Ho-166 부착풍선도자를 이용한 방사선 조사의 돼지 관상동맥 스텐트 재협착 예방 효과

김원 ( Kim Won ),정명호 ( Jeong Myeong Ho ),박옥영 ( Park Og Yeong ),정우곤 ( Jeong U Gon ),박우석 ( Park U Seog ),김주한 ( Kim Ju Han ),안영근 ( An Yeong Geun ),조정관 ( Jo Jeong Gwan ),박종춘 ( Park Jong Chun ),강정채 ( Kang Je 한국지질동맥경화학회 ( 구 한국지질학회 ) 2002 韓國脂質學會誌 Vol.12 No.1

배경 : 국내에서 개발된 방사선 동위원소 Holmium-166 (166Ho)은 주로 베타선을 방출하며, 166Ho을 부착한 풍선도자를 이용하여 돼지 관상동맥 재협착 모형에서 풍선확장술 후 신생내막 증식을 전신적 부작용 없이 안전하고 효과적으로 억제하였음을 보고한 바 있다. 본 연구에서는 돼지 관상동맥 스텐트 재협착 모형에서 스텐트 시술 후 신생내막 증식에 의한 재협착 병변을 166Ho 부착 풍선도자를 이용하여 치료하여 그 효과를 관찰하고자 하였다. 방법

Two new records of the genus Nola Leach, 1815 (Lepidoptera: Nolidae, Nolinae) from Laos

Yeong–Bin Cha,Ulziijargal Bayarsaikhan,Sol–Moon Na,Dong–June Lee,Jae–Ho Ko,Tak–Gi Lee,Hyeong–Kyu Kim,Chang–Moon Jang,Han–Ul Kim,Yang–Seop Bae 한국응용곤충학회 2019 한국응용곤충학회 학술대회논문집 Vol.2019 No.04

The genus Nola (Nolidae, Nolinae) was established by Leach (1815), with the Noctua palliola Denis & Schiffermüller, 1775 (a junior subjective synonym of Phalaena cucullatella Linnaeus, 1758) from Vienna, Austria. Nola comprises over 200 species: Africa and western Palearctic approximately described 100 speices (Hacker et al., 2012); Oriental and Eastern Palearctic regions have over 100 species (László et al., 2010; Sasaki et al., 2011; Kononenko and Pinratana, 2013). Two species of the genus Nola Leach; Nola euryzonata (Hampson, 1900) and Nola lucidalis (Walker, 1865), reported for the first time in Laos. Illustrations of adults and genitalia of all the examined species are provided.

Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

대장암 주변에서 관찰되는 백색반점의 병리조직학적 특성과 임상적 의의

김효종,조진만,장린,동석호,김윤화,장영운,박일랑,김병호,이정일 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.4

Background/Aims: To investigate the difference between colorectal adenocarcinomas with white spots (foamy cells) and those without white spots, clinically and histopathologically, were examined 37 cases of colorectal adenocarcinomas were classified in this study. Methods: Two groups: those with white spots and those without. In each case, evidence of lymph node and liver metastasis was sought. Immunoreactive staining for macrophage was performed. Results: Increased incidence of exophytic tumors was found (73%, p=0.028) in the group with white spots. The incidences of lymph node metastasis were 33% vs. 45% between the group with white spots and the group of without, but the difference was not statistically significant. Conclusions: These results suggested that foamy cells might have a beneficial role in colorectal cancer, although they were not statistically significant. Therefore, further prospective study be warranted.

Protective Effects of Hyperoside against Carbon Tetrachloride-Induced Liver Damage in Mice

Choi, Jun-Ho,Kim, Dong-Wook,Yun, Nari,Choi, Jae-Sue,Islam, Md. Nurul,Kim, Yeong-Shik,Lee, Sun-Mee American Chemical Society and American Society of 2011 Journal of natural products Vol.74 No.5

<P>In this study, the hepatoprotective effects of hyperoside (<B>1</B>), a flavonoid glycoside isolated from <I>Artemisia capillaris</I>, have been examined against carbon tetrachloride (CCl<SUB>4</SUB>)-induced liver injury. Mice were treated intraperitoneally with vehicle or <B>1</B> (50, 100, and 200 mg·kg<SUP>−1</SUP>) 30 min before and 2 h after CCl<SUB>4</SUB> (20 μL·kg<SUP>−1</SUP>) injection. Levels of serum aminotransferases were increased 24 h after CCl<SUB>4</SUB> injection, and these increases were attenuated by <B>1</B>. Histological analysis showed that <B>1</B> prevented portal inflammation, centrizonal necrosis, and Kupffer cell hyperplasia. Lipid peroxidation was increased and hepatic glutathione content was decreased significantly after CCl<SUB>4</SUB> treatment, and these changes were reduced by administration of <B>1</B>. Protein and mRNA expression of tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and heme oxygenase-1 (HO-1) and nuclear protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2) significantly increased after CCl<SUB>4</SUB> injection. Compound <B>1</B> suppressed TNF-α, iNOS, and COX-2 protein and mRNA expression and augmented HO-1 protein and mRNA expression and Nrf2 nuclear protein expression. These results suggest that <B>1</B> has protective effects against CCl<SUB>4</SUB>-induced acute liver injury, and this protection is likely due to enhancement of the antioxidative defense system and suppression of the inflammatory response.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2011/jnprdf.2011.74.issue-5/np200001x/production/images/medium/np-2011-00001x_0006.gif'></P>

