제2형 당뇨병 환자에서 혈청 아디포넥틴이 경동맥 죽상경화증의 진행에 미치는 영향

류혜진,최경묵 대한내분비학회 2012 Endocrinology and metabolism Vol.27 No.1

Variability of Metabolic Risk Factors: Causative Factor or Epiphenomenon?

류혜진 대한당뇨병학회 2022 Diabetes and Metabolism Journal Vol.46 No.2

Editorial

Body Mass Index and Mortality

류혜진 대한비만학회 2017 The Korean journal of obesity Vol.26 No.1

Although the prevalence of obesity, a well-known risk factor for various chronic diseases such as hypertension, type 2 diabetes and dyslipidemia, is rapidly increasing worldwide, the association of obesity with all-cause mortality remains controversial. Many previous epidemiologic studies have demonstrated a U-shaped relationship between obesity and mortality, suggesting that there is an obesity paradox. However, recent large-scale meta-analyses found contradictory results that both overweight and obese subjects exhibited a significant increase in all-cause mortality. This review summarizes the key epidemiologic studies on the association of obesity with mortality and thoroughly examines the causes of the obesity paradox and the precautions needed in the interpretation of this clinical evidence.

서체의 표현 방식이 가전제품(AI) 태도에 미치는 영향 : 노스텔지어 단서와 언어적 의미 고정의 조절 효과와 친숙성의 매개효과를 중심으로

류혜진,구동모,배준희 한국마케팅관리학회 2019 한국마케팅관리학회 학술대회 Vol.2019 No.04

L자형 평면 건축물의 비정형성을 고려한 풍하중 할증계수의 제안

류혜진,조현주,하영철 한국풍공학회 2020 한국풍공학회지 Vol.24 No.1

비정형 형태의 건축물에서 발생하는 풍하중은 KBC-2016의 풍하중 산정식으로 산정할 수 없기 때문에 풍동실험을 통해 풍하 중을 평가할 수밖에 없다. KBC-2016으로 비정형건축물을 정형적인 건축물로 가정하여 풍하중을 평가한다면 과소평가될 우려가 있 다. 그러므로 보다 합리적인 평가를 위해 풍하중을 할증시켜줄 필요가 있다. 본 연구에서는 평면형태가 L자인 건축물을 대상으로 풍력 실험을 실시하여 풍하중을 산정하였으며, 이를 KBC-2016으로 산정한 풍하중과 비교하였다. 풍동실험을 통해 구한 L자형 건축물의 풍 하중과 KBC-2016으로 L자형 건축물과 동일한 폭과 깊이를 가진 사각형평면 건축물을 대상으로 구한 풍하중의 비로 풍하중 할증계수 를 도출하였다. 풍하중 할증계수는 1.6~2.2로 나타났다. KBC-2016에 의해 평가한 사각형 건축물의 풍하중에 풍하중 할증계수를 곱하 면 L자형 건축물의 풍하중이 된다. Wind loads generated from irregular buildings can't be evaluated by KBC-2016, so wind loads should be evaluated by wind tunnel test. If the wind load is evaluated using KBC-2016, which assumes irregular buildings as regular buildings, it may be underestimated. Therefore the wind loads need to be increased for more reasonable evaluation. In this study, wind loads was evaluated by wind tunnel test on L-shaped buildings and compared with wind loads evaluated by KBC-2016. The amplification factor on wind load was derived from the ratio of wind loads by wind tunnel tests on L-shaped building to wind loads by KBC-2016 on rectangular building. The amplification factor ranged from 1.6 to 2.2. The wind load of a rectangular building evaluated by KBC-2016 is multiplied by the amplification factor to become the wind load of an L-shaped building.

Integrated Whole Body MR/PET: Where Are We?

