후두 및 하인두 암종에서 p53단백 발현과 Espstein-Barr Virus 검출

최영환,도남용,나한조,이도용,노용훈,김완수,최종선 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : When p53 cancer suppressor gene, occurs gene deletion or point mutation, malignancy develops by loss of p53 function with abnormal p53 protein. The Epstein-Barr virus (EBV) is the causative agent of certain type of lymphoma and undifferentiated nasopharyngeal carcinoma. However, the role of EBV as a causative factor in other head &eck tumors is not fully elucidated except nasopharyngeal carcinoma. This study, the author examined that p53 expression and detection rate of EBV correlate to development of laryngeal and hypopharyngeal squamous cell carcinoma(SCC) and play the possible role of prognostic indicators. Materials and Methods : Formalin-fixed, paraffin-embedded tissue specimen from 32 cases of larynx and hypopharyngeal squamous cell carcinomas were studied by immunohistochemical staining for p53 and EBV. The results of analysis were compared with clinicopathological parameters. Results : p53 expression was 56.3% (18 cases) and the detection rate of EBV was 43.6% (14 cases) of 32 cases in laryngeal and hypopharyngeal squamous cell carcinomas. p53 expression was correlate with histologic grade (p<05) only. Detection of EBV was not correlate with clinicopathological parmeters. Conclusion : These results suggest p53 expression and the detection of EBV may be related with development of laryngeal and hypopharyngeal squamous cell carcinoma. And, the expression of p53 protein can be used as a prognosticator in laryngeal and hypopharyngeal squamous cell carcinoma under certain limitation.

만성중이염의 골도청력변화

박선홍,노용훈,이도용,나한조,김용기,최봉남,도남용 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.1

We have usually experienced bone conduction impairment in chronic otitis media, but it is unclear that raised bone conduction threshold is due to the reflection of cochlear dam- age and / or Carhart effect ( an artificial elevation of bone conduction threshold due to conductive defect ) or both. The purpose of this study is to verify the influence of the artificial elevation of the bone conduction threshold in chronic otitis media and to estimate Carhart effect. A total of 336 cases of tympanoplasty with unilateral chronic otitis media without any other causes of sensorineural hearing loss was studied. The average threshold levels of the bone conduction in diseased ears ranged from 18.5dB at 4kHz to 12.1dB at 250Hz The longer duration of the disease, the larger perforation size, the more severe damage of the middle ear structure and the presence of the cholesteatoma made bone conduction threshold increased. The postoperative thresholds of bone conduction were Improved in 36 cases (40.4%) of the 89 cases that underwent operation with type I tympanoplasty technique without electrie drilling. The degree of the maximal improvement was 14.3dB at 2000Hz and the minimum was 8.8dB at 250Hz. but these result did differ from a statistically significant degree. The result suggest that the bone conduction threshold in chronic otitis media is elevated artificially by conductive defect and improved by successful reconstructive surgery.

접촉각 측정으로 본 표면 장력 관련 교육 내용 및 고등학교 학생틀의 이해 분석

최종국,박용남,백성혜 韓國敎員大學校 敎育硏究院 2009 敎員敎育 Vol.25 No.4

이 연구에서는 극성 액체인 물, 에탄올 및 비극성 액체인 사염화탄소를 극성 표변인 유리와 비극성고체인 PVC와 테플론판 위에 떨어뜨린 후 접촉각을 측정하고, 액체 증기, 고체 증기, 및 고체-액체의 경계간의 자유에너지 (□_(LV), □_(SV), □_(SL))와 표면장력을 계산하였다. 접촉각의 크기는 액체의 종류 또는 표면장력 뿐 아니라, 고제 판의 특성에 따라서도 달라진다는 것을 확인하였다. 또한, 접촉각의 크기는 액체의 표면 장력의 크기와 반드시 일치하지는 않았다. 7차 교육과정의 ‘화학 I’ 교과서 8종과 여러 평가 문항들을 분석한 결과, 접촉각과 표면 장력의 크기를 단순히 분자 간 인력에 따라 비례하는 것으로 표현하는 경우가 있었고, 교육과정에서 요구하는 수준을 념거나 현실적으로 관찰되지 않는 상황을 제시하는 경우도 있었다. 고등학교 학생들은 접촉각 표면장력 그리고 분자간 인력에 관련된 이해가 부족한 것으로 나타났다. Interfacial free energies(□_(LV), □_(SV), and □_(SL)) were calculated from the measured contact angles between various solid surfaces and liquids. Polar liquid, water and ethanol, as well as non-polar liquid such as carbon tetrachloride were examined on the polar surface such as glass as well as non-polar surface PVC and Teflon. The contact angle showed dependence on characteristics of both liquids and solid surfaces. More importantly, the order of contact angle did not agree with that of surface tension From the analysis of 8 types of 'Chemistry l' textbooks and several assesment items, the errors are found that the contact angle and surface tension are proportional to intermolecular interaction. In some cases, the required knowledge is above current educational level or some unrealistic situation is used as an example. The high school students are appeared to be incomprehensible to complex relationships between contact angle, surface tension, and intermolecular interactions.

