Effects of Adversities during Childhood on Anxiety Symptoms in Children and Adolescents: Comparison of Typically Developing Children and Attention-Deficit/Hyperactivity Disorder Group

You Bin Lim,Kukju Kweon,Bung-Nyun Kim 대한소아청소년정신의학회 2021 소아청소년정신의학 Vol.32 No.3

Objectives: Childhood adversity is a risk factor for anxiety symptoms, but it affects anxiety symptoms in attention-deficit/hyperactivity disorder (ADHD). The current study aimed to examine the association between childhood adversity and anxiety symptoms in participants with and without ADHD. Methods: Data were obtained from a school-based epidemiological study of 1017 randomly selected children and adolescents. The ADHD and non-ADHD groups were divided using the Diagnostic Interview Schedule for Children Predictive Scale (DPS). The DPS was also used to assess comorbidities such as anxiety and mood disorders. The childhood adversities were assessed using the Early Trauma Inventory Self Report-Short Form, and the anxiety symptoms were assessed using the Screen for Child Anxiety Related Disorders. Linear and logistic regression models were used to investigate the association between childhood adversity and anxiety in the ADHD and non-ADHD groups with adjustments for age and sex. Results: This study found that the ADHD group did not show any significant association between anxiety symptoms and childhood adversities, whereas the non-ADHD group always showed a significant association. In a subgroup analysis of the non-ADHD group, the normal group without any psychiatric disorders assessed with DPS demonstrated a statistically significant association between childhood adversities and anxiety symptoms. These results were consistent with the association between childhood adversities and anxiety disorders assessed using DPS, as shown by logistic regression. Conclusion: The association between anxiety symptoms and childhood adversities statistically disappears in ADHD; ADHD may mask or block the association. Further longitudinal research is necessary to investigate this relationship.

Comparison of characteristics of soy protein based patties with different types of binding agents

Su-Bin Lim,Tae-Hwi Moon,Sun-Goo Yim,Ye-Lim You,Sang-Jin Kang,Jung-Ah Han 한국식품영양과학회 2022 한국식품영양과학회 학술대회발표집 Vol.2022 No.10

독거노인 이중케어 시스템 개발 연구

임유빈 ( You-bin Lim ),추은정 ( Eun-jeong Chu ),한지민 ( Ji-min Han ) 한국정보처리학회 2020 한국정보처리학회 학술대회논문집 Vol.27 No.1

본 연구에서는 독거노인의 사회적 단절 문제 해결을 위해 방문후원자-독거노인, 독거노인-독거노인이라는 지속적인 방문 관계를 만들고 웹,모바일 어플리케이션과 방문 기록 리더기를 이용하여 관리하는 돌봄 솔루션을 제안한다.

아동청소년에서 운동의 항우울 효과와 BDNF와의 관련성에 대한 예비 연구

임유빈(You Bin Lim),김준원(Jun Won Kim),홍순범(Soon-Beom Hong),김재원(Jae-Won Kim) 대한소아청소년정신의학회 2016 소아청소년정신의학 Vol.27 No.1

Objectives: The purpose of this study was to evaluate anti-depressive effects of exercise on child and adolescent and its association with brain derived neurotrophic factor (BDNF). Methods: Twenty nine middle school boys (age 13.3±0.7) were divided into two groups, 15 boys for control group and 14 in the experimental group. The control group participated in a regular exercise program, 3 times a week for 15 weeks. During the same period, the experimental group participated in an aerobic exercise program specifically designed to enhance anti-depressive effect of exercise. Serum BDNF level and its performance of each group on the Beck Depression Index (BDI), Children’s Depression Inventory(CDI), Screen for Child Anxiety Related Emotional Disorders (SCARED), Aggression Questionnaire (AK-Q), and Stroop task were compared before and after the exercise program. Results: Scores of BDI, CDI, SCARED, and AK-Q were significantly lower in both groups after the exercise programs compared to those before the programs. The Stroop task performances were significantly improved after the programs. However, there were no significant differences between two exercise programs, except SCARED separation anxiety, AK-Q physical, and verbal aggression scores. Also, no association was found between serum BDNF level and anti-depressive effects of exercise. Conclusion: Our preliminary results suggest a possible effect of exercise on depression, anxiety, aggression, and cognition of child and adolescents.