류혜진,이재성,이정민 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.1

Whole body integrated magnetic resonance imaging (MR)/positron emission tomography (PET) imaging systems have recently become available for clinical use and are currently being used to explore whether the combined anatomic and functional capabilities of MR imaging and the metabolic information of PET provide new insight into disease phenotypes and biology, and provide a better assessment of oncologic diseases at a lower radiation dose than a CT. This review provides an overview of the technical background of combined MR/PET systems, a discussion of the potential advantages and technical challenges of hybrid MR/PET instrumentation, as well as collection of possible solutions. Various early clinical applications of integrated MR/PET are also addressed. Finally, the workflow issues of integrated MR/PET, including maximizing diagnostic information while minimizing acquisition time are discussed.

씀바귀 잎의 전처리 방법에 따른 항산화 활성 변화

류혜진,김영화 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

씀바귀는 우리나라에서 자생하는 여러해살이풀로 그 뿌리와 잎은 나물이나 민간요법으로 사용되는 식품원료이다. 본 연구에서는 씀바귀 잎을 다양한 방법(데치기, 찜, 과열증기)으로 전처리하였을 때 기능성 성분의 함량 및 항산화 활성의 변화를 알아보았다. 총 플라보노이드 함량은 생것(13.962 mg/g)과 과열증기(13.705 mg/g)를 한 시료에서 가장 높게 나타났다. 총 폴리페놀화합물의 함량은 생것(34.425 mg/g)에서 가장 높았으며, 전처리를 한 시료 중에서는 과열증기 시료(31.215 mg/g)에서 가장 높았다. 또한 데치기를 한 시료에서 가장 낮은 플라보노이드 및 총 폴리페놀화합물 함량을 보여주었다. 비타민 C의 함량을 분석한 결과, 생것은 980 mg/g이었으며, 전처리를 한 경우에는 모두 비타민 C의 함량이 현저히 감소하였다. 특히 씀바귀 잎을 찐 경우 비타민 C의 함량이 약 90% 감소(97.407 mg/g)하였으나, 과열증기를 한 경우 전처리한 시료 중에서 가장 높은 함량(246.747 mg/g)을 보여주었다. ABTS 및 DPPH 라디칼 소거능 측정 결과, 생것의 소거능이 가장 우수하였으며, 전처리한 시료 중에서는 과열증기한 시료의 소거능이 가장 높았다. 본 연구결과 과열증기 전처리는 데치기에 비하여 기능성 성분의 함량 및 항산화 활성이 전반적으로 뛰어났으며, 이는 건조하여 저장하는 많은 엽채류 및 나물류의 생리활성 보존에 긍정적인 방법이 될 수 있을 것으로 기대된다.

수술시 PTH 측정으로 진단한 부갑상샘 낭종성 선종에 의한 원발성 부갑상샘 기능 항진증 1예

류혜진,이영석,백세현,최동섭,김난희,박수연,김동진,박주리,양세정,김희영,서지아,이계원,김신곤,최경묵,이재복 대한내분비학회 2005 Endocrinology and metabolism Vol.20 No.3

Primary hyperparathyroidism is the most frequent cause of hypercalcemia, and its prevalence is increasing due to the routine examination of serum calcium levels. Primary hyperparathyroidims is most commonly caused by an adenoma or hyperplasia of the parathyroid gland. A cystic parathyroid adenoma is an extremely rare cause of primary hyperparathyroidism.In our case, a-79-year old female presented with lower back pain and constipation. Her serum calcium, phosphate and immunoreactive parathyroid homone levels were 15.6, 1.8mg/dL and 371.8pg/mL, respectively. Neck CT revealed a cystic mass and a contour bulging heterogeneous mass in the left inferior right thyroid gland, respectively. These mass lesions were removed, and the intra-operative parathyroid hormone levels monitored, to confirm the complete resection. After removing the left cystic mass to the inferior thyroid, the serum calcium and immunoreactive parathyroid hormone levels quickly returned to normal.We report a case of primary hyperparathyroidism, caused by a cystic parathyroid adenoma, with a brief review of the literature 저자들은 심한 고칼슘혈증을 동반한 부갑상샘 낭종에 의한 원발성 부갑상샘 기능 항진증을 경험하였고, 수술중 부갑상샘 호르몬 값을 측정함으로써 원인이 된 부갑상샘내의 병변이 완전 절제되었음을 확인한 후, 이를 통해 최소 침습적 수술을 시행한 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Safety and Efficacy of Modern Insulin Analogues

