급성하벽심근경색에서 전흉부유도 ST절 하강의 의의

정병천,배호상,곽동훈,김영태,배용학,황종현,임현주,류재근,조용근,채성철,전재은,박의현 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.2

목적 : 급성하벽심근경색증 환자에서 심전도상 흔히 동반되는 전흉부유도 ST절 하강의 의의를 알아보았다. 방법 : 심근경색후 24시간에서 48시간에 얻은 심전도를 기준으로 52명의 급성하벽심근경색증 환자를 전흉부유도에서 ST절의 하강이 있는 군과 없는 군으로 나누었으며 심도자, 관상동맥조영술, 심초음파도 및 방사성 핵종을 이용한 좌심구혈율 측정 등을 시행하였다. 결과 : 1) 좌심실확장기말압은 전흉부유도에서 ST절의 하강이 있는 경우에서 16.9±5.33mmHg로 없는 경우의 11.0±4.02mmHg보다 유의하게 높았다(p<0.05). 그러나 운동량 및 좌심구혈을은 흥부 유도상 ST절의 하강이 있는 경우 7.6±3.0 METs 및 53.9±9.1%로 없는 경우의 9.1±2.7 METs 및 54.6±9.5%보다 낮았으나 통계적 유의성은 없었다(p=0.180, p=0.823). 2) 관상동맥조영술상 전흉부 ST절의 하강이 동반된 군에서는 유의한 좌전하행지나 좌회선지의 협착이 있는 경우가 60.9% 및 57.9%로 ST절의 하강이 없는 군에서의 34.5% 및 7.7%와 비교해 좌관상동맥에 협착이 동반된 경우가 많았다(p=0.050, p=0.001). 3) 관상동맥조영술상 세 혈관질환의 빈도는 흉부유도상 ST절의 하강을 보인 23예에서 10예로 ST절 하강이 없었던 29예중 2예에 비하여 유의하게 많았고(P=0.007), 단 혈관질환의 빈도는 ST절의 하강을 보인 군에서 23예중 5예로 ST절 하강이 없었던 29예중 17예에 비하여 유의하게 적었다(P=0.002). 두 혈관질환의 경우에는 각각 8예와 10예로 양군간에 유의한 차이가 없었다. 4) 흉부유도상 ST절 하강의 빈도는 단 혈관질환 22예 중 5예에서, 두 혈관질환 18예중 8예, 세 혈관질환 12예 중 10예에서 관찰되어 협착이 있는 관상동맥의 수가 많을수록 ST절의 하강이 나타나는 빈도가 많음을 보였다(p=0.00308). 그러나 흉부유도상 나타난 ST절의 하강을 모두 합하여 구한 ST절 하강의 합은 협착이 있는 관상동맥의 수와 통계적인 유의성이 없었다. 5) 심초음파도상 좌심실 하벽의 벽운동은 ST절 하강을 보인 군에서는 akinesia가 83.3%, hypokinesia가 11.1%, 정상 벽운동이 5.6%로, ST절 하강이 없었던 군에서의 dyskinesia가 3.6%, akinesia가 39.3%, hypokinesia가 25.0%, 정상 벽운동이 32.1%와 비교하여 ST절의 하강이 있는 군에서 유의하게 벽운동의 장애가 빈번함을 보였다(p=0.03891). 그러나 좌심실전벽, 측벽 및 중격부위에서는 유의한 벽운동의 차이가 없었다. 결론 : 급성하벽심근경색증 환자의 전흉부유도에서 ST절의 하강이 동반되는 경우 다혈관 질환의 가능성이 높으며 좌심실확장기말압이 상승되었고 운동능력은 감소되어 있었다. 또한 심초음파도상 좌심실하벽의 벽운동장애도 심하였다. 따라서 전흉부 ST절의 하강을 동반한 급성하벽심근경색증 환자는 전흉부유도에 ST절 하강이 없는 경우보다 예후가 불량할 것으로 생각되며, 보다 적극적인 치료가 필요할 것으로 생각된다. The purpose of this study was to determine the significance of precordial ST segment depression appearing during acute inferior myocardial infarction and to assess the correlation of that with angiographic finding. 52 patients were allocated into two groups based on the existence of precordial ST segment depression : 23 patients with ST segment depression and 29 patients without ST segment depression. The extent of coronary artery disease as well as the prevalence of significant stenosis (≥70%) in left anterior descending artery were more frequent in patients showing precordial ST segment depression than in patients not showing them (p=0.050) and the result were similar in cases of left circumplex artery (p=0.001). On echocrdiographic examination of left ventricular (LV) wall motion, it showed more severely decreased inferior LV wall motion in patients showing precordial ST segment depression than in patients not showing them (p=0.03891) even though the other segment of LV wall motion didn't show the statistical difference between both groups. The other cardiac parameters such as LVEDP, exercise amount (METs) and ejection fraction were tend to showing bad profile in patients with precordial ST segment depression. From the above results, we could deduce that patients with precordial ST segment depression have relatively large infarction or concomitant left coronary artery disease, so they need more caution and intensive theraphy.

