정신분열병과 Neurotensin 수용체 유전자 다형성의 연합 연구

이유상,김형배,한진희,채영규,이정식,이혜순,주연호,김형섭,최인근,양병환 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: Neurotensin(NT)은 NT수용체와 결합하여 그 효과를 나타내는 neuromodulator 혹은 neurotransmitter로서 대뇌에서 도파민의 분비를 조절하는데 중요한 역할을 한다. 근래의 연구에 의하면 NT와 그 수용체는 대뇌에서 항정신병 약물의 효과를 매개하는 것으로 생각되고 있으며 약물치료를 받지 않은 정신분열병 환자의 뇌척수액에서 NT의 양이 적으로 보고되고 있어 이들은 정신분열병과 깊은 관련을 가지고 있을 것으로 추정된다. 최근 NT수용체의 유전자의 3`인접영역에서 정보가치가 높은 4 염기반복 다형성이 발견되어 이를 유전 표지자로 하여 정신분열병과의 연합을 알아보았다. 방 법: 서로 혈연관계에 있지 않은 정신분열병 환자 120명(남자 91명, 여자 29명)과 정상 대조군 106명(남자 84명, 여자 22명)을 대상으로 하였다. PANSS를 사용하여 양성 및 음성을 알아보았다. 말초혈액에서 DNA를 분리한 후에 중합효소연쇄반응을 사용하여 3`인접영역에 있는 4 염기 반복 다형성을 증폭하였고 silver staining한 후에 유전자형을 관찰하였다. chi-square 검증과 Bonferroni`s correction을 사용하여 환자군과 정상 대조군간의 대립유전자 빈도의 차이를 알아보았다. 또한 양성 및 음성 환자군으로 나누어 차이를 알아보았다. 결 과: 총 23개의 대립유전자가 관찰되었으며, 399bp의 대립유전자(A10)의 빈도가 환자군보다 정상대조군에서 통계적으로 유의하게 높았다(χ²=16.49, df=1, p<0.001). 음성 정신분열병 환자군과 정상대조군 사이의 비교에서는 정상대조군의 A10의 빈도가 환자군보다 유의하게 높았다(χ²=21.33, df=1, p<0.001). 성별 비교에서 남자 정신분열병 환자군은 대조군에 비하여 A10의 분포가 유의하게 적었다. (χ²=13.71, df=1, p<0.001) 결 론: NT 수용체 유전자와 정신분열병사이에 음성연합이 관찰되었다. NT 수용체 유전자가 일부 정신분열병의 발병과정에서 확실하지는 않지만 어떤 종류의 보호기능을 할 수도 있다는 것을 암시한다. Objectives: Neurotensin(NT), of which functions are evoked by its interaction with neurotensin receptors(NTR), coexists with mesolimbic dopamine and regulates endogenous dopamine release. Recent studies have shown that NT with NTR exerts neuroleptic-like activity within the central nervous system and may play an important role in the pathogenesis and in the treatment of schizophrenia. We have examined the gentic association between schizophrenia and tetranucleotide repeat polymorphism in the 3-flanking region of the NTR gene to investigate the possible contribution of the NTR gene to the schizophrenia susceptibility. Methods: Among 23 alleles identified, the subjects were 120 patients(male 91, female 29)with schizophrenia and 106 normal healthy controls(male 84, female 22). They were unrelated native Korean. PANSS was used to determine positive or negative subgroup in the schizophrenic patients. Using polymerase chain reaction and polyacrylamide gel electrophoresis, tetranucleotide repeat polymorphism(CCTT and CTT) in the 3`-flanking region of NTR gene was observed. For a comparison of NTR gene`s allelic frequencies between patients with schizophrenia and normal healthy controls, chi-square test and Bonferroni`s correction was performed. Results: The frequency of A10 allele(base pair size=399)was significantly higher in normal healthy controls than schizophrenia(χ²=16.4902, df=1, p<.000). In the comparison between schizophrenic patients with negative symptoms and normal controls, the frequency of A10 allele was significantly higher in normal healthy control subjects than patients with schizophrenia(χ²=21.33, df=1, p<0.001). In the case of male, the frequency of A10 allele of schizophrenia was significantly higher than normal controls(χ²=13.71, df=1, p<0.001). Conclusions: NTR gene was negatively associated with schizophrenia. NTR gene`s tetranucleotide repeat polymorphism may provide some protective function against schizophrenia.

