가감청영탕(加減淸營湯)에 효과를 보인 열성 아토피 피부염 환자 6례 증례 보고

서지혜,정창환,박선정,임소영,한수련,Seo, Ji-Hye,Jung, Chang?Hwan,Park, Seon-Jeong,Lim, So-Young,Han, Su-Ryun 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.3

Objective : The purpose of this study is to investigate the effect of Gagamchengyoung-tang($Ji\bar{a}ji\check{a}nq\bar{i}ngy\acute{i}ng-t\bar{a}ng$) for atopic dermatitis patients diagnosed as the febrile tendency. Method : This case study was done on 6 atopic patients with febrile tendency who have visited Korean Medicine Clinic from 2013.08.01. to 2014.04.30.. Gagamchengyoung-tang($Ji\bar{a}ji\check{a}nq\bar{i}ngy\acute{i}ng-t\bar{a}ng$) was prescribed to all 6 patients and evaluated the symptom change through photographs and questionnaire. Objective SCORAD Index(OSI) was used to evaluate the objective symptom and VAS was used to evaluate the subjective change. Results & Conclusion : The Objective SCORAD index and VAS were decreased in all patients. The average OSI reduction score was 26.3. Most symptoms of 6 patients were improved. Gagamchengyoung-tang ($Ji\bar{a}ji\check{a}nq\bar{i}ngy\acute{i}ng-t\bar{a}ng$) can be effective in patients who were diagnosed as febrile tendency.

Cross-talk between STAT6 and Ras/MAPK Pathway for the IL-4-mediated T Cell Survival

So, Eui-Young,Jang, Ji-Young,Lee, Choong-Eun Korean Society for Biochemistry and Molecular Biol 2001 Journal of biochemistry and molecular biology Vol.34 No.6

As a prototypic Thl vs Th2 cytokine, IFN-$\gamma$ and IL-4 activate distinct STAT proteins, STAT1 and STATE, respectively. In cytokine-producing Jurkat T cells, IL-4 is effectively rescued from cell death that is induced by dexamethasone, but IFN-$\gamma$ failed to do so. Since the Ras/MAPK pathway is known to play an important role in cytokine-induced cell survival, we investigated the mechanism of T cell survival through the analysis of functional cross-talk between Ras/MAPK and distinct STAT proteins that are activated by IL-4 and IFN-$\gamma$. Although IL-4 and IFN-$\gamma$ each induced the activation of STATE and STATI. in Jurkat T cells, respectively, only IL-4 was capable of inducing MAPK. Along with tyrosine kinase inhibitors, MEK/MAPK inhibitors also caused a significant suppression of the IL-4-induced STATE activity. This suggests a positive regulation of STATE by MAPK during IL-4 signal transduction. Furthermore, transfection studies with dominant active (da) vs dominant negative (dn) Ras revealed that daRas, but not dnRas, selectively up-regulated the expression and activity of STATE with a concomitant increase in MAPK activity. These results, therefore, suggest that there is a functional cross-talk between the Ras/MAPK and Jak/STAT6 pathways, which may have a role in the IL-4-induced T cell survival.

항암화학요법 관련 오심과 구토 완화를 위한 비약물요법에 관한 연구동향

소향숙,최자윤,조인숙,김영재,김지영,김애숙,김옥미,김춘심,김현오,설영애,안정옥,이애리,이영자 성인간호학회 2003 성인간호학회지 Vol.15 No.3

Purpose: Purposes of this study were to understand the current trends on complementary therapy in relieving chemotherapy-induced nausea and vomiting and to suggest the future research direction. Method: Subjects were selected on CINAHL, MEDLINE, Korean Academy Data Base from 1980 to 2001 which used nausea, vomiting, chemotherapy and complementary therapy as key words in experimental studies. Eight korean articles and twenty-one international articles were analyzed in terms of general characteristics, research methods, and types of complementary therapy. Data were analyzed by using descriptive statistical methods. Result: Since 2000, researchers have more actively used complementary therapy. In subject characteristics, mean age was 35.5 years old, 45% of the researchers were performed with high level of incidence of chemotherapy induced vomiting, 14% of them set limit of consecutive cycle during research, and 65% of them did not comment the selecting criteria of sample. About 60% of them were designed post-test only control group: 35% used INV by Rhodes, 31% used Likert scale, and 24% used VAS for dependent variable. Muscle relaxation therapy was mostly applied for relief of nausea and vomiting. Conclusion: Further studies will be needed to control extrinsic variables affecting nausea and vomiting in research design and to accumulate evidence with studies applying various complementary therapies.

