Equilibrium study of copper absorption to different types of soft contact lens

신수임,최문성 한국응용생명화학회 2017 Applied Biological Chemistry (Appl Biol Chem) Vol.60 No.2

To measure binding affinity of copper, one of the heavy metals in particulate matter (PM) was applied to soft contact lenses made of two different materials because contact lenses are readily exposed to PM. Copper binding to ionized silicon hydrogel lens yielded an equilibrium association constant Ka,eq value of 14.03 lM without color change of lens, compared to that of 19.16 lM for copper binding to de-ionized hydrogel lenses with color change of lens. The results indicated that the color change of lens is not consistent with the concentration of cooper deposition on lens, and copper bound relatively stronger in ionized silicon hydrogel lens than in de-ionized hydrogel lens. Therefore, the continuous exposure of contact lenses to high PM levels might lead to heavy metal deposition on the lens, which would be detrimental to ocular health.

F-7 특발성폐섬유화증 환자에서 종격동 림프절 비대가 예후에 미치는 영향

신수임,이경희,이연주,윤호일,이재호,이춘택,박종선 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.-

목적: 특발성폐섬유화증(IPF) 환자에서 종격동 림프절 비대가 흔하게 관찰되며 이는 폐섬유화 정도와 관련이 있다는 보고가 있다. 그러나 종격동 림프절 비대가 IPF 환자의 예후와 관련이 있는지에 대해서는 알려진 바가 없다. 본 연구에서는 IPF 환자에서 종격동 림프절 비대가 예후와 관련이 있는지 알아보고자 하였다. 방법: 분당서울대병원에서 2012년 1월부터 2016년 3월까지 등록된 간질성폐질환 코호트 환자 중 IPF 환자를 대상으로 하였다. 진단 당시 흉부 CT 스캔에서 종격동 림프절 비대와 폐실질의 섬유화, 간유리음영의 정도를 영상의학과 전문의가 평가하였고 종격동 림프절 비대유무에 따른 입원율, 사망률 차이를 후향적으로 분석하였다. 결과: 총 132명의 환자가 연구에 포함되었고 평균 연령 70±7.1세, 남자가 78.8%였다. 단축 1cm 이상의 종격동 림프절 비대가 있는 환자는 77명(58.3%) 이었으며 림프절 비대 유무에 따른 입원율은 차이가 없었다. 평균 관찰기간 5년 중 54명(40.9%)이 사망하였다. 림프절 비대가 없는 환자군의 중앙생존시간은 104.2±8.3개월, 림프절 비대가 있는 환자군의 중앙생존시간은 71.5±5.8개월 이었으며 Cox 회귀분석을 시행하였을 때 림프절 비대가 있는 군은 림프절 비대가 없는 군에 비하여 통계적으로 유의하게 사망률이 높았다(relative risk 1.99 [95% CI 1.085-3.659], p=0.026). 결론: IPF 환자에서 종격동 림프절의 비대는 환자의 사망률과 관계가 있고 예후를 예측하는데 지표로 쓰일 수 있을 것으로 생각된다.

사회주택 사업의 공공성에 관한 경험 연구

신수임 한국공간환경학회 2023 공간과 사회 Vol.33 No.3

The purpose of this paper is to find the characteristics of publicness in social housing based on the experiences of actors involved in social housing projects in order to resolve the difference in perspective on publicness that occurs in social housing projects. Through in-depth interviews, four key keywords such as “housing stability,” “community,” “public sphere,” and “self-realization” and nine sub-subjects were derived. Based on this, the meaning of social housing projects in publicness was comprehensively presented. In terms of subjectivity, there was the role of private businesses and tenants along with the government, and in terms of content, housing stability, self-realization, and social values could be presented. Public sphere was procedural aspect, and participatory democracy was embodied in daily life. In other words, the way to secure housing publicness in social housing is to cover social values and self-realization based on public sphere involving not only the government and public corporations, but also non-profit organizations, social enterprises, private companies, and individuals. The case of social housing project shows the changing times of the publicness value system and has implications for presenting and evaluating standards of publicness throughout the field of private and public collaboration.

