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상륙 중독에 의해 급성 신부전 및 기타 증상이 발현되었던 1예
이상희,강삼식,원경헌,최신은,조윤숙,임채남,최욱렬 대한신장학회 1998 Kidney Research and Clinical Practice Vol.17 No.4
Phytolaccae had been used as a pharmaceutical drug or food But nowadays, due to its toxicity, Phytolaccae is rarely used and cases of patients poisoned with it are seldom reported. The case presented here was of 43 year-old male who after ingesting extract of Phytolacca esculenta suffered from abdominal pain, diarrhea, nausea, vomiting, tachycardia, hypotension, pruritus, paresthesia, oliguria and azotemia. Kidney biopsy revealed tubular necrosis and some protein casts in tubular lumens. These findings suggested that acute renal failure was mainly caused by nephrotoxicity of Phytolacca extracts. Through continuous arteriovenous hemofiltration and two times of hemodialysis, he was completely recovered from acute renal failure. Other symptoms also disappeared by symptomatic management, but paresthesia of both lower extremities still remained. So we reported this case with a brief review of literature.
박정의,성지동,정진옥,권성욱,원경헌,김병진,조병렬,김명곤,이삭,김학진,임성훈,박승우 대한심장학회 2016 Korean Circulation Journal Vol.46 No.2
Background and Objectives When monotherapy is inadequate for blood pressure control, the next step is either to continue monotherapy in increased doses or to add another antihypertensive agent. However, direct comparison of double-dose monotherapy versus combination therapy has rarely been done. The objective of this study is to compare 10 mg of amlodipine with an amlodipine/valsartan 5/160 mg combination in patients whose blood pressure control is inadequate with amlodipine 5 mg. Subjects and Methods This study was conducted as a multicenter, open-label, randomized controlled trial. Men and women aged 20-80 who were diagnosed as having hypertension, who had been on amlodipine 5 mg monotherapy for at least 4 weeks, and whose daytime mean systolic blood pressure (SBP) ≥135 mmHg or diastolic blood pressure (DBP) ≥85 mmHg on 24-hour ambulatory blood pressure monitoring (ABPM) were randomized to amlodipine (A) 10 mg or amlodipine/valsartan (AV) 5/160 mg group. Follow-up 24-hour ABPM was done at 8 weeks after randomization. Results Baseline clinical characteristics did not differ between the 2 groups. Ambulatory blood pressure reduction was significantly greater in the AV group compared with the A group (daytime mean SBP change: -14±11 vs. -9±9 mmHg, p<0.001, 24-hour mean SBP change: -13±10 vs. -8±8 mmHg, p<0.0001). Drug-related adverse events also did not differ significantly (A:AV, 6.5 vs. 4.5 %, p=0.56). Conclusion Amlodipine/valsartan 5/160 mg combination was more efficacious than amlodipine 10 mg in hypertensive patients in whom monotherapy of amlodipine 5 mg had failed.
이상희,김나영,임선희,최신은,원경헌,임채남,최욱렬,이계희 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.6
Mucormycosis is an infection caused by fungi of the class Zygomycetes, order Mucorales. These are usual ubiquitous saprophytes but occasionally cause opportunistic infection in immunocompromised patients. Typically, these fungi invade blood vessels, and produce thrombosis and tissue infarction, so causing host fatality. These infections can be categorized into rhinocerebral, pulmonary, widely disseminated, gastrointestinal, cutaneous and miscellaneous form. Most of mucormycosis cases reported in Korea were rhinocerebral form except for three cases, which were gastrointestinal mucormycosis, accompanied with hematologic malignancy or immunosuppressing treatment. We experienced a 58-year-old male with gastric mucormycosis, who had diabetes and mild uremia without hematologic malignancy and immunosuppressive treatments. His chief complaints were abdominal pain and melena, and gastroscopy showed a 3 3 cm irregular edged ulcer considering malignancy. Its histological findings showed large, thin-walled, non-septate and right-angled branching fungal hyphae in necrotic tissue, diagnosed as mucormycosis. Finally he was dead due to severe hematemesis.
이상희,김나영,이계희,임선희,원경헌,조윤숙,최욱렬,임채남 대한소화기학회 1999 대한소화기학회지 Vol.32 No.6
We experienced a case of a 41 year old woman who had ingested sodium bromate solution to attemp a suicide. After the ingestion, nausea, vomiting, and abdominal pain were developed, and acute pancreatitis, anuric acute renal failure, and hearing loss were followed. To cure this, hemodialysis diet restriction, and fluid therapy were performed. Two weeks later, acute renal failure began to be quickly restored. However, acute pancreatitis was serious until the 40th hospital day and was slowly improved. Bromate, which is used as a neutralizer in home permanent cold wave hair kits, has been reported causing serious poisoning such as renal failure, deafness, peripheral neuropathy, but it has not been reported as a pancreatitis inducing chemical, yet to our knowledge. We report the case o bromate-induced acute pancreatitis with review of the literatures.