Production and Characterization of Enzymes Involved in Chitin Catabolic Cascade from a Bacterial Strain Isolated from Soil

( Ji Hyun Lee ),( Jeong In Lee ),( So Yeon Park ),( Yoo Kyeong Jang ),( You Bin Lim ),( Hye Yoon Lee ),( Young Min Jung ),( Hae Chang Lee ),( Jong Hwa Lee ),( Shaheen Amna ),( Jae Kweon Park ) 한국키틴키토산학회 2019 한국키틴키토산학회지 Vol.24 No.1

The present study was aimed to isolate the bacteria producing chitinolytic enzymes including chitin deacetylase (CDA) from soil origin. About 24 bacteria were screened for their chitinolytic enzymes producing ability on the basis of colloidal chitin. Amongst one of the most potent isolates designated to JI-02 was further selected as the most prominent chitinolytic and CDAlike enzyme (CDA-X) producer based on the ability of deacetylation of an artificial substrate pNP-acetamilide. The maximum production of CDA-X in crude enzyme from JI-02 was observed in the presence of 1% colloidal chitin at 37°C and pH 6.4 after 120 h of incubation. Potent enzyme activity of CDA-X was determined toward pNP-acetamilide, demonstrating that optimal pH, temperature and ionic strength of the CDA-X were assessed to be 7.0, 52°C and 125 mM, respectively. Unexpectedly, Nacetylglucosamine (GlcNAc) was not fully converted by the action of CDA-X to glucosamine (GlcN) under the established conditions. Further study on enzyme activity toward chitin-oligosaccharides consisting of multi-N-acetylglucosamine (GlcNAc)n, n=2-5 may be necessary to elucidate the mode of action which requires the minimum size of (GlcNAc)n. However, our data suggest that CDA-X can convert chitin to chitosan with the maximum yield of approximately 0.08g/L during the fermentation of the strain in the presence of chitin. Furthermore, we found that crude enzyme showed the significant chitosanolytic activity. Taken together, our data suggest that the strain JI-02 may be a potential candidate as a particular strain for better understating of chitin catabolic pathway.

Cross - talk between STAT6 and Ras / MAPK Pathway for the IL - 4 - mediated T Cell Survival

(Eui Young So),(Ji Young Jang),(Choong Eun Lee) 생화학분자생물학회 2001 BMB Reports Vol.34 No.6

As a prototypic Thl vs Th2 cytokine, IFN-γ and IL-4 activate distinct STAT proteins, STAT1 and STATE, respectively. In cytokine-producing Jurkat T cells, IL-4 is effectively rescued from cell death that is induced by dexamethasone, but IFN-γ failed to do so. Since the Ras/ MAPK pathway is known to play an important role in cytokine-induced cell survival, we investigated the mechanism of T cell survival through the analysis of functional cross-talk between Ras/MAPK and distinct STAT proteins that are activated by IL-4 and IFN-γ. Although 1L-4 and IFN-γ each induced the activation of STATE and STATI. in Jurkat T cells, respectively, only IL-4 was capable of inducing MAPK. Along with tyrosine kinase inhibitors, MEK/MAPK inhibitors also caused a significant suppression of the IL-4-induced STATE activity. This suggests a positive regulation of STATE by MAPK during IL-4 signal transduction. Furthermore, transfection studies with dominant active (da) vs dominant negative (dn) Ras revealed that daRas, but not dnRas, selectively up-regulated the expression and activity of STATE with a concomitant increase in MAPK activity. These results, therefore, suggest that there is a functional cross-talk between the Ras/MAPK and Jak/STAT6 pathways, which may have a role in the IL-4-induced T cell survival.

