Impact of nonsurgical periodontal therapy on oral malodor and microbial load of saliva

김명진,김성조,최점일,이주연,Kim, Myung-Jin,Kim, Sung-Jo,Choi, Jeom-II,Lee, Ju-Youn The Korean Academy of Periodontoloy 2007 Journal of Periodontal & Implant Science Vol.37 No.1

연구 목적 : 구취의 주된 화학적 요소는 휘발성 황 화합물 (VSCs)들이다. 이들은 치태, 설태, 타액과 혈액, 상피세포의 혐기성 그람 음성 세균에 의한 단백분해 변성으로 만들어 진다. 또한 구취는 치주질환과 타액내의 세균의 증가를 야기하는 불량한 구강 위생상태에서 기인한다고 보고되고 있다. 이 연구의 목적은 VSCs를 측정함으로 구취에 대한 비외과적 치주 치료의 영향을 평가하고, 타액내의 세균 수를 측정함으로써 VSCs와의 상관관계를 살펴보고자 하는 것이다. 연구 대상 및 방법 : 중등도의 만성치주염을 가지는 23명의 참가자들이 대조군과 실험군으로 분류되었다. 대조군은 구강위생교육 (치간청결기구와 혀세정 포함)만을 시행하였고 실험군은 구강위생교육과 함께 24시간 내에 전악 치석제거술과 치근활택술을 시행하였다. 치료 전과 치료 4주 후에 VSCs 농도를 $Halimeter^{(R)}$(Interscan Corp., CA, USA)를 사용하여 측정하였고 타액 시료는 혐기성과 호기성 조건에서 배양되었다. 결과 : 4주 후에 두 군 모두에서 휘발성 황화합물의 농도가 유의하게 감소하였고, 실험군에서의 감소량이 통계적으로 유의하게 더 크게 나타났다. 타액 내 세균의 배양에서 총세균수에 대한 혐기성 세균의 비율이 실험군에서만 통계적으로 유의하게 감소하였다. 그러나 세균의 비율과 휘발성 황화합물의 농도와의 상관관계는 낮게 나타났다. 즉 구취의 감소는 타액 요인 보다는 치주치료에 의한 다른 복합적인 인자의 작용에 의한 것으로 추론할 수 있었다. 결론 : 본 연구는 중등도의 치주염환자에서 구강위생교육만으로도 구취의 주요 화학적 요인인 휘발성 황화합물의 농도를 감소시킬 수 있으나 비외과적 치주치료를 동반하였을 때 더욱 큰 효과를 얻을 수 있는 것으로 해석된다. 그러나 실험 참가자의 수가 적었고 장기간의 분석이 이루어지지 않았으므로 앞으로 더 많은 연구가 구취에 대한 치주치료의 영향을 이해하기 위해서 필요할 것으로 사료된다.

Sequential ¹H MR Spectroscopy(MRS) Studies of Kaolin-Induced Hydrocephalic Cat Brain

김명진,황성규,황정현,장용민,김용선,김승래,Kim, Myung Jin,Hwang, Sung Kyoo,Hwang, Jeong Hyun,Chang, Yongmin,Kim, Yong Sun,Kim, Seung Lae The Korean Neurosurgical Society 2000 Journal of Korean neurosurgical society Vol.29 No.11

