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      • KCI등재

        In Vivo Expression of the PTB-deleted Odin Mutant Results in Hydrocephalus

        박선정,이혜령,박수철 한국분자세포생물학회 2015 Molecules and cells Vol.38 No.5

        Odin has been implicated in the downstream signaling pathway of receptor tyrosine kinases, such as the epidermal growth factor and Eph receptors. However, the physiologically relevant function of Odin needs to be further determined. In this study, we used Odin heterozygous mice to analyze the Odin expression pattern; the targeted allele contained a -geo gene trap vector inserted into the 14th intron of the Odin gene. Interestingly, we found that Odin was exclusively expressed in ependymal cells along the brain ventricles. In particular, Odin was highly expressed in the subcommissural organ, a small ependymal glandular tissue. However, we did not observe any morphological abnormalities in the brain ventricles or ependymal cells of Odin null-mutant mice. We also generated BAC transgenic mice that expressed the PTB-deleted Odin (dPTB) after a floxed GFP-STOP cassette was excised by tissue-specific Cre expression. Strikingly, Odin-dPTB expression played a causative role in the development of the hydrocephalic phenotype, primarily in the midbrain. In addition, OdindPTB expression disrupted proper development of the subcommissural organ and interfered with ependymal cell maturation in the cerebral aqueduct. Taken together, our findings strongly suggest that Odin plays a role in the differentiation of ependymal cells during early postnatal brain development.

      • KCI등재

        건강기능식품의 섭취 시 주의사항 표시제도 개선에 대한 연구

        박선정,양성범 한국식품영양학회 2019 韓國食品營養學會誌 Vol.32 No.3

        The objective of this study was to analyze labeling improvements and evaluate willingness to pay for health functional foods with a focus on the caution for intake. For this study, we conducted a survey on health functional food intake behavior, confirmation and improvements of cautions for intake. We assessed the willingness to pay for improvement of the caution for intake. Consumers anticipate improved immune function, and fatigue improvement after consumption of health functional foods. They mainly checked the function components related to efficacy and effectiveness, ingredients and their contents, ingestion amount and method, expiry date and best mode of storage, product name, and cautions associated with ingestion of health functional foods. They has been difficulties in obtaining sufficient caution information for intake from the current labeling method. Therefore, it is necessary to improve the labeling of caution for intake. The analysis indicated that about 5.14% of the respondents were willing to pay more if new labeling was introduces. However, there is still controversy over their safety, which is damaging to the consumers. Therefore, by providing consumers with accurate and detailed information on cautions for intake, it can contribute to securing safety and improving the quality of health functional foods. The objective of this study was to analyze labeling improvements and evaluate willingness to pay for health functional foods with a focus on the caution for intake. For this study, we conducted a survey on health functional food intake behavior, confirmation and improvements of cautions for intake. We assessed the willingness to pay for improvement of the caution for intake. Consumers anticipate improved immune function, and fatigue improvement after consumption of health functional foods. They mainly checked the function components related to efficacy and effectiveness, ingredients and their contents, ingestion amount and method, expiry date and best mode of storage, product name, and cautions associated with ingestion of health functional foods. They has been difficulties in obtaining sufficient caution information for intake from the current labeling method. Therefore, it is necessary to improve the labeling of caution for intake. The analysis indicated that about 5.14% of the respondents were willing to pay more if new labeling was introduces. However, there is still controversy over their safety, which is damaging to the consumers. Therefore, by providing consumers with accurate and detailed information on cautions for intake, it can contribute to securing safety and improving the quality of health functional foods. Key words: cautions for intake, health functional food, willingness to pay, improving labeling

      • KCI우수등재

        딥 스로틀링 가변 슬리브 인젝터의 추력제어 성능예측

        박선정,남정수,이건웅,구자예,황용석,Park, Sunjung,Nam, Jeongsoo,Lee, Keonwoong,Koo, Jaye,Hwang, Yongsok 한국항공우주학회 2018 韓國航空宇宙學會誌 Vol.46 No.6