사회주택에서의 주거 관리

신수임,Sin, Su-Im 한국주거학회 2015 住居 Vol.10 No.1

P-20 Factors associated with physical function, memory and quality of life in ICU survivors

신수임,이상훈,박종선,조영재,윤호일,이재호,이춘택,이연주 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-

Introduction: There is a lack of data on the lives of intensive care unit (ICU) survivors in Korea. To study post-intensive care syndrome (PICS), we investigated ICU survivor’s memory, physical function, quality of life and associated factors with these three aspects of PICS. Methods: From the prospective cohort of medical ICU in Seoul National University Bundang Hospital since July 2016, we used data of ICU survivors who completed 1week follow up after hospital discharge. At 1 week follow up, ICU survivors completed a set of structured questionnaires, including ICU memory tool (ICUM), Barthel index, and EuroQol 5-Dimensions (EQ-5D). Results: From April 2016 to August 2017, thirty eight patients completed 1week follow up. Median age of the patients were 71.5 years (58.8-76.0) and 25 (66%) patients were men. Median APACHE II score was 21 (14.8-27.0) and median ICU stay was 5.5 (3.0-8.0) days. At 1 week after hospital discharge, median Barthel index and EQ-5D score were 69.9 (58.0-98.8) and 8 (6-9), respectively. According to ICUM, 10 patients (26%) had no memory of ICU. In admission characteristics, only delirium was associated with all three aspect of PICS; lower Barthel index, lower EQ-5D score and the absence of ICU memory. Conclusion: This study suggests that ICU delirium is important factor in all three aspects of PICS in ICU survivors. Further long term study is needed.

Mortality risk and causes of death in patients with bronchiectasis

신수임,조재영,최선미,이진우,이상민,임재준,유철규,김영환,한성구,이창훈 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-

Objective: Mortality and causes of death in bronchiectasis patients have not been fully investigated. The aim of this study was to analyze mortality risk and causes of death in those with bronchiectasis compared with those without bronchiectasis. Methods: Patients with or without bronchiectasis based on chest computed tomography (CT) at Seoul national university hospital between 2005 and 2016 were enrolled. We compared mortality risk and causes of death between bronchiectasis and non-bronchiectasis group. Subgroup analyses were also performed according to pseudomonas or non-tuberculous mycobacteria isolation, airway obstruction, and smoking status among bronchiectasis group. Results: Of 217,702 who underwent chest CT, 18,134 bronchiectasis patients and 90,313 non-bronchiectasis patients were included. Two major causes of death were respiratory and malignancy-related in bronchiectasis group. Bronchiectasis group had higher all-cause mortality risk than non-bronchiectasis group (adjusted hazard ratio (aHR), 1.26; 95% CI, 1.09-1.47), respiratory (aHR, 3.49; 95% CI, 2.21-5.51), and lung cancer related mortality risk (aHR, 3.48; 95% CI, 2.33-5.22) than non-bronchiectasis group. In subgroup analysis, patients with airway obstruction or ever-smokers showed higher all-cause mortality risk among bronchiectasis patients. Conclusion: Those with bronchiectasis had increased risk of all-cause, respiratory, and lung cancer-related mortality compared to those without bronchiectasis. The risk of all-cause mortality was more prominent in those with airway obstruction or ever- smokers.

