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최봉남,김복열 대한마취과학회 1978 Korean Journal of Anesthesiology Vol.11 No.2
The effects of ether and halothane anesthesia, and surgery on blood sugar level in children were studied in twelve patients, Six patients were anesthetized with ether and other six patients with halothane. Blood samples were taken two times through a catheter in the external jugular vein after intravenous injection of pentothal 6 mg/kg and succinylcholine 1mg/kg during the anesthesia and. surgical procedure. Blood sugar was measured with the orthotoIuidine method. The mean vaIue of blood sugar in the ether group was elevated significantly from 68 mg/100 inl to 92. 2 mg/100 ml and also in the halothane group it was elevated' from 68. 8 mg/l00 ml to 81 mg/100 ml, with a significant difference that the blood sugar level was higher in the ether group than in the halothane group. Results were also compared with the hyperglycemic response to different types of surgery. The value of blood sugar under general anesthesia during intra-abdominal, body surface and other surgery was measured. The hyperglycemic response to intra-abdominal surgery was the largest and the next was in other surgery, and in body surface surgery it w$quot;s smallest, so it was shown there is a relationship between the degree of trauma and the rise in blood sugar.
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최봉남,Choe, Bong-Nam 대한병원협회 1993 대한병원협회지 Vol.22 No.11
이 글은 지난 5월 현대병원경영연구소 주최로 개최된 병원최고경영자 경영사례발표세미나에서 발표된 내용을 녹음으로 취합하여 편집한 것이다.경영난에 고심하는 병원들에 참고 되기를 바라 게재하며, 현대병원경영연구소에서 녹취와 정리를 해주었다. -편집자-
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다발성 외상환자에서 Diazepam의 기관내 삽관에 따른 혈중 Catecholamine의 변황에 미치는 영향
김용배,조남수,최봉남 대한응급의학회 1997 대한응급의학회지 Vol.8 No.3
Background: The concentration of the blood including ACTH, catecholamine, serum prolactine, cortisol is increased due to responding on stress by carrying out endotracheal intubation upon the mutiple trauma patients who were taken to the emergency room. Diazepam is a kind of benzodiazepine pharmacon and common pharmacon used for stability of the patients, relief and pretreatment as a booster for the relaxation of skeletal muscle. This research aims to know how effectively medication of diazepam before endotracheal intubation helps to constrain the reaction on the part of cardiovascular system due to laryngoscopy and endotracheal intubation, and makes concentration of catecholamine in blood changed. Methods: The subjects are consisted of the patient asked for endotracheal intubation instantly, suffering from caput trauma (GCS 8.0) among the multiple trauma patient, more than 20-year-old who were taken to the emergency room in Chosun university hospital from October 1, 1995 to September 30, 1996. They were devided into 2 classes, 30 people each class, and one (group Ⅰ) was carried out endotracheal intubation without injecting diazepam, 0.3㎎/㎏, and the other (group Ⅱ) was done with the endotracheal intubation by injecting diazepam, 0.3㎎/㎏. Group Ⅰ and group Ⅱ were measured blood pressure and heart rate before intubation and at 1, 3, 5, 7minute after endotracheal intubation, sampled arterial blood from femoral artery, and then compared and analyzed. All of the data were recorded by mean, standard deviation, and percentage and repeated measures ANOVA test was used for the statistical test and the data was regarded as statistically significant when p value is below 0.05. Results" 1) They were no significant differences statistically between 2 groups in the distribution of the age, weight, sex of the patients. 2) The changes in the systolic blood pressure had no statistical significance in the comparison between group Ⅰ and group Ⅱ, but diastolic blood pressure and the change of heart rate had statistical significance because p value was shown below 0.05. 3) Norepinephrine of blood was significantly lower in group Ⅱ than group Ⅰ. 4) Epinephrine of blood was significantly lower in group Ⅱ than group Ⅰ. Conclusion : It was shown that medication of diazepam before endotracheal intubation made stability of the patients and it changed significantly the reaction on the part of cardiovascular system from stress caused by laryngoscopy and endotracheal intubation. So it will be a good things to inject diazepam for pretreatment to bring relief of the patients and cardiovascular stability before endotracheal intubation.