        환형 갭과 핀틀갭의 면적을 동시에 제어할 수 있는 가변 슬리브 인젝터의 분무특성을 실험적으로 분석하고, 넓은 추력범위에서 일정한 성능으로 제어할 수 있는 방안을 연구하였다. 슬리브의 개도에 관계없이 일정한 차압을 설정한 경우 설계유량을 만족하지 못하는 것을 확인하였다. 이를 개선하기 위해 개도에 따라 환형 갭과 핀틀 갭에서의 차압을 개도에 따라 다르게 적용하였다. 운용범위 내에서 설계 유량을 만족하였고, 선형적인 슬리브 면적으로 25%에서 100%까지 선형적으로 추력제어가 가능한 것을 확인하였다. Experimental analysis of the spray characteristics of the movable sleeve injector, which can simultaneously control the area of the annular gap and the pintle gap, has been studied and a method for controlling the uniform performance over a wide thrust range has been studied. It is confirmed that the design flow rate is not satisfied when the constant pressure difference is set regardless of the opening distance of the sleeve. In order to improve this, the differential pressure in the annular gap and the pintle gap was applied differently according to the opening distance. It was confirmed that the design flow rate was satisfied within the operating range and thrust control was linear from 25% to 100% in linear sleeve area.

      • KCI등재

        모아상호작용 중재에 관한 국내 연구논문의 통합적 고찰

        박선정,김신정,강경아 한국아동간호학회 2014 Child Health Nursing Research Vol.20 No.2

        Purpose: The purpose of this study was to describe the components and content of nursing intervention studies on mother-infant interactionsand to present strategies for future studies. Methods: Four electronic databases in the Korean language were searched to identify studies donebetween January 1998 and December 2011. The search yielded 145 articles. From these articles, 19 studies met the inclusion criteria. Results:Mother-infant interactions in these studies were found to include verbal and non-verbal communication basic for optimal growth and developmentof the child. Six kinds of interventions for mother-infant interactions were identified as follows: sensory stimulation, education program,whole body massage, kangaroo care, visiting support, and music therapy. Conclusion: Further studies with well designed clinical trials need to bedone in the area of child nursing to provide evidence based data for the development of strategies to promote positive mother-infant interactions. 목적 본 연구는 기존 문헌의 체계적인 고찰을 통해 국내에서 영유아를대상으로 수행된 모아상호작용에 관해 보고된 중재 연구의 특성과 중재내용을 분석, 평가하여 최적의 중재를 적용하기 위한 근거자료를 제공하고자 시도되었다. 방법 본 연구는 영유아를 대상으로 한 모아상호작용 중재 효과를 객관적으로 규명하기 위한 통합적 문헌고찰 연구이다. 결과 19편의 논문 중 18편(94.7%)이 비 무작위 대조연구(NRCCT)였고 1편은 단일군 사전사후설계연구이었다. 신생아 대상 논문이 9편, 미숙아 대상 논문이 5편, 장애 영아 대상 논문이 1편, 중환자실에 입원한영아 대상 논문이 1편, 영유아를 대상으로 한 연구가 3편이었다. 모아상호작용에 적용한 중재연구를 내용 분석한 결과, 전신 마사지를 포함하여 총 6종류의 중재가 적용되었으며, 감각자극을 적용한 논문이 8편으로 가장 많았고, 교육 및 증진프로그램을 적용한 중재연구는 4편, 전신 마사지를 적용한 중재연구 3편, 캥거루식 돌보기를 적용한 논문 2편, 방문지원 1편, 음악요법 1편이었다. 결론 추후 연구에서는 대상자 수를 확대하여 통합적 문헌고찰에 적합한연구설계를 적용할 필요가 있으며, 모아상호작용 중재효과의 지속시기에 대한 연구가 수행됨으로 모아상호작용 증진에 보다 적합한 간호중재임을 증명할 수 있는 과학적인 근거가 축적될 수 있어야겠다.