8년간(1992~1999) 산업안전보건연구원에 의뢰된 직업병 심의 사례 분석

강성규,김규상,김양호,최정근,안연순,진영우,최병순,양정선,김은아,채창호,최용휴,김대성,박정선,정호근 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : Pneumoconisis and noise-induced hearing loss (NIHL) have been reported as main occupational diseases by the Special Health Examination. The Industrial Accident Compensation Insurance has reported various work-related diseases, however, these two diseases occupied almost a half of compensated cases. Therefore, it was not well known about the status of occupational diseases other than pneumoconiosis, NIHL, and cardio-cerebrovascular accident (CVA). This study was conducted to analyze claimed cases as an occupational disease, that was requested to the Korea Industrial Safety and Health Agency (KOSHA). Methods : The local office of the Korea Labor Welfare Corporation (KLWC) has asked the KOSHA for confirmation of claimed cases as an occupational disease. We analyzed 379 cases requested from KLWC, the Ministry of Labor, employers, unions and occupational health agencies from 1992 to 1999. Results : Male was 80.7 % of the requested cases. Their mean age was 42 years old and 75.5 % of them were more than 35 years old. The requested cases were increased rapidly from 25 cases in 1992 to 108 cases in 1999 and the accept rate was 50.7 %. The majority of requested cases were respiratory diseases(22.4%), cancers(18.5%), Neuropsychiatric problems(14.5%), and musculoskeletal problems(13.5%). The accept rate was high in reproductive, respiratory, musculoskeletal and digestive disorders and low in neuropsychiatric, renal and otologic problems and occupational cancers. 73.6% of them were caused by chemical agents, especially 28.5 % were by organic solvents. 67% of them were clinically confirmed at university hospitals. A half of the cases were from KyongIn area, even the request came from the whole country. Conclusions : A claim was common in workers whose age was over 35 years old and exposure history was over 10 years. The respiratory diseases and neuropsychiatric disorders were still main problems in occupational health and occupational cancers was increasing even though its accept rate was not high yet.

Antioxidant and Anti-Inflammatory Effects of Rhei Rhizoma and Coptidis Rhizoma Mixture on Reflux Esophagitis in Rats

Kwon, O Jun,Kim, Min Yeong,Shin, Sung Ho,Lee, Ah Reum,Lee, Joo Young,Seo, Bu-il,Shin, Mi-Rae,Choi, Hyun Gyu,Kim, Jeong Ah,Min, Byung Sun,Kim, Gyo-Nam,Noh, Jeong Sook,Rhee, Man Hee,Roh, Seong-Soo Hindawi Publishing Corporation 2016 Evidence-based Complementary and Alternative Medic Vol.2016 No.-

<P>The purpose of this study was to investigate the antioxidant and anti-inflammatory effects of the combined extract of Rhei rhizoma and Coptidis rhizoma (RC-mix) in experimental model of acute reflux esophagitis. The antioxidant activity was assessed by<I> in vitro</I> 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. RC-mix was given at 100, 200, and 400 mg/kg body weight 2 h prior to induction of reflux esophagitis (RE). After 5 h, the effects of RC-mix treated rats were compared with those of normal and control rats. The representative flavonoid contents of RC-mix, such as sennoside A, epiberberine, coptisine, palmatine, and berberine, were detected using HPLC. The elevated esophageal mucosa damage was markedly ameliorated by RC-mix treatment in a dose-dependent manner. Furthermore, the administration of RC-mix reduced the increase of serum reactive oxygen species (ROS) and peroxynitrite (ONOO<SUP>−</SUP>). The improvement of superoxide dismutase (SOD) and heme oxygenase-1 (HO-1) levels were marked in the group given RC-mix. Moreover, the elevation of inflammatory mediators and cytokines by nuclear factor-kappa B (NF-<I>κ</I>B) activation in control rats decreased by RC-mix pretreatment. These results indicate that RC-mix treatment reduces the pathological states of esophagitis<I> via</I> regulating NF-<I>κ</I>B mediated inflammation related to oxidative stress. </P>

