도인승기탕에 의한 당뇨병성 혈관장애 개선효과

이윤정,김언국,김혜윰,윤정주,이소민,이용표,이건목,강대길,이호섭,Lee, Yun Jung,Kim, Eon Kuk,Kim, Hye Yoom,Yoon, Jung Joo,Lee, So Min,Lee, Yong-Pyo,Lee, Geon Mok,Kang, Dae Gill,Lee, Ho Sub 대한한의학방제학회 2013 大韓韓醫學方劑學會誌 Vol.21 No.1

Objectives : Diabetes mellitus is the leading cause for vascular complications such as atherosclerosis. The present study is to investigate whether Doinseunggi-tang (DST) improves diabetic vascular dysfunction in type II diabetes. Methods : The db/db mice were treated with high fat/high cholesterol diet and DST (200 mg/kg/day) for 8 weeks. Results : DST significantly lowered blood glucose and systolic blood pressure. In addition, DST also markedly decreased total plasma cholesterol, triglyceride, and LDL-cholesterol, whereas increased the HDL-cholesterol. Vascular relaxation of aortic rings by acetylcholine or SNP was ameliorated by DST in a dose-dependent manner. Damage of vascular intima and hypertrophic of media was improved by DST. Immunohistological study revealed that DST attenuated the increase of ICAM-1, VCAM-1, and ET-1 expression in thoracic aorta. Conclusions : Taken together, DST suppressed hyperglycemia and diabetic vascular dysfunction in type II db/db mice. The present data suggests that Doinseunggi-tang may be prevent a development of diabetic atherosclerosis.

고지혈증 동물모델에서 홍삼과 천마 혼합투여에 의한 혈관 염증 개선연구

이윤정,김혜윰,윤정주,이소민,고정현,이호섭,최경민,강대길,Lee, Yun-Jung,Kim, Hye-Yoom,Yoon, Jung-Joo,Lee, So-Min,Kho, Joung-Hyun,Lee, Ho-Sub,Choi, Kyung-Min,Kang, Dae-Gill 대한한의학방제학회 2012 大韓韓醫學方劑學會誌 Vol.20 No.1

Objectives : This experimental study was designed to investigate the inhibitory effects of combination with Korean red ginseng and Gastrodia rhizoma on vascular dysfunction in high-fat/cholesterol diet-induced hyperlipidemia. Methods : Sprague-Dawley rats were fed with 7.5% cocoa butter and 1.25% cholesterol for 10 weeks, with Panax ginseng (PG), and mixtures of Panax ginseng and Gastrodia rhizoma (PGM), respectively. Results : Chronic treatment with PG and PGM significantly decreased body weight. The aortic expression of cell adhesion molecules such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin were markedly increased in hyperlipidemia rats. Interestingly, PGM significantly decreased cell adhesion molecules expression. However, there was no significant decrease in PG group. In addition, PG and PGM group inhibited high-fat/cholesterol diet-induced cytokine such as monocyte chemoattractant protein (MCP-1) mRNA expression. Furthermore, PG and PGM group significantly decreased c-reactive protein protein (CRP) level. Especially, PGM significantly accentuated the decrease of MCP-1 mRNA expression and CRP level. Conclusions : the present study provides an evidence that combination with Panax ginseng and Gastrodia rhizoma enhances anti-vascular protective effects through suppression of vascular inflammation in hyperlipidemic rats.

Salmonella typhimurium 에서 무산소 환경 유도유전자들에 대한 조절유전자들의 특성 및 클로닝

이윤정,방일수,이인수,이영록,박용근 ( Yun Joung Lee,Iel Soo Bang,In Soo Lee,Yung Nok Lee,Yong Keun Park ) 한국환경생물학회 1993 환경생물 : 환경생물학회지 Vol.11 No.2

New regulatory loci which participate in the anaerobic environment inducible gene(ani) expression in Salmonella typhimurium were identified. These regulators (oxr) showed negative regulatory effect on the anaerobiosis inducible operon fusions of this organism in aerobic environment (oxr 107 and oxr 108 to ani 2001, oxr 109 to ani 2007). They were identified as the trans-acting regulators, and increased β-galactosidase activity of ani-lacZ fusion strains up to about 10-240 fold in aerobic environment. By using the library of S. typhimurium chromosomal DNA, two negative regulators (oxr 101 and oxr 109) were cloned. The insert fragment of each clone, pPK32 for oxr 101 and pPK33 to oxr 109 were 7.8Kb and 9.3Kb, respectively. The recombinant plasmid pPK32 didn`t complement the mutation effect of oxr 101 on minimal media but rich media, pPK33 complemented the mutation effect of oxr 109 on both minimal and rich media.

