Wool 기반의 산검출 텍스타일 센서를 위한 Bromocresol Purple의 Halochromic 특성 연구

이예진,고승효,이정진 한국섬유공학회 2022 한국섬유공학회지 Vol.59 No.2

Acid or base compounds in industries as well as acid rain are colorless so that they have difficulty in detecting. In the previous studies, we investigated a nylon chemosensor for detecting acidic liquids. In this study, we attempted to investigate a wool-based textile sensor using bromocresol purple as a pH-indicating dye. Dyeing properties of bromocresol purple on a wool woven fabric were investigated. The pH sensing property was also investigated by dipping the dyed wool fabric in aqueous solution with different pH values. Bromocresol purple in an aqueous solution showed maximum absorption at 432 nm with yellow color at a pH of 2-4, whereas the maximum absorption changed to 589 nm showing violet color at pH 7. Color yields (K/S) of bromocresol purple on wool were highly dependent on the dyebath pH. The wool fabric showed a strong orange color when dyed at pH 2. The color of wool dyed at pH 3-6 was yellowish brown or reddish brown, and the color at pH 7 was grayish blue. The percent exhaustion of bromocresol purple on wool increased as the pH of dyebath decreased, and a high exhaustion value of 98 to 99% could be obtained at pH 2-4. When the yellowish brown sample, dyed at pH 4, was immersed in a solution with a pH range of 4-5, its original color was maintained. Then, the color turned to yelloworange when immersed in a solution of pH 2-3. When immersed in a solution of pH 6, the color of the sample changed into brown. The color was also markedly changed into grayish purple when the sample was dipped in a solution of pH 7-8. The wash fastness of the wool fabric dyed at pH 3-5 was good to very good. The rubbing fastness were excellent, and dry cleaning fastness was very good.

Pulmonary Histoplasmosis Identified by Video-Assisted Thoracic Surgery (VATS) Biopsy: a Case Report

이예진,강혜린,송진화,신수임,이상민 대한의학회 2018 Journal of Korean medical science Vol.33 No.2

Histoplasmosis is a common endemic mycosis in North, Central, and South America, but Korea is not known as an endemic area. We treated an immunocompetent Korean patient who had histoplasmosis. A 65-year-old Korean man presented with multiple pulmonary clumps of tiny nodules in the both lungs. He had been diagnosed 40 years earlier with pulmonary tuberculosis (TB) and a fungus ball had been diagnosed 4 years earlier. He denied any history of overseas travel. The patient visited our hospital with dyspnea, blood-tinged sputum, and weight loss, which had appeared 2 months earlier. The patient underwent video-assisted thoracic surgery (VATS) lung biopsy. The biopsy sample showed necrotizing granuloma and the presence of multiple small yeast-like fungi. Tissue culture confirmed Histoplasma capsulatum, and he was finally diagnosed with pulmonary histoplasmosis. Therapy was initiated with 200 mg itraconazole orally once per day. The symptoms disappeared 1 week after the start of treatment. After 4 months, low-dose chest computed tomography showed improvement in the ground glass opacity and size of the lung lesions. In conclusion, we report a case of an immunocompetent patient who developed histoplasmosis in Korea. When a patient shows unexplainable progressive infiltrative lung lesions, histoplasmosis should be considered as one of differential diagnoses although Korea is not an endemic area.

