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흡입기관지유발시험의 표준화 : Pari Inhalierboy와 Pulmo Aide Dosimeter의 비교
윤호주,조상헌,최동철,민경업,김유영 대한천식알레르기학회 1995 천식 및 알레르기 Vol.15 No.1
Inhalation bronchial provocation tests have been used extensively for severaI decades as a means of diagnostic testing, occupational screening, research, and epidemiology. To improve comparison of results obtained at different times and in different laboratories, standardization of inhslation bronchial provocation tests and comparison of methods of aerosol gen- eration and inhalation is required. We compared two widely used methods in Korea by measuring provocative concentration producing a 20 % decrease in FEV,(PC20net) in 19 patients with bronchial asthma. In continuous nubulizer, Pari Inhalierboy method, acrosol was inhaled during self controlled deep inspiration for 5times from functional residual capacity(FRC) to total lung capacity(TLC). In the other Pulmo Aide dosimeter method using DeVilbiss 646 nebulizer, aerosol was inhaled during the first 0.6 second of each of 5 inspiratory capacity breaths from FRC. The measurements with each other were performed at an interval of at least 4 days in random order. The results were as follows.' 1. A good correlation between Pari Inhalierboy method and Pulmo Aide dosimeter method existed(4 = 0.91). Z. There was a significant difference between the Pcvalues by Pari Inhalierboy and those by dosimeter method(12.91 mg/ml vs 7.73 mg/ml) In conclusion, dosimeter methods showed a good correlation with Pari Inhalierboy. Since PC,et values measured by dosimeter method is lower than those by Pari Inhalierboy method, it is necessary to try methacholine concentration upto 50 mg/ml in some cases using Pari Inhalierboy method.