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송승미,김종명,김종률,신재국,김은영,Song, Seung-Mi,Kim, Jong-Myoung,Ghim, Jong-Lyul,Shin, Jae-Gook,Kim, Eun-Young 대한임상약리학회 2012 臨床藥理學會誌 Vol.20 No.1
Background: Demands for complicated and long-term administration clinical trials have been increased since investigators actively involved in early stage clinical trials including first-in-human (FIH) trials. Research wards in our clinical trial center were mainly used for phase 1 trials. In order to perform several clinical trials simultaneously during a short period with a minimum number of rooms, beds, and equipment, staffs have to spend a lot of time for efficient operation of limited numbers of facilities. In this study, automated bed-allocation system was developed for efficient scheduling of the research ward based on clinical trial condition and status like experts. Methods: The system was developed based on clinical trial design, schedule, and the information on research bed and availability stored and updated in database (DB). Automatic assignment system was designed to find an optimal schedule according to the given information using expert rules and algorithms. The optimal solution can be visualized on Gantt chart using C# and Chart FX API. Results: The system was developed to demonstrate the schedule on color chart. It turned out to be well-designed to find an optimal schedule for bed allocation. The system also allows automatic updating of the schedule and information in the DB. Conclusion: Automated bed-allocation system developed in this study could save time and improve the efficiency for using space and equipment in clinical trial center. The system can be also applied to similar works or tasks in other fields.
광 가상사설망에서 우선순위기반 최소간섭 경로 멀티캐스트 라우팅 알고리즘 연구
서상보(Sang-Bo Seo),송승미(Seung-Mi Song),이종근(Jong-Geun Lee),김성운(Sung-Un Kim) 대한전자공학회 2007 대한전자공학회 학술대회 Vol.2007 No.7
OVPN(Optical Virtual Private Network) based on DWDM (Dense Wavelength Division Multiplexing) backbone framework is considered as a promising approach for the future VPN. This paper proposes a new routing algorithm, called PMIPMR(Priority-based Minium Interference Path Multicast Routing) algorithm which finds an alternate route considering node priorities when the congestion is occurred in a network. The PMIPMR algorithm tries to improve blocking probability and wavelength utilization by avoiding congested path for potential future connection requests.
김성운(Kim Sung-Un),서상보(Seo Sang-Bo),송승미(Song Seung-Mi),조찬효(Jo Chan-Hyo),황종규(Hwang Jong-Gyu),조현정(Jo Hyun-Jeong) 한국철도학회 2008 한국철도학회 학술발표대회논문집 Vol.- No.-
Safety-critical systems related to the railway communications are currently undergoing changes. Mechanical and electro-mechanical devices are being replaced by programmable electronics that are often controlled remotely via communication networks. Therefore designers and operators now not only have to contend with component failures and user errors, but also with the possibility that malicious entities are seeking to disrupt the services provided by theirs systems. Recognizing the safety-critical nature of the types of communications required in rail control operations, the communications infrastructure will be required to meet a number of safety requirements such as system faults, user errors and the robustness in the presence of malicious attackers who are willing to take determined action to interfere in the correct operation of a system. This paper discusses the safety strategies employed in the railway communications and proposes a security mechanism for Korean railway communication system. We present the developed communication safety evaluation tool based on the proposed security mechanism and also evaluate its protecting capability against the threats of masquerading, eavesdropping, and unauthorized message manipulation.