제주도 고산지역의 뇌전 특성과 기상요소와의 관계

소선섭,임남숙,허지영 公州大學校 基礎科學硏究所 2004 自然科學硏究 Vol.11 No.-

Choose 4 areas among Korea's weather observatory to search relation with thunder and lightning and separation weather element and analyzed report data of 2001. Recognize change by graph thunder and lightning occurrence postwar days choosing atmospheric pressure, temperature, precipitation, street stall deflection to separation weather essential and produced correlation coefficient to search quantitative relation between these. As a result, high mountain is shown effect of oceanic climate by time and inclination such as Korea's thunder and lightning occurrence special quality by monthly-year is seen and thunder and lightning that connect with precipitation and street stall deflection.

습도센서용 MgFe_2O_4 세라믹스의 특성

소지영 순천대학교 공업기술연구소 1994 工業技術硏究所論文集 Vol.8 No.-

To be expected use of humidity sensor ceramics, MgFe_2O_4 ceramics material was manufactured by two-stage sintering method and was measured porosity and pore size distribution characteristics. And obtained following results. The porosity of this studied result as 29[%], the pore size distribution of this studied result is 6000[Å]. Therefore, it is proved that MgFe_2O_4 ceramics is applied humidity sensing materials.

Strontium Barium Niobate 단결정에서 광굴절 부피격자를 이용한 동적 광편향

소지영,이권연 순천대학교 공업기술연구소 1997 工業技術硏究所論文集 Vol.11 No.-

In this paper, we report the results of a theoretical and experimental investigation of a dynamic photorefractive deflector. This device is based on the diffraction from a dynamic volume grating photoinduced in Cedoped strontium barium niobate(Sr_0.6Bα_0.4Nb_2O_6) single crystal by the interference of two writing beams. The diffraction properties of dynamic volume gratings, including the effect of additional two - beam coupling, are also considered.

국내 체중 감량 약물 사용 현황: 자발적으로 온라인에 게시한 처방적 분석

이소영,이지은,김미리,정은아,조은 건강보험심사평가원 2023 HIRA RESEARCH Vol.3 No.2

Background: Multiple medications have been used for weight loss (WL); however, research on the regimens of WL treatment in Korea have been limited. This study aimed to characterize the medications prescribed for WL in real-world settings. Methods: The study sample comprised WL prescriptions (Rxs) shared via a portal site for 1 year (from June 2022 to May 2023). WL drugs were classified into four categories: (1) on-label WL drugs; (2) off-label WL drugs; (3) medication-induced symptom management drugs; (4) dietary supplements and others. We calculated prescribing occurrence rates for each category and drugs. Further, we investigated the usage of off-label and psychotropic drug prescribing. Results: The study sample included 66 Rxs consisting of 63 active ingredients. The average number of medications per Rxs was seven (range, 1–13). Acetaminophen/caffeine/(pseudo)ephedrine (59.1%) and topiramate (54.5%) were the most commonly used medicines. The most frequently prescribed drug regimen involved a combination of on-label WL, off-label WL, and medication-induced symptom management drugs. Conclusion: Psychotropic appetite suppressants have been prescribed with unapproved WL drugs or psychotropic anti-anxiety/hypnotics. Further research is needed to provide evidence on drug combinations to ensure the safety of WL treatments.

MgFe₂O₄-LiMgVO₄세라믹스의 습도 센서특성 시뮬레이션

소지영 순천대학교 공업기술연구소 1991 工業技術硏究所論文集 Vol.5 No.-

To improve the characteristics of MgFe_2O_4 humidity sensor ceramics, raw material Li_2CO_3 and V_2O_5 are additioned to MgFe_2O_4 ceramics, and MgFe_2O_4 LiMgVO_4 ceramics are obtained. And measuring following parameters-porosity, pore size distribution, sensor characteristics, humidity variation respond speed, and cleaning characteristics-and obtained following results. The porosity of this studied result is improved from 29[%]-34[%] (MgFe_2O_4 ceramics) to 34.5[%]-39[%]. From the pore size distribution of this studied result, average pore size is decreased from 600[Å],(MgFe_2O_4 ceramics) to 1635[Å], therefore sensitivity of humidity variation is improved. The sensor characteristics are varied from 10^7[Ω] order variation to 10^6[Ω] order variation, and humidity variation respond speed is improved about 10 seconds. Also, using Kelvin equation and pore size distribution, theoratical characteristics were obtained from computer simulation(using model sensor), and obtained results are compared with measured results.