2016 양계산업 현황과 과제 - 14/15 HPAI 발생과 예방대책

이윤정,Lee, Yun-Jeong 대한양계협회 2016 월간 양계 Vol.48 No.2

집합주택단지의 옥외공간에 있어서 고령자 이바쇼(居場所)의 특징고찰 - 일본 치바현(千葉縣)의 카시와시(柏市) 토요시키다이(豊四季台)단지를 대상으로 -

이윤정,변경화,유창균,Lee, Yunjeong,Byun, Kyeonghwa,Yoo, Changgeun 한국주거학회 2015 한국주거학회 논문집 Vol.26 No.6

The purpose of this study is to analyze the characteristics of exterior spaces used by the elderly of housing complex. The exterior spaces are used for going out in everyday life with the view point that the elderly have to go out from the inside home in order to prevent isolating the elderly from local community. For that Toyoshikidai housing complex in Kashiwa city of Chiba prefecture, Japan is selected and carried out questionnaire survey and field survey targeting residents. The results are following as. For spatial characteristics, the location installed benches, location occupied in one part by roof, wall, or plants, place connecting to moving flow of the aged, and an open expanse getting safety from vehicle are taken advantages for the elderly. For using benches, the elderly of 70.1% do not have experience using benches installed in all those places. The the biggest reason is that they are not tired. However, 36.8% of the elderly are using benches in order to take a rest and 20.8% of them are using benches in order to talk with the other people. Bench is ibasho of the elderly.

전자코와 GC/MS를 이용한 포도 품종별 저장 조건에 따른 휘발성 향기 성분 연구

이윤정,이기택,Lee, Yun-Jeung,Lee, Ki-Teak 한국식품영양과학회 2007 한국식품영양과학회지 Vol.36 No.7

품종에 따른 포도를 이용하여 3일 동안 $4^{\circ}C$와 실온에 각각 저장함에 따라 변화하는 전체적인 향의 패턴을 전자코를 통하여 분석하였고 SPME-GC/MS 분석 결과를 통하여 휘발성분을 분리 동정하였다. 대표적인 포도의 주요 휘발 성분은 alcohols, esters, acids, terpenes 등으로 GC/MS 분석 결과 butanoic acid/ethyl ester와 1-hexanol, hexanoic acid/ethyl ester, phenylethyl alcohol 등이 주요 성분으로 동정되었다. 캠벨은 다른 품종에 비해 다양한 휘발 성분이 동정되었고 레드글로브와 머루 품종에서는 1-hexanol, 2-decene, 8-methyl-(z)/1-dodecanol 등을 제외한 나머지 휘발 성분은 거의 나타나지 않았다. 또한 전자코를 이용하여 휘발성 향기성분 패턴 분석결과 $4^{\circ}C$와 실온 저장한 시료의 제 1주성분 값의 기여율은 각각 99.30, 99.36%로 품종에 따라 구분이 가능하였다. $4^{\circ}C$ 저장 시 저장 기간에 따른 제 1주성분 값의 변화 범위는 실온에서 저장한 것에 비해 적었음을 확인할 수 있었다. Volatile flavor compounds of 4 grape species (Campbell, Sheridan, Red globe, and Meoru) were identified during 3-day storage at either $4^{\circ}C$ or room temperature. Each sample was analyzed by solid-phase micro-extraction (SPME) method combined with gas chromatography-mass spectrometry. Also electronic nose composed of 12 different metal oxide sensors was used to differentiate flavors of grapes. Sensitivities (delta $R_{gas}/R_{air}$) of sensors from electronic nose were obtained by principal component analysis (PCA). Proportion of the first principal component was 99.30% at $4^{\circ}C$ and 99.36% at room temperature, respectively. In our result, flavor patterns of grape can be differentiated according to the storage period. The major volatile flavor compounds were 1-hexanol, hexanoic acid and its ethyl ester, and phenylethyl alcohol with the presence of butanoic acid and its ethyl ester, acetic acid, benzeneacetic acid and its ethyl ester.

