월경전 기분 변화와 출산후 불안-우울 증상간의 상관성

한창수,김용구,이낙우,김 탁,김해중,김 현,조숙행 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.1

To investigate the relationship between premenstrual mood changes and anxiety, and mood symptoms in the perinatal period , questionaire survey was carried out. There was no significant correlation between premenstrual symptom scale value and Edinburgh postpartum depression scale value. And theme was no relationship between premenstrual symptom scale value and state anxiety inventory scale value in the perinatal period. This findings suggest that premenstrual mood changes are not directly correlated with mood changes in the perinatal period.

묵논의 식생천이에 관한 연구

이창석,박현숙,유영한,홍선기 서울여자대학교 자연과학연구소 1998 자연과학연구논문집 Vol.10 No.-

폐경년도가 다른 묵논에서 식생요인과 환경요인의 변화를 분석하여 천이계열 및 천이의 추진 기작을 밝혔다. 조사지소는 경작 중인 논, 폐경 후 3년(초기 묵논), 7년(중기 묵논) 및 10년째의 묵논(후기 묵논) 및 묵논에 인접한 계곡림(극상림)의 5단계로 구분하였다. 경작 중인 논, 초기 묵논, 중기 묵논, 후기 묵논 및 계곡림에서 각 조사지소의 우점종으로 판단한 천이계열은 뚝새풀군락→사마귀풀군락→갯버들군락→오리나무군락의 순서로 나타났다. 천이단계별 우점종의 분포와 그것의 생활령을 분석하여 파악된 천이의 추진기작은 내성모델을 따르는 것으로 밝혀졌다. 천이단계에 따른 다양성지수의 변화에서 종품부도와 종다양성지수는 초기에 증가하고 중기에 감소하였다가 그 이후 다시 증가하는 경향을 보였으나 균등성지수는 큰 변화가 없었다. 직경급분포도에서 중기 묵논의 갯버들개체군은 정규분포형을, 후기 묵논의 것은 역 J자형을 보여 전자는 그들이 과거적 어느 한 시기에 동시적으로 출현하였음을 반영하고, 후자의 것은 그들이 현재 경쟁상태에 있음을 반영하였다. 후기 묵논에 성립된 오리나 무개체군의 직경급분포도는 역 J자형을 보여 그들이 침입단계에 있음을 반영하였고, 계곡립의 것은 정규분포형을 보여 그들이 안정상태에 있음을 반영하였다. 이러한 식생요인에 대한 분석 결과, 현재 논으로 이용되고 있는 지역의 잠재자연식생은 오리나무군락이 될 것으로 판단되었다. 천이의 진행에 따른 토양환경요인의 변화에서 수분한량은 초기 묵논에서 현저히 증가되었고, 중기 이후의 묵논에서 감소하였다. pH는 큰 변화를 나타때지 않았고, 유기물, N, P, K, Ca 및 Mg함량은 천이의 진행에 따라 증가하는 경향을 보였다. To clarify the vegetational sere and driving mechanism of succession, vegetation and soil environmental factors were investigated in the old paddy field with different in the lapsed years after abandonment, Study sites were divided into 5 stages of the paddy field under cultivation, the old paddy fields of the initial, middle and late stages, and the climax forest of the mountainous valley near to the abandoned paddy fields. Sere estimated from dominant species of above mentioned study sites was shown in the order of Alpecurus aequalis var. amurensis community, Aneilema keisak community, Juncus effusus var. decipiens community, Salix gracilityla community, and Alnus japonica communt. y. Driving mechanism of succession inferred from the distribution of dominant species in each successional stage and their life form was based on the tolerance model. Species richness and diversity indices steadily increased since the middle stage but evenness index did not show any distinct change. In frequency distribution diagrams of diameter classes, Salix gracilistyla population of the middle and the late stages showed normal and reverse J-shaped distribution patterns, respectively. Result of the former reflects that individuals composing of that poulation were invaded simultaneously in a given time of the past and that the latter suggests that they are in state of intraspecific competition. Distribution diagram of Alnus japonica population in the late stage showed reverse J-shaped distribution pattern reflects that those individulas are in the stages of invasion and that of the valley forest showed normal distribution pattern suggests that they are in stable stage. From the results of analyses on those vegetation data, it was interpreted that potential natural vegetation of the present paddy field might be Alnus japonica community. In changes of soil environmental factors with the progression of succession, soil moisture content rapidly increased in the initial stage and then decreased since the middle stage. Organic matter, N. P. K, Ca and Mg contents tended to increase with the succession stage but pH did not show any distinct change.

