야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

뇌경색 환자의 혈중 호모시스틴치 (예비 연구)

정두신,송인욱,조상걸,성기범,박형국,신현길,장성근 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

뇌간 경색증 후 핵간 안근마비를 동반한 수구증후군

정두신,이보람,조상걸,박형국,신현길,성기범 대한신경과학회 1998 대한신경과학회지 Vol.16 No.2

林道의 迂廻係數 算出 : 江陵營林署의 國有林道를 대상으로 National forest roads of Kangnung national forest office

曺丘鉉,池炳潤,車斗松 江源大學校 林科大學 森林科學硏究所 1994 Journal of Forest Science Vol.10 No.-

본 연구는 林道開設을 위한 기초자료로서 江陵營林署의 5개 管理所(강릉, 양양, 삼척, 정선, 평창관리소)의 國有林道를 대상으로 傾斜別 林道迂廻係數를 산출하였다. 그 결과, 林道迂廻係數는 경사도 5%이하에서 0.33, 6∼10%에서 0.39, 11∼15%에서 0.50, 16∼20%에서 0.58, 및 21%이상에서는 0.63으로 나타났다. This study was carried out to estimate forest road elongation coefficients for providing the basic information of forest road construction. As the results, road elongation coefficients were calculated 0.33 less than 5% of road gradient, 0.39 between the gradient of 6% and 10%, 0.50 between the gradient of 11% and 15%, 0.58 between the gradient of 16% and 20%, and 0.60 greater than the gradient of 20%.

미세수술에 의한 난관 문합술후의 원발성 난소임신 1례

박윤정,조기현,이두룡 啓明大學校 醫科大學 1990 계명의대학술지 Vol.9 No.3

Primary ovarian prehnancy is rare form of ectopic pregnancy. We have experienced a case of ovarian pregnancy recently, it was asociated with tubal reanastomosis. We report it with a brief review of literatures.

Pyrogallol Induces G0/G1 Cell Cycle Arrest and Apoptosis through Mitochondrial Pathway in PC-3 Human Prostate Cancer Cells

Hyun Dong Cho,Du Hyun Kim,Jeong Ho Kim,Yeong Seon Won,Kwon Il Seo 한국식품영양과학회 2018 한국식품영양과학회 학술대회발표집 Vol.2018 No.10

Precision of the milled full-arch framework fabricated using presintered soft alloy: A pilot study

Hyun-Wook Woo,Sung-Am Cho,Cheong-Hee Lee,Kyu-Bok Lee,Jin-Hyun Cho,Du-Hyeong Lee 대한치과보철학회 2018 The Journal of Advanced Prosthodontics Vol.10 No.2

PURPOSE. This study aimed to evaluate the marginal discrepancy of full-arch frameworks in implant-supported prostheses fabricated using pre-sintered soft alloy (PSA). MATERIALS AND METHODS. Full-arch metal frameworks were fabricated on the edentulous implant model using casting alloy (CA), fully-sintered hard alloy (FHA), and PSA (n = 4 in each group). To evaluate the misfit of the framework to the abutments, the absolute marginal discrepancy (AMD) values of the frameworks were measured in cross-sectional images that had been drawn as part of the triple-scan protocol. The AMD values were compared among the tested alloy groups using the Kruskal-Wallis test, with a post hoc Mann-Whitney U test (α=.05). RESULTS. The FHA and PSA groups showed lower marginal discrepancies than the CA group (P<.001). However, the FHA group did not differ significantly from the PSA group. CONCLUSION. Soft alloy milling is comparable to hard alloy milling, and it is more precise than casting in terms of the marginal fit of implant-supported, full-arch prostheses.

