정신분열병과 기분장애 환자의 언어적 기억능력과 기억과정의 특성에 대한 연구

이소연,이분희,이정애,김계현,김용구,박선화,Lee, So-Youn,Lee, Bun-Hee,Lee, Jung-Ae,Kim, Kye-Hyun,Kim, Yong-Ku,Park, Sun-Wha 대한생물정신의학회 2005 생물정신의학 Vol.12 No.2

Objectives:This study was to compare verbal memory ability among patients with schizophrenia, bipolar manic patients and unipolar depressive patients, and to understand their charicteristics of memory process. Methods:All subjects were hospitalized patients and had been interviewed by using the Structured Clinical Interview for DSM-IV(SCID). Schizophrenic patients(N=40), bipolar manic patients(N=17), and unipolar depressive patients(N=20) were assessed with K-AVLT for verbal memory and with K-WAIS for verbal IQ. Three groups were compared regarding total immediate recall, delayed recall, delayed recognition, learning curve, memory retention, and retrieval efficiency under controlled verbal IQ. Multiple regression analysis was performed to find which clinical factors have an influence on verbal memory ability. Results:In MANCOVA, differences of verbal memory test scores among the groups were statistically significant(F=1.800, p<.05). In post hoc analysis, Patients with schizophrenia and bipolar mania showed poorer performance in immediate recall, delayed recall, delayed recognition, retrieval efficiency than unipolar depres- sive patients. And schizophrenics performed poorly in delayed recall, delayed recognition, retrieval efficiency than nonpsychotic affective disorder group, but no difference in total immediate recall, delayed recall, delayed recognition, retrieval efficiency between the schizophrenic group and the psychotic affective group. Conclusions:These results partially confirm previous reports of verbal memory ability among major psychiatric disorders. Our results showed that psychotic symptoms were related with verbal memory, and longer duration of illness was related with poorer performance in schizophrenia and unipolar depression.

Association between Lung Cancer Susceptibility Variants Identified by Genome-Wide Association Studies and Survival of Non-Small Cell Lung Cancer

이소연,( Mi Jeong Hong ),( Yi Young Choi ),( Hyo Sung Jeon ),( Seung Soo Yoo ),( Shin Yup Lee ),( Jaehee Lee ),( Seung Ick Cha ),( Chang Ho Kim ),( Eung Bae Lee ),( Jae Yong Park ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

Introduction: A number of genome-wide association studies (GWASs) have identified chromosomal regions containing genes associated with the risk of lung cancer. Genetic polymorphisms influence not only the development of cancer, but also cancer progression and prognosis. Therefore, we investigated the impacts of genetic variants associated with susceptibility to lung cancer in GWASs on the prognosis of NSCLC. Materials and Methods: This study included patients (n=363) with stage I, II, or IIIA (micro-invasive N2) NSCLC who under-went curative surgical resection at the Kyungpook National University Hospital, Daegu, Korea between September 1998 and December 2007. Eight single nucleotide polymorphisms (SNPs) in the six chromosomal regions (CRP rs2808630, FAM13A rs7671167, HHIP rs1489759, GYPA rs2202507, TERT rs2736100, CLPTM1L rs402710, BAT3 rs1052486, and CHRNA5 rs16969968) were genotype by a PCR-RFLP analysis. Results: None of the eight SNPs were significantly associated with overall survival and disease-free survival. In addition, when the patients were categorized according to age, gender, smoking status, tumor histology and pathologic stage, there were no significant associations between the eight SNPs and survival outcomes. Conclusions: These results suggest that the genetic variants identified by GWASs for lung cancer susceptibility are not sig-nificantly associated with the prognosis of patients with early stage NSCLC.