목 적 : 실험적으로 유발된 고양이 수두증 모델을 통하여 양자 자기공명 분광상의 수두증에서의 임상적 적응과 경시적 뇌 대사산물의 변화를 규명하는데 목적이 있다. 대상 및 방법 : 30마리의 고양이에서 뇌대조내에 kaolin을 주입후 수두증을 유발한후 양자 자기공명 분광상을 이용하여 kaolin 주입전, 주입후 1, 3, 7, 14, 21, 28일째에 주요 대사산물인 N-acetyl aspartate(NAA), creatine(Cr), choline (Cho), lactate(Lac)의 분광상을 분석하였다. 결 과 : 30마리의 고양이에서 모두 수두증이 유발되었고, 급성기에 NAA/Cr비가 감소하는 소견보였으며, 1마리에서 lactate peak이 관찰되었다. 만성기(>14 days)까지 생존한 4마리의 고양이에서 NAA/Cr비의 증가가 관찰되었으며 이는 임상적 증상의 회복과 상응하는 결과를 나타내었다. 결 론 : Kaolin 유발 수두증모델에서 양자 자기공명 분광상은 급성기의 진단적 정보의 제공과 수두증에서의 뇌대사 및 생화학적 결과를 반영해 준다. 그리고, 급성기에서 lactate peak없이 NAA/Cr비의 감소와 만성기의 NAA/Cr비의 회복은 수두증으로인한 뇌실질의 손상이 신경세포 자체보다는 축색손상을 의미한다. 급성기말까지 초기 NAA/Cr비 감소가 회복없이 lactate peak이 동반되는 경우는 불량한 예후인자가 된다. 만성기의 NAA/Cr비의 정상화는 NAA/ Cr비의 감소를 보이는 뇌피질위축의 경우와의 감별진단에 실마리를 제공한다. Objectives : The aim of this study is to evaluate the sequential metabolic changes in experimental hydrocephalus and the clinical applicability to the diagnosis and prognosis of hydrocephalus using proton MR spectroscopy. Methods : Hydrocephalus was experimentally induced in 30 cats(2-3kg body weight) by injecting 1ml of sterile kaolin suspension(250mg/ml) into the cisterna magna. Proton MRS was performed with a 1.5 T MRI/MRS unit (Vision Plus, Siemens) at pre-treatment and at 1, 3, 7, 14, 21, and 28 days after the kaolin injection. PRESS(TR/TE=1500/270msec) technique was employed. The major metabolites which include N-acetyl aspartate (NAA), creatine(Cr), choline(Cho), and lactate(Lac) were quantitatively analyzed and the relative concentrations ratios were evaluated. Multislice $T_2$-weighted images were also obtained using fast spin echo sequence(TR/TE= 2500/96msec) to monitor the morphologic changes along with progression of hydrocephalus. Results : Hydrocephalus was successfully induced in all 30 cats. Twenty five cats died within 3 days and one at the end of the second week. In all animals, the NAA/Cr ratios initially decreased during the acute stage. In 4 surviving cats, the NAA/Cr ratios initially decreased during the acute stage(<14 days) and then gradually increased to the prekaolin level as follows : pre-kaolin($1.49{\pm}0.04$), day 1($1.11{\pm}0.07$), day 7($1.17{\pm}0.04$), day 14($1.40{\pm}0.03$), day 21 ($1.46{\pm}0.06$), day 28($1.43{\pm}0.03$). These levels were relatively well correlated with the symptomatologic improvement. Lactate peak, which reflects the evidence of ischemia, did not appear throughout the entire period except in one case which expired at the end of the second week. Conclusions : The NAA/Cr ratio of the sequential proton MRS in kaolin-induced hydrocephalic cats reflects a metabolic aspect of the hydrocephalus at each stage. A decreased NAA level at the early stage is from both neuronal and axonal damage which may provide diagnostic information in the acute stage of hydrocephalus. In addition, the initial fall of NAA/Cr ratio and recovery in the late stage, when no lactate peak emerges, may suggest that the main insult of the parenchyma is not to the neuron itself but to the axon, which may be related to a good prognosis. However, emergence of the lactate peak and unrecoverable NAA/Cr at the end of the acute phase may be a poor prognostic factor. In the chronic stage, recovery of NAA/Cr ratio may provide a diagnostic clue for the differentiation between hydrocephalus and cortical atrophy.

제 II 형 치상돌기 골절에서 전방경유 나사못 고정술

김명진,황정현,성주경,황성규,함인석,박연묵,김승래,Kim, Myung-Jin,Hwang, Jeong-Hyun,Sung, Joo-Kyung,Hwang, Sung-Kyu,Hamm, In-Suk,Park, Yeun-Mook,Kim, Seung-Lae 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.11

Objective : The aim of this study is to evaluate clinical outcome of anterior screw fixation for type II odontoid fractures for the prliematim of atlanatoaxial mobility. Methods : Between 1995 and 1999, we treated 15 cases of type II odontoid fractures by anterior screw fixation among 44 cases of odontoid fractures. Thece included 14 males and 1 female aged from 23 to 63 years, with a mean age of 39.7 years. The causes of trauma were traffic accident in 13 cases, slip down in 1 and fall down in 1. The fracture type was type II-P in 7 cases, type II-A in 3, type II-N in 2 and type II-A and P in 3. The fracture line was oblique downward and backward in 6 cases, oblique downward and forward in 3 and horizontally in 6. The range of follow up was 4 to 47 months(mean 26.5 months). Results : Adequate reduction and fixation were obtained in 12 cases. Three cases in which fracture type and line were type II-A and oblique downward forward were failed, so posterior transarticular screw fixation was performed. All except 3 failed cases had adequate cervical movement and stability. There were no operative mortality nor morbidity. Conclusion : Anterior screw fixation provides the best anatomical and functional results for type II odontoid fracture with intact transverse ligament when fracture line is horizontal or oblique downward and backward. But it is limited when fracture line is oblique downward and forward.

