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이교철,신총식,김순호 건국대학교 1977 建農學報 Vol.8 No.1
This experiment was carried out to know the digestibility of soybean-curd when treated with different thickness, frying temperature and amount of salt. The result, were as follows ; 1.Digestibility was the frying temperature was maintained at 150℃ than that lower or higher. 2.Digestibility was the best when the thickness of soybean-curd was 5mm rather than 10mm or 15mm. 3.Digestibility was the test when salt was added at rate of 10 ratter than 5% or 10%.
朱鉉圭,李敎喆 建國大學校附設 農業資源開發硏究所 1980 論文集 Vol.5 No.-
韓國 고유의 간장을 開發코자 Aspergillus oryzae, Aspergillus niger 및 Rhizopus delemar와 Bacillus natto 菌으로 製麴하고 kogi의 配合比를 달리하여 간장을 담구고 熟成(7週) 過程 중에 化學成分의 調査와 관능검사를 실시한 結果는 다음과 같다. 1) 간장시료 중의 아미노태 질소함량은 혼합미생물시험구(0.57∼0.79%)가 Asp.oryzae만의 대조구(0.48%)보다 많았고 그중 Asp. oryzae+Rhiz. delemar 시험구(0.79%)가 가장 많았으며 Asp. niger의 혼합은 Rhiz. delemar보다 아미노태 질소의 유리량이 적었다. 2) 혼합미생물처리구(4.37∼7.96%)의 환원당량은 대조구(3.53%)보다 많았으며 그중 Asp. niger+Rhiz. delemar시험구가 제일 많았다. Asp. oryzae에 Rhiz. delemar의 복합은 Asp.niger보다 환원당량이 많았다. 3) 혼합미생물처리구의 총산량(0.38∼0.82%)은 대조구(0.33%)보다 많았고 그중 Asp. oryzae+Rhiz. delemar구(0.81%)와 Asp. oryzae+Rhiz. delemar+Bacillus nato구(0.82%)가 제일 많았으며 Asp. oryzae+Rhiz. delemar구는 Asp. oryzae+Asp. niger구보다 더 生酸量이 많았다. 4) 관능검사의 총점수에서 대조구(25점)보다 많은 시험구는 3구인데 그중 Asp. oryzae+Rhiz. delemar+Bacillus nato구(30점)가 가장 良好하고 다음 Asp. oryzae+Asp. niger, Asp. oryzae+Asp. niger+Rhiz. delemar구(29점)이다. In order to develop better soy-sauce, the research made different kinds of Koji, using microorganism such as Aspergillus oryzae, Aspergillus niger, Rhizopus delemar. and Bacillus natto each. Several kinds of soy-sauce, in which Kojis were mixed by different rate, were compared each other for their changes of chemical components during fermentation period (Seven weeks) and their quality examined by panel test. The results were summarized as follows; 1. The soy-sauce using the mixed koji, Asp. oryzae+Rhiz, delemar., showed the the highest NH₂-N content by 0.79% and the soy-sauce using the Koji made by composite microorganism showed higher NH₂-N content (0.57∼0.79%) than that of standard soy-sauce using Asp. oryzae Koji (0.48%). The content of NH₂-N in soy-sauce of Asp. oryzae+Asp. niger Koji was less than in soy-sauce of Asp. oryzae+Rhiz. delemar Koji. 2. The content of reducing sugar in soy-sauce was highest when the mixed Koji, Asp. niger+Rhiz, delemar was used, the nest was the composite microorganism Koji by 4.37∼7.96%, and the lowest was the standard commercial Koji by 3.53%. The mixed Koji using Asp. oryzae and Rhiz. delemar showed higher reducing sugar content than that of Asp. oryzae+Asp. niger Koji. 3. Total acid content in soy-sauce was highest when the mixed Kojis, Asp. oryzae+Rhiz. delemar and Asp. oryzae+Rhiz. delemar+Baillus natto., both by 0.81% and 0.82%, respectively. Total acid content in soy-sauce using composite microorganism Koji showed higher(0.38∼0.82%)than that of standard Koji(0.33%), and Asp. oryzae+Rhiz. delemar showed higher value than Asp. oryzae.+Asp.niger in total acidcontent. 4. Panel test score was highest for the soy-sauce used the mixed Koji, Asp. oryzae+Rhiz. delemar+Bacillus natto and the two kinds of soy-sauce used the mixed Koji, Asp. oryzae+Asp. niger and Asp. oryzae+Asp. niger+Rhiz, delemar., were judged as better than standard soy-sauce.
