선천성 완전방실차단이 동반된 신생아 루프스 1예

정재현,이은지,이은주,황진원,송영진,최병진,김일환,김종윤,허민영,김동욱 인제대학교 2009 仁濟醫學 Vol.30 No.-

Neonatal lupus is a rare syndrome occurring In neonates with tranplacentally acquired maternal autoantibodies, In particular anti-SSA/Ro-SSB/Ra antibodies. Manifestations include congenital heart block, cutaneous lesions, thrombocytopenia, neutropenia, pulmonary or neurological disease and hepatitis. The non-cardiac manifestations resolve by 6 months of age, congenital heart block is irreversible. We experienced a case of neonatal lupus with congenital complete heart block in a newborn of asyptomatic mother with anti-SSA/Ro-SSB/Ra antibodies.

Ketoprofen 첩포제(Ketotop : )의 경피적용에 따른 혈장농도 및 피부자극의6 검토

임동석,장인진,신상구,유재학,은희철 大韓臨床藥理學會 1994 臨床藥理學會誌 Vol.2 No.1

사군자탕이 L1210 세포를 이식한 마우스의 면역세포에 미치는 영향

殷載淳,金大根,柳東和,權鎭,徐龍勳,蘇俊魯,全焄,吳贊鎬 우석대학교 의약품개발연구소 1997 藥學硏究誌 Vol.2 No.-

The purpose of this research was to investigate effects of Sa-Kunja-Tang(SKT) on immune cells of L1210 cell-transplanted mice. The apoptosis and T lymphocytes subopoulation were tested using a flow cytometry, and the proliferation was tested using a MTT assay. Nitric oxide production from mouse peritoneal macrophage was tested using a Griess reagents, and the phagocytic activity of mouse peritoneal macrophage was tested using a lucigenin chemiluminescence. SKT suppressed apoptosis of T-lymphocytes induced by L1210 transplantation. SKT decreased nitric oxide production from mice peritoneal macrophages increased by L1210 transplantation, and the phagocytic activity decreased by L1210 transplantation. These results suggest that SKT suppresses T lymphocyte apoptosis and macrophage activity in L1210 transplanted mice.

L1210 세포증식에 대한 Glycyrrhizin의 억제작용 기전

殷載淳,徐龍勳,權鎭,柳東和,吳贊鎬,蘇俊魯,全焄,黃甲洙 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

The purpose of this research was to investigate the mechanism of inhibitory action of Glycyrrhizin(GZ) on the proliferation of mouse leukemia cell-line, L1210 cells. The cytotoxic activity was tested using a colorimetric tertrazolium assay(MTT assay), the apoptosis was tested using flow cytometry. Nitric oxide(NO) production form mouse peritoneal macrophage was tested using a Griess method and the phagocytosis of human polymorphonuclear cells was tested using a lucigenin chemiluminescence. GZ ingibited the proliferation of L1210, BALB/c 3T3 cells and mouse thymocytes at 50 ug/ml/ GZ did not affect nitric oxide production from mouse peritoneal macrophages in vitro, but ingibited nitric oxide production from lipopolysaccharide and y-interferon treated macrophages. Macrophages of GZ-administered mice accelerated NO production. The proliferation of L1210 cells apoptosis of L1210 cells were induced by co-culture with macrophage of GZ-administered mice. The apoptosis of L1210 cells were induced by co-culture with macrophage of GZ-administered mice. GZ increased the phagocytosis of human polymorphonuclear cells. These results suggest that GZ inhibit the proliferation of L1210 cells not only as a direct cytotoxic agent o tumor cells, but also by the enhancement of NO production and phagocytic activity.

음성 인식 헬스케어 시스템

신진우,조우승,조성빈,김재훈,정지은,사예지,백경동,박동규 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

As modern people's interest in health grows, wearable healthcare-related technologies that can collect biometric information and receive health-related services regardless of time and place are developing. This paper proposes the healthcare system based on voice recognition function. Unlike conventional wearable healthcare systems, the proposed system provides real-time telemedicine and diagnosis and the direct connection with doctors is possible through it. And almost all functions of the application in it are operated with voice commands to lower user access barriers. Because it deals with personal information including medical information, encryption algorithms have been applied between all data movements. Finally, the healthcare system proposed in this paper is expected to increase convenience in health care and reduce the medical gap.

사군자탕이 항암제를 투여한 마우스의 면역세포에 미치는 영향

殷載淳,金大根,柳東和,權鎭,洪鍾星,蘇俊魯,全焄,吳贊鎬 우석대학교 의약품개발연구소 1997 藥學硏究誌 Vol.2 No.-

The purpose of this research was to investigate effects of Sa-Kunja-Tang(SKT) on immune cells of antitumor drugs administered mice. The apoptosis and T lymphocytes subpopulation were tested using a flow cytometry, and the proliferation was tested using a MTT assay. The administration of etoposide. vincristine or doxorubicin increased the apoptosis of T-lymphocytes, but the action of doxorubicin was decreased by the administration of SKT. The administration of etoposide or vincristine decreased helper T and cytotoxic T cells population of T lymphocytes, but the action of vincristine was recovered by the administration of SCT. The administration of etoposide, vincristine or doxorubicin decreased the proliferation of T-lymphocytes, but the action of doxorubicin was increased by the administration of SKT. These results suggest that SKT has a regulative function of T-lymphocytes in anti-tumor drugs administered mice.

