2010)
중년여성의 가시위근 봉합술전 어깨뼈 안정화운동이 통증과 ROM향상에 미치는 영향
김태엽 ( Tae Yeob Kim ),유병국 ( Byung Kook Yoo ) 대한통합의학회 2014 대한통합의학회지 Vol.2 No.1
Purpose : The purpose of this study was to ascertain the effects of scapular stabilization exercise before rotator cuff surgery on pain and range of motion of middle-aged women. Method : 20 subjects who agreed on this experiment and were diagnosed with rotator cuff rupture participated in this study. Experimental groups were treated while 40 minutes a day, 5 times per week, for 2 weeks before surgery. The effects of scapular stabilization exercise were evaluated on VAS and range of motion. Collected data were analyzed with SPSS for windows ver. 20.0 program. One-way repeated ANOVA was used to examine a significance of each variable by time. Two-way repeated ANOVA was applied to examine a significance of the experimental group against the control group. In all statistical tests, the significance level was set by =.05. Result : The results of this study are as follows: 1) In both control and experimental groups, VASs were decreased significantly according to intervention period. There was no significant difference between VASs of two groups. 2) In both control and experimental groups, ROMs of shoulder, flexion, abduction and external rotation were increased significantly according to intervention period. In these three flexibility measurement variables, there were significant differences between ROMs of two groups. Conclusion : In view of all the results in this study, scapular stabilization exercise on before rotator cuff surgery proved to be effective in improving their pain, range of motion after surgery. It will be sufficient data to perform with their own exercise program.
반도체 라인의 효율적 계측을 위한 자동 계측 샘플링 방식에 관한 연구
김태엽(Tae Yeob Kim),선동석(Dong Seok Sun),이지형(Jee?Hyung Lee) 대한전기학회 2009 전기학회논문지 Vol.58 No.12
Semiconductor processes need measurement to confirm where there are problems in quality after progresses manufacturing process. This paper suggests equipment and automatic measure sampling method that control monitoring ratio according to change point occurrence availability of process that is not measure method by the existent simple ratio rate. This paper defines measure section as ailment section, metastable section and stability section by change point standard and create statistical model of each section and developed suitable measure rate model by section. As a result, we have accomplished maximum throughput and minimum sampling number that needs to maintain constant level of quality. Proposed method minimizes load of measure process by brings production quality sophistication and decrease of process badness and lowers measure rate in stable section making perception about problem occurrence quick heightening measure rate at change point occurrence.
만성 B형 간염 및 항바이러스제 내성 B형 간염의 모니터링과 치료 전략
김태엽 ( Tae Yeob Kim ),손주현 ( Joo Hyun Sohn ) 대한소화기학회 2007 대한소화기학회지 Vol.49 No.6
Clinical management of chronic hepatitis B is rapidly evolving after the recent development of new antiviral drugs. These agents have been shown to be effective in improving virological, biochemical, and histological features in high proportion of the patients with chronic hepatitis B. However, these drugs can not eliminate hepatitis B virus (HBV) directly. It can only suppress HBV replication. Furthermore, the emergence of drug resistant HBV has become problematic according to the long-term use of oral antiviral drugs. Therefore, physicians should be careful in selecting whom to treat, when to start treatment, how long to treat, how to monitor patients before, during and after the treatment, which drug to choose, and how to manage patients with drug resistance. This review will focus on the monitoring and treatment strategy for chronic hepatitis B and drug resistant hepatitis B, quoting some clinical data of recently introduced or promising future drugs. (Korean J Gastroenterol 2007;49:346-355)
초기 간세포암종을 동반한 간경변증 환자에서 생존 예측에 있어서의 간정맥압력차와 연관인자
김태엽 ( Tae Yeob Kim ),김문영 ( Moon Young Kim ),장재영 ( Jae Young Jang ),석기태 ( Ki Tae Suk ),정승원 ( Soung Won Jeong ),김동준 ( Dong Joon Kim ),손주현 ( Joo Hyun Sohn ),백순구 ( Soon Koo Baik ) 대한간암학회 2014 대한간암학회지 Vol.14 No.1
Background/Aims: To analyze the usefulness of hepatic venous pressure gradient (HVPG) in survival prediction in cirrhotic patients with early and very early hepatocellular carcinoma (HCC). Methods: We consecutively collected data of 45 stable cirrhotic patients (male 41, median age 57.2 years, BCLC A 29) with early-stage HCC undergoing HVPG measurement. Prognostic accuracy of HVPG was analyzed by the area under curve (AUC). Survival curves and the associated factors of HVPG status were obtained using Kaplan-Meier method and logistic regression analysis, respectively. Results: The AUC value for prediction of survival by HVPG were 0.754 (95% CI, 0.603-0.870, P=0.006). The cut-off value of HVPG to predict death was 12 mmHg. Among the 45 patients, 11 patients (24.4%) died: 11 of 28 patients in the high HVPG group and none of 17 patients in the low HVPG group during followup period (P=0.003). The survival rate with high HVPG group was higher than those of low HVPG group (log rank P=0.008). In Child-Turcott-Pugh (CTP) class, the survival rate with CTP A class was higher than that with CTP B class (log rank P<0.001). The only associated factor with HVPG ≥12 mmHg in CTP A class and early-stage HCC was the presence of medium or large sized esophageal varices (odds ratio 66.8, 95% CI, 1.3-3530.4, P=0.038). Conclusions: HVPG ≥12 mmHg may be suggested a predictor of survival in cirrhotic patients with early-stage HCC. In CTP A class, the presence of medium or large sized esophageal varices were associated with high HVPG.
Management of HCC Patients with Locoregional Therapy (RFA & PEIT)
Tae Yeob Kim(김태엽) 한국간담췌외과학회 2014 한국간담췌외과학회 학술대회지 Vol.2014 No.4
There are many difficulties to establish treatment strategy in hepatocellular carcinoma due to progression of chronic hepatitis or liver cirrhosis. Although surgery and liver transplantation are known as the curative therapy of HCC, its applications to most of the patients are limited because of poor residual liver functions, difficult location, donor insufficiency, or other reasons. In these patients, locoregional therapies are approved by several international guidelines as a non-surgical tool, especially for treatment of early hepatocellular carcinoma. The role of locoregional therapy is growing with progress in techniques and merging other treatment together. Percutaneous ethanol injection therapy and radiofrequency ablation, well known standard locoregional therapy for HCC, will be reviewed in this article.