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노쇠의 지표로서 보행능력이 패혈증 환자의 예후에 미치는 영향
정창환,차경만,소병학,김형민,정원중 대한응급의학회 2021 大韓應急醫學會誌 Vol.32 No.3
Objective: The vulnerable and frail elderly individuals are at a compounded risk of worsening, rather than recovering, from external stress such as sepsis. Ambulation is majorly considered as a phenotype and determining factor of frailty. This study was undertaken to determine whether inability of ambulation is predictive for the prognosis of elderly patients afflicted with sepsis. Methods: Data were collected retrospectively from the medical records of an emergency medical center, from 1 November 2016 to 28 February 2017. Patients older than 65 years, who underwent blood culture or with a diagnosis of sepsis or septic shock and with Sequential Organ Failure Assessment (SOFA) score above 2 points, were included in the study. The predictive ability of the clinical factors was analyzed by comparing with the primary outcome of in-hospital mortality. Results: A total of 105 patients were included in the study; 58 (55.2%) male and 47 (44.8%) female patients, with median age 78 years (range, 65-96 years). Of these, 89 (84.8%) patients were independently ambulatory before presentation. The median SOFA score was 3 (2-12), and 20 (19%) patients had expired in the hospital. Logistic regression revealed that inability of ambulation is not predictive of mortality (odds ratio, 0.872; 95% confidence Interval, 0.176-4.309; P=0.866). However, correlation analysis with the SOFA score revealed an association with inability of ambulation (r=0.277, P=0.004), and multiple regression analysis also showed that ambulation affects the SOFA score (t=2.435, P=0.017; t=-2.521, P=0.013). Conclusion: Inability of ambulation does not predict in-hospital mortality, but affects the SOFA score of elderly patients afflicted with sepsis or in septic shock.
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Alloxan 處理 糖尿病 마우스의 膵臟 glucokinase 및 hexokinase에 對한 (枇杷葉)의 效果에 關한 硏究
鄭昌煥,尹哲浩,鄭智天,金鐵虎 동국대학교 한의학연구소 1997 東國韓醫學硏究所論文集 Vol.6 No.1
Alloxan은 glucokinase 酵素가 基質인 glucose의 結合部位인 -SH基를 競爭的으로 沮害함으로써 glucose의 初期 燐酸化를 抑制하여 糖尿病을 誘導시키는 化學物質이다. 本 硏究에서는 alloxan處理 糖尿 마우스에 對하여 淸凉生津, 解渴止嘔의 效能이 알려진 枇杷葉이 어떠한 效果가 있는지를 알아보고자 하였다. 實驗動物을 alloxan으로 處理하여 糖尿病을 誘發시킨 後 glucose의 燐酸化에 關與하는 glucokinase와 hexokinase의 活性을 살펴보았다. 그 結果, 枇杷葉은 糖尿病으로 因하여 增加된 glucose의 減少 效果와 insulin 分泌의 正常 回復能이 認定되었으며, glucokinase와 hexokinase를 活性化시키는 것으로 나타나 糖尿病에 效果가 있는 것으로 思料된다. We have investigated the in vivo. effect of an aqeuous extract from Eriobotryae folium on glucokinase and hexokinase activities of diabetes mellitus induced by alloxan. After 1 week of alloxan injection, the levels of serum glucose and insulin secretion were dramatically increased, however, the insulin secretion was decreased with administration of Eriobotrype folium. Alloxan injection allowed the serum glucose level increased and the level was decreased by Eriobotryae folium administration. Furthermore, it was observed that Eriobotryae folium was effective in recovering the levels of insulin secretion. Enzyme activities of the glucokinase and hexokinase were decreased by alloxan treatment. In contrast, Eriobotryae folium administration to the mice allowed proportional increasing. These results suggested that Eriobotryae folium is highly effective in treatment of diabetes mellitus induced by alloxan.
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