      • KCI등재

        Simulation on a Photocathode-based Microtron Using a 3D PIC Code

        박선정,정영욱,박성희,장규하,Nikolay A. Vinokurov,김은산 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.3

        The Korea Atomic Energy Research Institute (KAERI) has used a microtron accelerator basedon a thermionic cathode for operating a compact terahertz (THz) FEL, where the electrons areemitted and accelerated automatically during the radio-frequency (RF) macro-pulse over thresholdpower for their emission. Usually a thermionic cathode is embedded inside the microtron cavity forelectron-beam emission, and at the same time acceleration is due to the input RF source. In thiscase, the accelerator scheme is simple, but just a fraction of the emitted electrons are accelerated,and the electron bunch length is uncontrollable due to the RF phase condition for acceleration. In this paper, a photocathode-based microtron which is able to produce high peak (∼100 A) andultrashort (∼1 ps) electron bunch is studied to adapt it for an electron injector of a THz generator. Especially, we analyzed the electron beam dynamics along the accelerating trajectory with a 3DPIC-code to find the optimized RF phase and laser input time.

      • KCI등재

        관계 상실 경험 대학생이 지각한 사회적 지지가 외상 후 성장에 미치는 영향 : 의도적 반추의 매개효과

        박선정 한국학교사회복지학회 2015 학교사회복지 Vol.0 No.30

        본 연구의 목적은 관계 상실을 경험한 대학생이 지각한 사회적 지지와 의도적 반추, 외상 후 성장 간의 관계를 규명하고 사회적 지지와 외상 후 성장 간의 관계에서 의도적 반추의 매개효과를 검증하여 부모의 이혼, 이별, 실연, 절교 등의 관계 상실 외상을 경험한 대학생들의 외상 후 성장을 지원하는 실천적 방안을 모색하는데 있다. 이를 위해 부산․경남 지역 대학생 1,750명을 대상으로 설문을 실시하였다. 회수된 설문지 중 19세-24세 후기청소년기에 해당하며, 관계 상실 경험을 가장 충격적인 사건이라고 응답하고 사건당시 주관적 심각도를 ‘보통’이상으로 보고한 314명의 자료를 최종분석에 사용하였다. 자료 분석은 2단계 모형 접근(two-step approach)에 따른 구조방정식 모형 분석을 실시하고 매개효과 검증을 위해 Bootstrapping 방법을 적용하였다. 연구결과 사회적 지지가 의도적 반추에 유의한 영향을 미치고, 의도적 반추가 외상 후 성장에 유의한 영향을 미치는 것으로 나타났다. 또한 사회적 지지가 외상 후 성장에 유의한 영향을 미쳤으며, 의도적 반추는 사회적 지지와 외상 후 성장 간의 관계를 부분 매개하는 것으로 나타났다. 연구결과를 바탕으로 관계 상실 경험 대학생들의 외상 후 성장을 위한 실천적 방안을 논의하였다. The purpose of this study is to explore practical ways to support university students who had relational loss experience such as parents divorce, breakup, broken heart, cessation of friendship by identifying the relational between social support perceived by university students who had relational loss experience, deliberate rumination and posttraumatic growth and by verifying the mediating effect of deliberate rumination on the relational between social support and posttraumatic growth. To achieve this, 1,750 university students in Busan and Gyeongnam area were surveyed. This study finally analyzed the data of 314 students those who were in post-adolescence aged 19 to 24 and replied that the most traumatic event was relational loss experience and reported that subjective severity at the time of the incident was more than above average. In the data analysis, structure equation modeling analysis according to the two-step approach was conducted and bootstrapping method was applied for verification of mediating effect. According to the study, social support has a significant impact on the deliberate rumination and deliberate rumination has significant impact on posttraumatic growth. In addition, social support has a significant impact on posttraumatic growth and deliberate rumination was found to partially mediate the relational between posttraumatic growth and social support. Based on these results, this study discussed practical way to deal with posttraumatic growth of university students who had relational loss experience.

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