열안정형 카테콜-O-메틸전이효소 유전자의 클로닝

홍경만,최용복,정갑용,지은정,장현신,박현,백문기 圓光大學校 醫科學硏究所 1998 圓光醫科學 Vol.14 No.2

Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is the enzyme which catalyzes the transfer of methyl group to the catecholamine neurotransmitters from its methyl donor S-adenosyl-L-methionine. Partially purified COMT from rat liver has been used to measure the concentration of catecholamines in the blood through solvent extraction and thin layer chromatography after converting ^3H-methyl derivatives of catecholamines. To improve this inconvenient and fluctuating method, an attempt was made to use COMT gene for the measurement of catecholamines. Specific primers, COMT5P (5'-TGC TCA GAG GTG CTT TGA AG-3') and COMT3P (5'-GGA GCC GCA GAA GGT CA G-3'), were used to amplify COMT gene from human placenta cDNA library. The amplified COMT gene through 35 cycles of polymerase chain reaction was cloned into T-vector and the nucleotide sequences are determined by automatic sequencer. Human COMT has two common variants, a thermostable high activity form which has valine at amino acid 158 and a thermolabile low activity form which Has methionine at the same position. The cloned COMT gene in this study has both variants. Clone 4 and 5 have valine at amino acid 158 (guanine at nucleotide 472) and clone 1-3 have methionine at this site (adenine at nucleotide 472). In addition to this, there are other DNA polymorphisms in COMT gene at nucleotide 101, 102 (amino acid 34, a structural mutation cysteine/serine) and nucleotide 186 (a silent mutation). All of the clones have cysteine at amino acid 34 (guanine and adenine at nucleotides 101 and 102) and cytosine at nucleotide 186 except clone 3 which has thymine at this nucleotide. Clone 4 and 5 are thermostable high activity variants, suggesting being more useful for the measurement of catecholamines after expressing the gene.

위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

레스토랑 체인에서 사용되는 전략적 모델들의 조합에 대한 연구

정현영 공주영상정보대학 1998 논문집 Vol.5 No.-

레스토랑의 경영층들은 급변하는 시장환경에 대응하고 지속적인 경쟁력을 유지하기 위하여 여러 기관들이나 학자들이 제시한 전략적 모델을 사용하고 있다. 그러나 각각의 모델들은 어떤 특정한 상황을 분석하기 위하여 만들어진 모델이거나 현재의 상황에 맞지 않게 경제적 환경이나 기업에 영향을 미치는 세력들이 상호 독립적 관계에 있다는 것을 가정하고 만들어진 모델이기 때문에, 또는 시간적인 흐름에 따라서 사용 해야할 적절한 모델을 제시하는데 실패를 하고 있기 때문에 실제적으로 적용을 하는데는 많은 문제를 내포하고 있다. 이러한 문제점들을 보완하기 위하여 두개 이상의 모델을 조합하여 이용함으로서 그리고 이 조합된 모델을 제품의 수명주기 또는 기업의 수명주기에 적절한 적용을 함으로서 각각의 모델을 사용함에 있어서의 부족한 부분을 채워 줄 수 있을 뿐만 아니라 시간적인 흐름을 고려하고 있지 않는 모델에 대하여는 제품 또는 기업의 수명주기에 따라서 사용해야할 적절한 전략적 모델을 제시 할 수 있다.

친환경 도시에서의 자원활용에 관한 연구 : 빗물의 다목적 활용을 위한 빗물저장조의 운전방법 Operation method of rain storage tank for using rainwater as multipurpose

정용현 한국환경과학회 2003 한국환경과학회지 Vol.12 No.3

Ecological society and energy conservative systems has become a subject of world wide attention. To examine the technologies of such systems as resource recycling society, this study is proposed for using rainwater as energy source and water resources in urban area. Useful informations for planning of utilizing rainfall as energy source, water resources, emergency water and controlling flood are discussed with model systems in urban area. It is calculated that the rate of utilizing rainwater, amounts of utilizing rainwater, substitution rate of supply water, amounts of overflow rainwater according to rain storage tank volume. By applying the past weather data, The optimum volume of rain water storage was calculated as 200㎥ which mean no benefits according to the increase of storage tank volumes. For optimum planing and control method at the model system, several running method of rainwater storage tank was calculated. The optimum operating method was the using weather data as 3hours weather forecast.