Integration of Geographic Information System and Air Dispersion Model

김명진,한의정,강인구,김정수,Kim, Myung-Jin,Han, Eui-Jung,Kang, In-Goo,Kim, Jeong-Soo 한국환경영향평가학회 1996 환경영향평가 Vol.5 No.1

Environmental Impact Assessment (EIA) in Korea has worked toward environmental conservation and decision making since the Environmental Impact Statement of 1981. In order to implement the EIA process effectively, we have developed a system for and various methods of EIA. Among these methods, the Geographic Information System (GIS), which was introduced recently in Korea, can be used to integrate geographic and attribute data effectively. So GIS begins to increase the necessity of the application in EIA process. This study includes the integration method of the GIS and air dispersion model on the odor impact assessment of $NH_3$ emission in landfill sites. First, it computes surface values by grids using the Digital Elevation Model (DEM). Second, it presents predicted data considering topography and climate by grids. Third, it shows the overlaying analysis of the administrative map including population and odor predictive data. The results could systematically analyze impact areas, and assess residential impact by alternatives. Integration analysis of the air predictive model and GIS as a residential area assessment can support negotiations of public and proponent in EIA. 환경영향평가는 1981년 환경영향평가서가 작성된 이후로 환경보전과 의사결정용 위한 수단으로 발전해 왔다. 환경영향평가 과정을 효과적으로 실행하기 위하여 환경영향평가 제도개선과 기법개발을 하고 있으며, 최근에는 도면자료와 속성자료를 효과적으로 통합할 수 있는 지리정보체계가 도입되었다. 그리고 지리정보체계의 환경영향평가 과정에 적용을 위한 필요성이 점차적으로 증가하고 있다. 이 연구는 폐기물매립지에서 $NH_3$ 악취물질의 예측과 평가에 대하여 지리정보체계와 대기확산모델의 통합방법을 제시하는 데 있다. 첫째로 수치고도모델을 이용하여 각 그리드별 고도를 추출하고 둘째, 이 고도자료와 기후, 오염원 자료를 확산모델에 입력하고 셋째, 통 리별 인구를 포함한 행정구역도와 악취예측자료의 중첩분석 방법을 제시한다. 이 결과들은 주거지역에 대한 영향평가와 영향지역을 체계적으로 분석한 수 있고, 이러한 체계적인 분석은 사업자와 주민의 환경분쟁의 협상시 지원될 수 있다.

다양한 치주 골내낭과 이개부 병변의 처치를 위한 $BBP^{(R)}$ 이식재의 임상적 효과

김명진,이주연,김성조,최점일,Kim, Myung-Jin,Lee, Ju-Youn,Kim, Sung-Jo,Choi, Jeom-Il 대한치주과학회 2008 Journal of Periodontal & Implant Science Vol.38 No.1

Purpose: Periodontal intrabony defects have great deal of importance since they contribute to the development of periodontal disease. Current treatment regimens for intrabony defects involve grafting of numerous bony materials, GTR using biocompatible barriers, and biomodification of root surface that will encourage the attachment of connective tissue. Xenograft using deproteinized bovine bone particles seems to be very convenient to adjust because it doesn't require any donor sites or imply the danger of cross infections. These particles are similar to human cancellous bone in structure and turned out to be effective in bone regeneration in vivo. We here represent the effectiveness of grafting deproteinized bovine bone particles in intrabony defect and furcation involvements that have various numbers of bony walls. Materials and methods: Open flap debridement was done to remove all root accretions and granulation tissue from the defects within persisting intrabony lesions demonstrating attachment loss of over 6mm even 3 months after nonsurgical periodontal therapy have been completed. Deproteinized bovine bone particles($BBP^{(R)}$, Oscotec, Seoul) was grafted in intrabony defects to encourage bone regeneration. Patients were instructed of mouthrinses with chlorohexidine-digluconate twice a day and to take antibiotics 2-3 times a day for 2 weeks. They were check-up regularly for oral hygiene performance and further development of disease. Probing depth, level of attachment and mobility were measured at baseline and 6 months after the surgery. The radiographic evidence of bone regenerations were also monitored at least for 6 months. Conclusion: In most cases, radio-opacities increased after 6 months. 2- and 3-wall defects showed greater improvements in pocket depth reduction when compared to 1-wall defects. Class I & II furcation involvements in mandibular molars demonstrated the similar results with acceptable pocket depth both horizontally and vertically comparable to other intrabony defects. Exact amount of bone gain could not be measured as the re-entry procedure has not been available. With in the limited data based on our clinical parameter to measure pocket depth reduction following $BBP^{(R)}$ grafts, it was comparable to the results observed following other regeneration techniques such as GTR.