달맞이꽃 종자 추출물의 생리활성

조현동(Hyun-Dong Cho),김두현(Du-Hyun Kim),김민근(Min-Geun Kim),이용석(Yong-Suk Lee),서권일(Kwon-Il Seo) 한국생명과학회 2018 생명과학회지 Vol.28 No.9

본 연구에서는 달맞이꽃 종자 물, 에탄올, 메탄올 및 70% 에탄올 추출물의 총 폴리페놀 및 플라보노이드 함량, 항산화, 신경세포 손상 억제, 항암, 대식세포 면역조절 활성 및 에 대하여 비교하였다. 달맞이꽃 종자 추출물 중 메탄올 추출물에서 각각 31.90 mg GAE/g 및 20.66 mg QE/g의 총 폴리페놀 및 총 플라보노이드 함량을 나타내었으며 나머지 추출물과 비교하여 가장 활성이 높았다. 라디칼 소거능 및 환원력 활성은 달맞이꽃 종자 추출물의 처리에 따라 농도의존적으로 증가하였다. 또한 물, 에탄올 및 메탄올 추출물을 25-100 μg/ml의 농도로 전처리 하였을 때 글루탐산에 의해 유도되는 신경세포 손상 효과를 감소시키는 것으로 확인되었다. 암세포의 경우 메탄올 추출물이 간암, 폐암, 유방암 및 흑색종 피부암의 세포 생존율을 효과적으로 감소시켜 낮은 IC50 값을 보였으며 대장암과 전립선암에서는 물 추출물과 에탄올 추출물이 가장 낮은 IC50 값을 나타내었다. 또한, 달맞이꽃 종자70% 에탄올 추출물은 RAW 264.7 마우스 대식세포의 생존율에 영향을 미치지 않는 농도에서 유의적으로 산화질소(nitric oxide, NO)의 생성을 통해 대식세포의 면역활성을 유도하였다. 따라서, 달맞이꽃 종자 추출물은 풍부한 폴리페놀 함량과 다양한 생리활성 효능을 나타내며 이를 통해 달맞이꽃 종자 추출물을 기능성 식품 원료 및 천연물 의약품으로 이용할 수 있을 것으로 사료된다. In the current study, comparisons of Oenothera Biennis seed extracts with water, ethanol, methanol, and 70% ethanol in their total polyphenolics contents, anti-oxidant, anti-neurotoxicity, anti-cancer, and immune-modulatory activities were investigated. Compared with other extracts, those concentrations of total phenolics and flavonoids were the highest in MeOH extract (31.90 mg GAE/g and 20.66 mg QE/g). The radical scavenging and reducing power activities were dose-dependently increased by treatment of O. Biennis seed water, EtOH, MeOH, and 70% EtOH extracts. Furthermore, pretreatment of water, EtOH, and MeOH extracts significantly reduced glutamate-induced cytotoxicity in HT22 hipocampal neuron cells. In the case of cancer cells, MeOH extracts showed lower IC50 values in HepG2 (74.21 μg/ml), A549 (188.24 μg/ml), MCF-7 (186.42 μg/ml), and B16 (101.80 μg/ml) than other extracts, where those water (101.96 μg/ml) and EtOH (788.39 μg/ml) extracts showed the lowest IC50 activity in HT-29 and PC-3 cells, respectively. O. Biennis seed extracts did not show any cytotoxicity in RAW 264.7 macrophages at the concentration of 1-10 μg/ml, whereas 70% EtOH extract dose-dependently enhanced nitric oxide (NO) production in RAW 264.7 cells. Overall, we evaluated that various bioactive potentials of O. Biennis seed extracts which would relate with phenolic compounds abundance, thus these can be useful to future developments as functional food ingredients and natural medicines.

수수 추출물에 의한 primary 전립선 암세포의 caspase 의존성 apoptosis 유도 및 대식세포 면역활성 증가

조현동(Hyun-Dong Cho),김정호(Jeong-Ho Kim),홍성민(Seong-Min Hong),이주혜(Ju-Hye Lee),이용석,김두현(Du-Hyun Kim),서권일(Kwon-Il Seo) 한국생명과학회 2016 생명과학회지 Vol.26 No.12