‘사회주택’은 대안이 될 수 있는가

신수임 뉴 래디컬 리뷰 2020 뉴 래디컬 리뷰 Vol.- No.86

악성종양으로 인한 기도압박을 보이는 환자에서 기관 내 두 개의 스텐트 삽입에 관한 1례

신수임,이예진,강혜린,송진화,박영식 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

Introduction: Airway stenting has become a common technique in inoperable airway strictures. The main classes of stents are metal stents, silicone stents, recently commercialized hybrid stents. Common complications of airway stent are stent migration, growth of granulation tissue, obstruction of the stent by accumulated respiratory secretions, airway wall perforation, stent fracture. Hybrid stents were designed to remedy the drawbacks of silicone stents and metal stents. There are few cases of complications and long term efficacy of hybrid airway stent, especially EGIS airway stent, hybrid stent of SNG biotech. Case Report: This report describes a 35-years-old man with malignant large cell neuroendocrine carcinoma in whom primary mediastinal involvement was associated with life-threatening airway obstruction. We inserted two EGIS airway stents in a line for airway patency with a rigid bronchoscope under general anesthesia. After inserting the stents, we experienced impending obstruction of the stents by accumulated respiratory secretions, so repeated bronchoscopic toileting was required. Three months later, distal stent was fractured. Therefore we removed the stent successfully and reinserted new one. Thereafter the patient has maintained the stents about 5 months without complication untill now. The case is unique because there are rare cases of two EGIS airway stents for such a long term and complications had resolved successfully.

Effect of antiplatelet agents on long-term clinical outcomes in patients with COPD: a propensity score-matched analysis of real-world data

신수임,최선미,이진우,박영식,이창훈,이상민,임재준,김영환,한성구,유철규 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-

Introduction: Previous studies reported that antiplatelet agent reduced mortality in COPD patients attributed to protective cardiovascular effects. We sought to investigate the effect of antiplatelet agent on clinical outcomes of COPD regardless of cardiovascular events. Methods: In this retrospective cohort study, COPD patients were divided into antiplatelet and non-antiplatelet agent groups. Annual rate of forced expiration volume in 1 second (FEV1) decline and the incidence rate of exacerbation in both groups were compared with and without propensity score-matching. Results: Among 316 patients, 234(74%) and 82(26%) patients were categorized into antiplatelet and non-antiplatelet agent groups respectively. There were no significant differences between the 2 groups in the annual rate of FEV1 decline (30.1mL/year in non-antiplatelet group vs 96.1mL/year in antiplatelet group, p=0.072). Antiplatelet agent group had lower rate of overall AECOPD compared with non-antiplatelet agent group (adjusted IRR 0.59, 95% CI 0.369-0.945) after propensity score matching. Incidence rate of moderate acute exacerbation was especially decreased in anti-platelet agent group in both whole patients and propensity score matched patients analyses (adjusted IRR 0.62 95% CI 0.393-0.973, adjusted IRR 0.45 95% CI 0.274-0.747 respectively). Conclusion: In COPD patients, antiplatelet agents had no significant effects on FEV1 decline. However, patients taking antiplatelet agents had lower incidence of moderate acute exacerbation.

Metabolic syndrome and risk of lung cancer : A analysis of Korean National Health Insurance Service database

신수임,이창훈,한경도,이진우 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-

Objective: It has been known that metabolic syndrome is associated with increased risk of several cancers. However, the association between lung cancer and metabolic syndrome remains unclear. We investigated the impact of metabolic syndrome on lung cancer incidence. Methods: Examinees of health screen by the Korean National Health Insurance between Jan 2009 and Dec 2012 were enrolled. Those with lung cancer diagnosis within 5 years before baseline were excluded. The incidence of lung cancer based on ICD-10 code was observed until Dec 2016. We analyzed the risk of lung cancer according to 1) presence of metabolic syndrome, 2) components of metabolic syndrome (fasting plasma glucose, abdominal obesity, triglycerides, high density lipoprotein, hypertension) and 3) number of components of metabolic syndrome. Results: During the study period, 71,792 incidence of lung cancer was observed among 22,809,722 persons (3.14 per 1000 person year). The hazard ratio of metabolic syndrome and all of its components (except for hypertension in females) remained significant in a multivariate model adjusted for age, smoking status, body mass index, physical activity (HR of metabolic syndrome 1.16, 95% CI=1.145-1.181 in males, HR of metabolic syndrome 1.06 95% CI=1.032-1.085 in females). Furthermore, the risk of lung cancer increased with the number of components present. The association between metabolic syndrome and lung cancer was more obvious in males than female participants. Conclusion: Metabolic syndrome is associated with increased risk of lung cancer incidence, especially in men.