CONTOUR RECONSTRUCTION OF FACIAL DEFECT WITH SPLIT STERNOCLEIDOMASTOID MUSCULAR FLAP FOLLOWING PAROTIDECTOMY

김명진,김택경,유준영,KIM, Myung-Jin,KIM, Taek-Kyoung,YOU, Jun-Young Korean Association of Maxillofacial Plastic and Re 1991 Maxillofacial Plastic Reconstructive Surgery Vol.13 No.2

외상이나 종양의 적출 등으로 인하여 악안면부에 발생된 결손이나 안면 경부 기형의 교정을 위하여 여러 근피판을 이용하여 악안면부 재건술이 시행되어지고 있다. 흉쇄유돌근은 안면부의 일차적 혹은 이차적 재건에 안전하고 유용한 근피판 또는 근피부피판으로 널리 사용되고 있다. 이하선부에 발생된 종양의 적출술 후 나타날 수 있는 이하선부의 안모 변형 방지를 위하여 흉쇄유돌근 근피판을 이용하여 안모 재건이나 술후 가상형성으로 발생 가능한 적출부의 감염, 반흔조직 형성과 술후 천충으로 노출되는 안면신경을 보호하는데 사용할 수 있다. 전 흉쇄유돌근 근피판이나 다른 경부 근피판 사용시 이하선부의 과잉돌출, 안면경부 기형 및 경부운동 제한 등의 부작용이 발생될 수 있다. 이러한 단점을 보완하고자 저자등은 부분 흉쇄유돌근 근피판을 형성하여 기능적 이하선 적출술 후 노근피판 전위를 통하여 이하선부 연조직 결손으로 인한 안모 변형이나 사강형성 예방 등을 만족할 만한 결과를 얻었기에 문헌고찰과 함께 보고하고자 한다. Various muscular flaps are used in oral and maxillofacial reconstructive surgery for the defects caused by tumor resection and trauma or for the correction of head and neck deformities. The sternocleidomastoid(SCM) muscle may be widely used as a muscular or myocutaneous flap in these lesion. The authors used SCM muscular flap for the expected parotid defect following benign tumor related conservative parotidectomy in three cases. We expected that prevention of post-operative facial deformity, reduction of dead-space and protection of denuded facial nerve etc. is lead by SCM muscular flap. But the total SCM flap can lead to some complications such as "flat neck deformity", limitation of neck movement and overcontouring of parotid defect. Therefore, the authors used split pedicled SCM muscular flap and it lead good favorable results of post-operative functional and esthetic problems.

구순구개열 환자의 Le Fort I 골절단술 후 상악골의 위치적 안정성에 관한 연구 ; 예비보고

김명진,유호석,김종원,김규식,Kim Myung-Jin,Yu Ho-Seok,Kim Jong-Won,Kim Kyoo-Sik 대한구순구개열학회 1999 대한구순구개열학회지 Vol.2 No.1

It is well known that the postoperative skeletal instability after Le Fort I osteotomy for advancement of maxilla in the cleft patients is one of the major surgical problems. So we had tried to compare the amount of relapse after Le Fort I advancement surgery in the horizontal and vertical positional change, angular change of reference points between cleft patients and non-cleft patients. Longitudinal records of 10 consecutive cleft patients (test group) and 20 non-cleft patients (control group) were analyzed. Lateral cephalograms were taken preoperatively, immediately postoperatively, and 2, 6, 12 months postoperatively. We measured horizontal and vertical changes (ANS, PNS, AI) and angular change (SNA) of the reference points and lines. In the test group, horizontal relapse of ANS, PNS, AI point are 36.4%, 37.5%, 32.0% respectively at 12 months postoperatively. The vertical relapse of ANS, PNS, AI are 25.3%, 32.3%, 39.1% respectively at 12 months postoperatively. The angular change of SNA is 33.6% at 12 months postoperatively. In the control group, horizontal relapse of ANS, PNS, AI point are 23.8%, 30.2%, 21.7% respectively at 12 months postoperatively. The vertical relapse of ANS, PNS, AI are 22.7%, 27.3%, 25.1% respectively at 12 months postoperatively. The angular change of SNA is 22.2% at 12 months postoperatively. The cleft patients have a larger tendency of skeletal and dental relapse compared with non-cleft patients after Le Fort I surgery. So the oral and maxillofacial surgeons must keep in mind these facts in order to minimize the relapse phenomenon from the beginning of surgical planning to postoperative care.