이력자료 참조일수에 따른 고속도로 교통량 예측에 관한 연구

이소연,정소연,Lee, So-Yeon,Jung, So-Yeon 한국재난정보학회 2018 한국재난정보학회 논문집 Vol.14 No.2

연구목적: 현재 국내에서는 지능형 교통체계(Intelligent transport system)의 일환으로 실시간 교통정보를 수집하여 도로운영의 효율성을 높이고 있다. 하지만 실시간 자료를 기반으로 한 교통정보는 운전자가 경험하게 될 교통상황과는 차이가 존재한다. 연구방법: 본 연구에서는 기존 교통량 이력자료 바탕으로 이력자료의 과거참조일수를 3일, 5일, 10일로 조정하여 요일별, 시간대별로 장래의 고속도로 교통량 예측을 수행하였다. 연구결과: 과거 참조일수가 적을수록 예측오차가 작게 나타나는 것을 알 수 있었다. 5번의 과거이력을 참조하여 월요일을 예측한 결과는 10번의 과거이력을 참조했을 때보다 오차가 크게 나타났는데 이는 분석대상 기간인 2016년의 6번째 월요일이 명절이기 때문에 평소의 월요일 교통흐름과는 다소 차이가 있었기 때문으로 판단된다. 결론: 본 연구를 통해 교통량예측 시 과거이력의 참조일수가 적을수록 비교적 오차가 적은 것을 알 수 있었으며 특수한 날에는 해당 이벤트의 교통량이력의 자료를 사용하면 보다 정확도 높은 결과를 나타낼 수 있을 것으로 판단된다. Purpose: In Korea, traffic information is collected in real time as part of Intelligent Transportation System to enhance efficiency of road operation. However, traffic information based on real-time data is different from the traffic situation the driver will experience. Method: In this study, forecasts were made for future highway traffic by day and time period by adjusting the Archived data reference days to 3, 5 and 10 days based on existing traffic Archived data. Results: Fewer days of reference in the past showed smaller errors. The prediction of Monday based on five past histories showed greater errors than the 10 past histories, as the traffic flow on the sixth Monday of 2016 was somewhat different from the usual holiday. Conclution: This study shows that less of the reference days of the past history when estimating traffic volume, the more accurate the data of the traffic history of the event can be used on special days.

전자기록의 속성에 기반한 기록관리의 과제

이소연,Lee, So-Yeon 한국기록학회 2008 기록학연구 Vol.0 No.18

디지털유산의 장기적 보존: 국가정책 수립을 위한 제안

이소연,Lee, Soo Yeon 한국기록학회 2004 기록학연구 Vol.0 No.10

As the penetration of information technology into everyday life is accelerated day by day, virtually all kinds of human representation of knowledge and arts are produced and distributed in the digital form. It is problematic, however, because digital objects are so volatile that it is not easy to keep them in fixed form. The fatal fragility makes it extremely tricky to preserve the digital heritage of our time for the next generation. The present paper aims to introduce current endeavors made at the international and the national levels and to provide with suggestions for Korean national strategy of digital preservation. It starts with reviewing the global trends of digital archiving and long-term preservation, focusing on standardization, preservation strategies and current experiments and projects being conducted for preserving various digital objects. It then sketches national strategies of several leading countries. Based on the sketch, twofold suggestions for Korean national strategy are proposed: establishing a central coordinating agency and accommodating the digital preservation issue in the legislative and regulatory framework for the information society. The paper concludes with the necessity of cooperation among heritage organizations, including libraries, archives, museums. They should cooperate with each other because they have traditionally been trusted with the custodianship of collective memory of humankind and the digital heritage cannot be passed onto the next generation without their endeavor. They should also work together because any single institution, or any single nation could cover what it takes to complete the task of long-term preservation of our digital heritage.

저회/석고 활용 긴급복구 유동성 채움재의 개발 및 현장적용 사례

이소연,정혁상,권순협,임대성,공진영,Lee, So-Yeon,Jung, Hyuk-Sang,Kwon, Soon-Hyeop,Lim, Dae-Sung,Kong, Jin-Young 한국건설순환자원학회 2018 한국건설순환자원학회지 Vol.13 No.3

최근 18년간 한국 소아 Helicobacter pylori 유병률의 변화: 기능성 반복성 복통 소아에서 연도별 내시경 진단 양성률의 감소에 관한 연구

이소연,고재성,서정기,Lee, So-Yeon,Ko, Jae-Sung,Seo, Jeong-Kee 대한소아소화기영양학회 2009 Pediatric gastroenterology, hepatology & nutrition Vol.12 No.2