지역학으로서의 독일학 육성을 위한 정보자료의 디지털화와 활용방안에 관한 연구

최병진,정동규,천미애,남유선 한국독어독문학회 2003 獨逸文學 Vol.88 No.-

In dieser Arbeit wurde vor allem versucht, den Blick auf zwei Punkte zu richten: Erstens sollte das Forschungsvorhaben, das im Rahmen eines zweija¨hrigen Projekts unter finanzieller Unterstu¨tzung des Koreanischen Research Foundation (KRF) durchgefu¨hrt wurde, in grobem Abriss vorgestellt werden. Zweitens werden die Probleme skizziert, die wa¨hrend der Durchfu¨hrung des Projekts auftauchten, und aus denen sich schließlich unmittelbar einige Verbesserungs- vorschla¨ge ergeben. Das Projekt hatte die Aufgabe, ein auf digitalisierten Daten basierendes Informationssystem u¨ber Deutschland zu erstellen. Das System der Wissenschaftsinformationen, das in der vorliegenden Arbeit vorgestellt wurde, wird beispielsweise aufgrund seiner umfangreichen Informationsdaten dem Fach Germanistik zur weiteren und vertiefenden deutschlandeskundlichen Forschung von großem Nutzen sein. Daru¨ber hinaus aber kommt es auch den Lehrenden zugute, da ihnen dann ein vielseitiges und reichhaltiges Lehrveranstaltungsmaterial als Veranstaltungsthemen zur Verfu¨gung steht. Um ein solches Wissenschaftssystem der Deutschlandforschung zu erstellen und weiter zu entwickeln, wird jedoch nicht nur vie1 Zeit, sondern eine sta¨ndige Aktualisierung der Datenbank no¨tig werden. Um diese Aufgaben zu bewa¨ltigen, sollten mo¨glichst viele Germanisten fu¨r das Projekt zur Verfu¨gung stehen. Zurzeit findet das Internet im privaten und o¨ffentlichen Bereich breite Anwendung wie noch nie zu vor, und diese Tendenz wird sich noch versta¨rken. Forscher suchen und sammeln Informationen anhand des Internets. So nimmt es im Forschungsleben als Forschungswerkzeug einen wichtigen Platz ein. In Zukunft wird sich der Service im Bereich des Netzwerks weiter entwickeln/verbessern. Dies bedeutet fu¨r die Forscher eine Chance im Hinblick auf die Zukunft der Forschung, wenn sie gemeinsam ein wissenschaftliches Kooperationssystem entwickeln, um Wissen unter einander auszutauschen.

지역 유기농업의 실태와 그 개선방안의 연구 : 경북지역 유기농가 81호에 대한 실증조사를 중심으로 A case Study of 81 Farm Households in Kyungpook Province

이호철,유병규,석태문 慶北大學校出版部 1993 經商論集 Vol.21 No.3

農業構造의 變化와 農民意識 : 경북 9개지역의 조사연구를 중심으로 A Case Study of 9 Areas in Kyung Pook Province

李鎬澈,兪炳圭 경북대학교 경제경영연구소 1992 經商論集 Vol.20 No.4

필로폰 남용 환자와 알코올 남용 환자의 MMPI 비교

유택규,박상규,김미영,유은희,강병조 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2

This study was performed to identify personality trait of patients with methamphetamine and alcohol abuse by analyzing MMPI profiles. 93 methamphetamine abuse patients, 59 alcohol abuse patients and 52 healthy subjects completed MMPI. Each MMPI profile in three groups was analyzed by F-test and discriminant function analysis. Alcohol abuse patients showed higher scores n F, Sc(8), and Si(0) profiles of MMPI than the patients with methamphetamine abuse. 3 variables(F, Si, Pd) were discriminated in there two groups. Methamphetamine abuse patients showed higher cores in F. K. Hs(1), Hy(3), Pd(4), Pa(6), Sc(8), and Ma(9) profiles of MMPI than the normal controls. 5 variables (Pa, Pd, Si, K, L) were well discriminated in these two groups. The alcohol abuse patients showed higher scores in F, Hs(1), D(2), Hy(3), Pd(4), Mf(5), Pa(6), Pt(7), Sc(8), and Ma(9) profiles of MMPI than the normal controls, but lower scores in K subscale, 3 variables(F, Pb, Pa) were well discriminated in these two groups. Specially these results indicated that alcohol abuse patients had more psychotic symptoms than methamphetamine abuse patients. These results may suggest that addicted individuals have personality traits to be drug addicts, but it was unclear that these results were ue to predisposing personality traits or results of drug abuse.

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

건물용 태양광 컨버터의 최대전력 추종 기법 개발

유병규(Yu Byung-Gyu),유권종(Yu Gwon-Jong) 한국태양에너지학회 2011 한국태양에너지학회 학술대회논문집 Vol.2011 No.4

This paper proposes a novel sensorless maximum power point tracking (MPPT) algorithm for PV systems. The method is based on dividing the operating time into several intervals in which the PV terminals are short circuited in one interval and the calculated short-current of the PV is obtained and used to determine the optimum operating point where the maximum output power can be obtained. The proposed MPPT algorithm has been introduced into a current-controlled boost converter whose duty ratio is controlled to the maintain MPP condition. The same sequence is then repeated regularly capturing the PV maximum power. The main advantage of this method is eliminating the current sensor. Meanwhile, this MPPT algorithm reduces the power oscillations around the peak power point which occurs with perturbation and observation algorithms. In addition, the total cost will decrease by removing the current sensor from the PV side. Finally, simulation results confirm the accuracy of the proposed method.