모듈화된 구조에 기반한 H.263 비디오 코덱 VLSI의 설계

김명진,이상희,김근배,Kim, Myung-Jin,Lee, Sang-Hee,Kim, Keun-Bae 대한전자공학회 2002 電子工學會論文誌-SP (Signal processing) Vol.39 No.5

본 논문에서는 H.263 비디오 코덱 구현을 위한 효율적인 하드웨어 구조를 제안하고, 이에 기반한 VLSI 구현을 기술한다. 제안 구조는 부호화 및 복호화에 사용되는 내부 하드웨어 블록들간의 연결 및 이 블록들과 내부 RISC 프로세서간의 연결에 단일화된 인터페이스 방법을 사용한다. 이러한 단일화된 인터페이스의 사용은 블록들의 모듈화된 설계를 가능하게 하며, 하드웨어/소프트웨어의 적절한 분할 및 효과적인 파이프라인 동작을 가능하게 한다. 개발된 VLSI는 H.263 버전 2의 프로파일 3 @ 레벨 10을 지원하고, 제어용 프로토콜인 H.245와 다중화 프로토콜인 H.223을 지원한다. 따라서 외부에 오디오 코덱 칩을 추가함으로써 완전한 ITU-T H.324 또는 3GPP 3G-324M 멀티미디어 터미널 기능 구현에 사용될 수 있으며, 하드웨어 블록들을 최대한 활용하면서 소프트웨어적으로 H.263++와 MPEG4 코덱을 구현 할 수 있는 구조이다. 구현된 H.263 코덱은 40MHz의 동작 주파수에서 초당 15 프레임 이상의 성능으로 QCIF 크기의 영상의 부호화 및 복호화를 동시에 수행할 수 있다. In this paper, we present an efficient hardware architecture for the H.263 video codec and its VLSI implementation. This architecture is based on the unified interface by which internal hardware engines and an internal RISC processor are connected one another. The unified interface enables the modular design of internal blocks, efficient hardware/software partitioning, and pipelined paralled operations. The developed VLSI supports the H.263 version 2 profile 3 @ level 10, and moreover, both the control protocol H.245 and the multiplexing protocol H.223. Therefore, it can be used for the complete ITU-T H.324 or 3GPP 3G 324M multimedia processor with the help of an external audio codec. Simultaneous encoding and decoding of QCIF format images at a rate greater than 15 frames per second is achieved at 40 MHz clock frequency.

토지이용과 환경영향평가 관련 법규분석

김명진,방규철 ( Myung Jin Kim,Kyu Chul Bang ) 한국환경영향평가학회 1995 환경영향평가 Vol.4 No.1

성심지황탕(醒心地黃湯)이 노화(老化) 백서(白鼠)의 혈액변화(血液變化) 및 혈청(血淸)과 뇌조직(腦組織)의 항산화물활성(抗酸化物活性)에 미치는 영향(影響)

김명진,이상룡,Kim Myung-Jin,Lee Sang-Ryong 대한한방신경정신과학회 1999 동의신경정신과학회지 Vol.10 No.2

This study was to investigate the effects of SUNGSIMJIHWANGTANG(SSJHT) on the blood and brain tissues of aged rats. For the experiment, the aged rats were divided into three groups : Non treated group(NC), distilled water fed group(PC), SSJHT fed group(SSJHT). Each group was fed for ten days before administration of scopolamine. Then, we injected scopolamine intraperitoneally to PC and SSJHT group for 5 days. We observed the changes of their blood cell(WBC, RBC, platelet), blood serum(BUN, creatinine, glucose, uric acid), erythrocyte hemolysis, and the activities of cholinesterase and measured the amounts of malondialdehyde in the serum, catalase, and SOD in the brain tissue. The main results of this investigation are as follows. 1. In respect of the number of WBC, SSJHT group exhibited significant increase in comparison with PC. 2. In respect of the amount of creatinine and uric acid in the blood serum, SSJHT group exhibited significant decrease in comparison with PC. 3. In respect of erythrocyte hemolysis, SSJHT group exhibited significant suppression in comparison with PC. 4. In respect of the activity of cholinesterase in the serum, SSJHT group exhibited significant activation in comparison with PC. 5. In respect of the amounts of malondialdehyde in the serum, SSJHT group exhibited significant decrease in comparison with PC. 6. In respect of the activity of catalase in brain tissue, SSJHT group didn't exhibit significant change in comparison with PC. 7. In respect of the activity of SOD in brain tissue, SSJHT group exhibited significant activation in comparison with PC. As a result of this study, SSJHT is expected to have antiaging effect by suppressing the formation of free radicals, the accumulation of antioxidants and further study needs to be carried on about SSJHT.