Vitamin K 유도체를 이용한 산화 메카니즘의 연구
Lee, Kyo Chul,Ham, Seung Wook 中央大學校 基礎科學硏究所 1993 基礎科學硏究所 論文集 Vol.7 No.-
Vitamin K in its hydroquinone form, vitamin KH₂, is required as a cofactor a microsomal enzyme that converts N-terminal glutamate in proteins of the blotting clotting cascade to Υ-carboxyglutamate. In enzymic studies, it was suggested that the novel base strength enhancement by molecular oxygen was the key to understanding how vitamin K functions. In this work, the nonenzymic oxidation pathways of 2,3-dimethyl-and 2-methyl-1,4-naphthohydroquinone are examined. These data provide the chemical evidence suggesting the mechanism of action of vitamin K as well as the base amplication in the course of oxidation.
The production and application of therapeutic 67Cu radioisotope in nuclear medicine
김계홍,이교철,박지애,안광일,임상모,김정영,김병일 대한방사성의약품학회 2015 Journal of radiopharmaceuticals and molecular prob Vol.1 No.1
Radioisotopes emitting low-range highly ionizing radiation such as β-particles are of increasing significance in internal radiotherapy. Among the β-particle emitting radioisotopes, 67Cu is an attractive radioisotope for various nuclear medicine applications due to its medium energy β-particle, gamma emissions, and 61.83-hour half-life, which can also be used with 64Cu for PET imaging. The production and application of the β-emitting radioisotope 67Cu for therapeutic radiopharmaceutical are outlined, and different production routes are discussed. A survey of copper chelators used for antibody labeling is provided. It has been produced via proton, alpha, neutron, and gamma irradiations followed by solvent extraction, ion exchange, electrodeposition. Clinical studies using 67Cu-labelled antibodies in lymphoma, colon carcinoma and bladder cancer patients are reviewed. Widespread use of this isotope for clinical studies and preliminary treatments has been limited by unreliable supplies, cost, and difficulty in obtaining therapeutic quantities. J Radiopharm Mol Probes 1(1):23-30, 2015
남경록,한상진,이교철,최재용 대한방사성의약품학회 2022 Journal of radiopharmaceuticals and molecular prob Vol.8 No.1
Alteration of the mGluR5 density is closely related to various brain diseases including schizophrenia, depression, Parkinson’s disease, and Alzheimer’s disease. Therefore, mGluR5 is considered as a valuable imaging biomarker for brain disease and many radiopharmaceuticals have been developed so far. Among them, [18F]FPEB has favorable pharmacokinetic characteristics, and this is the most frequently used radiopharmaceutical for preclinical and clinical studies. In the present study, we want to introduce the optimized radiosynthetic method for the routine production of [18F]FPEB using a GE TRACERlabTM FXFN pro module. In addition, the entire process was monitored with a webcam to solve the problems arising from the synthetic process. As a result, [18F]FPEB was prepared by nucleophilic substitution from its nitro- precursor at 120oC for 20 min in dimethyl sulfoxide. Radiochemical yield was 13.7 ± 5.1% (decay-corrected, n = 91) with the molar activity of 84 ± 17 GBq/μmol at the end of synthesis. The radiochemical purity was determined to be above 96%. The manufactured [18F]FPEB injection for quality controls were carried out in accordance with an KIRAMS approved protocol, as per ICH and USP guidelines.