한의학 기반 반려동물용 치료기술 개발 관련 특허 분석

이지혜,김성호,이수은,남현화,박준홍,천진미,서윤수,김보혜,이정민,문창종,김중선,문병철,Lee, Ji Hye,Kim, Sung Ho,Lee, Sueun,Nam, Hyeon-Hwa,Park, Jun Hong,Chun, Jin Mi,Seo, Yun-Soo,Kim, Bohye,Lee, Jeongmin,Moon, Changjong,Kim, Joong Sun,Moon 대한본초학회 2022 大韓本草學會誌 Vol.37 No.6

Objective : In this study, we conducted to analysis the patents about Korean medicine based treatment technology for pet. Methods : We collected the Korean, Japan, USA, China, EU and PCT patent for the Korean medicine-based treatment technology for pet using WIPSON data base registered by October 4, 2020 were selected. Results : Patents for the development of pet Korean medicine-based treatment technology have been constantly applied since the mid-2000s, starting in 1990, with a total of 84 applications. The number of patent applications filed in Korea was the largest, after Japan and China. The detailed composition of the applications reported until now is pharmaceutical compositions for the treatment of pet were the most applied with 39%(33 cases), followed by feed used as stocks for pet at 36%(30 cases). According to the patent application rate by disease, most of applications rate composed to be associated with immunity in 2009 to 2013 with 40% of applications. In 2014 to 2018 43% of patent applications are associated with gastrointestinal/digestive system. In this regard, multiple applications were filed in the order of immunity, digestive system, obesity and urinary system. Conclusion : This study analyzed the trend of 84 patents about Korean medicine-based treatment technology for pet to date to establish the basis for future research and development. There were many applications related to immunity from 2009 to 2013, and since then, related to digestive disease from 2014 to 2018.

액션러닝 기반 온라인 실습이 간호대학생의 자기주도적 학습능력, 학업적 자기효능감과 협업능력에 미치는효과

이지혜,한미라,Lee, Jihye,Han, Mira 국제문화기술진흥원 2022 The Journal of the Convergence on Culture Technolo Vol.8 No.6

The purpose of this study was to identify the effects of online practicum based on action learning on self-directed learning ability, academic self-efficacy, and cooperation ability of nursing students. Similar experimental study of single group pre-post test design was used to investigate the effects of this online class. A total of 47 nursing students who were junior grade from one college participated in this study and self-administered questionnaire was used for data collection. Data were analyzed by frequencies, paired t test using the SPSS/Window 21.0 program. The result of this study showed that the improvement after online practicum based on action learning was significant in self-directed learning ability(t=3.832, p<.001), academic self-efficacy(t=4.258, p<.001), and cooperation ability(t=3.853, p<.001). These findings imply the value of online practicum based on action learning to enhance competency of nursing students. In the future, more studies should be conducted in the same group including control group and blended learning method using action learning to validate the effectiveness.

보중익기탕 및 발효보중익기탕의 단회투여 독성에 대한 연구

이지혜,황윤환,곽동훈,김태수,마진열,Lee, Ji-Hye,Hwang, Yoon-Hwan,Kwak, Dong-Hoon,Kim, Tae-Soo,Ma, Jin-Yeul 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.4

Objectives : The aim of this study was to evaluate the single oral dose toxicity and safety of Bojungikgi-tang (Buzhongyiqi-tang) and fermented Bojungikgi-tang (Buzhongyiqi-tang) extracts in male and female ICR mice. Methods : In the single oral dose toxicity study, non-fermented and fermented Bojungikgi-tang (Buzhongyiqi-tang) were administered to male and female ICR mice as an oral dose of 1250, 2500 and 5000 mg/kg. Changes of body weights, general behaviors, adverse effects and mortality were determined throughout the experimental period. Hematological parameters, serum chemistry, organ weights and necropsy findings were evaluated at the end of the experiment. Results : There was no mortality or sign of toxicity in the single oral dose toxicity study. There were also no significant differences in body weights, organ weights, and hematological parameters, serum chemistry values between treatment and control groups. Conclusions : The results obtained in this study suggest that the 50% lethal dose of fermented Bojungikgi-tang (Buzhongyiqi -tang) in both female and male mice can be considered as well over 5,000 mg/kg, so these medicines can be safe in clinics.