갑상선기능저하증에 동반된 가로선백색손발톱(Transverse Leukonychia)

장희선 ( Hee Sun Chang ),한태영 ( Tae Young Han ),이현경 ( Hyun Kyung Lee ),손숙자 ( Sook Ja Son ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.5

Transverse leukonychia, also termed leukonychia striata, usually occurs in association with trauma, nutritional deficiencies, exposure to toxin, and various combinations of chemotherapy. It also has been reported to be associated with various systemic diseases, including acute infection, myocardial infarction, lymphoma, hepatic failure, renal failure, and systemic lupus erythematosus. A 50-year-old woman with several months` history of nail changes presented with multiple discrete transverse white bands involving the entire width of the nail plates of her fingers. According to the patient`s medical history, she had experienced fatigue, constipation, and cold intolerance for 6 months, and antithyroid antibodies were detected before noticing these nail changes. The patient was diagnosed as having an autoimmune hypothyroidism. Repeated KOH microscopic examination did not demonstrate fungal infection. We diagnosed this case as transverse leukonychia associated with hypothyroidism. This case report underlines the possible association of transverse leukonychia with hypothyroidism. (Korean J Dermatol 2011;49(5):480∼482)

Nitric Oxide에 의한 난소 과립세포의 Apoptosis 조절에 대한 연구

강한승,이석자,김외리,이채관,신창숙,김성태,강성구 인제대학교기초과학연구소 1998 자연과학 Vol.2 No.-

여포의 퇴화가 진행되는 기작에서 apoptotic cell death 와 nitric oxide (NO)의 연관성에 관하여 실험하였다. 난소의 apoptosis는 GnRH에 의해 유도되고 스테로이드에 의해 억제된다. 여포에서 과립 세포의 apoptosis에 대한 호르몬의 영향과 NO 생산효과를 조사하기 위하여 중간크기 (직경 5-6 ㎜)의 여포에서 non-apoptotic 과립세포를 분리하여 스테로이드, GnRH agonist, GNRH agonist+SNP, 그리고 NO 공여체인 SNP를 처리하여 24시간동안 배양하였다. 배양된 과립세포에서 게놈 DNA를 추출하여 apoptotic DNA절편화 경향을 알아보았고, 배양액과 griess reagent를 반응시켜 nitrite 농도를 측정하였다. 스테로이드 호르몬을 처리하였을 때, 대조군에 비해 NO 생성이 다소 증가하였으며 apoptotic DNA 절편화도 억제되었다. GnRH agonist 처리군에서는 apoptotic DNA 절편화가 가속화 양상을 나타내었으며 NO 생성은 다소 감소하였다. 그러나 GnRH agonist+SNP 그리고 SNP 처리군에서는 apoptotic DNA 퇴화가 억제되었으며 NO 농도는 대조군에 비해 현저히 높았다. 위의 실험 결과로 보아 과립세포 분화와 여포성숙과 퇴화과정에서 호르몬과 NO가 밀접한 관련이 있는 것으로 사료된다. To study the regulation of porcine follicular cell apoptosis by steroids, GnRH agonist and nitric oxide, we have analyzed DNA fragmentation, the hallmark of apoptosis, and nitrite production in porcine granulosa cells. In, ovarian apoptosis is induced by GnRH but is prevented by steroids. Apoptosis is confined to the granulosa cells but it was not clear whether apoptosis of granulosa cell was regulated by NO in vitro. So non-apoptotic granulosa cells isolated, grown at 37℃, for 24 hrs, and treated with / without SNP, GnRH agonist, and sterioid, respectively. In cultured granulosa cells were used to extract genomic DNA and culture media was assayed for nitrite concentration. Nitrite production of culture media was increased and apoptotic DNA fragmentation was supressed in SNP treated groups, GnRH agonist+SNP, and estrogen, progesterone. Nitrite concentration in culture media was decreased and apoptotic DNA was induced treated with GnRH agonist. These data suggest that NO production and apoptosis may be involved of granulosa cell differentiation and ovarian follicular atresia by SNP, estrogen and progesterone. Moreover, NO can overcome the granulosa cell apoptosis induced by GnRH agonist.