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Phenobarbital이 백서의 간세포 소기관 및 간세포막의 Na^(+),K^(+) ATPase의 활성도에 미치는 실험적 연구
김학렬,최봉남,전호종 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1
Phenobarbital (60㎎/㎏) was injected intraperitoneally in the female Sprague-Dowley rat to evaluate the influence of phenobarbital on the ultrastructural alterations of hepatocyte cell organelle and the ultrastructural Na^(+), K^(+) ATPase activities of the hepatocyte cell membranes. The results obtained were as follow. 1. Phenobarbital induced the hypertrophy of the granular and agranular endoplasmic reticulum and widening of the interendoplasmic reticulum with formation of vesicles and vacuoles, and resulted in focal necrotic changes and fatty droplet changes of the hepatocyte cell organelle. 2. Mitochondha showed local disruptions of double membrane and loss of mitochondrial cristae. 3. The endothelium of hepatic sinusoid showed prominent vacuolic changes. 4. The enzyme activity of Na^(+), K^(+) ATPase was decreased in the sinusoidal surface of microvilli of hepatocyte and was markedly decreased in the microvilli of bile canaliculi. In conclusion, phenobarbital induced deformity of hepatocytic cell organelle and marked decrease in Na^(+), K^(+) ATPase activity on the microvalli of bile canaliculi. Above results suggest that phenobarbital would induced cholestasis.
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추락사고 환자에서의 β - endorphin과 Cortisol 변화에 대한 연구
조남수,조수형,최봉남 대한외상학회 1997 大韓外傷學會誌 Vol.10 No.2
The aim of this research is to study the change of B-endorphin and cortisol, one of the hormones that discharged, responsing stress, to a trauma patient by measuring the rate of B-endorphin and cortisol for the patient suffering from multiple injury by 'fall down' The method of this research is as follows: Multiple injury patient by fall down, who was appealing serious ache, never visited other hospitals, and within less than l hour when he or she was injured was chosen. The patient was exsanguinated and measured as soon as he arrived at the hospital, and a week later when the patient became stable, he was exsanguinated once more and then those were compared each other and analyzed. The results are as follows: 1. The range of blood plasma B-endorphin when the patient visited, was from 3.8pg/dl to 29pg/dl, and the mean was l0.8+6.2pg/dl. The rane of cortisol was from 9.2pg/ml to 43.9pg/ml and the mean was 28.2+10.4pg/ml. 2. One week after the patient visited at the hospital. When the patient stable. Thc range of B-endor- phin was from 2.5pg/ml to 7.0pg/ml and the mean was 5.12+1.6pg/ml. The range of cortisol was from 1.1pg/ml to 14.7pg/ml and the mean was 6.81+ 3.2pg/ml. 3. The rate of B-endorphin was 2.10 times. Cortisol 4.14 times higher than when they were stahle and all of I 8 patients showed more increased numerical value. When they arrived at the hospital than they were stahle. In the relative coniparison of B-endorphin and cortisol, cortisol was 2.61 times higher than usual when they were arrived at the hospital but increased 1.33 times when stable. 4. Revised trauma score was average 11.3 and average blood pressure was 105.27+ 18.2mmHg in systole and 65.0+ 11.5mmHg in diastole when the patients arrived at the hospital, while average blood pressure was 116.11+ 11.95mmHg in systole and 73.88+7.7mmHg in diastole when stable. Pulse rate was 91.44+ 16.4 rates/min when they were taken, but 70.88+6.3 rates/min when stable. 5. The injury type is as follows: Six people in mono injury and 12 people in multiple injury. With regard to usual styles of injury, there were 9 people in compression fracture in lumbar spine, 6 in fracture of lower extremity. There were 4 in emergency operation, 8 in delayed operation, 6 in conservative treatment. It is concluded that the numerical value of blood plasma B-endorphin and cortisol of the patient, who appealed serious ache caused by multiple injury, was all increased and these reacted on stress. But it is considered that much more broad study on the impact of our body caused by this is required.
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鼻閉塞환자에서 수술전후 Rhinomanometry에 의한 총 비저항치의 변화
김용기,문문만,최봉남 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1
For over 100 years, the interest has been shown in evaluation of the nasal airway. As a nasal obstruction can be a subjective complaint, there is wide variation in the interpretation of the nasal symptoms. Rhinomanometry is objective, reliable, easily quantitated and a reproducible method to evaluate the nasal obstruction. 51 patients with nasal obstruction were evaluated with the active anterior rhinomanometry before and after nasal surgery and 60 patients with nomal rhinoscopic findings were evaluated with same methods as a control group. The results were as follows. 1) The mean total nasal resistance was : 1.386CmH_(2)O/LPS in control group. 2.523CmH_(2)O/LPS in patient group(p<0.05). 2) The preoperative total nasal resistance by rhinomanometry was highly correlated with subjective assessment of nasal obstruction, especially for the patient with moderate to severe symptoms of nasal obstruction. 3) In the comparison of preoperative with postoperative total nasal resistance during inspiration according to the different surgical procedure, the total nasal resistance after polypectomy was significantly decreased and the obstructive symptoms were more improved in patients who have recieved polypectomy. 4) The total nasal resistance after nasal surgery was significantly decreased from the preoperative 2.523CmH_(2)O/LPS down to the postoperative 1.512CmH_(2)O/LPS(p<0.05). 5) Therefore rhinomanometry is objectively reliable in evaluation of the nasal obstruction and the effect of nasal surgery.
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