복합식 히트펌프 설계를 위한 액체건조제 제습기의 성능 특성에 관한 실험적 연구

이수동,정진은,박문수 한국기술교육대학교 2004 論文集 Vol.10 No.2

A liquid desiccant for hybrid heat pump system undergoes various influences by several working factor. This paper presents the study of six options in related with the dehumidification rate and efficiency absorption in the dehumidification system. The effect of operating variables such as inlet solution concentration, inlet solution flow rate, inlet solution temperature, inlet air flow rate, inlet air temperature, and brine temperature was analyzed. The experimental dehumidifier has been designed to study the dehumidi- fication characteristics of the aqueous triethylene glycol(TEG) system. The performance characteristics of the absorption dehumidification system can be used effectively to save energy by reducing latent heat load. The result of this experiment can provide useful data for hybrid air conditioning system.

고도보정 공간내삽에 의한 전국의 1km²단위 기상실황 추정

윤진일,이동석,최재연,조성인,박은우,황헌 한국농업정보과학회 1999 농업정보과학 Vol.1 No.1

Conventional method of generating meteorological surfaces over geographic areas often neglects the elevation effect which is considered to be a single most important control over local climate. Deviation of the estimates may exrled practical limits at some areas with complex toprlgraphy. A digital map featuring coordinates and elevation data of 72 weather stations in Korea were joined with hourly weather(trmperature, relative humidity, precipitation and wind speed) observations at the stations by using a geographic information system software. An inverse distanre weighted interpolation was done on the point features to generate prim-itive meteorological and elevation surface grids consisting of 430×600 cells, respectively. Elevation difference at each cell between the United States Geological Survey's 1 km digital elevation model and this virtual ele-vation surface was calculated. Known relationships between meteorological elements and the elevation differ-ence were used to derive "correction grids" representing the potential effects of elevation difference at each grid cell. The correction grids were added or multiplied to the primitive meteorological surfaces to obtain ele-vation-corrected estimates for corresponding elements. This srheme was applied to hourly data of 27 March 1998 to generate the elevation-corrected mrteorological surfaces. Observed data of 350 automated weather sta-tions were used to partially validate the accuracy of the results. This simple scheme sHelved a feasibility of a near-real time generation of hourly meteorological surfaces for temperature and rainfall with an affordable error range.

Thiopental Sodium, Propofol(Diprivan^�) 및 Midazolam이 안압에 미치는 영향

최정은,서경덕,서동선,최세진 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

Intraocular pressure(IOP) were measured during induction of anesthesia with thiopental sodium(n = 10), propofol(n=10), and midazolam(n=10). IOP were measured using a Schioetz tonometer before and after induction, and 1min and 3min after endotracheal intubation. All patients were divided into three groups as follows ; Group Ⅰ(n=10) : thiopental sodium 5mg/kg was administered intravenously for induction of anesthesia Group Ⅱ(n=10) : propofol 2mg/kg was administered intravenously for induction of anesthesia Group Ⅲ(n=10) : midazolam 0.2mg/kg was administered intravenously for induction of anesthesia Succinylcholine 1mg/kg were administered intravenously for endotracheal intubation in all groups. The results were as follows ; 1) Induction of anesthesia with propofol and thiopental sodium are associated with a significant reduction in IOP. 2) Induction of anesthesia with propofol is associated with more significant reduction in IOP than thiopental sodium. 3) Induction of anesthesia with midazolam is not associated with reduction in IOP. From above results, propofol can be used as effectively as thiopental sodium for general anesthesia in patients who undergo ophthalmic surgery.

RAPD-PCR을 이용한 누에 계통간 유연관계분석

강은영,김성근,이진성,황재삼,서동상 성균관대학교 생명과학자원연구소 1996 生命資源科學硏究 Vol.3 No.1

We have analyzed the genetic relationship among the silkworm (Bombyx mori) strains using RAPD-PCR. A total of 45 polymorphic RAPD markers amplified from 9 different primers were used to analyze the genetic relationship among the seven silkworm strains. The genetic similarity coefficients among the seven silkworm strains were estimated using the RAPD markers by UPGMA method. The genetic similarity coefficient between 127 and CS120 was 0.261. This value was lower than any other genetic similarity coefficient among the strains tested. And 127-specific RAPD band patterns were observed in 3 primers from 9 polymorphic primers used. This study makes possible phylogenetic identification among the Bombyx mori strains in the molecular level using RAPD-PCR techniques.