일부 보건소 내소 여성의 유방자가검진과 유방암 검진의 관련요인

최종숙,박재용,한창현 韓國保健敎育.健康增進學會 2001 보건교육건강증진학회지 Vol.18 No.1

The purpose of this research was to find out plans to promote the fulfillment of the breast self-examination and breast cancer screening, which is preventive health behavior about women's having breast cancer exam in some part of our country with searching for the primary causes which have an effect on their fulfillment. The subjects of the study were 540 literate volunteers who were of age from 20 to 69 and who visited 8 health centers in Taegu. The survey research was made through questionares in the 8 health centers in Taegu from the 15th to the 30th of September, 1998. Based on Becker's health belief model asking medical staff's opinions with bibliographies, the major findining from the survey was as follow. The fulfillment rate of the breast self-examination and the breast cancer screening was 37.8%(204 subjects), 27.6% (149 subjects) each. Getting breast self-exam varied significantly depending on subject's age, income of family, religion, occupation and the number of children. As far as the breast cancer screening was concerned, there was remarkably significant difference in accordance with their age, marital status, religion, occupation, income of family, the number of children, ways of nursing and parturition age of the first baby. The subjects in their forties accounted for the highest rate. Based on the fulfillment of the breast self-examination and the breast cancer screening, the average points of all the variables presented from the health belief as well as the points of the susceptibility, seriousness, benefits, knowledge and level of health concern of interest in health were significantly higher than the points of non-fulfillment of them in the statistical analysis whereas the barriers was lower than them. In consequence of the multiple-logistic regression analysis putting the breast self-examination and the breast cancer screening in dependent variables, occupation, knowledge, seriousness, benefits, barriers and cues to action had significant effects on breast self-examination against breast cancer. Looking more attainments, thinking diseases more seriously, feeling more usefulness and there being any patient around with breast cancer led to the higher rate of the breast self-examination against it. On the other hand, feeling more impedition as well as housewives caused the lower rate of it. The breast cancer screening was significantly affected by age, sensitivity, usefulness, impedition and behavior momentum as well. The cases who are older, feeling more sensitivity against breast cancer, more usefulness of the examination and where any patient around, the fulfillment rate was higher. Contrarily the more impedition they felt, the lower the fulfillment rate was. Accordingly, the study of the causes, which have significant effects on the fulfillment of the self-examination and the breast cancer screening in order to find it in an early stage, and the development of health education programs as well as proper education for public health through carrying on campaigns and stepping up public relations must be indispensable.

레지스터 할당이 프로세서 성능에 미치는 영향

表昌祐,韓京淑 弘益大學校 科學技術硏究所 1998 科學技術硏究論文集 Vol.9 No.1

We compared several register allocation algorithms. Register utilization, avoiding memory reference, is the most crucial factor of processor performance. Register allocation strategy should consider the following aspects of programs; size of live ranges, program control structures, and number of array variable references to scalar variable references. In particular, these factors have strong influence on spill code insertion. Instruction scheduling should be considered together with register allocation, since they have adverse effect on each other. Register file structure is also a factor when embedded processors are targeted.