양측성 관상동정맥루 1예

최용원,오석규,이재훈,이상재,권경희,최은경,김남호,정진원 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.1

저자들은 호흡곤란, 흉부불쾌감, 심계항진 등을 주소로 내원한 환자에서 경흉부 및 경식도 심초음파 검사상 주폐동맥에서 이완기에 전행하는 지속적인 혈류의 흐름을 관찰하고, 관상동맥 조영술을 통해 좌전하행지 중간부위와 우관상동맥 근위부에서 각각 기시하여 공통경로를 이루면서 주폐동맥으로 유입되는 양측성 관상동정맥루를 보이는 드문 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. A coronary arteriovenous fistula is infrequently encountered vascular communication between a coronary artery and a cardiac chamber, a great artery or the vena cava. It is the most common congenital anomaly that can affect coronary perfusion. Bilateral involvement of coronary fistula constitutes an uncommon subgroup of coronary arteriovenous fistulas. A 69 year-old female patient presented with chest discomfort, palpitation, and dyspnea. In the echocardiography, doppler color flow imaging visualized abnormal flow signals with mosaic appearance in the main pulmonary artery during diastolic phase. Coronary angiography revealed arteriovenous fistula arising from the left anterior descending artery and the right coronary artery. Both coronary arteriovenous fistulas drained into the main pulmonary artery. We report a case of bilateral coronary arteriovenous fistula that was confirmed by echocariography and coronary angiography.

소아나 협조가 힘든 환자에서 봉합사 제거가 쉬운 봉합법

남수봉,오흥찬,강철욱,최수종,배용찬 부산대학교 병원 암연구소 2009 부산대병원학술지 Vol.- No.25

서울 지역 대학생의 식습관 및 식생활태도에 관한 조사

최순남,정남용,윤미은 한국식생활문화학회 2002 韓國食生活文化學會誌 Vol.17 No.1

This study was to investigate the food habits and the dietary behaviors of university students. Questionnaires were completed by 492 students in five different departments. The data were analyzed by SAS program. The results are summarized as follows: Fifty(10.2%) of respondents were vegetarians, 81(16.4%) were heavy meat eaters and all the others were light meat eaters. All students had their biggest meal at supper. Three hundred and ninety-three(79,9%) of the respondents usually had rice for breakfast. Three hundred -sixteen(64.2%} ate 3 meals a day, 155(31.5%) ate 2 meals and all the others ate 1 meal or more than 3 meals. The length of mealtime was 30 minutes in 268(54.5%), 10 minutes in 209(42.5%) and more than 1 hour in all the others. Respondents considered taste the most important meal factor with nutrition, hygiene, and amount ranked accordingly. A majority(63.0%) of respondents ate occasionally ate between meals, while 28.1% snacked frequently, and 8.9% ate no snacks. Although nutrition dept. students had studied nutrition subject, some results of nutrition dept. students were desirable and others were undesirable in dietary behaviors. Therefore they should have a nutritional education program to improve their food habits and the dietary behaviors for students' health. And nutritional education program should be organized practically and systematically.

환경친화성 계면활성제를 이용한 어병균의 살균효과

최상원,정관용,오남희,김은영,방정환,김정우,여문환 한국환경과학회 2000 한국환경과학회지 Vol.9 No.5

The antibacterial effect amino acid-copper(Ⅱ) surfactant on fish pathogens was studied. Fish pathogens of Edwardsiella tarda, Vibrio anguillarum, Aeromonas hydrophila and Streptococcus sp. were selected, cultured in nutrient agar and adjusted at 2 × 10 exp (5)∼10 exp (6) CFU/㎖ in phosphate buffer saline before the addtion of amino acid-copper(Ⅱ) surfactant with different concentrations. All tested pathogens died within 1 hour with 1 ppm of amino acid-copper(Ⅱ) surfactant. In comparison with formalin and ET, amino acid-copper(Ⅱ) surfactnat was more effective in antibacterial capacity.

ARMAX프로세스를 위한 최적기구변수법

南炫道,崔龍雲 단국대학교 1988 論文集 Vol.22 No.-

In this paper, the recursive optinal instrumental vairable method, which estimates noise dynamics as well as system dynamics using pre-filtered data, was propsed. In case of no pre-filtering, the computational burden of this algorithm is equal to that of extended least squares(ELS) methods and less than that of the rescursive maximum likelihood(RML) method. But in case of prefiltering the computational burden of this algorithm is equal to that of the RML, but this algorithm shows faster convergence than ELS and RML algoorithms. Also, vaeious instrumental variables were proposed, and various types of prefilters were prposed to improve the performance of the proposed algorithms. Computer simulations were performed to illustrate the efficiency of the proposed methods.

