소아에서 엡스타인-바 바이러스 감염과 관련한 막성 신병증 1례

이은희,임동희,임형은,유기환,원남희,홍영숙,이주원,Lee, Eun-Hee,Lim, Dong-Hee,Yim, Hyung-Eun,Yoo, Kee-Hwan,Won, Nam-Hee,Hong, Young-Sook,Lee, Joo-Won 대한소아신장학회 2008 Childhood kidney diseases Vol.12 No.1

Infection of Epstein-Barr virus(EBV) gives rise to a broad spectrum of clinical manifestations in children. Although renal involvement is rare, diverse renal manifestations are known from hematuria to acute renal failure. Secondary membranous nephropathy(MN) associated with systemic EBV infection is an uncommon renal pathology and only two cases have been reported. We are adding another case of MN associated with EBV infection in a child. An 8-year-old girl was admitted for renal biopsy. She had been followed up for microscopic hematuria and intermittent proteinuria for 5 months. There had been no specific findings in serology and radiology. Tonsil biopsy had been done due to exudative tonsillar hypertrophy and enlarged multiple cervical lymph nodes. And it showed EBV-associated lymphoproliferative findings. Serologic tests for EBV showed positive evidence of recent infection; viral capsid antigen(VCA) IgM was borderline positive, VCA IgG and early antigen IgG were positive, and EB nuclear antigen IgG was negative. In Situ Hybridization of tonsil for EBV mRNA was positive. Because her proteinuria and hematuria were aggravated at that time(protein 3 +, RBC >60/HPF), renal biopsy was done. Renal biopsy showed the findings of MN, characterized by thickened capillary walls with epimembranous spikes on light microscopy and subepithelial, mesangial and subendothelial electron dense deposits on electron microscopy. On immunofluorescence microscopy, IgG, C1q, kappa and lambda chains were positive. After steroid administration, proteinuria and hematuria resolved gradually within 6 months. 막성 신병증은 성인에 비해 소아에서는 드문 신병증으로 감염, 자가면역, 종양에 의한 이차성 신병증이 알려져 있다. 그 중에서도 엡스타인-바 바이러스 감염과의 관련은 잘 알려지지 않아, 최근 1개 보고에서 면역기능이 저하된 2례를 소개한 바 있을 뿐이다. 이에 저자들은 면역기능이 정상으로 보이는 소아에서 엡스타인-바 바이러스 감염과 관련한 막성 신병증 1례를 경험하였기에 보고하는 바이다.

사람 융모 성선 자극 호르몬에 의한 복강 대식세로로부터 산화질소의 발생

이은희,신태용,김형민,Lee, Eun-Hee,Shin, Tae-Yong,Kim, Hyung-Min 대한약학회 1997 약학회지 Vol.41 No.3

Human chorionic gonadotropin (hCG) is a placental hormone and is involved in maintenance of the corpus luteum during pregnancy. In the present study, effect of hCG on nitiric ox ide (NO) generation from peritoneal macrophage was examined. hCG ahd no effect on NO generation by itself, whereas recombinant interferon- ${\gamma}$ (rIFN-${\gamma}$) alone had modest activity. When hCG was used in combination with rIFN-${\gamma}$, there was a marked cooperative induction of NO generation in a dose-dependent manner. The optimal effect of hCG on NO generation was shown at 6 hr after treatment with rIFN-${\gamma}$. Furthermore, northern blot analysis of showed that hCG increased the expression of inducible NO synthase(iNOS) gene. These results suggest that hCG induces NO generation from macrophages by increasing the expression of iNOS gene.