유방암과 섬유선종의 방사선학적 소견 : 유방 단순촬영술과 유방 초음파검사 소견의 비교 연구 Studies on mammographic and ultrasonographic findings evaluation

임한혁,최득린,고은석,이혜경,임철완,이상진,홍현숙,최교창,김영화,박재성 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Purpose : To evaluate the utility of mammography and ultrasonography in study of morphologic differential diagnosis between malignant and benign mass. Materials and Methods : Average age of patients with breast cancer was 48.4 year-old, and that of fibroadenoma was 29.4 year-old. The equipments used for examination were MF-159 high frequency mammography(Bennet Co.) and Acoustic image 5200S. We evaluated mammographic findings about breast parenchymal pattern, calcification, margin and size of the mass associated tumor nature, and ultrasonographic findings about shape, height and width, internal homogenicity and echo pattern, wall contour, boundary echo, and posterior shadow in breast mass. Thirty-seven of mammographic findings and 34 cases of ultrasonogreaphic findings in pathologically proven breast cancer and 34 case of mammographic findings and 71 cases of ultrasonographic findings in breast fibroadenoma were reviewed retrospectively. Results : In mammographic study, the parenchymal patterns of breast cancer according to Wolfe classification were NI(16.2%), PI(24.3%), P@(37.8%), and DY(21.6%) and those in fibroadenoma were NI(3.1%), Pl(11.7%), P2(35.2%),and DY(50%). Mammographic findings about presence of calcification were as follows; only calcification(16.2%), only mass(51.3%), and mass with calcification(32.5%) in breast cancer, and only mass(91.2%), mass with calcification(8.8%) in fibroadenoma. The features of mass margins were classified as ill-defined margin(45.9%), well-defined(5.4%), and well-defined with partial spiculation(48.6%) in breast cancer and ill-defined(20.5%), well-defined(73.5%), and well-defined with partial spiculation(5.8%) in fibroadenoma. The mass were grouped by size; 1-2cm(37.8%), 2-4cm(45.9%), and 4-6cm(16.3%) in breast cancer and 1-2cm(79.4%), 2-4cm(17.6%), and 4-6cm (3.0%) in fibroadenoma. On ultrasonographic study, the shape of masses in breast cancer were lobulated(82.3%),oval(14.7%), and round(3.0%),and those in fibroadenoma were lobulated(14.0%), oval(57.7%), and round(18.3%). The cases that the height was longer than width were 32.3% in breast cancer and 0% in fibroadenoma. The findings about homogenecity and echo patterns were as follows; hypoechoic(52.9%) and mixed(47.1%) in breast cancer and hypoechoic(2.8%), hypoechoic(63.4%), and mixed(33.8%) in fibroadenoma. The margin of masses were smooth in 85.9% of fibroadenoma, and irregular in 73.6% of breast cancer. The boundary echoes of masses and decreased posterior echo shadow were seen only in 61.8% and 55.9% of breast cancer, respectively. Conclusion: The margin and calcifications are more clearly delineated on mammography but breast cancer and fibroadenoma, both are more commonly developed in dense parenchymal pattern(P2+DY),and there findings are easily obscured in mammography. So ultrasoography is very useful in these masses evaluation, especially amoung young patients.

대학식당에서의 영양교육에 실태 분석

박영숙,이은미,박명희,한재라,양창미 순천향대학교 기초과학연구소 2000 순천향자연과학연구 논문집 Vol.6 No.2

We studied about nutrition education at campus cafeterias and the customer's requirement for the nutrition education. All of the materials used for nutrition education at two cafeterias for 1 year were collected. Also a survey was performed to 300 male students eating there frequently. Analysis of the collected 34 materials resulted to indicate the shortage of nutrition education frequency, motonous educating media and inappropriate contents of nutrition education. We found that the nutrition education performance was 34 cases and mostly they were the posters. As clasified media, they were maily printed materials and some were modules like food models. A survey to students indicated that the most considerating matter on their meal preparation was short time for breakfast, cost/preference for lunch, preference/habit for dinner and preference/short time for snake time. When comparing knowledge on healthㆍnutrition, the attitude to the knowledge was 1.72±0.70, which evaluated between 'very much positive' and 'a little positive'. And ability to the knowledge was 1.92±0.74, which meant between 'possible' and 'a little possible'. Practice to learn was 2.42±0.82, which evaluated between 'sometimes' and 'little'. When comparing action on healthㆍnutrition, the attitude to action was 1.78±0.67, which evaluated between 'very much positive' and 'a little positive'. And ability to action was 1.83±0.68, which meant between 'possible' and 'a little possible'. Practice to action was 2.17±0.67, which evaluated between 'sometimes' and 'little'. We found that the practice was lower than the attitude or the ability in the case of knowledge and action on healthㆍnutrition(K<A<P). Therefore nutrition education should stress the practice on healthㆍnutrition. We concluded that the industry foodservices were expected to offer the knowledge of healthㆍnutrition for the customers and nutrition education should focus to the practice, especially to the specific contents like whats and hows.

