성인에서 발생한 발진성 가성 혈관종증

서상희 ( Sang Hee Seo ),장호선 ( Ho Sun Jang ),목혜수 ( Hye Soo Mok ),김성준 ( Sung Jun Kim ),김병수 ( Byung Soo Kim ),김문범 ( Moon Bum Kim ),오창근 ( Chang Keun Oh ),권경술 ( Kyung Sool Kwon ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.8

Background: Eruptive pseudoangiomatosis (EPA) is a rare, benign, spontaneously regressing childhood exanthem. It is characterized by the sudden onset of several bright red angioma-like papules surrounded by pale halos with a distinct histopathology from true angiomas. Objective: This study was performed to evaluate the clinical and histopathologic characteristics of EPA occuring in adults. Methods: Ten adult patients who visited Pusan National University Hospital and Mok Hye-SooㆍJang Ho-Sun Dermatology Clinic from March 2005 to September 2006 were evaluated. We prospectively evaluated the sex, age, onset season, past medical history including immunosuppressive abnormalities, systemic disorders and other diseases including allergies. We also investigated the relations of mosquito biting, patients` occupations and outdoor activities to occurrence of EPA. In addition, simultaneous occurrence in family members, the clinical, histopathologic, laboratory findings, disease courses and responses to treatment were evaluated. Based on medical records, photographs and pathologic slides, we retrospectively diagnosed another 20 EPA patients suspected as insect bite from October 2003 to March 2005. The same questions were inquired as for the 10 patients who prospectively underwent evaluation. Results: In the study, female predominance (76.7%) was observed and the average age of onset was 54.2 years. Interestingly, there was no child patient during the period of study. Multiple, 2∼5 mm sized, red angiomatous papules surrounded by pale halos occurred on exposed areas such as the arms (86.7%), legs (50%), and face (46.7%), although it could also occur to a non-exposed area. EPA occuring in adults usually appeared in summer (80%). The mean disease duration was 3.4 weeks. Although EPA spontaneously regressed, it had the potential of recurrence (46.7%). Histopathologic findings showed dilated dermal blood vessels without the evidence of increase in numbers, and perivascular lymphocytes infiltration. Inside the lumen of dermal blood vessels, plump endothelial cells were found. Conclusion: EPA occuring in adults usually happened to exposed sites in summer, so it can be misdiagnosed as insect bite. We suggest that dermatologists should be concerned about EPA in adults and conduct further investigation to have a better understanding of the disease. (Korean J Dermatol 2007;45(8):797∼803)

Clozapine 투여후 발생한 급성 간염

장순주,이호택,백주희,이상연 대한신경정신의학회 1999 신경정신의학 Vol.38 No.1

Clozapine 투여 후에 급성 간염이 발생했던 두 명의 환자에 대한 증례로, 두 명 모두 이전에 약물에 이한 간염이 발생한 과거력이 있었던 환자로서 무증사의 급성 간염이 발생한 후에 보존적 치료 후에 호전 되었다. 간염이 발생한 후에 간효소수치에 대해 정기적으로 검사를 하면서, 사용하고 있던 clozapine의 용량을 낮춘 후 간장제를 투여함으로써 간효소수치는 정상화되었다. Clozapine과 비교하면 clozapine은 간세포의 cytochrome P450에 영향을 미치는 것으로 생각되고 있고 chlorpromazine은 간내 담즙저류에 영향을 미치는 것으로 생각된다. 과거 약물에 의한 간염을 경험한 환자는 clozapine에 의해 유도된 감염에 보다 취약성을 보일 가능성이 있으며, 이런 관점에서 이전의 간 기능 이상을 경험했거나 물질 사용 장애 등의 병발이 있을 경우 정기적인 간기능 평가가 임상적으로 중요할 것으로 판단된다. The authors report two cases of clzapine-induced acute hepatitis. Two patients developed asymptomatic hepatitis and got better with conservative care. We decreased the dosage of clozapine and added hepatic protections, resulting in normalized laboratory findings. The authors also reviewed side effects of clozapine in this report. We reviewed the suggested mechanism of either clozapine or chlorpromazine-induced hepatitis. clozapine influences the liver cell via cytochrome P 450 and chlorpromazine does so via mild cholestasis. There may be a possibility that a patient who has experienced drug-induced hepatitis is vulnerable to clozapine-induced acute hepatitis. In this respect, those who have experienced drug-induced hepatitis must be observed more closely.

