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양성재,김용,정덕,김준호,김성규,손영진,유병철,정은정,김태웅,한인숙,조재열 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.6
(E)-3-Phenyl-1-(2-pyrrolyl)-2-propenone (PPP) is a pyrrole derivative of chalcone, in which the B-ring of chalcone linked to bcarbon is replaced by pyrrole group. While pyrrole has been studied for possible Src inhibition activity, chalcone, especially the substituents on the B-ring, has shown pharmaceutical, anti-inflammatory, and anti-oxidant properties via inhibition of NF-kB activity. Our study is aimed to investigate whether this novel synthetic compound retains or enhances the pharmaceutically beneficial activities from the both structures. For this purpose, inflammatory responses of lipopolysaccharide (LPS)-treated RAW264.7 cells were analyzed. Nitric oxide (NO) production, inducible NO synthase (iNOS) and tumor necrosis factor-a (TNF-a) mRNA expression, and the intracellular inflammatory signaling cascade were measured. Interestingly, PPP strongly inhibited NO release in a dose-dependent manner. To further investigate this anti-inflammatory activity, we identified molecular pathways by immunoblot analyses of nuclear fractions and whole cell lysates prepared from LPS-stimulated RAW264.7 cells with or without PPP pretreatment. The nuclear levels of p50, c-Jun, and c-Fos were significantly inhibited when cells were exposed to PPP. Moreover, according to the luciferase reporter gene assay after cotransfection with either TRIF or MyD88 in HEK293 cells, NF-kB-mediated luciferase activity dose-dependently diminished. Additionally, it was confirmed that PPP dampens the upstream signaling cascade of NF-kB and AP-1 activation. Thus, PPP inhibited Syk, Src, and TAK1 activities induced by LPS or induced by overexpression of these genes. Therefore, our results suggest that PPP displays anti-inflammatory activity via inhibition of Syk, Src, and TAK1 activity, which may be developed as a novel anti-inflammatory drug.
재고미의 가공처리에 따른 in vitro, in situ 소화율 및 발효성상 평가
양성재,정은상,김한빈,신택순,조병욱,조성근,김병우,서자겸,Yang, Sung-Jae,Jung, Eun-Sang,Kim, Han-Been,Shin, Taek-Soon,Cho, Byung-Wook,Cho, Seong-Keun,Kim, Byeong-Woo,Seo, Ja-Kyeom 한국유기농업학회 2018 韓國有機農業學會誌 Vol.26 No.2
This study was conducted to evaluate the effect of different processing of rice on rumen fermentation in in vitro and in situ experiments. Different processing treatments (extruding, roasting, and steaming) were used in this study and all treatments were ground through a cyclone mill (Foss, Hillerød, Denmark) fitted with a 1 mm screen. Non-treated rice was considered to a control substrate. Then, all treatments were used in in vitro and in situ experiments. Total gas production and dry matter digestibility in control were lower than any other treatment at all incubation times (P<0.01). The lowest ammonia nitrogen ($NH_3-N$) concentration was observed in control among treatments at 6, 12, and 24 h incubation (P<0.01). Extruding had a highest total volatile fatty