류혜진,박근용,박강서,안규정,민경완,박정현,장상아,차봉수,김동준,김용성,오태근,전숙,남궁일성,김미진,김혜순,최영식,안유헌,이소라,백세현 대한당뇨병학회 2013 Diabetes and Metabolism Journal Vol.37 No.3

Background: A1chieve was a noninterventional study evaluating the clinical safety and efficacy of biphasic insulin aspart 30,insulin detemir, and insulin aspart. Methods: Korean type 2 diabetes patients who have not been treated with the study insulin or have started it within 4 weeks before enrollment were eligible for the study. The patient selection and the choice of regimen were at the discretion of the physician. The safety and efficacy information was collected from the subjects at baseline, week 12, and week 24. The number of serious adverse drug reactions (SADRs) was the primary endpoint. The changes of clinical diabetic markers at week 12 and/or at week 24compared to baseline were the secondary endpoints. Results: Out of 4,058 exposed patients, 3,003 completed the study. During the study period, three SADRs were reported in three patients (0.1%). No major hypoglycemic episodes were observed and the rate of minor hypoglycemic episodes marginally decreased during 24 weeks (from 2.77 to 2.42 events per patient-year). The overall quality of life score improved (from 66.7±15.9to 72.5±13.5) while the mean body weight was slightly increased (0.6±3.0 kg). The 24-week reductions in glycated hemoglobin,fasting plasma glucose and postprandial plasma glucose were 1.6%±2.2%, 2.5±4.7 mmol/L, and 4.0±6.4 mmol/L, respectively. Conclusion: The studied regimens showed improvements in glycemic control with low incidence of SADRs, including no incidence of major hypoglycemic episodes in Korean patients with type 2 diabetes.

도심지 도로변의 골바람 효과에 의한 풍압할증의 특성

류혜진,김병조,김효정,하영철 한국풍공학회 2016 한국풍공학회지 Vol.20 No.3

According to increasing construction of tall building in cities, damages of cladding on building surface caused by funneling effect between buildings are occurred frequently. Studies on funneling effect were focused on the wind loads of structural main frames. This study investigates the increasement of wind pressure on claddings caused by funneling effect between buildings in city through wind tunnel test. A city which may be occurred funneling effect was constructed by preliminary wind tunnel test. Characteristics of increasement of wind pressure by funneling effect were analyzed by the variation of the aspect ratio of building and the width of road. Also those were analyzed by the shape of building arrangement, such as a clustered buildings or a single building. It was found that wind pressures by funnel effect were increased when the aspect ratio of building is larger and the width of road was narrower. Wind pressures on the arrangement of a clustered buildings were larger about 1.8 than those of a single building. And the maximum wind pressure increasement by funneling effect was appeared to the frontal bottom area of side surface of building. 도시화로 인해 건축물이 고층화, 밀집화 되면서 건물간의 골바람 효과에 의해 외장재 탈락이나 파손 등의 피해가 발생하고있다. 골바람 효과에 대한 이전의 연구들은 대부분 구조골조용 풍하중에 중점을 두어 수행되었다. 본 연구는 도심지 골바람 효과에 의해 건축물 외장재의 풍압이 얼마나 증가되는지를 풍동실험을 실시하여 정량적으로 규명하였다. 예비실험을 통하여 골바람이 형성될수 있는 도심지를 구성하였다. 본 실험을 통하여 형상비와 도로 폭이 변함에 따라 골바람효과에 의해 풍압이 증가하는 특성을 분석하였고, 건축물이 밀집 배치된 경우와 단독 배치된 경우로 나누어 골바람효과로 인한 풍압할증의 정도를 분석하였다. 그 결과 형상비가커질수록, 도로 폭이 좁아질수록 풍압은 증가하였다. 밀집배치된 건축물의 경우가 단독 배치된 경우에 비하여 풍압이 최대 약 1.8배 증가하였다. 또한 골바람효과로 인한 풍압의 증가현상은 건물 측벽 전면 하단부에서 가장 큰 것으로 나타났다.