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Dynamic Lot-Sizing with Stepwise Transportation Costs
Jae-Gon Kim(김재곤),Dong-Ho Lee(이동호),Seong-Hoon Choi(최성훈),Seung-Kil Lim(임승길) 한국산업경영시스템학회 2007 한국산업경영시스템학회지 Vol.30 No.4
본 논문에서는 운송비용과 재고유지비용의 합을 최소화하는 것을 목적으로 유한 계획기간 동안의 수요를 충족시키는 동적 랏사이징 문제를 다룬다. 운송비용을 고려하는 기존의 랏사이징 모형들과는 달리 운송 트럭의 대수에 따라 계단형으로 운송비용이 증가하는 경우를 다루고 있다. 이 문제를 선형정수모형으로 모델링하며 그리디 방식의 휴리스틱을 제안한다. 제안된 휴리스틱의 성능을 평가하기 위해 계산실험을 수행하며, 그 결과 매우 짧은 시간 안에 최적해에 가까운 해를 찾을 수 있음을 보여준다.
급성 간성 포르피리아가 동반된 인슐린 의존성 당뇨병 1 예
권혁문(Hyuck Moon Kwon),김경래(Kyung Rae Kim),김복성(Bok Seong Kim),임승길(Sung Kil Lim),허갑범(Kap Bum Huh) 대한내과학회 1986 대한내과학회지 Vol.30 No.6
N/A Acute intermittent porphyria may be defined most simply as an inborn error of metabolism characterized chemically by the excessive excretion of porphyria precursors(porphobilinogen and usually aminolevulinic acid) and characterized clinically by episodes of neurologic dysfuntion. The disaese is complex, involving variable patterns of autonomic and peripheral neuropathy as well as central nervous system manifestions. There may be alterations in carbohydrate, lipid, water, and electrolyte metabolism in addition to clinically inapperent endocrine abnormalities. The fundamental defect is though to be a 50% decrease of porphobilinogen deaminase, the third enzyme of the heme biosynthetic pathway. This is associated with a marked increase of hepatic δ-aminolevulic acid synthetase, the first and rate controlling enzyme of the pathway. We experienced that 30 year old female admitted to our hospital due to recurrent attacks of abdominal pain, nausea and vomiting just before mensturation or during pregnancy. On past history, she has suffered from juvenile onset insulin dependent diabetes mellitus and used insulin(NPH 16 units) for 10 years. She was diagnosed as acute hepatic porphyria by the positive PBG test of Haesch method, and treated by hypertonic dextrose solution with insulin. Although the glucose tolerance test is abnormal by classical criteria in many patients, paricularly during activity of the disease, the association of porphyria and diadetic ketoacidosis is rare. In this situation, the accurate diagnosis and prompt treatment may be delayed because of similar clinical manifestation and there is complexed problem between hypertonic dextrose solution required for porphyria and hypertonic dextrose solution aggrevated for diabetic ketoacidosis.