Petrology of Granitoids in the Vicinity of Hamyang - Namweon , Korea

이은희,이용종 ( Eun Hee Lee,Yoon Jong Lee ) 한국지구과학회 1992 지구과학교육 학술발표회 Vol.1992 No.-

하이퍼써미아 응용을 위한 하이브리드 에어로젤 내 분산된 마그네타이트 나노입자

이은희,좌용호,김창열,Lee, Eun-Hee,Choa, Yong-Ho,Kim, Chang-Yeoul 한국재료학회 2012 한국재료학회지 Vol.22 No.7

Magnetite nanoparticles(NPs) have been the subject of much interest by researchers owing to their potential use as magnetic carriers in drug targeting and as a tumor treatment in cases of hyperthermia. However, magnetite nanoparticles with 10 nm in diameter easily aggregate and thus create large secondary particles. To disperse magnetite nanoparticles, this study proposes the infiltration of magnetite nanoparticles into hybrid silica aerogels. The feasible dispersion of magnetite is necessary to target tumor cells and to treat hyperthermia. Magnetite NPs have been synthesized by coprecipitation, hydrothermal and thermal decomposition methods. In particular, monodisperse magnetite NPs are known to be produced by the thermal decomposition of iron oleate. In this study, we thermally decomposed iron acetylacetonate in the presence of oleic acid, oleylamine and 1,2 hexadecanediol. We also attempted to disperse magnetite NPs within a mesoporous aerogels. Methyltriethoxysilicate(MTEOS)-based hybrid silica aerogels were synthesized by a supercritical drying method. To incorporate the magnetite nanoparticles into the hybrid aerogels, we devised two methods: adding the synthesized aerogel into a magnetite precursor solution followed by nucleation and crystal growth within the pores of the aerogels, and the infiltration of magnetite nanoparticles synthesized beforehand into aerogel matrices by immersing the aerogels in a magnetite nanoparticle colloid solution. An analysis using a vibrating sample magnetometer showed that approximately 20% of the magnetite nanoparticles were well dispersed in the aerogels. The composite samples showed that heating under an inductive magnetic field to a temperature of $45^{\circ}C$ is possible.

논문편 : 소비자정보요구와 관련요인 연구

이은희,이기춘 ( Eun Hee Lee,Kee Choon Rhee ) 대한가정학회 1991 Family and Environment Research Vol.29 No.1

An Electromyographic Study on Changes of Mandibular Position

이은희,서봉직,오희명,Lee, Eun-Hee,Suh, Bong-Jik,Oh, Hee-Myung The Korean Academy of Orofacial Pain and Oral Medi 1999 Journal of Oral Medicine and Pain Vol.24 No.1

저자는 하악의 위치변화가 저작근에 미치는 영향을 근전도학적으로 평가하고자, 측두하악장애의 징후와 증상이 없는 정상성인 28명을 대상으로 중심위 교합장치(centric relation splint), 중심교합위 교합장치(centric occlusion splint), 전방 재위치 교합장치(anterior repositioning splint)를 장착시킨 상태에서 하악의 중심의, 중심교합위, 전방위률 유도한 후 최대 이악물기 상태의 좌우측 교근 및 전측두근의 근전도를 채득, 분석, 평가한 결과 다음과 같은 결론을 얻었다. 1. 전측두근에서 하악의 위치변화에 따른 최대 근활성도의 차이가 나타났으나(p<0.05), 교근에서는 나타나지 않았다. 2. 전측두근의 경우 중심교합위에서 최대 이악물기 상태의 최대 근활성도는 교합 장치물을 장착하지 않은 경우 및 중심위에서와 비교하여 감소하였다(p<0.05). 3. 전측두근의 경우 전방위에서 최대 이악물기 상태의 최대 근활성도는 교합 장치물을 장착하지 않은 경우 및 중심위에서와 비교하여 감소하였다(p<0.001). 4. 교근과 전측두근의 좌우 비대칭지수(asymmetry index)는 하악의 위치변화에 따른 차이가 나타나지 않았다.