國民學校 藝ㆍ體能 敎育의 現在와 未萊

金永洙,崔鍾浩 大邱敎育大學校 1992 論文集 Vol.27 No.-

Activator를 장착한 Ⅲ급 부정교합 아동에서 일부 저작근에 대한 근활성도 분석

김영석,양규호 大韓小兒齒科學會 1991 大韓小兒齒科學會誌 Vol.18 No.1

The purpose of the present study was to investigate the influence of activator on EMG activity of some masticatory muscles in Angle Class Ⅲ malocclusion.The subjects were consisted of 23 children with class Ⅲ malocclusion,13 boys and 10 girls,ranging in age from 7 to 12 years(mean 8.9 years). The EMG activity from the anterior temporal and masseter muscles was recorded during maximal biting in centric occlusion before,immediately after,twenty days and three months after wearing the activator. The following results were obtained; 1.Before wearing the activator,there was no significant difference in EMG activity between the masseter and anterior temporal muscles. 2.Immediately after wearing the activator,the EMG activity in the masseter and temporal muscles was markedly reduced. 3.Twenty days after wearing the activator,the EMG activity in the masseter and temporal muscles was markedly increased compared to that obtained immediately after wearing the activator and was not siginificantly different from that obtained before wearing the activator. 4.The significant difference appeared in EMG activity between masseter and anterior temporal muscles after twenty days of wearing the activator,but disappeared after three months of wearing the activator.

Goethe의 "Faust" 에 關한 硏究(Ⅰ) : Prolog im Himmel의 장면과 Nacht의 장면을 중심으로 In der Szene des Prologs im Himmel und der Nacht

金永鎬 慶尙大學校 1981 論文集 Vol.20 No.2

Diese Abhandlung stellt sich die Aufgabe, den Prolog im Himmel und die Nacht in Goethes Faust zu analysieren. Faust enfaltet sich in seiner Doppelnatur als Geist und Materie zugleich, zwischen Gott und Teufel gestellt. Das faustische Wesen ist damonisch, weil sie zum hochsten Gipfel hinauftragen, aber auch zum tiefsten Abgrund hinabreiβen kann. Mephisto ist undamonisch und deshalb unschopferisch. Sein Tatigkeit besteht im Abbauen schlechthin und er ist der Geist, der stets verneint, und der Widersacher. Das ewig quellende Leben ist ihm ein steter Vorwurf. Sein Ziel ist die Zerstorung, die Vernichtung. Er setzt der ewig, der heelsam schaffenden Gewalt die kalte Teufelsfaust entgegen. Da Fausts Seelendrang Wirkung des Welten fulle selbst ist, bleibt ihm dessen Streben nach der Weltenfulle unbegreiflich. Die Doppelheit des Faustischen Wesens, Daβ auf das Himmlische und das Irdische zugleich gerichtet ist, erscheint vom Teufel aus gesehen als Torheit. Mephisto glaubt, daβ er Faust auf dem satanischen Weg fuhren kann, und er bietet dem Herrn eine Wette, einen solchen aufs Empor angelegten Lebensweg in eine Hinab zu verkehren. Gott liefert Faust dem Teufel aus, wie er weiβ, daβ Faust zwar irren, niemals aber sich ganz verlieren kann und in dieser gottlichern Weltordnung braucht man die mephistophelischen Widerstande und Versuchungen, weil er sonst wohl gern "beruhigt sich auf ein Faulbett leten" konnte. Das teufelischen Nein wird fruchtbar, Weil es im Menschen eine verborgene Kraft weckt. Es wird zur groβen tragischen Paradoxie der Faust-Dichtung, da der Mensch unr durch den Teufel zu Gott gelangen kann. So bleibt Mephisto immer nur Funkion innerhalb der ganzen, gottgewollten Ordnung. Der Teufel hat bei Goethe nicht mehr die urspringliche Kraft des Urbosen, sondern ist als Gegensetzung in Gottmit eingegriffen und kann daher, ohne zur Last zu fallen, in dessen Hausgesinde aufgenommen werden. Das Wesen Gottes ist Schaffen. Daher ist Fausts Streben auch die Sehnsucht aller Gottahnlichen Geister ; Schaffen zu konnen wie Gott und am gottlichen Schaffen teilnehmen tu konnen. Faust hat nicht nur alle Fakultaten durchstudiert und alle Schatze des Menschengeistes erworben, aber er fuhlt, Daβ es vergebens war, weil dadurch "innerlich doch keine neue Kraft quillt", er "dem Unendichen nicht naher" gelange ist. Das Zwielichthafte des faustischen Damonischen wird am deutlichsten sichtbar in Fausts Bundnis mit der Magie. Die magisch andrangende Geisterwelt, in die Faust hineingestellt ist, zeigt sich als schopferisch und vernichtend, als steigernd und herabziehend zugleich. Die Sehnsucht geht auf mehr als auf mystische Erkenntnis. So wird er weitergetrieben von der Beschworung des Makrokosmus zur Beschworung des Erdgeistes. Aber die Magie genugt nicht, um seine eigentiliche Sehnsucht zu stillen. Auf den Wissenschatlichen und dem magischen Versuch folgt der mephistophelische Versuch, der den eigentlichen Gegenstand der Dichtung bildet.