효소제 및 호르몬제의 품질관리에 관한 연구(Ⅰ) : 데옥시리보뉴클레아제 제제 Deoxyribonuclease (DNase) preparations
공학수,최돈웅,김도훈,김미정,김희성,정기숙,송승미,조수열 식품의약품안전청 1997 식품의약품안전청 연보 Vol.1 No.-
데옥시리보?트렐이제(DNase)는 분자량 약 62kDa의 핵산(DNA)분해효소로서 소염작용이 있어 기관지염, 요도염, 낭포성섬유종등의 화농성질환의 채료에 사용되고 잇다. 이 약의 정량법으로는 효소-기질반응에 의하여 기질의 점도변화를 측정하는 효소학적 정량법이 사용되고 있으나, 숙련된 실험자를 요구하며, 시험자간의 오차가 크고, 정확성 및 재현성이 떨어지는 문제점이 제기되어 왔다.따라서 본 연구에서는 모세관전기영동분석기(Capillary Electropho-resis, CE)를 이용하여 데옥시리보뉴클레아제 및 그 함유제제에 대한 재현성과 정확성이 높은 분석법을 확립하고자 하였다. 데옥시리보뉴크레아제 원료 및 그 ㅏㅁ유제제를 가지고 모세관, Run buffer, 검출기, 표준액 및 검액 전처리법, 내부표준물질을 검토하여 모세관전기영동분석기그이 분석조건을 검토하고, 검액 및 표준액을 가지고 검량선작성, 재현성 시험, 시판품의 정량 등을 실시한 결과, 데옥시리보뉴크레아제 및 그 함유제제의 CE 분석조건으로 Capillary:50μm×40㎝,fused silica;검출기:자외부흡광광도계(측정파장 200nm);Run buffer:75mM potassium phosphate buffer (pH 2.5);Run voltage:15kV를 사용하였을 때 inter, intra-day 재현성(%RSD)이 모두 1% 이하로 양호하였다. 이 방법은 조직이 간편하고 정확하게 정량할 수 잇어 데옥시리보뉴클레아지 제제? 품질 평가법으로 활요될 수 있을 것이다. Deoxyribonuclease (DNase) is the lytic enzyme used for the treatment of purulent diseases such as broncopulmontary infections, cystic fibrosis etc. For separation, identification and deterraination of deoxyribonuclease in final drug preparations, a capillary electrophoresis (CE) method has been developed. The influeuces of the buffer pH, electrolyte composition, temperature and voltage were investigated to determine the best analytical conditions. Separation of Deoxyribonuclease was achieved with a 75mM potassium phosphate buffer (pH2.5) and UV detection (200nm). Efficient separations occur in less than 15min with good repeatability giving a relative standard deviation of less than 1%. The precision of the method was evaluated from inter-and intra-day replicate injection of deoxyribonuclease standard solutions. The products from two manufacturers were analyzed and qualitative differences between two products were compared.
한국인에서 21-hydroxylase 결핍에 의해 초래되는 선천성 부신피질 과형성의 유전자형과 임상형에 관한 연구
김흥식,박성준,이진성,이동환,진동규,오필수,김덕희,유한욱,송승미,김정심,황혜진,온화영,고시환,엄미령,신재훈,한헌석,고철우 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.2
Background : Congenital adrenal hyperplasia(CAH) results from an inherited defect in enzymatic steps required to synthesize cortisol from cholesterol. 21-hydroxylase deficiency accounts for 95% cases of CAH. It appears that the frequency and the type of the responsible mutations differ according to the ethnic background and the type of mutation can predict the clinical outcomes such as salt losing type(SL), simple virilizing type(SV) and non-classic type(NC). Methods : We have analyzed CYP21 genes in 55 Korean cases(110 chromosomes) of CAH by Southern blotting, PCR-dot hybridization and PCR amplification-created restriction site method. The patients include 43 cases of SL and 12 of SV. None of the NC was found. Results : We found the mutations in 94%(103/110) of the examined chromosomes. A total of 10 types of mutations were discovered. The mutations include aberrant splicing of intron 2(i2, 35%), CYP21 gene deletion(32%) and I172N(11%) in order. When the relationship between the clinical types and genotypes were correlated, most of the SL patients have either i2(42%) or CYP21 gene deletion(41%), while SV patients have I172N(33%) or P30L(21%). The parents' mutation was investigated in 20 cases. In 4 families, one of the parents was not the obligatory heterozygote carrier i.e. did not have a mutation. The results suggest the high incidence of de novo mutation. Conclusion : We have identified the frequency of mutations of the CYP21 in Korean AGS patients. Our results shows that the clinical type of AGS can be predicted from the genotypes of CYP21. Also the high incidence of de novo mutation of CYP21 confirmed the genetic instability of major histocompatibility III region where the CYP21 is located(J Kor Soc Endocrinol 15:237-247, 2000).