동적 재컴파일에 의한 성능 향상 예측

表昌祐,韓京淑 弘益大學校 科學技術硏究所 1997 科學技術硏究論文集 Vol.8 No.-

We have measured potential speedup by dynamic recompilation. Dynamic recompilation is a run-time program optimization by using the information available when programs are executed. Input data may be classified into two categories: one is for fixing program structures, and the other, for problem-domain dependent computations. Branches and loops can be optimized by using input data values related to program structures. After three input values were injected into the program adm from Perfect benchmark, copy propagation, constant folding and dead code elimination were applied to the program. We have got the speed up of 1.52. The number of branches was reduced by 17.3%, the number of loops, by 12.3%, and the number of subroutine calls, by 4.7%. These figures imply the potentially maximal performance gain when the tested optimization techniques are applied at run-time. Though our experiment is limited to a single benchmark program, the result shows that dynamic recompilation is worth to investigate further. A framework for dynamic recompilation should be developed, in particular, for multiprocessor systems.

일 농촌지역의 우울 증상에 관한 역학연구 -위험요인 및 요인구조분석

하양숙,홍진표,김한규,이군희,한경자,조맹제,김용익,송미순,박성애,김창윤 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.2

연구목적 : 세계적으로 널리 사용되는 우울증 척도인 the Center for Epidemiologic Studies Depression Scale(CES-D)을 이용하여 지역사회 주민의 우울증상의 정도를 평가하고, 우울증상의 위험요인을 분석하고, 한국인에서 우울증상의 요인구조를 알기 위해 본 연구를 실시하였다. 방 법 : 경기도 일 농촌 지역의 30세 이상 주민에 대해 무작위 군집 집락 추출을 실시하였고, 훈련된 면담원들이 가정 방문을 통하여 면접 및 자기보고 검사인 CES-D를 실시하였다. 총 1,315명에서 응답을 하였고 응답율은 59.3%이었다. 결 과 : CES-D에 의한 우울증 점수는 0∼5점이 57%정도를 차지하였고, 평균 점수는 남자 7.8점 여자 9.5점으로 비교적 낮은 편이었다. ANCOVA 분석 결과 비결혼, 저학력, 여성이라는 위험요인은 독립적으로 우울증상을 악화시키는 요인이었으나 연령은 통계적으로 유의하지 않았다. CES-D 결과를 요인분석을 시행한 결과 4가지 요인이 추출되었는데 우울증상 및 신체증상이 한 개의 요인으로, 다른 나라에서 보고되지 않는 정서적 고통이 별도의 요인으로 추출되었다. 결 론 : 국내 역학 조사에서도 외국과 유사한 우울점수 및 위험요인이 확인되었으나 우울증의 요인에서는 특이한 요인이 추출되었다. 한국인에 독특한 우울 반응에 관한 추가 연구가 필요하다. Objectives :The rates, correlates, and factor structure of depressive symptoms in a Korean rural sample were examined using Korean version of the Center for Epidemiologic Studies Depression Scale(CES-D). Methods : Door to door visiting survey was conducted by trained interviewers. A random cluster sample of 1,315 respondents, aged 30 and over completed the CES-D scale along with additional sociodemographic questionnaire. Results : In this sample, mean CES-D score of male and female were 7.8 and 9.5, respectively which were lower than those reported previously. Symptoms of depression were most common among the less educated, non-married and female according to ANCOVA. Age was not a significant risk factor for depressive symptoms. Different factor structures emerged from this sample as compared to other studies using this approach. Somatic symptoms and affective symptoms were combined as one factor and emotional hardship emerged as a separate factor. Conclusion : Symptoms scores and risk factors were similar to the results reported in other countries but unique factor structures were found in this study. Further research is needed about the Korean depressive symptomatology and related areas.