자원순환형 소각열 이용시스템에 관한 평가

정용현 한국환경과학회 2003 한국환경과학회지 Vol.12 No.4

How to plan the energy system is one of the key for constructing the Environment -Friendly City. For this reason, an great number of surveys for utilizing unused energy have conducted by a planner. In regard to unused energy, the heat from incineration plants classify as a unused energy having high-exergy-energy. From this point of view, It is studied about the plant systems providing heat to district heating & cooling(D.H.C) and producing electric power. It is divided four system models as system Ⅰ(10K[㎏f/㎠] vapor as outlet of boiler, supply for 10K vapor and return to 60℃ as supply condition of district heating), system Ⅱ (30K vapor as outlet of boiler, supply for 5K vapor and return to 60℃ as supply condition of district heating), system Ⅲ(30K vapor as outlet of boiler, supply for 85℃ hot water and return to 60℃ as supply condition of district heating), system Ⅳ(30K vapor as outlet of boiler, supply for 47℃ hot water and return to 40℃ as supply condition of district heating). The results from the upper condition of four system, System Ⅱ got a proper on economical benefits and system Ⅳ calculated as benefiting on energy saving effects, and suggest indifference curve as the total evaluation method of both economical benefits and energy saving.

생태도시에서의 자원활용에 관한 연구 : 하수 에너지 활용을 위한 보유열량 평가 Evaluation of the Potential Heat Capacity of Sewage For Utilizing as Sewage Energy

정용현 한국환경과학회 2003 한국환경과학회지 Vol.12 No.6

The research on potential energy was conducted to conserve the high-exergy energy like primary energy and utilize waste heat from sewage. From the point of view in using the waste heat, the energy potential of waste water from the model house was simulated. From the results, when the heated water was supplied to the model house side in order to put unused energy to practice use, heated water had higher energy potential than unheated water, which was due to the discharge of most of unused energy. The possessing heat capacity of sewage from heated water was increased to 40-70 percents in comparison with that from the unheated water. Therefore, it can be used as energy source for improving coefficient of performance of heat pumps. By adopting the multiple heat pump into a model house, It showed that the possessing heat capacity of sewage was reduced. It was also found that the heat was recovered as energy source for multiple heat pump in a model house.

생태도시에서의 자원활용에 관한 연구 : 주택 에너지 시스템 개선을 위한 하수 에너지흐름 분석 Evaluation of Energy Flows of Sewage for Enhanced energy system of residence

정용현 한국환경과학회 2003 한국환경과학회지 Vol.12 No.9

When the city water was heated for the optimum use of unused energy, the energy flows and losses were calculated and evaluated to improve the value of heated water systems at dwelling side. To obtain this purpose, It was simulated on heat flows under two conditions like with heat pumps or not and calculated the energy savings. Furthermore, recycling water system was suggested for enhancing the value of heated water system. From this results, the energy flows without heat pumps showed that it was 3-4 percents of heat losses from pipes, 62 percents of energy savings from hot water uses and 34 percents of unutilized heat. When the heated water system adopt the recycling water system at dwelling side. it was improved 12 percents of total energy savings.

國內藥草의 抗癌成分硏究 (1) : 馬兜鈴, 石蒜, 三稜, 無花果皮, 碧梧桐皮, 人參 등 70餘種에 對하여

丁明鉉,李敦日,金永洙,朱興珪,劉永鐘,金成鎬,鄭鐘南 朝鮮大學校 1977 綜合論文集 Vol.1977 No.-

Alcohol, water, ether, and petroleum ether extracts of 75 species Korean medicinal plants have been tested for their antitumor activity. Most of the extracts had slight activity only. Some extracts had more pronounced acitivity. For antitumor activity, ddD-Mice of weighing 18-25g were used. 0.2 ml of cell suspension in 0.9% saline-glucose solution containing 10?? ascites tumor cells of either Sarcoma 180, Ehrlich carcinoma was transplanted intraperitoneally into each mouse. The control group animals in a given experiment consisted of 14 mices and the experimental group, 7 mices. The materials to be tested were administered once a day by intraperitoneal injection, commencing the day after tumor transplantation until the test animal died, and then the control group was received only 0.5% carboxy methyl cellulose (CMC). The mean survival time of each group was calculated according to the formula indicated in the protocols of the Cancer Chemotherapy National Service Center. In the antitumor activity screening, extracts had pronounced greater prolongation of survival time (50%-100%) were Aristo-lochia contorta, Lycoris radiata, Scirpus maritimus, Ficus carica, Firmiana platanifolia, Panax ginseng, Piper nigrum among the 75 species. The antitumor screening result were tabulated in Table II.

광양만권의 유동장 및 대기오염농도예측

정용현 한국환경과학회 2000 한국환경과학회지 Vol.9 No.5

Numerical simulation model using nesting method and considering topographic features was developed to predict atmospheric environments, atmospheric flow, temperature and diffusion of air pollutants in Kwangyang bay where having complex areas of point sources, Korea. In addition, developed simulation model was used tracing of spreading range of pollutants when a gas leaks suddenly from Yeo-cheon industrial complex. By comparing the measured and calculated data on atmospheric flow, temperature and diffusion of air pollutants, the results showed that this model can be well applied and complicated topography affected the diffusion of air pollutants.