소음인(少陰人) 보중익기탕(補中益氣湯)과 후세방(後世方) 보중익기탕(補中益氣湯)이 양허병증(陽虛病證)에 미치는 영향(影響)

안광무,송일병,고병희,An, Kuang Mu,Song, Il Byung,Ko, Byung Hee 사상체질의학회 1995 사상체질의학회지 Vol.7 No.2

In order to investigate experimentally the effects of $So{\breve{u}}m$-In Bojungikit'ang and Dong-Won Bojungikit'ang on Yang-Insufficient syndrome(陽虛證) induced by Hydrocortisone acetate(HA) in experimental animals(Mice and Rats), the author experimented with various activities. Body temperature(BT), Body weight(BW), Exercise time, Cyclic-AMP, the Ra's Hair condition was measured. The results obtained are as follows : 1. In body temperature, the Dong-Won Bojungiki'ang treated group was increased significantly and the $So{\breve{u}}m$-In Bojungikit'ang treated group showed no significance. 2. In body weight, the $So{\breve{u}}m$-In Bojungikit'ang treated group had increased significantly and the Dong-Won Bojungikit'ang treated group showed no significance and there was a significant difference between the $So{\breve{u}}m$-In Bojungikit'ang and the Dong-Won Bojungikit'ang. 3. In exercise time. the $So{\breve{u}}m$-In Bojungikit'ang and the Dong-Won Bojungikit'ang treated groups were significantly increased. 4. In cyclic AMP, both experimental groups showed increasing tendancy, but showed no significance. 5. In the Rat' s hair condition. the $So{\breve{u}}m$-In Bojungikit'ang showed significance. 6. There was no significant difference between the $So{\breve{u}}m$-In Bojungikit'ang and the Dong-Won Bojungikitang except the body weight. from the above findings. (1) it has been demonstrated thet the $So{\breve{u}}m$-In Bojungikit'ang and Dong-Won Bojungikit'ang groups seem to produce the effecticeness on the recovery from depression of metabolism induced by Bydrocortisone acetate. (2) In body temperature response the Dong-Won Bojungikit'ang had effectiveness during recovery. (3) In body weight response the $So{\breve{u}}m$-In Bojungikit'ang had the effecticeness during recovery. (4) In exercise time. Both experimental group had the effectiveness during recovery. (5) In cyclic AMP response. both experimental group had no effectiveness during recovery. (6) In the Rat's hair condition response the $So{\breve{u}}m$-In Bojungikit'ang group had the effectiveness during recovery. Therefore in is suggested theat the $So{\breve{u}}m$-In Bojungikit'ang and Dong-Won Bojungikit'ang groups had effecticeness during recovery from Yang-Insufficient syndrome more of less.