開化期 國語敎科書 硏究

張相浩 朝鮮大學校 敎育大學院 國語敎育學會 1981 國語敎育論叢 Vol.1 No.-

수용성 키틴이 백서 창상치유에 미치는 영향

강장석,조용남,정상훈,유 결,임진수,권 호,조용우,고석원 大韓成形外科學會 2001 Archives of Plastic Surgery Vol.28 No.1

답손(Dapsone)중독환자의 예후와 특성 분석

장석준,정성필,김승환,구홍두,심호식 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

We reviewed 26 dapsone intoxication patients who had visited Severance Hospital Emergency Care Center from January 1991 to January 1995 : 13 of them ingested intentionally, but the other ingested accidentally. Among the admitted patients the highest and lowtheest initial value of methemoglobin level is 59.6% & 10.1%. The frequency of symptoms at presentation was following 16 patients complained cyanosis of lip area, 10 patients complained dyspnea, 4 patients complained mental change, 4 patients complained vomiting, 2 patients complained nausea. The inital level of methemoglobin was less than 50% except in one patient. In the view points of total doses of methylene blue used, less than 100mg was used in 9 patients(34.6%) but in one case, amount of 6400mg was loaded. There were 5 patients(19.2%) in September & 4 patients (15.4%) in January. In respect of result, there were 13 discharged cases (50%) for symptom improvement, and 5 mortality cases(19.2%). The transferred cases from Gangwondo account 19 patients(73.1%). All of them is not directly emergency care center visiting patients but transferred patients from remotely located hospitals. Dapsone intoxication results in severe tissue hypoxic symptoms from malfunction of normal hemoglobin thus only with appropriate available doses of methylene blue & activated charcoal, good outcomes will be expected. If aggressive therapy such as hemodialysis is introduced in treatment of severe dapsone intoxication, the outcomes may be slightly improved better than in other supportive care cases.

스포츠센터 관계마케팅 실행요인이 관계품질, 구매행동에 미치는 영향

장호성,석용근 龍仁大學校 體育科學硏究所 2008 體育科學硏究論叢 Vol.17 No.1

The meaning of this research work lies in providing useful basic resources which can be utilized in the strategic respect of internal marketing by investigating how sports center customer in relation to relationship marketing implement factors on relationship quality and purchasing behavior, and by identifying how their service orientation affect business performance taking service quality as parameter. Customer of sports centers in Chungnam region were selected as the subjects of this survey and 248 participants were sampled by Convenience Sampling Method. Resulting data were processed by Frequency Analysis, Exploratory Analysis, Correlation Analysis, Regression Analysis using SPSS 11.0 program. The results from these research methods and analyses revealed the followings: First, results from regression analysis of performance factors of relationship marketing and relations quality revealed that customer-relations orientation, responsiveness and incentive had significant influences on reliability, and that customer-relations orientation and responsiveness, on involvement. Second, results from regression analysis of performance factors of relationship marketing and purchase behavior exhibited that incentive had a significant influence on repurchase intention, and that responsiveness and incentive, on positive word of mouth. Third, results from regression analysis of relationship quality and purchase behavior revealed that there were significant influences of all variables including reliability and involvement on repurchase intention and positive word of mouth.

SAN을 이용한 큐잉모델 해결방법

장경수,신호진,이상호,김병기,신동렬 成均館大學校 科學技術硏究所 2000 論文集 Vol.51 No.2

Queueing analysis, in general., has the intrinsic problem of large state space dimension and complex computation. In fact, the petri net is a graphical and mathematical model. It has been used for the modeling of various applications, in particular, manufacturing systems. It can deal with parallelism, concurrence, deadlock avoidance, and asynchronism. Currently it has been applied to the performance of computer networks and protocol verifications. This paper presents a technique for modeling and analyzing queueing model using stochastic activity networks (SANs). And then some examples are showed for the verification of the technique presented in this paper.