주민 소득과 지방정부 재정 규모의 관계 분석

이예진 이화여자대학교 스크랜튼대학 스크랜튼학부 2014 ATE Vol.4 No.-

뇌졸중 환자에게 적용한 이중과제 훈련이 미치는 효과에 대한 체계적 고찰

이예진,정민예 대한신경계작업치료학회 2016 재활치료과학 Vol.5 No.1

목적 : 본 연구는 이중과제 훈련을 뇌졸중 환자에게 적용하여 미치는 효과를 살펴본 국외 연구에 대해서 분석하는 것이다. 연구방법 : 2007년부터 2015년까지 국외 학회지에 게재된 논문을 Pubmed를 통하여 검색을 실시했다. 분류 및 선정 과 배제조건을 통해 총 5개의 실험연구 논문을 포함논문으로 선정하였다. 결과 : 선정된 5편의 문헌은 모두 사전사후 대조군 설계로, PEDro score은 6점 이상으로 높은 편에 속했다. 사용된 중재에서 채택된 운동과제는 모두 보행과제였으며, 인지과제는 다양한 과제를 포함하여 범위가 넓었다. 사용된 평 가도구는 표준화된 평가도구부터 조작적 정의에 의한 평가가 사용되었고, 더 나아가 이중과제 훈련을 위하여 고안 된 평가도구도 포함되어 다양한 측면을 평가하는 것이 가능하였다. 고찰 : 본 연구를 통하여 이중과제 훈련이 뇌졸중 환자의 운동 및 인지기능의 향상 뿐 만 아니라 이중과제 수행에 긍정적인 영향을 주는 것을 확인할 수 있었지만, 이와 같은 결과를 통하여 현재까지 진행된 뇌졸중 환자 대상의 이중과제 훈련의 제한점 또한 알 수 있었다. 이러한 결과는 작업치료 분야에 적용을 위하여 보완점을 제시하는 기초자료로서의 역할과 효과적 치료를 알리는 데 도움이 될 것으로 사료된다.

F-162 Clinical characteristics of screen-detected lung cancer in never smoker

이예진,최선미,이진우,이창훈,이상민,임재준,유철규,김영환,한성구,박영식 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-

Purpose: National Lung Screening Trial (NLST) showed effect of screening in high risk population. However, screening in low risk population, especially never smoker is not recommended. Nevertheless, owing to easy access to medical care and affordable CT in Korea, many never smokers also take a medical check-up including chest CT. Therefore, we evaluated the clinical characteristics and outcomes of screening-detected lung cancer in never smoker. Materials and methods: This retrospective cohort study included never smoker lung cancer patients diagnosed between 2011 and 2016 in a tertiary referral hospital. The definition of screening-detected lung cancer is diagnosed from medical check-up chest x ray or chest CT without any symptom. The clinical characteristics and survival were analyzed compared to symptom-detected lung cancer. Results: Of 1,213 never smoker lung cancer patients, 705 (58.1%) were screening-detected. Younger age, more prevalent adenocarcinoma, early stage, superior performance status and lung function were observed in screening group. This group showed significant better prognosis than who were detected with symptom in Cox proportional hazard model (hazard ratio = 1.36, 95% CI 1.03-1.80). There was no significant survival difference between screening methods (chest x ray vs. chest CT) in screening group. Conclusion: Screening-detected group showed superior prognosis compare to symptom-detected group in never smokers. But in screening-detected group, there was no survival differences according to screening methods.

2P-490 A-D-A Type Small Molecule Acceptor Based on New End-group for Ternary Blended System in Polymer Solar Cells

이예진,전성재,최준영,문두경 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1

Recently polymer solar cells (PSC) blended with a fullerene derivative has been increasing over 10% of power conversion efficiency (PCE). But fullerene derivatives have some disadvantages such as cost, limited spectral absorption and stability. Most PCE for PSC devices due to the self-aggregation of the fullerene is decreased as time goes by. To overcome these shortcomings, the introduction of ternary blended system is considered as a solution. Thus we designed small molecule acceptor ‘IDT-E2’ using a new end-group. It introduced active layer as a third component. ‘IDT-E2’ makes a hydrogen bonding between another molecules. Hydrogen bonding in active layer can reduce the distance of molecules and increase the charge carrier transport properties. Furthermore its hydrophilicity can make locked morphologies, so we can prevent the self-aggregation of fullerene. In this study, we characterized the new small molecule acceptor of ‘IDT-E2’ and it fabricated inverted devices.