건물 에너지 분석의 개념과 활용

이윤정,김상훈,전준용,Lee, Yun-Jeong,Kim, Sang-Hun,Jeon, Jun-Yong 한국건설관리학회 2012 한국건설관리학회 논문집 Vol.13 No.3

비중격만곡증 환자의 눈물주머니코안연결술의 임상예후

이윤정,문상원,조희윤,정진혁,Yoon Jung Lee,M,D,Sang-Won Moon,M,D,Hee Yoon Cho,M,D,Jin-Hyeok Jeong,M,D 대한안과학회 2008 대한안과학회지 Vol.49 No.5

Purpose: Septal deviation has few subjective symptoms. However, a difficulty remains in doing DCR (dacryocystorhinostomy) in these patients. We investigate the clinical course of DCR in patients with a septal deviation. Methods: Acquired nasolacrimal duct-obstructed patients who had undergone DCR with septal deviation from 2003 to 2006 in our hospital were retrospectively analyzed. We measured the septal distance using paranasal computed tomography taken preoperatively and compared the sex and age of patients, the kinds of operations, outcome of surgery, and ocular and nasal complications in our analysis. Results: Twenty-two eyes of 22 patients with a mean age of 55.3 years (range 29~74) were analyzed (4 males, 18 females). Mean septal distance was 4.84 mm (range 2.18~6.99 mm). Nineteen eyes had endonasal DCR, and three had external DCR. Two had DCR combined with septoplasty. Three had septoplasty as a secondary operation, Nasal complication was synechiae in 9 eyes. DCR success was seen in 15 eyes, and DCR failure in 7 eyes. Septal distance was not correlated with DCR success but was correlated with nasal complication (Mann-Whitney test, p=0.003) Conclusions: In the case of DCR with septal deviation, the surgical technique used will need to minimize the mucosal injury and ensure appropriate nasal correction to prevent future complications.

사체를 이용한 아래눈꺼풀지방의 해부학적 연구

이윤정,강일봉,신선영,백두진,Yoon Jung Lee,M,D,Il Bong Kang,M,D,Sun Young Shin,M,D,Doo Jin Paik,M,D 대한안과학회 2007 대한안과학회지 Vol.48 No.7

Purpose: This study investigated the anatomy of infraorbital fat and the relationship between surrounding structures and infraorbital fat. Methods: Forty-one orbits from adult Korean cadavers were dissected. Among them 20 orbits were male and 21 orbits were female. The cadavers were perfused and embalmed in formalin solution. The skin and orbicularis oculi muscle were dissected to expose the arrangement and compartments of infraorbital fat. A punctal probe was used to find a deeper fat compartment lying under the another compartment. The width of each compartment and the distances from the inferior orbital rim and from the lower lid margin to the topmost point of each compartment were measured using a digital caliper. The distance from the top of the medial compartment and lower lid margin to the first appearance of the inferior oblique muscle, located between the medial and the central fat compartments, were measured, respectively. Results: The width of the medial compartment was 11.49±2.54 mm, the central compartment was 21.78±5.69 mm, and the lateral compartment was 17.94±4.99 mm. The distance from the inferior orbital rim to the medial compartment was 8.13±2.72 mm, to the central compartment was 9.91±3.44 mm, to the lateral compartment was 9.58±3.76 mm. The distance from the lower lid margin to the medial compartment was 5.55±1.22 mm, to the central compartment was 7.09±3.22 mm, and to the lateral compartment was 5.41±3.07 mm. The distance from the inferior oblique muscle to the medial compartment was 9.09±2.63 mm, and to the lower lid margin was 13.60±2.27 mm. Conclusions: Our study evaluates the normal anatomy of the infraorbital fat compartments in Korean patients and suggests a useful index for lower blepharoplasty and lower orbital surgery.

