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방광의 소세포 신경내분비 암종의 요 세포학적 소견 - 1 예 보고 -
김동훈,강동욱,김경희,김주헌,박미자,Kim, Dong-Hoon,Kang, Dong-Wook,Kim, yuug-Hee,Kim, Ju-Heon,Park, Mee-Ja 대한세포병리학회 2002 대한세포병리학회지 Vol.13 No.2
We report the cytologic features of a case of primary small cell carcinoma of the urinary bladder with high grade transitional cell and signet ring cell carcinomatous components. A 64-year-old male presented with gross hematuria for one week. Computed tomography revealed an ill-defined mass in the left lateral wall of the urinary bladder. Urinary cytology showed hypercellularity with predominantly isolated single cells and clustered cells. They have scanty cytoplasm and naked hyperchromatic nuclei with finely granular nuclear chromatin and rare nucleoli. The tumor cells occurred predominantly singe cells, but a few in clusters. Nuclear molding was prominent. No glandular formation or nesting was noted. The second tumor cells had high nuclear/cytoplasmic ratio, irregular nuclear membrane, and coarse granular chromatin. The background was inflamed and necrotic. The histoiogic findings of transurethral resection were mainly composed of small cell carcinoma, and partly transitional cell and signet ring cell carcinomatous components. Small cell neuroendocrine carcinoma have distinctive cytologic features to make a proper diagnosis.
리튬이온이차전지용 LiCoO<sub>2</sub>-유기전해액의 충전상태에 따른 열적 안정성
김동훈,이영호,신혜민,정영동,도칠훈,진봉수,김현수,문성인,오대희,김기원,Kim, Dong-Hun,Lee, Young-Ho,Shin, Hye-Min,Chung, Young-Dong,Doh, Chil-Hoon,Jin, Bong-Soo,Kim, Hyun-Soo,Moon, Seong-In,Oh, Dae-Hui,Kim, Ki-Won 한국전기전자재료학회 2007 전기전자재료학회논문지 Vol.20 No.5
Thermal behavior of $Li_{1-x}CoO_2$ has been investigated employing DSC (Differential Scanning calorimetry) and TGA (Thermogravimetry Analyzer), and the crystal parameters were calculated from XRD (X-ray diffraction).for the commercial rectangular pouch cell(1000 mAh).The cathode materials coated over aluminium foil current collector is made up of a blend consisting of active material $LiCoO_2$(size $20\;{\mu}m$, 94 wt%), conducting material super p black (SPB, 3 wt%) and binder polyvinylidene fluoride (PVDF, 3 wt%). The anode is a mix consisting of carbon (92 wt%) and PVDF(8 wt%) coated over copper foil. The cells for the experiments were first preconditioned by cycling three times and stabilized at OCV=3.0, 3.5, 4.2, 4.35 and 4.5 V. The stabilized cathode material was used for thermal and crystal parameter investigations.
한열성향(寒熱性向)에 따른 신문혈(神門穴) 애구(艾灸) 효능(效能)의 비교(比較) 연구(硏究)
김동훈,김종덕,김은정,김경태,류성룡,정지철,박영배,Kim, Dong-hoon,Kim, Jong-deog,Kim, Eun-jung,Kim, Kyung-tae,Rhu, Seong-ryong,Jung, Ji-chul,Park, Young-bae 대한침구의학회 2004 대한침구의학회지 Vol.21 No.4
Objective: Moxibustion is one of major healing technique in oriental medicine. It has been widely used in many disease. There is an text which suggest moxibustion is more efficient to the situation of han(寒) and heo(虛) than yeal(熱) and sil(實) in Huangdineijing <黃帝內經>. The aim of this study is to research the effect of moxibustion at Shinmun(H7) is different according to cold or heat tendendy man by analyzing the electroencephalogram(EEG). Methods: We classified objects by their cold or heat tendency using questionnare for cold - heat patternization. (12 cold tendency man, 19 heat tendency man) Before and after moxibustion at Shinmun(H7), EEG raw data were measured during 5 minutes. The correlation dimension(D2), the correlation dimension variability rate(${\Delta}D2$), largest lyapunov exponent(L1) and largest lyapunov exponent variability rate(${\Delta}L1$) were calculated. We analyzed D2, ${\Delta}D2$, L1, ${\Delta}L1$ to see the effect of moxibustion at Shinmun(H7) was statistically different according to Cold or Heat tendendy man. Results : Paired t-test showed significant differences between before and after moxibustion at Shinmun(H7) on the Fp2 in D2(p<0.05), on the Fp2, F3 and F4 in ${\Delta}L1$(p<0.05). Student Hest showed significant differences between cold and heat tendendy man on the F3 in ${\Delta}L1$(p<0.05). Conclusion: These results suggest that moxibustion at Shinmun has an effect on stabilizing mind and it is more efficient to the cold tendendy man than the heat tendendy man.
Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF)의 첨가가 생쥐 수정란의 발생과 착상관련 유전자 발현에 미치는 영향
김동훈,고덕성,이회창,이호준,강희규,김태전,박원일,김세웅,Kim, Dong-Hoon,Ko, Duck-Sung,Lee, Hoi-Chang,Lee, Ho-Joon,Kang, Hee-Gyoo,Kim, Tai-Jeon,Park, Won-Il,Kim, Seung-Samuel 대한생식의학회 2002 Clinical and Experimental Reproductive Medicine Vol.29 No.2
Objective : The purpose of the current series of experiments were to assess the effect of GM-CSF, as a medium supplement, on the development of mouse embryos and the expression of LIF and IL-1? mRNA. Materials and Methods: Mouse 2-cell embryos were collected from the oviducts of 6 weeks old ICR mice at 48 hours after hCG injection. Embryos were cultured in P-1 medium supplemented with mouse GM-CSF (0, 1, 5, 10 ng/ml). The embryo development to blastocysts and hatching blastocysts was assessed and the cell number in blastocyst was also examined. Using RT-PCR, the expressions of LIF and IL-1? mRNA in blastocyst were evaluated in the GM-CSF supplemented group and control group. Results: In mouse, the addition of GM-CSF increased the percentage of blastocysts (65.5%, 68.6%, 73.0% and 76.1% for control and 1, 5 and 10 ng/ml, respectively), and increased the proportion of hatching blastocysts (35.2%, 36.4%, 43.2% and 53.0% for control and 1, 5 and 10 ng/ml, respectively). The mean cell numbers in blastocyst were significantly increased in GM-CSF supplemented groups compared to control group. LIF and IL-1? expression in blastocyst were significantly higher in GM-CSF supplemented group than in control group. Conclusion: The results of experiment by mouse embryos showed beneficial effects of GM-CSF as a medium supplement. Furthermore, the addition of GM-CSF significantly increased the expression of LIF and IL-1? in mouse embryos. These results suggest that GM-CSF might be a important molecule in embryo implantation.
김동훈,Kim Dong-Hun 한국군사과학기술학회 2004 한국군사과학기술학회지 Vol.7 No.3
This paper deals with the development of simulation model for the horizontal launch at submarines in the preliminary design phase. The simulation model is composed of submarine motion model, cross flow force model in the bow of submarine, and weapon motion model In launch through torpedo tubes. Using submarine and weapon characteristics and simulation condition, it can simulate the exit velocity of weapon through torpedo tubes and reaction forces. It should be helpful for the analysis of the safe launch and design requirements in the preliminary design phase of a submarine or a weapon launched through torpedo tubes.
기술현황분석 - 공작기계 채터진동 감지용 임베디드 디바이스 개발 및 CNC 자율보정
김동훈,송준엽,Kim, Dong-Hun,Song, Jun-Yeop 재료연구소 2012 機械와 材料 Vol.24 No.2
채터진동은 공작기계에서 가공중에 소재와 공구사이에 나타나는 급격한 상대진동을 말한다. 이러한 진동은 가공 소재 품질에 심각한 영향을 미치는 요소일 뿐만 아니라 가공툴과 기계에 손상을 유발시키는 인자이기도 하다. 본 연구는 공작기계의 구동 중 발생되는 채터진동을 실시간으로 감지하여 공구의 회전속도와 이송 속도를 제어하여 자율보정함으로써 보다 빨리 채터진동의 영향을 보상함을 물론 보다 정밀한 가공물을 생산할 수 있는 채터진동 감지 및 보정에 관한 것이다. 실시간 처리를 위하여 본 연구에서의 공작기계의 채터진동 보상장치는 공작기계에 임베디드 형태의 디바이스로 개발되었으며, 구성은 공작기계의 채터진동을 감지하는 센서와 센서로부터 감지된 채터진동에 따라 보상값을 예측하여 산출하는 채터보상기를 포함하여 공작기계의 CNC제어기의 연계 구성됨을 특징으로 한다.
김동훈,신지환,김찬기,Kim, Dong-Hun,Shin, Ji-Hwan,Kim, Chan-Ki 한국시뮬레이션학회 2007 한국시뮬레이션학회 논문지 Vol.16 No.4
본 논문에서는 미래의 수중 교전 시뮬레이션에서 공통적으로 사용될 수 있도록 재사용성 및 상호운용성과 공학 시뮬레이션 등 앞으로의 확장성을 고려하여 수중 교전에 사용되는 잠수함 체계에 대한 표준모델을 어떠한 개념에서 어떠한 형태로 정립할 것인가에 대해 기술하였다. 본 연구를 통해 교전 수준 잠수함 체계 표준모델에 대한 모델아키텍쳐를 정립하고 개별 구성요소에 대한 모델링 방안을 개발하였으며 모델의 입출력 자료 및 정보 흐름도를 도출하였다. 본 연구에서는 비음향 탐지 모델 및 비음향 스텔스 모델 등 수중 교전에 해당하지 않는 분야는 제외하였으므로 향후 이에 대한 추가 연구가 필요하다. This paper describes and explains that the engagement level model of submarine can be used in underwater engagement simulation taking reuse, interoperability, and extension to the engineering leveled simulation into consideration. WBS(Work Break-down Structure), internal data interface, and I/O data about the engagement level model of submarine are developed. It describes the modeling method of components of submarine model as well. In this paper, the non-acoustic detection and stealth models are excluded because those models are not related to the underwater engagement, so the excluded models need to be developed in the future.