청각장애아동의 조음훈련을 위한 디지털 콘텐츠 서비스 연구

이예진,이재은,김채윤,이윤지,박수이 한국정보통신학회 2019 한국정보통신학회논문지 Vol.23 No.4

Hearing - impaired children who have difficulty hearing and hearing go through pronunciation training. The purpose of this study is to provide the pronunciation training system based on digital contents that can be used for repeated hearing training while maintaining interest in hearing – impaired children. For this purpose, we conducted an interview survey for users and experts. Based on the results, we developed a digital content based pronunciation training system. Finally, to verify the effect of the digital service implemented, the user test was conducted for the hearing - impaired children. As a result of the interview, repeated training and interest factors were found to be essential factors affecting pronunciation training. In implementing digital services, we have used fairy tales and a variety of interactive elements to derive children's interests and designed a user flow that can train multiple words and sentences for effective repetition training. As a result of the test, this digital content was evaluated positively. 듣고 말하는 어려움이 있는 청각장애 아동은 원활한 의사소통을 위해 긴 시간 동안 청력 훈련인 조음 훈련 과정을 거친다. 본 연구의 목적은 청각장애 아동을 대상으로 흥미를 유지하며 반복적인 청력 훈련을 할 수 있는 디지털 콘텐츠 기반의 조음훈련시스템을 제공하는 것이다. 이를 위하여 우선 사용자와 전문가를 대상으로 인터뷰 조사를 진행하였고, 이 결과를 바탕으로 디지털 콘텐츠 기반의 조음훈련 서비스를 개발하였다. 마지막으로 앞서 구현된 디지털 서비스의 훈련 효과를 검증하기 위하여, 청각 장애 아동을 대상으로 사용자 테스트를 진행하였다. 인터뷰 분석 결과, 조음훈련에 영향을 미치는 중요 요인으로 반복훈련과 흥미 요인이 도출되었다. 디지털 서비스를 구현하는데 있어서, 아동들의 흥미 도출을 위해 동화와 다양한 인터랙션 요소를 활용했고, 효과적인 반복훈련을 위해 복수의 단어와 문장을 훈련할 수 있는 사용자 흐름을 설계하였다. 개발된 서비스에 대한 청각장애 아동의 테스트 결과, 본 디지털 콘텐츠는 조음 훈련의 효과와 흥미에 대하여 긍정적으로 평가되었다.

Characterization and Prognostic Significance of Cutaneous Adverse Events to Anti-Programmed Cell Death-1 Therapy

이예진,김학태,원종현,장성은,이미우,최지호,이우진 대한의학회 2019 Journal of Korean medical science Vol.34 No.26

Background: Anti-programmed cell death-1 (PD-1) immunotherapy using antibodies such as nivolumab or pembrolizumab has shown promise for treating various types of cancer. In this study, we reviewed the frequency and spectrum of cutaneous adverse events (AEs) caused by PD-1 antibodies and their possible correlation with treatment response. Methods: We reviewed records of all patients from a single institution treated with either nivolumab or pembrolizumab from August 1, 2014 to April 1, 2017. Results: Of 211 patients included in the study, 134 (63.5%) were treated with nivolumab and 77 (36.5%) with pembrolizumab. Thirty-five patients (16.4%) developed cutaneous AEs. Cutaneous AEs were significantly associated with longer treatment cycles (P = 0.001). The prevalence of cutaneous AEs did not differ between nivolumab (17.2%) and pembrolizumab (15.6%). Patient age, gender, baseline Eastern Cooperative Oncology Group scale and underlying malignancy were not associated with development of cutaneous AEs. Median time until onset of cutaneous AEs was 50.0 days (range, 1–378 days). Anti-PD-1 therapy was tolerable in most of patients with grade 1 (65.2%) and grade 2 (23.9%) cutaneous AEs. Pruritus (32.6%) and eczema (21.7%) were the most commonly reported cutaneous AEs. In lung cancer patients, cutaneous AEs were not associated with better treatment outcomes after adjusting for the number of treatment cycles. Conclusion: Both pembrolizumab and nivolumab exhibited tolerable cutaneous safety profiles in a variety of cancer patients undergoing anti-PD-1 therapy. Cutaneous AEs of anti-PD-1 therapy were not associated with antibody type, underlying malignancy, patient characteristics, or improved response.