ICR 마우스를 이용한 자음강화탕 및 자음강화탕 발효물의 단회투여 독성시험

이지혜,곽동훈,황윤환,박화용,마진열,Lee, Ji-Hye,Kwak, Dong-Hoon,Hwang, Yoon-Hwan,Park, Hwa-Yong,Ma, Jin-Yeul 대한한방내과학회 2013 大韓韓方內科學會誌 Vol.34 No.2

Objectives : This study aimed to evaluate the single oral dose toxicity of Jaeumganghwa-tang (Ziyinjianghuo-tang) and Jaeumganghwa-tang (Ziyinjianghuo-tang) fermented with Lactobacillus acidophyllus in male and female ICR mice. Methods : In this single oral toxicity study, non-fermented and fermented Jaeumganghwa-tang (Ziyinjianghuo-tang) were administered to male and female ICR mice as an oral dose of 500, 1000 and 2000 mg/kg. After single administration, body weight changes, general behavior, adverse effects and mortality were determined for 14 days. Serum chemistry, organ weights and necropsy findings were evaluated at the end of the experiment. Results : There were no mortality or signs of toxicity for 14 days. There were also no significant differences in body weights, organ weights, or serum chemistry values between treatment and control groups. Conclusions : These results indicate that the 50% lethal dose of Jaeumganghwa-tang (Ziyinjianghuo-tang) fermented with Lactobacillus acipophullus may be over 2000 mg/kg. This finding can be expected to provide scientific evidence for the safety of Jaeumganghwa-tang (Ziyinjianghuo-tang) fermented with Lactobacillus acidophyllus.

MODIS 전천후 기상자료 기반의 생물리학적 벼 수량 모형 개발

이지혜,서범석,강신규,Lee, Jihye,Seo, Bumsuk,Kang, Sinkyu 대한원격탐사학회 2017 大韓遠隔探査學會誌 Vol.33 No.5

