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대장내시경 시행 전 맑은 유동식이 시행 여부에 따른 대장정결도 비교
정우신 ( Woo Shin Jeong ),박동일 ( Dong Il Park ),석효선 ( Hyo Sun Seok ),김성은 ( Seong Eun Kim ),이석호 ( Suck Ho Lee ),이창균 ( Chang Kyun Lee ),은창수 ( Chang Soo Eun ),한동수 ( Dong Soo Han ) 대한장연구학회 2012 Intestinal Research Vol.10 No.3
Background/Aims: Adequate bowel preparation is essential for full visualization of colonic mucosa because detection of small polyps and neoplasms depends on the quality of bowel cleansing. The aims of this study were to compare the efficacy, tolerability of preparation and side effect between two groups: clear-liquid diet with polyethylene glycol (PEG) solution versus no diet restriction with PEG solution. Methods: This was a randomized single-blind prospective study. A total of 330 patients were randomly assigned to receive either 2 L PEG solution with a clear-liquid diet on the day before colonoscopy and another 2 L PEG solution on the day of the procedure (group 1) or 2 L PEG solution with a general diet on the day before colonoscopy and another 2 L PEG solution on the day of the procedure (group 2). Results: 162 patients were assigned to group 1 and 168 patients to group 2. The satisfactory quality of bowel preparation was not significantly different between the two groups (80.2%, 78.6%, P=0.707). Patient`s compliance of the clear-liquid diet in group 1 was 50%. The satisfactory quality of bowel preparation was weakly better when the clear-liquid diet was given 2 or 3 times a day (group 1A) than 0 or once a day (group 1B) (74.1%, 86.4%, P=0.048). The tolerability of the PEG solution and side effects of preparation were not significantly different in the two groups (P=0.573, 0.686). Conclusions: Bowel preparation with no diet restriction and split-dose PEG solution was similar to preparation with a clear-liquid diet in efficacy, tolerability and side effect. Therefore, the use of the clear-liquid diet protocol should improve patient`s compliance. (Intest Res 2012;10:272-279)
아밀로이드베타단백으로 자극된 사람 별아교세포종에 Ibuprofen 투여 후 세포 내 유전자 발현 탐색
최영숙,은정우,남석우,김상호 대한노인병학회 2011 Annals of geriatric medicine and research Vol.15 No.3
Background: The molecular events leading to the development of sporadic late-onset Alzheimer's disease(AD) have not been defined. A number of mechanism for the protective effects of non-steroidal anti-inflammatory drugs(NSAIDs) in AD have been proposed. We investigated the ibuprofen effect of global gene expression on the amyloid-β25-35(Aβ25-35)-stim ulated human astrocytoma cell. Methods: U373MG, a human astrocytoma cell line, was incubated with 25 μM of aggregated Aβ25-35 or aggregated Aβ25-35 plus 100 μM ibuprofen at 37℃ for 24 hours. Cells treated with ibuprofen alone were used as the negative control. Diffe- rential gene expression analysis was carried out with the Illumina human whole genome microarray. Real-time reverse transcriptase polymerase chain reaction(RT-PCR) was also done to validate the gene expression changes. After Welch's t-test, the significant subset of outlier genes were identified by an expression change cut-off 1.5 fold, p<0.05. Kyoto Encyclope- dia of Genes and Genomes database was used for cellular signaling pathway analysis. Results: A total of 371 differentially expressed genes were identified from 16,692 detectable signals in Aβ25-35 peptide stim- ulated U373MG cells- 182 up-regulated genes with 21 biological pathways including biosynthesis of steroid, peroxisome proliferator-activated receptor signaling pathway and focal adhesion and 189 down-regulated genes with 14 biological pathways including transforming growth factor-beta signaling pathway, axon guidance and mitogen activated protein kinase signaling pathway. Ibuprofen suppressed the up-regulated expression of immunity/inflammation(especially, SERPINE1), signal pathway, metabolism and cancer-related genes. The expression of microarray data was confirmed by real-time RT-PCR. Conclusion: Aggregated Aβ25-35 induces expression of widespread transcriptional alterations, namely 21 functional groups 182 up-regulated genes and 14 functional groups 189 down-regulated genes in U373MG cells. Ibuprofen, a commonly used NSAID, suppressed Aβ25-35-induced increase of global changes in transcription of sets of genes especially immunity/inflam- mation, signal pathway, metabolism and cancer-related genes.