본 연구에서는 수수 에탄올 추출물(ethanol extract of Sorghum bicolor L., SE)을 이용하여 RC-58T/h/SA#4 primary 인체 전립선 암세포에 대한 apoptosis 유도효과 및 RAW 264.7 마우스 대식세포에 대한 면역활성 증진효능에 대해 알아보고자 하였다. SE의 처리는 RC-58T/h/SA#4 세포의 증식을 억제하였으며 세포수축을 통한 형태학적 변화를 유발하였다. 또한 apoptosis 관련 지표현상인 apoptotic body 및 핵의 형태변화를 관찰할 수 있었다. RC-58T/h/SA#4 세포에 SE를 처리하였을 때 caspase-8, -9, -3 단백질 활성을 증가시켰으며 pro-apoptotic 단백질인 Bax, p53, 분절된 PARP 및 세포질의 cytochrome c 단백질은 증가시킨 반면, anti-apoptotic 단백질인 Bcl-2 단백질은 감소시켰다. 이는 z-VAD-fmk로 caspase 활성을 억제시켰을 때 SE에 의한 세포증식 억제효과가 감소되었으며 이를 통해 SE에 의한 세포증식 억제효과는 caspase 의존적임을 확인할 수 있었다. 면역반응에서 nitric oxide(NO)의 증가는 면역활성 지표로 여겨지며, 본 연구에서 SE를 처리하였을 때 RAW 264.7 세포에서 NO 생성능이 증가하는 것으로 나타났다. 본 연구의 결과들은 SE가 primary 전립선 암세포에서 caspase 의존형 apoptosis를 유도하며 대식세포의 면역활성을 증가시킨다는 것을 나타낸다. 따라서 수수를 전립선 암 예방 및 면역활성을 증진효능이 있는 기능성 식품 소재로 활용할 수 있을 것으로 생각된다. Sorghum bicolor L. is one of the important minor cereals in Asia, Africa, and the central United States, and it is considered a rich source of polyphenols, flavonoids, and dietary fiber. However, there is a lack of data on the anti-cancer activity of Sorghum in prostate cancer cells and immune activity in macrophages. This study aims to investigate the potential effects of an ethanol extract of S. bicolor L. (SE) on inducing apoptosis in RC-58T/h/SA#4 cells and immunomodulatory activity in RAW 264.7 cells. SE significantly inhibited the viability of RC-58T/h/SA#4 primary prostate cancer cells in a dose-dependent manner. The morphology of RC-58T/h/SA#4 cells treated with SE was shrunken and involved the formation of an apoptotic body and nuclear condensation. In addition, SE markedly activated caspase-8, -9, and -3; increased the protein levels of Bax, p53, cleaved PARP, and cytosolic cytochrome c; and decreased Bcl-2 protein expression. Furthermore, the inhibition of caspases in RC-58T/h/SA#4 cells with z-VAD-fmk attenuated SE-induced cell growth inhibition. The production of nitric oxide (NO) was also elevated by SE treatment, as revealed by immune response parameters. These results suggest that SE inhibits growth and induces apoptosis in primary human prostate cancer cells in a caspase-dependent manner, and it modulates the immune functions in macrophages. Therefore, Sorghum bicolor L. may be used as a functional food to prevent prostate cancer and enhance immune activity.

Protection of Surgical Team from COVID-19 during Bipolar Hemiarthroplasty in an Infected Elderly Patient

Sang-Hyun Um,Du-Han Kim,Moon-Yul Youn,Chul-Hyun Cho,Hyun-Ah Kim,Byung-Woo Min,Ki-Cheor Bae,Kyung-Jae Lee 대한정형외과학회 2020 Clinics in Orthopedic Surgery Vol.12 No.3

The novel coronavirus disease 2019 (COVID-19), which began in Wuhan, China, has rapidly flared up all over the world, evolving into a pandemic. During these critical times, we should give emphasis on infection prevention for the health care staff as well as appropriate patient management in order to maintain the health care system. We report our experience in protecting a surgical team from COVID-19 infection during a bipolar hemiarthroplasty in an infected patient. This case highlights the importance of appropriate protection of the health care staff and education in minimizing the risk of transmission of the infection and maintaining the health care system.