목 적: Helicobacter pylori (H. pylori) 감염 유병률은 사회 경제적 수준에 따라 다르게 나타난다. 최근 우리나라가 경제적 성장을 이루면서 H. pylori 유병률에 변화가 있을 것으로 생각되나 소아를 대상으로 한 보고가 없다. 이번 연구에서는 기능성 반복성 복통 환아를 대상으로 지난 18년간의 H. pylori 유병률 변화를 알아보고자 하였다. 방 법: 1991년 7월부터 2008년 12월까지 반복성 복통으로 서울대병원을 찾은 1,194명(남아 499명, 여아 695명)의 환아들을 대상으로 하였으며 평균나이는 9.2${\pm}$3.1세였다. 모든 환아들은 상부위장관 내시경 검사를 시행 받았으며 CLO test로 H. pylori 감염을 판단하였다. 지난 18년간 H. pylori 감염률의 변화와 성별, 연령에 따른 감염률의 변화를 분석하였다. 결 과: 반복성 복통 환아의 H. pylori 감염률은 1991~1993년 25.1%, 1994~1996년 23.1%, 1997~1999년 19.3%, 2000~2002년 16.1%, 2003~2005년 11.3%, 2006~2008년 10.8%로 지난 18년간 유의하게 감소하였으며(p<0.001) 성별, 연령과 상관없이 모두 감소하였다. 결 론: 반복성 복통 환아에서 지난 18년간 H. pylori 감염률은 유의하게 감소하였으며 이는 사회 경제적 발전에 의한 것으로 생각한다. Purpose: The aim of this study was to evaluate observed changes in the prevalence of biopsy-proven Helicobacter pylori infection in Korean children with functional recurrent abdominal pain during the past 18 years. Methods: Between July 1991 and December 2008, 1,194 children with functional recurrent abdominal pain (499 males and 695 females) 9.2${\pm}$3.1 years of age were included. Upper gastrointestinal endoscopies were performed in all patients. H. pylori infection was assessed by the CLO test. Changes in the prevalence of the endoscopic diagnosis of H. pylori infection during 18 years were analyzed. Results: The prevalence of H. pylori infection between 1991 and 1993, 1994 and 1996, 1997 and 1999, 2000 and 2002, 2003 and 2005, and 2006 and 2008 were 25.1% (56/223), 23.1% (45/195), 19.3% (28/145), 16.1% (39/242), 11.3% (24/213), and 10.8% (19/176), respectively; these serial decreases in the prevalence over 18 years were statistically significant (p<0.001). Regardless of gender and age, the prevalence of H. pylori infection decreased. This decrease was inversely related to socioeconomic improvement as represented by the per capita gross national income growth of Korea. Conclusion: The prevalence of H. pylori infection has decreased significantly for the past 18 years in Korean children. This decrease might be caused by an improvement in socioeconomic status.

Combined Effect of Kimchi Powder and Onion Peel Extract on Quality Characteristics of Emulsion Sausages Prepared with Irradiated Pork

이소연,김현욱,황고은,송동헌,최민성,함윤경,최윤상,Ju Woon Lee,이시경,김천제 한국축산식품학회 2015 한국축산식품학회지 Vol.35 No.3

This study was conducted to investigate the effects of kimchi powder and onion peel extract on the quality characteristics of emulsion sausage manufactured with irradiated pork. The emulsion sausages were formulated with 2% kimchi powder and/or 0.05% onion peel extract. The changes in pH value of all treatments were similar, depending on storage periods. The addition of kimchi powder increased the redness and yellowness of the emulsion sausage. The addition of onion peel extract decreased the thiobarbituric acid reactive substances value of the emulsion sausages prepared with irradiated pork. The volatile basic nitrogen value of the emulsion sausage prepared with kimchi powder was the highest, whereas that of the emulsion sausage prepared with onion peel extract was the lowest. The treatment without kimchi powder or onion peel extract and the treatments prepared with onion peel extract showed lower microbial populations than the other treatment. Sensory evaluations indicated that a higher acceptability was attained when kimchi powder was added to the emulsion sausages manufactured with irradiated pork. In conclusion, our results suggest that combined use of kimchi powder and onion peel extract could improve quality characteristics and shelf stability of the emulsion sausage formulated with irradiated pork during chilled storage.