축력과 양단 대칭모멘트를 받는 스테인리스 각형강관 기둥의 좌굴내력에 관한 실험적 연구

장호주,서성연,양영성 대한건축학회 2005 大韓建築學會論文集 : 構造系 Vol.21 No.2

This study is a series of experimental investigation on the buckling strengths of eccentrically compressed cold-formed stainless steel square hollow section columns. The principal parameters in this study are slenderness ratios(λ=30, 50, 70) and magnitude of eccentricity e(0, 2.5, 5.0, 7.5, 10cm) on the symmetrical end-moment. Objectives of this paper are to obtain the maximum loads by performing an experimental work and to compare the experimental behaviors with analytical results. The ultimate buckling strength of square section members are evaluated by a numerical method in accordance with the bending moment-axial force(M-P) interaction curves. The behavior of each specimen is displayed in the form of moment-angle(M-θ) relationship. The numerically obtained ultimate buckling interaction curves of beam-columns showed a reasonably good agreement with the available experimental results.

혈청 감마지티(gamma glutamyl transferase)치와 대사증후군의 연관성

장미,유병욱,조용진,오정은,홍성호,조주연 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.1

Background: Serum gamma glutamyl transferase(GGT) level has been widely used as an index of liver dysfunction and a marker of alcohol intake. But, recently it is identified that the elevated GGT level was associated with insulin resistance. This study aimed to examine the association between metabolic syndrome and elevated GGT level in the women who had less alcoholic influence generally. Methods: From 585 women who received their annual health check-up, 577 women were selected for analysis except for 28 women who had hepatitis B surface antigen positive or antibody to hepatitis C virus positive, Categories of serum GGT were classified into four groups by quartile and then evaluated. Results: A abnormal GGT level(≥52U/L) was seen in 29(5.2%) of the 557 women. As GGT level increased, the prevalence rate of factors(body mass index≥25kg/m2, hypertension, hemoglobin≥14g/dL, total cholesterol≥220mg/dL, triglyceride≥150mg/dL, fasting plasma glucose≥110mg/dL, HDL-choles tero1<50mg/dL) except for hyperuhcemia was increased. The GGT level was correlated with age, body mass index, thglyceride and uric acid in women with fatty liver, but not in women without fatty liver. Factors independently contributing to elevated GGT level was diabetes, hyperthglycehdemia and obesity. Conclusion: The elevated, albeit normal, GGT level was strongly associated with the factors of metabolic syndrome in Korean women. Because measurement of serum GGT level is easy, reliable, and not expensive, it might have more important implication as predictive factor of metabolic syndrome.

편심 압축력을 받는 스테인리스 각형강관 기둥의 곡률형상에 따른 좌굴내력에 관한 실험적 연구

장호주,서성연,양영성 대한건축학회 2005 大韓建築學會論文集 : 構造系 Vol.21 No.2

This study is a series of experimental investigation on the buckling strengths of eccentrically compressed cold-formed stainless steel square hollow section columns. The principal parameters in this study are slenderness ratios(λ=30, 50, 70) and magnitude of eccentricity e(0, 2.5, 5.0, 7.5. 10cm) on the direction of end-moment. The direction of end-moment means 3 different bending moment distributions. Objectives of this paper are to obtain the maximum loads and moments by performing an experimental work and to compare the experimental behaviors with the design standard curves, AIK-LSD and AISC-LRFD, AIJ-LSD, SIJ-ASD curves. The ultimate buckling strengths and bending moments of square section members were evaluated by a method in accordance with design standard curves. Therefore this paper attempts design standard for the use of these stainless steel columns as structural compression members. The numerically obtained ultimate buckling strengths and bending moments design standard curves of beam-columns showed a reasonably good agreement with the available experimental results.