벼 등 식량작물 작황 추정의 경제, 산업적 중요성이 증가함에 따라 생물리 모형과 원격탐사 기반의 위성자료를 활용한 작황 추정 연구가 활발히 진행되고 있다. 이 연구에서는 위성 기반의 전천후 기상 입력자료(i.e. 기온, 대기 수증기압 포차, 일사량)와 빛 이용효율 모형을 이용한 생물리적 작물 성장 알고리즘을 벼에 적용하여 벼의 수확량을 수확 시기 보다 이르게(9월 중순 경) 추정하는 것을 목적으로 하였다. 2003년부터 2014년까지 12년간 경상권을 제외한 국내의 군 단위 행정구역별 벼 수확량을 추정하고, 이를 통계청에서 제공하는 현미 생산량 통계와 비교, 평가하였다. 벼 건중량, 수확지수 그리고 수확량 추정 결과는 각각 지도로 작성하여 공간적 분포 양상을 분석하였다. 연도별 전국 평균 추정 건중량은 평균오차(ME)가 0.56%, 평균절대오차(MAE)가 5.73%로 유의미한 결과를 보였다. 연도별 군 단위 건중량은 ME가 0.10%에서 2.00%, MAE가 2.10에서 11.62%의 범위를 보였다. 추정된 건중량은 강원지역에서 상대적으로 과대 모의하고, 충청 이남의 도심과 서해 인근지역에서 과소 모의하는 경향을 보였다. 건중량과 유관한 통계청 자료(i.e. 볏짚 생산량)와는 상반된 변동 양상을 보였는데, 이는 입력자료의 해상도(1 km)로 인한 픽셀 내 토지피복 이질성으로 인한 오차로 사료된다. 또한 생육기간 이후 수확시기의 생육상황을 고려하지 못하는 점을 향후 연구에서 개선할 필요가 있다. With the increasing socio-economic importance of rice as a global staple food, several models have been developed for rice yield estimation by combining remote sensing data with carbon cycle modelling. In this study, we aimed to estimate rice yield in Korea using such an integrative model using satellite remote sensing data in combination with a biophysical crop growth model. Specifically, daily meteorological inputs derived from MODIS (Moderate Resolution imaging Spectroradiometer) and radar satellite products were used to run a light use efficiency based crop growth model, which is based on the MODIS gross primary production (GPP) algorithm. The modelled biomass was converted to rice yield using a harvest index model. We estimated rice yield from 2003 to 2014 at the county level and evaluated the modelled yield using the official rice yield and rice straw biomass statistics of Statistics Korea (KOSTAT). The estimated rice biomass, yield, and harvest index and their spatial distributions were investigated. Annual mean rice yield at the national level showed a good agreement with the yield statistics with the yield statistics, a mean error (ME) of +0.56% and a mean absolute error (MAE) of 5.73%. The estimated county level yield resulted in small ME (+0.10~+2.00%) and MAE (2.10~11.62%),respectively. Compared to the county-level yield statistics, the rice yield was over estimated in the counties in Gangwon province and under estimated in the urban and coastal counties in the south of Chungcheong province. Compared to the rice straw statistics, the estimated rice biomass showed similar error patterns with the yield estimates. The subpixel heterogeneity of the 1 km MODIS FPAR(Fraction of absorbed Photosynthetically Active Radiation) may have attributed to these errors. In addition, the growth and harvest index models can be further developed to take account of annually varying growth conditions and growth timings.

Kinetic Spray 공정으로 제조된 탄탈륨 코팅층의 열처리 분위기에 따른 미세조직 및 물성

이지혜,김형준,이기안,Lee, Ji-Hye,Kim, Hyung-Jun,Lee, Kee-Ahn 한국분말야금학회 2015 한국분말재료학회지 (KPMI) Vol.22 No.1

The effect of heat treatment environment on the microstructure and properties of tantalum coating layer manufactured by kinetic spraying was examined. Heat treatments are conducted for one hour at $800^{\circ}C$, $900^{\circ}C$, and $1000^{\circ}C$ in two different environments of vacuum and Ar gas. Evaluation of microstructure and physical properties are conducted. High density ${\alpha}$-tantalum single phase coating layer with a porosity of 0.04% and hardness of 550 Hv can be obtained. As heat treatment temperature increases, porosity identically decreases regardless of heat treatment environment (vacuum and Ar gas). Hardness of heat treated coating layer especially in Ar gas environment deceases from 550 Hv to 490 Hv with increasing heat treatment temperature. That in vacuum environment deceases from 550 Hv to 530 Hv. The boundary between particles became vague as heat treatment temperature increases. Oxygen distribution of tantalum coating layer is minute after heat treatment in vacuum environment than Ar gas environment.

식코가 남긴 과제

이지혜,Lee, Ji-Hye 대한병원협회 2008 대한병원협회지 Vol.37 No.3

Differential Effects of Two Individual Acupuncture Points (BL62, KI6) on Heart Rate Variability in Healthy Volunteers : A Randomized, Single-Blind, Self-Controlled Trial

이지혜,최영준,신병철,구성태,Lee, Ji-Hye,Choi, Young-Joon,Shin, Byung-Chul,Koo, Sung-Tae Society for Meridian and Acupoint 2010 Korean Journal of Acupuncture Vol.27 No.2