황련아교탕(黃連阿膠湯)이 Free Cholesterol에 의한 혈관내피세포 손상에 미치는 영향

이소연,윤현덕,신오철,신유정,박치상,Lee, So-Yeon,Yoon, Hyun-Duk,Shin, Oh-Chul,Shin, Yoo-Jung,Park, Chi-Sang 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.3

Hwangryunagyotang is supposed to have significant effects on some sorts of cardiovascular diseases like atherosclerosis. For this study. ACAT inhibitor was put in LDLR -/- mice to derive free cholesterol from it. This was to examine the effectiveness of Hwangryunnagyotang on its protecting and recovering function with endothelial cells damaged by free cholesterol through experimental. The results reported below. Hwangryunagyotang suppressed the crystallization of reactive oxygen species in macrophages and the numbers of free cholesterol crystal plate structured and reduced fragmentation of nucleus in ECV 304 cell strain by ACAT inhibitor significantly. Hwangryunagyotang also suppressed the necrosis of tissue in LDLR -/- mice' (treated with ACAT inhibitor) inflammatory portion which is adjacent to aortic root, proximal aorta and carotid artery by immunohistochemistry and fluorescence microscopy. On the whole, Hwangryunagyotang suppressed the necrosis of endothelial cells and especially it's effcet for the necrosis of para-myocardial tissues by free cholesterol. With this result, I suggest Hwangryunagyotang might have protective and recovery effects on atherosclerosis, so we need to carry on this study henceforth clinically and experimentally as well.

즉시 광중합과 지연 광중합이 이원 중합 레진시멘트의 중합 수축량에 미치는 영향

이소연,김성훈,하승룡,최유성,김희경,Lee, So-Yeoun,Kim, Sung-Hun,Ha, Seung-Ryong,Choi, Yu-Sung,Kim, Hee-Kyung 대한치과보철학회 2014 대한치과보철학회지 Vol.52 No.3

Purpose: This study was designed to compare the amount of polymerization shrinkage of dual-cure resin cements according to different polymerization modes and to determine the effect of light activation on the degree of polymerization. Materials and methods: Four kinds of dual-cure resin cements were investigated: Smartcem 2, Panavia F 2.0, Clearfil SA Luting and Zirconite. Each material was tested in three different polymerization modes: self-polymerization only, immediate light polymerization and 5 minutes-delayed light polymerization. The time-dependent polymerization shrinkage-strain was evaluated for 30 minutes by Bonded-disk method at $37^{\circ}C$. Five recordings of each material with three different modes were taken. Data were analyzed using one-way ANOVA and multiple comparison Scheffe′test (${\alpha}$=.05). Results: All materials, except Panavia F 2.0, exhibited the highest polymerization shrinkage-strain through delayed light-activated polymerization. No significant difference between light activation modes was found with Panavia F 2.0. All materials exhibited more than 90% of polymerization rate in the immediate or delayed light activated group within 10 minutes. Conclusion: As a clinical implication of this study, the application of delayed light activation mode to dual-cure resin cements is advantageous in terms of degree of polymerization. 목적: 본 연구에서는 세 가지 중합 방법에 따른 이원 중합 레진 시멘트의 중합 수축률을 비교하고 광조사가 중합 정도에 미치는 영향에 관하여 알아보고자 하였다. 재료 및 방법: 네 가지 종류의 이원 중합형 레진 시멘트(Smartcem 2, Panavia F 2.0, Clearfil SA Luting, Zirconite)가 사용되었다. 각 재료 당 세가지 서로 다른 중합 방법(자가 중합, 즉시 광중합, 5분 지연 광중합)으로 중합하였으며, 각 방법 당 5개의 시편을 사용하였다. Bonded disk method를 사용하여 $37^{\circ}C$에서 30분간, 시간에 따른 중합 수축률을 측정하였다. 측정값은 일원분산분석과 다중 분석을 위한 Scheff$\acute{e}$ test를 사용하였고, 유의수준은 0.05으로 하였다. 결과: Panavia F 2.0를 제외한 나머지 세 종류의 이원 중합 레진 시멘트들은 지연 광중합 반응에서 가장 높은 중합 수축률을 보였다. Panavia F 2.0의 중합 수축률은 중합 방법간에 통계학적 유의성이 없었다. 중합이 개시된 초기 10분 내에 즉시 혹은 지연 광중합에서 모든 시멘트는 90% 이상의 중합수축을 보였다. 결론: 이원 중합 레진 시멘트의 지연 광중합이 중합 효율을 높인다.