acids (VFA) concentration at 6, 12 h incubation (P<0.01) and Steaming exhibited a highest total VFA at 24 h (P<0.01). The lowest total VFA concentration was observed in control at 6, 12, and 24 h (P<0.01). In an in situ, The highest value of soluble fraction, degradation rates, effective degradability was observed in extruding (P<0.01). It was considered that feed processing increased dry matter digestibility, total VFA concentration, and decreased pH as well as $NH_3-N$ concentration indicating that processing may increase nutrient degradation of rice in the rumen. 본 연구에서는 재고미의 사료가치 평가를 위해 무처리(Control)를 비롯한 Extruding, Roasting, Steam 처리구들의 영양소 성분분석, in vitro 소화율, in situ 소화율을 분석하였다. In vitro 실험에서 Extruding은 건물 소화율과 gas 발생량이 타 처리구에 비해 상대적으로 높았고, 가장 낮은 pH를 보였으며, 특히 배양 시간 초기에 소화가 신속히 발생하였다. $NH_3-N$ 함량은 배양 6 h 이후에서 Control이 Extruding, Roasting, Steam에 비해 유의적으로 높은 값을 보였고, 이는 가열처리된 단백질의 반추위 미생물의 이용성 저하에 따른 결과로 보이나, 더 정확한 결과를 위해 건물 소화율 분석뿐 아니라 CP 소화율 분석이 필요할 것으로 사료된다. VFA 발생량에서는 Extruding이 다른 처리구들에 비해 배양 6, 12 h에서 유의적으로 높았는데 이는 Extruding 처리구의 분해가 배양 초기에 주로 이어져 발생한 결과로 추정된다. 전분을 발효시키는 박테리아에 의해 높은 비율로 생산되는 propionate 증가 폭에서도 같은 경향을 보였다. In situ 소화율은 in vitro의 소화율과는 다소 차이가 있는 것으로 여겨지나, 이는 실험 방법에 대한 오차로 여겨질 수 있으며, ED(유효분해율)를 통해 in vitro 시험과 소화율의 경향성이 유사한 것을 알 수 있었다. 따라서 본 연구결과를 근거로 상대적으로 적합한 사료가공 처리방법은 무처리, Roasting 및 Steaming인 것으로 보여진다. 또한 무처리(control)의 경우 가공처리에 따른 추가비용 발생이 없으므로 경제적으로 유리할 것으로 판단된다. 재고미가 TMR의 원료로 이용될 수 있다면 국내에서 자급 가능한 사료원료로써 우수한 경제성을 지닐 수 있을 것이다.
양성재,김한빈,문준범,김나은,박중국,박병기,이세영,서자겸 충남대학교 농업과학연구소 2018 Korean Journal of Agricultural Science Vol.45 No.4
This study was conducted to evaluate the nutritional value of total mixed rations (TMR) containing rice grain in an in vitro rumen fermentation system. Three types of grains (corn, wheat, and rice), timothy, and soybean meal (SBM) were used to prepare the experimental TMR: Corn TMR, Wheat TMR, and Rice TMR. The rumen fermentation characteristics of all the experimental TMRs were evaluated by an in vitro anaerobic system using rumen fluid for 24 and 48 h. The digestibility of the nutrients (dry matter [DM], crude protein [CP], and neutral detergent fiber [NDF]), pH, ammonia (NH3-N), and volatile fatty acids (VFA) were determined. Rice TMR showed a higher DM digestibility than that of the Corn TMR at 48 h (p < 0.05). In all treatments, the CP digestibility was more than 80% at 48 h, but no significant differences were observed among the treatments. The NDF digestibility tended to be the lowest in the Wheat TMR (p = 0.06), and the pH tended to be the lowest in the Rice TMR (p = 0.09) among the treatments for the 48 h incubation. The Wheat TMR had the highest NH3-N concentration among the treatments (p < 0.01). Rice TMR had a lowest total VFA concentration among the treatments (p = 0.05) at 24 h, but no significant differences were observed at 48 h. Based on this in vitro result, it was considered that a rice grain has the potential to replace conventional grain ingredients when the TMR was formulated.