도시근교농업의 복합산업화와 공간 활용

유병규(Byung Gyu Yu) 한국농촌사회학회 2000 農村社會 Vol.10 No.-

도시근교농업은 지가상승과 도시계획에 의한 개발수요의 증대, IMF, WTO 농산물재협상과 같은 농업외적 요인으로 인해 농업생산 기능만을 더 이상 고집할 수 없게 되었다. 이제 이러한 농업생산 기능뿐만 아니라 `농촌`이라는 공간적 특성을 이용함으로써 도농통합형 지역의 도시농업을 유지해 나가는 접근방법이 필요하다. 따라서 이 논문은 도시근교농업이 갖고 있는 원래의 1차 산업적 의미인 `생산` 개념과 함께 `농촌`이라는 공간적 개념을 중시하되 2·3차 산업의 개념을 도입하여야 하는데, 이러한 내용을 여기서는 `도시농업`이라고 정의하고 이의 활성화 방안에 초점을 맞추고자 하였다. 이러한 `도시농업`을 활성화하기 위한 방향으로서는 크게 두 가지로 나눌 수 있다. 첫째는 도시농업의 큰 물 속에서, 현존의 생산중심 농업을 어떻게 유지해 나가느냐 하는 것이다. 둘째는 농업도 유지하면서 농촌을 유지시켜 나가는 것이 바로 농업을 살리는 것이라는 인식 하에서 도시통합형 농촌의 공간적 개념에서 이를 어떻게 활성화하느냐 하는 것이다. 여기에서는 두 번째 방법을 중심으로 도시통합형 농촌의 공간적 개념에서 이를 활성화하는 농업의 복합산업화 전략을 제시하고자 하였다. 이의 구체적 내용의 하나가 `도시농업마을`의 조성이다. 이 `도시농업마을`은 `농촌`이라는 공간적 개념에서 접근하여 도심권에서 가까운 광역도시 내의 근교농업지역을 그대로 이용함을 말한다. 결과적으로 이 논문은 도시농업이 활성화되기 위해서는 현재의 농업을 유지해 나가는 것도 중요하지만, 무엇보다 이제 농업 그 자체만을 발전시켜 나가자는 시각에서 벗어나 농민들이 살고 있고 도시민들이 오고 갈 수 있는 `농촌`이라는 공간적 개념을 중요시하여 이를 활성화할 수 있는 방안을 제시하는데 초점을 두었다. 따라서 도시농업 속에서 농촌이 살아나면 농업도 유지될 것이라는 인식전환에 대한 내용을 담고 있다. The circumstances of agricultural production in the suburb have been made worse than ever before due to the non- agricultural factors such as IMF-controlled economic policies, gradual increases of land demands by city-development plans, and of land prices that are currently tend to be fallen down though. So it is far more necessary to retain suburban agriculture in the areas that show the mixtures of rural and urban attributes simultaneously, making uses of the characteristics, that are, of both `the function of agricultural production` and `the spatial utilization of suburban areas`. Accordingly, this study is mainly to clarify the concept of suburban agriculture as a mixed industry in the areas, considering the basic concept of `agricultural production as the primary industry` and `spatial utilization as a rural village` to be focused at the same time. For vitalizing suburban agriculture fundamentally, above all the things, we have to turn away the sole idea of developing farming even though it is also important to keep up the present status of farming level. Therefore, this study intends to suggest the ways of vitalization of suburban agriculture with the spatial concept of the suburban village that common urbanities are accessible to use easily. Conclusively, this have tried to show the conversion of following cognition that everything will get on well to retain the agriculture sectors, only if a farm village survive steadily in the suburban areas.

태양전지 모듈용 태양광 전력변환장치 기술 동향

유병규(Yu Byung-Gyu),유영덕(Yoo Young-Duk),유권종(Yu Gwon-Jong) 한국태양에너지학회 2010 한국태양에너지학회 학술대회논문집 Vol.2010 No.11

As photovoltaic (PV) systems have been installed widely across the world due to evironmental pollution and shortage of fossil fuel, the component technologies of PV have been improved and upgraged. Especially, in the field of PV inverter, the module integrated converter has been received a recent attention because it is easy to install as plug and play and flexible to expand the system capacity, etc. In this paper, the recent technical trend of photovoltaic module integrated converter is presented. The kinds of module integrated converters and their features are compared.

디지털농업과 농업정책목표의 설정

유병규 ( Byung Gyu Yu ) 한국축산경영학회 2003 농업경영정책연구 Vol.30 No.1