각종 위장관 악성 종양에 있어서 TATI의 임상적 고찰

안광무,윤호주,함준수,이종철,이민호,기춘석,박경남 大韓消化器病學會 1988 大韓消化器病學會誌 Vol.20 No.3

각종 간질환에서 Ursodeoxycholic Acid(U-S(r))의 임상효과

안광무,윤호주,함준수,이종철,이민호,기춘석,박경남 大韓消化器病學會 1988 大韓消化器病學會誌 Vol.20 No.3

少陰人 補中益氣湯과 後世方 補中益氣湯이 陽虛病證에 미치는 影響

宋一炳,高炳熙,安光武 慶熙大學校韓醫科大學韓醫學硏究所 1995 慶熙韓醫大論文集 Vol.18 No.2

In order to investigate experimentally the effects of Soum-In Bojungikit'ang and Dong-Won Bojungikit'ang on Yang-Insufficient syndrome(陽虛證) induced by Hydrocortisone acetate(H.A.) in experimental animals(Mice and Rats), the author experimented with various activities. Body temperature(BT), Body weight(BW), Exercise time, Cyclic-AMP, the Rat's Hair condition was measured. The results obtained are as follows ; 1. In body temperature, the Dong-Won Bojungikit'ang treated group was increased significantly and the Soum-In Bojungikit'ang treated group showed no significance. 2. In body weight, the Soum-In Bojungikit'ang treated group had increased significantly and the Dong-Won Bojungikit'ang treated group showed no significance and there was a significant difference between the Soum-In Bojungikit'ang and the Dong-Won Bojungikit'ang. 3. In exercise time, the Soum-in Bojungikit'ang and the Dong-Won Bojungikit'ang treated groups were significantly increased. 4. In cyclic AMP, both experimental groups showed increasing tendancy, but showed no significance. 5. In the Rat's hair condition, the Soum-In Bojungikit'ang showed significance. 6. There was no significant difference between the Soum-In Bojungikit'ang and the Dong-Won Bojungikit'ang except the body weight. From the above findings, ① it has been demonstrated that the Soum-In Bojungikit'ang and Dong-Won Bojungikit'ang groups seem to produce the effectiveness on the recovery from depression of metabolism induced by Hydrocortisone acetate. ② In body temperature response the Dong-Won Bojungikit'ang had effectiveness during recovery. ③ In body weight response the Soum-In Bojungikit'ang had the effectiveness during recovery. ④ In exercise time, Both experimental group had the effectiveness during recovery. ⑤ In cyclic AMP response, Both experimental group had no effectiveness during recovery. ⑥ In the Rat's hair condition response the Soum-In Bojungikit'ang group had the effectiveness during recovery. Therefore it is suggested that the Soum-In Bojungikit'ang and Dong-Won Bojungikit'ang groups had effectiveness during recovery from Yang-Insufficient syndrome more or less.

위암조직에서 Ribonuclease와 Ribonuclease Inhibitor의 상호작용에 관한 연구

박경남,안광무,고재경 한양대학교 의과대학 1994 한양의대 학술지 Vol.14 No.1

In order to understand the processes involved in carcinogenesis and suppression of stomach cancer, activities of ribonuclease(RNase) and RNase inhibitor were measured in the stomach cancer tissue and were compared with those in the control tissue of the stomach. Also separated were RNases and RNase inhibitors from stomach cancer tissue by a DEAE cellulose colimn chromatography to find out the RNase and RNase inhibitor specific to the stomach cancer. Activities of acid and neutral RNase were signigicantly decreased in stomach cancer tissue and positive rates of the enzymes as markers for the stomach cancer were high suggesting the use of RNases as a biochemical marker for the stomach cancer. Activity of RNase inhibitor expressed as latent RNase activity was unchanged, although it tended to be decreased. RNases in the stomach cancer tissue was separated by a DEAE-cellulose column chromatography into six isozymes, of which RNase isozyme Ⅱ was found to be specific to the cancer and RNase isozyme V was activated. The RNase isozyme Ⅲb isolated in the control tissue disappeared from the cancer tissue. Of the RNase isozymes isolated from the stomach cancer tissue, RNase Ⅰ,Ⅱ and Ⅲ isozymes were nonseretory type of RNase active against RNA as substrate, RNase Ⅳ and Ⅴ isozymes secretory type of RNase active against poly C and RNase Ⅳ mixed type of RNase. On the other hand, RNase isozymes from the control tissue of the stomach were all secretory type of RNase except for RNase isozyme I. This indicated that RNase isozymes Ⅲ and Ⅵ isolated from the cancer tissue appeared to be different in nature from those from the control tissue. Activity of RNase inhigitor measured with poly C as a substrate was increased in RNase isozymes Ⅳ,Ⅴ and Ⅵ of the stomach cancer tissue, being increased greatly in the RNase isozyme Ⅴ. Observations that the RNase isozyme V isolated from the stomach cancer tissue was activated and exhibited higher acctivity of RNase inhibitor suggested that interaction between RNase isozyme V and RNase ingibitor play an important role in carcinogenesis and suppression of stomach cancer.