경남 창녕군 증산리 일대 방사집수정을 활용한 강변 여과수 개발량 평가

이은희,현윤정,이강근,김형수,정재훈,Lee, Eun-Hee,Hyun, Yun-Jung,Lee, Kang-Kun,Kim, Hyoung-Soo,Jeong, Jae-Hoon 한국지하수토양환경학회 2010 지하수토양환경 Vol.15 No.4

Well production by a riverbank filtration facility with multi-radial collector well systems in Jeungsan-ri, Changnyeong gun, Korea was evaluated. In this study, the drawdown at collector wells due to pumping and groundwater inflow rates along the horizontal arms of the collector wells were computed through numerical simulations. Sensitivities of the well production to hydraulic conductivity and well flow coefficient, which represents the resistance to the flow from the aquifer to the horizontal arms, were analyzed. Simulation results showed that, with given proposed pumping rate conditions, the drawdown in the caisson exceeded maximum drawdown constraints in the study site and the adjustment of the pumping rate at each well is needed. The drawdown is affected by the hydraulic conductivity of the main aquifer and the well flow coefficient, which means the profound field investigation of the study site is needed to accurately estimate the efficiency of riverbank filtration through radial collector wells.

신생아기에 진단된 Netherton 증후군 1례

이은희,김애란,김기수,조범진,고재경,피수영,Lee, Eun-Hee,Kim, Ellen Ai-Rhan,Kim, Ki-Soo,Cho, Beom-Jin,Koh, Jai-Kyoung,Pi, Soo-Young 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.4

Netherton 증후군은 어린선양 피부병증, 머리카락이상, 아토피 소질 등 3가지 임상양상을 특징으로 하는 드문 질병이다. 저자들은 임상소견, 피부조직 검사와 머리카락 현미경 소견을 통하여 신생아기에 Netherton 증후군으로 진단하고 추적 관찰하고 있기에 간단한 문헌 고찰과 함께 보고하는 바이다. Netherton's syndrome is an unusual disorder which consists of triad of ichtyosiform dermatosis, multiple defects of hair shaft and an atopic diathesis. The finding of bamboo hair is pathognomic in Netherton's syndrome and the ichthyosiform dermatosis may consist of either ichtyosis linearis circumflexa or congenital ichthyosiform erythroderma. Often, variability in the clinical features leads to a delay in diagnosis in many cases. We report a case of Netherton's syndrome diagnosed in the neonatal period. The patient presented with severe ichthyosis and confirmed microscopically distinctive bamboo hair.

콩 싹의 Acetohydroxyacid Synthase 의 성질과 피이드백 저해에 관한 연구

이은희,안태우,최정도 ( Eun Hee Lee,Tae Woo Ahn,Jung Do Choi ) 생화학분자생물학회 1991 BMB Reports Vol.24 No.3

Acetohydroxyacid synthase (AHAS) is the first common enzyme in the biosynthetic pathways to valine, leucine, and isoleucine. AHAS has been partially purified from dark grown pea shoots approximately 2000 fold using DEAF-cellulose affinity elution, Sephadex G-150, and leucine-agarose chromatography. The rate of product acetolactate formation from pyruvate shows a sigmoidal relationship with substrate at low pyruvate concentrations. The enzyme preparation has a K_m value for pyruvate of 4 mM, a pH optimum of 7.5 to 8.5, and a temperature optimum of 35℃ to 45℃. The enzyme is inhibited by valine, leucine, and isoleucine singly, and synergistically by the pair of the amino acids, indicating more than one binding site of the enzyme for branched amino acids. The level of the inhibition decreases with increasing substrate concentration, and kinetic analysis shows the inhibition to be mixed type in which the inhibitor affects on both V_(max) and K_m. The degree of inhibition is pH-dependent as it decreases drastically above pH 8.

의료보험본인부담금액에 관한 연구

이은희 대구보건대학 1994 대구보건대학 論文集 Vol.14 No.-

Patients have paid the cost shaving devices of the medical insurance because of protection of insurance public finance as medical cost increase 65.5 percent In the senior nation the cost shaving devices is 0~11 percent but In Korea the cost sharing is 50 percent. These days it is increasing. Insurance public finance has profited since 1986. While people in the lower brackets of income is decreasing medical request because of increasing of the cost shaving devices. The cost shaving devices will be decreased on account of disobedience in medical insurance which pursuits common profited.