T-cell immune regulator 1 enhances metastasis in hepatocellular carcinoma
양희두,은정우,이경분,Qingyu Shen,김형석,김상연,서동완,박원상,이정용,남석우 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Recurrence and metastasis are major challenges in the management of hepatocellular carcinoma (HCC) patients after resection. To identify a metastasis-associated gene signature, we performed comparative gene expression analysis with recurrent HCC tissues from HCC patients who underwent partial or total hepatectomy and from non-metastatic primary HCC tissues. From this, we were able to identify genes associated with HCC recurrence. TCIRG1 (T-Cell Immune Regulator 1) was one of the aberrantly overexpressed genes in patients with recurrent HCC who had undergone total hepatectomy. The significant overexpression of TCIRG1 was confirmed using the Liver Hepatocellular Carcinoma dataset from The Cancer Genome Atlas. High expression of TCIRG1 was significantly associated with poor 5-year disease-free and recurrence-free survival of HCC patients. TCIRG1 knockdown suppressed tumor cell growth and proliferation in HCC cell lines; caused a significant increase in the proportion of cells in the G1/S phase of cell cycle; induced cell death; suppressed the metastatic potential of HCC cells by selectively regulating the epithelial–mesenchymal transition (EMT) regulatory proteins E-cadherin, N-cadherin, Fibronectin, Snail and Slug; and significantly attenuated the metastatic potential of ras-transformed NIH-3T3 cells in vitro and in vivo. These findings suggest that TCIRG1 functions as a metastatic enhancer by modulating growth, death and EMT in HCC cells. TCIRG1 could be a therapeutic target for the treatment of liver malignancy and metastasis.
Oligonucleotide Microarray와 cDNA Microarray를 이용한 위암조직의 대단위 유전자 발현 비교
정광화,김정규,노지헌,은정우,배현진,이석형,박원상,유남진,이정용,남석우 대한약학회 2007 약학회지 Vol.51 No.3
Gastric cancer is one of the most comon malignancies in Korea, but the predominant molecular event under-lying gastric carcinogenesis remain unknown. Recently, DNA microaray technology has enabled the comprehensive anal-ysis of gene expression level, and as such has yielded great insight into the molecular nature of cancer. However, despitethe powerful approach of this techniques, the technical artifacts and/or bias in applied array platform limited the liability ofsuch as olignucleotide microaray and cDNA microaray, to identify gastric cancer related large-scale molecular signatureof the same human specimens. When thirty sets of matched human gastric cancer and normal tissues subjected to oli-gonucleotide microaray, total 623 genes were resulted as differently expresed genes in gastric cancer compared to normaltissues, and 252 genes for cDNA microaray analysis. In addition, forty three outlier genes which reflect the characteristicexpression signature of gastric cancer beyond array platform and analytical protocol was recapitulated from two differentexpression profile. In conclusion, we were able to identify robust large-scale molecular changes in gastric cancer by applyingKeywords . cDNA microaray, oligonucleotide microaray, gastric cancer
이운정,김인수,신소영,박기철,양금진,은정우,설해정,정시경 대한독성 유전단백체 학회 2016 Molecular & cellular toxicology Vol.12 No.3
We investigated the expression profiles of miRNAs in acute lung injury (ALI) rats after hypothermia treatment. ALI rats were induced with lipopolysaccharide (LPS) and maintained with hypothermia (HT) or normothermia (NT) for 6 hours. HT attenuated inflammatory cell infiltration in the lung and improved biochemical indicators of multi-organ dysfunction. Nineteen miRNAs were significantly differentially expressed in the HT group compared with the NT group. miR-142, miR-98, miR-541, miR-503, miR-653, miR- 223, miR-323 and miR-196b exhibited opposite patterns of expression between the two groups. These dysregulated miRNAs were mainly involved in the immune and inflammatory response on functional annotation analyses. This study shows that HT has lung protective effects and influences expression profiles of miRNAs in ALI. And dysregulated miRNAs after HT modulate the immune and inflammation in ALI. These results suggest that dysregulated miRNAs play a role in the mechanism of the lung protective effects of HT in ALI.