갈색세포종의 임상적 고찰

박정수,이진무,허갑범,이현철,임승길,이은직,김경래,안광진,정윤석,안신기 대한내분비학회 1991 Endocrinology and metabolism Vol.6 No.3

Medical records of 28 patient with pheochromocytoma diagnosed and treated at the Yonsei University Medical Center between 1971 and 1991 were reviewed. The diagnosis was confirmed with pathology. There were 17 males and 11 females, with a mean age of 44.8 years. The characteristic symptoms and signs were spells such as paroxysmal hypertension, paroxysmal headache and palpitation with average duration of 17.3 months. The overt diabetic patients were 11 cases among 20 patients with hyperglycemia. There were 5 malignant cases (17.9%), 3 bilateral cases (10.7%), 5 extraadrenal cases (17.9%) and 1 case of multiple endocrine neoplasia type Iia (pheochromocytoma, parathyroid adenoma, thyroid medullary carcinoma). The test for catecholamine showed 89.3% of sensitivity. There was no difference in sensitivity between Ucat and UVMA. The most useful localizing procedure was computed tomography. There were remakable hemodynamic changes during operation in 22 cases among 28 surgery-cases. Studies of the effect of the preoperative preparation on intraoperative blood pressure failed to demonstrate that preoperative treatment was effective. After surgical treatment, majority patient were symptom-free. There was no operative mortality. (J Kor Soc Endoornol 6:245~253, 1991)

만성 간질환 환자에 있어서 Urazamide(Recover^(�))의 치료효과

윤호주,이재호,안광무,함준수,이민호,기춘석 최신의학사 1987 最新醫學 Vol.30 No.10

복수의 성상을 감별진단함에 있어서 복수내 지질측정의 의의

윤호주,이재호,안광무,함준수,이민호,박경남,기춘석 大韓消化器病學會 1988 大韓消化器病學會誌 Vol.20 No.3

Intratumoral distribution of 64Cu-ATSM and 18F-FDG in VX2 tumor xenografted rabbit

유란지,이지웅,이교철,안광일,오인옥,정위섭,박지애,김경민,최양규,강주현,임상무,이용진 대한방사성의약품학회 2015 Journal of radiopharmaceuticals and molecular prob Vol.1 No.2

64Cu-labeled diacetyl-bis(N4-methylthiosemicarbazone) is a promising agent for internal radiation therapy and imaging of hypoxic tissues. In the study, we confirmed hypoxia regions in VX2 tumor implanted rabbits with injection 64Cu-ATSM and 18F-FDG using positron emission tomography (PET)/computed tomography (CT). PET images with 18F-FDG and 64Cu-ATSM were obtained for 40 min by dynamic scan and additional delayed PET images of 64Cu-ATSM the acquired up to 48 hours. Correlation between intratumoral O2 level and 64Cu-ATSM PET image was analyzed. 64Cu-ATSM and 18F-FDG were intravenously co-injected and the tumor was dissected and cut into slices for a dual-tracer autoradiographic analysis. In the PET imaging, 64Cu-ATSM in VX2 tumors displayed a specific uptake in hypoxic region for 48 h. The uptake pattern of 64Cu-ATSM in VX2 tumor at 24 and 48 h did not match to the 18F-FDG. Through ROI analysis, in the early phase (dynamic scan), 18F-FDG has positive correlation with 64Cu-ATSM but late phase (24 and 48 h) of the 64Cu-ATSM showed negative correlation with 18F-FDG. High uptake of 64Cu-ATSM in hypoxic region was responded with significant decrease of oxygen pressure, which confirmed by 64Cu-ATSM PET imaging and autoradiographic analysis. In conclusion, 64Cu-ATSM can utilize for specific targeting of hypoxic region in tumor, and discrimination between necrotic- and viable hypoxic tissue. J Radiopharm Mol Probes 1(2):123-129, 2015

消化性 潰瘍에 對한 sulfated glycopeptide(Glide^(�))의 治療效果

尹鎬周,高允錫,安明洙,孫周鉉,安光武,奇椿錫 최신의학사 1987 最新醫學 Vol.30 No.9