사회적 배제와 중·고령 노인 우울의 연관성: 성별 차이를 중심으로

이예진,노영민,김진욱,하영은,이주현,노진원 한국디지털정책학회 2019 디지털융복합연구 Vol.17 No.2

The purpose of this study is to redefine 7 social exclusion factors and to derive association between social exclusion factors and depression of middle and older elderly, focused on gender differences. The elderly aged over 50 years old were extracted from the data of the Korean Longitudinal Study of Ageing (KLoSA) in 2016. The data was analyzed by descriptive analysis, chi-squared test, and binary logistic regression analysis, using SAS 9.4. As a result, the elderly who were excluded from labor, residence, health, and relationship were found to be associated to depression. In addition, male with resident exclusion were associated with depression compared to non-excluded. Therefore, it is necessary to improve the local community programs in which elderly people can participate in labor and cultural activity. It is necessary to improve labor and culture exclusion by increasing the participation opportunities of various cultural programs. In addition, it is needed to establish specific guidelines for eliminating the social exclusion of overall elderly. 본 연구는 중·고령 노인의 우울과 연관이 높은 사회적 배제 요인 7가지를 새롭게 정의하고, 각 사회적 배제 요인과 노인의 우울의 연관성을 성별 차이를 중심으로 도출하는 것을 목적으로 한다. 이에 고령화연구패널조사(KLoSA) 6차년도(2016년) 자료 중 50세 이상 중·고령 노인을 추출하여 분석에 활용하였다. 자료의 분석은 SAS 9.4를 이용하여 기술분석, 카이제곱검정 및 이분형 로지스틱 회귀분석을 수행하였다. 그 결과, 노동, 주거, 건강, 관계가 배제된 노인이 우울과 연관이 있는 것으로 나타났다. 또한 남성은 주거 배제된 노인이 그렇지 않은 노인보다 우울과 연관이 있는 것으로 나타나 우울 연관 요인에서 성별 차이가 확인되었다. 이에 사회적 배제가 높게 나타난 요인인 노동과 문화에 대해 노인이 참여할 수 있는 지역사회 프로그램 개선이 필요하며, 다양한 문화 프로그램의 참여 기회를 높여 노동과 문화 배제 해소를 통해 우울을 개선해야 한다. 또한 전반적인 노인의 사회적 배제 해소를 위한 구체적 지침의 마련이 필요하다.

Response of Arabidopsis Thaliana Microbiota Community by Scenedesmus sp. CHK0059

이예진,이화정,조경준,곽연식 경상국립대학교 농업생명과학연구원 2022 농업생명과학연구 Vol.56 No.6

Microalgae are a group of photosynthetic microorganisms living in the water. They are in the spotlight as biostimulators and biofertilizers in modern renewable and sustainable agriculture system, attributed to characteristics such as photosynthetic, and metabolism of various industrial wastes and to increase production when treating crops. Scenedesmus sp. CHK0059 is also one of the microalgae with these characteristics, and it has been reported to suppress various diseases in crops and promote the health of vegetables. However, the mode of action that has a positive effect on plants is not yet well understood. This study was designed to focus on the modulation in diversity change of plant microbiota community, which was the result of the preliminary study, and to determine the direct changes in microbial members that trigger the diversity change in the Arabidopsis model system. As a result, there was no change in the phenotype of Arabidopsis and the microbiota community structure in the rhizosphere during the treatment period, but two bacteria genera, Brevibacterium and Pseudomonas, dominance in the rhizosphere was positively correlated with the CHK0059 treatments. And the bacteria had a positive network correlative relationship with 24 other bacteria. Our findings suggest that the application of microalgae was correlated with several microbiota members in the rhizosphere and was expected to affect the microbiota community structure modification in long-term treatment.