목적 : 이 연구는 서로 다른 두 경혈이 심박변이도에 미치는 영향을 비교하고, 자율신경계에 미치는 영향을 평가하기 위해 수행하였다. 재료 및 방법 : 13명의 지원자가 3개의 세션에 균등하게 무작위 배정되었다. 각 세션에서 지원자들은 신맥(BL62), 조해(KI6), 또는 비경혈에 각각 침처치를 받았다. 10분간 휴식을 한 후에 자침 전, 유침기간, 발침 후 기간에 5분 동안 심박변이도 측정을 하였다. 유침기간에는 2분 간격을 두고 2회 심박변이도를 측정하였다. 결과 : 신맥에 자침한 군에서는 자침후 기간에 total power(TP)와 standard deviation N-N interval(SDNN)이 유의하게 증가하였다. 유침기간 중 첫 5분 동안의 TP와 SDNN은 자침전 값과 유의한 차이가 없었으며 유침기간 중 마지막 5분 동안에는 다소 증가하는 경향은 있었지만 통계적인 유의성은 없었다. 반면에 조해와 비경혈에 자침한 군에서는 TP와 SDNN에 유의한 변화가 관찰되지 않았다. 발침 후에 신맥자침군에서는 조해와 비경혈 자극군과 비교해서 TP가 유의하게 변화하였다. 그러나 SDNN은 발침 후에 세 군 사이에 유의한 차이가 없었다. 결론 : 이 실험 결과는 조해와 비교했을 때 신맥에 자침한 경우 심장 기능 및 자율신경계와 관련이 있는 대체적인 활성이 증가한다는 것을 보여주었다. 이 결과는 신맥 자침이 자율신경계와 관계되어 있는 심장의 기능에 미치는 영향을 통해서 경혈의 특이성을 관찰할 수 있음을 의미한다.

Development of science program using astronomical data in the history of Korea

이지혜,신동희,Lee, Ji Hye,Shin, Dong Hee 한국천문학회 2012 天文學會報 Vol.37 No.2

Science we have perceived as genuine science is based on western scientific enterprise, that is, western modern science(WMS). The K-12 science curriculum in Korea absolutely contains WMS content. Elkana(1981) criticized the indifference of comparative science in the field of science, whereas there have been a lot of comparative studies of art, religion, ethics, and politics. Science is the product not only based on 'western' culture but all cultural around the world including Korea. People have consistently observed and tested for such a long period of time all over the world. Traditional science of Korea can be related to multiculturalism, which has become important in many fields. Korea has a lot of great scientific enterprises, such as astronomical instruments of Chosun Dynasty and ancient data of natural phenomenon in Samguk-saki or Samguk-Yusa. It is expected that students will consider them as more 'objective' and 'realistic' things rather than 'artistic' and 'distinguished' things. Astronomy was also very important in the East because they believed sky as king, which results in the development of a lot of astronomical data and instruments in Korean history. In this study, we developed three units of science programs using astronomical enterprises in Korea: 1) Activities with our sundial, Angbuilgu:, 2) data interpretation of natural phenomenon in ancient Korea, 3) experience in Gyeongbokgung Palace. From these programs, we expect that students will develop a profound understanding and take pride in our science.

마우스를 이용한 발효쌍화당의 급성독성 실험

이지혜,엄영란,심기석,전원경,이재훈,마진열,Lee, Ji-Hye,Um, Young-Ran,Shim, Ki-Suck,Jeon, Won-Kyung,Lee, Jae-Hoon,Ma, Jin-Yeul 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.4

Purpose : This study was carried out to investigate the acute toxicity and safety of fermented Ssanghwa-tang extract. Methods : To evaluate their acute toxicity and safety, 0(control group), 1250, 2500 and 5000 mg/kg of Ssanghwa-tang and fermented Ssanghwa-tang extracts were orally administered to 20 male and 20 female ICR mice. After a single administration, we observed survival rates. general toxicity. changes of body weight, and autopsy. Results : Compared with the control group, we could not find any toxic alteration in any of the treated groups (1250, 2500 and 5000 mg/kg). Conclusions : $LD_{50}$ of Ssanghwa-tang and fermented Ssanghwa-tang extracts might be over 5000 mg/kg and it is very safe for ICR mice.