서류 및 구근류의 중금속 함량

최순남,정남용 한국조리과학회 2003 한국식품조리과학회지 Vol.19 No.2

우리 나라 국민이 많이 섭취하는 서류 및 구근류를 종류별로 나누어 가식부만 취해 중금속 함량을 측정한 결과는 다음과 같다. 1. 조사된 서류 및 구근류의 Cu 함량 분포는 0.021~0.510ppm으로 0.489ppm의 차이가 났으며 양파의 Cu 함량 분포대는 0.038ppm으로 가장 좁게, 인삼 4년근의 Cu함량 분포가 0.325ppm으로 가장 넓게 나타났다. As 함량을 보면 최저는 고구마와 양파로 0.012ppm, 최고는 인삼 6년근으로 0.027ppm이었다. As 함량의 전체적인 분포는 N.D~0.070ppm으로 분포대가 가장 좁은 것은 생강으로 0.002ppm, 가장 넓은 것으로 감자로 0.070ppm이었다. Zn 함량 분포대는 0.143~3.137ppm으로 분포대가 가장 좁은 것은 고구마로 0.046ppm, 가장 넓은 것은 마늘로 2.475ppm이었다. 2. Pb 함량 분석 결과 최저는 감자 0.001ppm, 최고는 고구만 0.112ppm으로 나타났다. 더덕, 생강의 Pb 함량은 각각 0.100, 0.107ppm으로 비교적 높게 나타났으며 도라지 Pb 분포대가 N.D~0.372 ppm으로 가장 넓게 나타났다. Cd 함량에서 최저는 무, 알타리무로 검출되지 않았으며, 최고는 우엉과 더덕이 0.005ppm으로 대부분의 시료들에서 거의 미량 검출되었다. Cd 함량 분표는 N.D~0.009ppm으로 분포범위가 비교적 좁게 나타났다. Hg 함량 분포는 0.001~0.195ppm으로 0.194ppm 분포대를 보였으며, 생강이 0.001ppm으로 가장 좁게 알타리무가 0.184ppm으로 가장 넓은 분포대를 보였다. 3. 중금속 섭취량에 따른 안정성 평가에서 서류에 의한 각 중금속의 주간 섭취량을 보면 Cu 0.807㎍, As 0.064㎍, Zn 2.596㎍, Pb 0.243㎍, Cd 0.009㎍, Hg 0.026㎍, 구근류에 의한 각 중금속의 주간 섭취량은 Cu 4.700㎍, As 0.628㎍, Zn 18.224㎍, Pb 2.249㎍, Cd 0.066㎍, Hg 0.430㎍으로 잠정주간섭취허용량(PTWI)과 비교하였을 때 매우 낮은 수준으로 섭취시 위해성은 거의 없을 것으로 조사되었다. ▷표 삽입◁(원문을 참조하세요.) This study was conducted to estimate the contents of 6 trace metals in potatoes and root vegetables purchased in wholesale market in the Seoul region. specifically, Cu, As, Zn, Pb, Cd and Hg. The minimum and maximum results obtained for each metal are summarized as follows for potatoes; Cu : 0.094 ~ 0.344, As : N.D ~ 0.070, Zn : 0.247 ~ 1.547, Pb : N.D ~ 0.268, Cd : N.D ~ 0.005, Hg : 0.001 ~0.027, and for root vegetables; Cu : 0.021~0.510, As : 0.004 ~ 0.045, Zn : 0.143 ~ 3.137, Pb : N.D ~ 0.372, Cd : N.D ~ 0.009, Hg : 0.001 ~O.195. The daily intakes of trace metals from potatoes and root vegetables were estimated on the basis of the daily intake of these foods by Koreans, which were 0.073 ~22.253 and 0.567 ~ 156.219㎍ from potatoes and root vegetables, respectively. The weekly intakes of trace metals were 0.009 ~2.596 and 0.066 ~ 18.224㎍ for potatoes and root vegetables, respectively. The weekly intakes of trace metals for potatoes and root vegetables were very much lower than the PTWI(provisional tolerable weekly intake), enough to be within a safe range.

비수용매에서 전이금속 Ni(II) 착물의 전기화학적 연구

최용국,채희남 全南大學校 觸媒硏究所 1997 觸媒硏究 論文集 Vol.19 No.-

Tridentate schiff base ligand salicylidene-2-iminophenol(SIPH₂) was prepared by the reaction of salicylaldehyde with 2-aminophenol, a its Ni(II) complex was synthesized. The structure and properties of the ligand and its complex were studied by elemental analysis, ¹H-NMR, IR, UV-visible spectroscopy, and thermogravimetric analysis. The mole ratio of Schiff base to the metal of complex was found to be 1:1. Ni(II) complex was contemplated to have hexa-coordinated octahedral configuration containing three water molecules. The redox process of ligand and complex in DMSO solution containing 0.1 M TBAP as supporting electrolyte was investigated by cyclic voltammetry and differential pulse voltammetry with glassy carbon electrode. The redox process of the tridentate Schiff base ligand was totally irreversible. The redox process of Ni(II) complex was quasi-reversible and diffusion-controlled as one electron by one step process Ni(II)/Ni(I). Therefore we conclued that the redox process of complex are as follows : ??