Precision-TPA를 이용한 구치부 회전시 근심 및 원심삽입법에 따른 동적인 치아이동 양상에 관한 실험 연구
양성재,정성권,노준,전윤식 대한치과교정학회 1999 대한치과교정학회지 Vol.29 No.4
회전된 구치를 개선시키기 위해 사용하는 precision-TPA(transpalatal arch)를 삽입방법들-근심삽입법, 원심삽입법, 확장력을 부여한 근심삽입법 (이하 근심확장법) -에 따라 동적인 치아이동의 양상과 치열궁의 변화를 비교하기 위해 본교실에서 개발, 제작한 Calorific machine을 이용하여 실험한 후 회전된 치아와 고정치간의 이동양상을 계측하여 통계처리한 결과 다음과 같은 결론을 얻었다. 1. 구치간 폭경은 근심삽입법에 의해 감소하였고, 원심삽입법과 근심확장법에 의해서는 증가하였다. 2. 원심삽입법에 의해서 치열궁 장경이 가장 증가하였고, 근심확장법, 근심삽입법순으로 증가하였다. 3. 근심삽입법의 회전중심은 근심소와(mesial pit)와 중심소와(central pit)사이에위치하였고, 원심삽입법에서는 원심소와(distal pit)와 원심설측교두 (distolingual cusp)사이에, 근심확장법은 원심소와(distal pit)에 위치하였다. Dr. Youn-Sic Chun and coworkers invented the new machine for getting information about the relative effectiveness of the orthodontic appliances and we named it Calorific machine. The author and colleagues used this machine to compare with tooth moving mechanism by 3 types of the insertion method of precision-TPA for derotating the posterior teeth. We measured the distance of tooth movement and found out the rotational center on the occlusal X-ray film and the tooth movement on the occlusogram and then processed paired t-test by SAS program. The results were as follows : 1. In the intermolar width, the mesial insertion method showed the loss of distance, and the other methods (-distal insertion method, mesial expansion method-) showed the increase of distance. 2. In the arch length, the distal insertion method was exhibited as most recommandable way for increasing the arch length. 3. The rotation center of the mesial insertion method for derotating the molar, was located between mesial pit and central pit of the lower 2nd molar. And, in the distal insertion method, it was located between distal pit and distolingual cusp. and in the mesial expansion method was located at distal pit.
초음파 투사에 따른 흙시료 내 투수속도의 증가와 그 영향인자의 변화
김영욱,양성재,김지형 한국지반공학회 2004 한국지반공학회논문집 Vol.20 No.7
This paper presented results of the laboratory tests conducted to investigate ultrasonically enhanced flow rate using specially designed and fabricated equipment. Influencing factor, αi was verified to investigate the effect of ultrasound on soil matrix and flowing liquid. The test conditions involve soil types, temperature and ultrasonic energy. The test results indicate that ultrasound enhances the flow rate significantly. The degree of enhancement and the values of influencing factors, however, vary with test conditions.
Ultrasonically Enhanced Liquid Flow through Porous Media and Variance of Influencing Factors
김영욱,양성재,김지형,Kim Young-Uk,Yang Sung-Jae,Khim Jee-Hyeong Korean Geotechnical Society 2004 한국지반공학회논문집 Vol.20 No.7
초음파 투사에 의한 흙시료 내 투수속도 증가에 관한 연구를 특별히 제작되어 준비된 실내실험 기구를 이용하여 수행하였다. 이 현상의 정확한 메커니즘을 이해하려는 노력의 일환으로 본 연구에서는, 초음파 투사시 투수속도 변화를 지배하는 영향인자를 도출하였다. 그리고, 다양한 실험 조건 하(시료의 종류, 초음파 조사의 유무, 그리고 온도 등)에 초음파에 의한 투수속도의 증가와 함께 이에 대한 메커니즘을 영향인자의 변화를 통해 살펴보았다. 연구결과에 의하면 초음파에 의해 시료내의 간극수 흐름이 크게 빨라졌으나 시험조건에 따라 그 값의 변화 폭이 크게 나타났다. This paper presented results of the laboratory tests conducted to investigate ultrasonically enhanced flow rate using specially designed and fabricated equipment. Influencing factor, ${\alpha}_i$ was verified to investigate the effect of ultrasound on soil matrix and flowing liquid. The test conditions involve soil types, temperature and ultrasonic energy. The test results indicate that ultrasound enhances the flow rate significantly. The degree of enhancement and the values of influencing factors, however, vary with test conditions.