의류학 전공 대학생들의 패션디자인 독창성에 대한 자기효능감 연구

이윤정,Salusso, Carol J.,Lee, Jaeil 한국패션디자인학회 2016 한국패션디자인학회지 Vol.16 No.1

본 연구는 앨버트 밴듀라(Albert Bandura)의 자기효능감 이론에 근거하여 의류학 전공 대학생들의 패션디자인 독창성에 대한 자기효능감 수준을 알아보고 이에 대한 선행요인들, 즉, 과거 성과, 대리 경험, 언어적 설득, 생리적 피드백과 인구통계적 특성의 영향을 알아보는 것을 목적으로 하였다. 의류학 전공 대학생들의 창의성과 윤리성을 고양시키기 위해서는, 학생들이 창의적 과정을 적극적으로 추구하면서 동시에 윤리적인 결정을 내릴 수 있도록 충분히 높은 자기효능감을 갖도록 하는 것이 중요하다. 따라서 학생들의 패션디자인 독창성에 대한 자기효능감에 영향을 미치는 것으로 선행연구에서 제시된 변수들의 영향을 알아보고자 하였다. 이를 위하여 전국의 의류학 관련 학과에서 패션디자인 과제를 수행해 본 경험이 있는 학생들을 대상으로 설문조사를 실시하였고, 총 174부를 분석하였다. 패션디자인 독창성에 대한 자기효능감에 대한 선행요인으로 과거 성과, 대리 경험, 언어적 설득, 생리적 피드백 및 인구통계적 특성의 효과를 알아보기 위하여 단계적 회귀분석을 실시하였다. 첫 번째 단계에서는 과거 성과, 대리 경험, 언어적 설득, 생리적 피드백을 독립변수로 투입하였으며, 두 번째 단계에서는 인구통계적 특성을 독립변수로 추가 투입하였다. 그 결과 첫 단계에서는 과거 성과, 대리 경험, 생리적 피드백이 유의한 패션디자인 독창성에 대한 자기효능감에 대해 유의한 효과를 갖는 것으로 나타났다. 즉, 과거에 창의적·윤리적 패션디자인을 수행한 경험이 있거나, 다른 사람이 이러한 작업을 하는 것을 지켜본 경험이 있는 경우, 그리고 이러한 작업에 대한 스트레스를 적게 받는 경우 패션디자인 독창성에 대한 자기효능감이 높은 것으로 나타났다. 이러한 경향은 두 번째 단계에서 인구통계적 특성을 통제하였을 때에도 변화가 없었다. 단계 2에서 추가 투입된 인구통계적 특성 중에서는 성별만이 유의한 효과를 가졌는데, 여성보다 남성이 패션디자인 독창성에 대한 자기효능감이 높은 것으로 나타났다. 연구의 결과에 근거하여 대학의 교육자들이 학생들을 지도하는 데 도움을 주기 위한 교육적 함의가 제시되었다. The purpose of this study was to examine the influences of performance outcomes, oral persuasion, vicarious experience, and physiological feedback on fashion design and merchandising students’ creativity and ethical fashion design self-efficacy, based on Bandura’s theory. In order to foster both creativity and ethics among apparel design and merchandising students in higher education, it is essential to encourage students to have sufficiently high self-efficacy to make sound ethical decisions while actively pursuing their creative processes. South Korean college students majoring in fashion design and merchandising from ten different universities were surveyed through an online survey website. A total of 174 questionnaires were collected. Stepwise regression was used to analyze the data. On the first stage, creativity and ethical fashion design self-efficacy was regressed on performance outcomes, oral persuasion, vicarious experience, and physiological feedback. On the second stage, the dependent variable was regressed on demographic characteristics including age, gender, residence, and subjective social status in addition to the four precedent variables entered on the first stage. The results showed that performance outcomes and vicarious experience are positively correlated with self-efficacy and physiological feedback is negatively correlated with self-efficacy, even when the effects of demographic characteristics were controlled for. Among the demographic variables that were added on the second stage, only gender had significantly positive relationship with self-efficacy. Specifically, men showed higher creativity and ethical fashion design self-efficacy than women. Educational implications were suggested based on the results for the educators at a higher education level.