결착제 종류에 따른 식물소재기반 패티 제조 및 품질특성

임수빈(Su-Bin Lim),문태휘(Tae-Hwi Moon),임선구(Sun-goo Yim),유예림(Ye-Lim You),한정아(Jung-Ah Han) 한국식품과학회 2023 한국식품과학회지 Vol.55 No.3

본 연구에서는 1% 히알루론산과 카라기난, 구아검을 결착제로 첨가한 식물성 패티를 제조하고 그 특성을 평가하였다. 색도평가시, 명도와 황색도에서 시료 간의 유의적인 차이는 없었으나 적색도는 대조군이 결착제 첨가군보다 유의적으로 높은 값을 나타냈다. pH는 검을 첨가한 시료군이 대조군과 HA 첨가군보다 유의적으로 낮은 값을 보였다. 수분함량과 가열수율은 HA, GG, HA+GG 첨가군에서 유의적으로 높은 값을 보였으며 직경감소율은 HA, GG, HA+GG군이 유의적으로 낮은 값을 보여 서로 상응하는 결과를 보였다. 전자현미경을 이용하여 패티의 미세구조를 관찰한 결과 결착제 첨가군에서 결착제의 친수성 상호작용으로 인해 대조군에 비해 표면공극의 수가 감소하여 표면 개선에 도움을 준 것을 확인할 수 있었으나 GG 첨가군은 높은 점성으로 인해 큰 공극이 형성되면서 불규칙한 구조를 확인할 수 있었다. 조직감 측정결과 결착제를 첨가한 패티가 대조군보다 유의적으로 낮은 경도와 씹힘성, 그리고 높은 탄력성을 보였다. 시제품 2종과 GG, HA+CG, HA+GG 첨가군을 대상으로 관능검사를 실시한 결과 외관은 시제품 2종과 GG첨가군에서 유의적으로 높은 평가를 받았으며 향도 시제품 2종에서 유의적으로 높은 평가를 보였다. 맛과 부드러움은 HA+GG 첨가군이 유의적으로 높은 값을 보였으며, 전반적인 기호도 또한 HA+GG와 HA+CG가 유의적으로 높은 평가를 받았다. 강도평가에서 촉촉함은 HA+GG, HA+CG 첨가군이 가장 높았고 시제품 2종은 상대적으로 낮은 평가를 받았으며, 조직감은 시료 간의 유의적인 차이를 보이지 않았다. 이상의 결과로 식물성 패티 제조 시 히알루론산과 구아검을 결착제로 첨가하는 경우 패티의 수분함량과 가열수율은 향상시키고 직경감소율을 감소시켜 제품의 촉촉함과 부드러움을 개선시킬 수 있을 것으로 보인다. Plant-based patties with different binders were developed as meat analogues, and their properties were compared. Hyaluronic acid, carrageenan (CG), guar gum (GG), and a mixture of the gums (HA+CG and HA+GG) were used as binders. Samples with HA, GG, and HA+GG showed significantly higher moisture content and cooking yield and lower reduction in diameter after cooking than the control samples. In addition, microstructure analysis using scanning electron microscopy showed that the samples with binders had an improved surface structure and smaller pores than the control, except for those with GG. Patties with binders also exhibited lower hardness and higher springiness than the controls. In the sensory evaluation, patties with HA+GG showed significantly higher values for taste, moistness, tenderness, and overall acceptability than others. These results indicate that HA+GG can be used as an effective binder to improve the quality of plant-based meat analogue.

Gaetbulibacter jejuensis sp. nov., Isolated from Seawater

You-Sung Oh,강형일,Byoung-Jun Yoon,Duck-Chul Oh,Jae-Ho Joa,Dong-Heon Lee,Sang-Bin Lim 한국미생물학회 2010 The journal of microbiology Vol.48 No.3

A novel marine bacterium, designated strain CNURIC014T was isolated from coastal seawater of Jeju Island in Korea. Strain CNURIC014T formed yellow colonies on marine agar 2216 and the cells were Gram-negative, non-motile, strictly aerobic, rod-shaped. The temperature, pH and NaCl ranges for growth were 15-37°C, pH 6.0-9.0 and 1.0-7.0% NaCl. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain CNURIC014T was most closely related to Gaetbulibacter marinus and Gaetbulibacter saemankumensis, with a sequence similarity of 95.1% and 94.6%, respectively. The DNA G+C content of the strain was 33.1 mol% and the major respiratory quinone was menaquinone-6. The major cellular fatty acids were iso-C15:1 (22.8%), iso-C15:0 (18.8%), summed feature 3 (iso-C15:0 2-OH/C16:1 ω7c, 12.9%) and iso-C17:0 3-OH (11.5%). On the basis of phenotypic, phylogenetic, and genotypic data, strain CNURIC014T represents a novel species within the genus Geatbulibacter, for which the name Gaetbulibacter jejuensis sp. nov. is proposed. The type strain is CNURIC014T (=KCTC 22615T =JCM 15976T).

Aquimarina litoralis sp. nov., Isolated from a Coastal Seawater

You-Sung Oh,Hyung-Yeel Kahng,Young Sun Lee,Byoung-Jun Yoon,Sang-Bin Lim,정재성,Duck-Chul Oh,Dong-Heon Lee 한국미생물학회 2010 The journal of microbiology Vol.48 No.4

A strictly aerobic, red-pigmented, non-motile, catalase- and oxidase-positive, Gram-staining-negative bacterium,designated strain CNURIC011T, was isolated from seawater off the coast of Jeju Island in Korea. A phylogenetic analysis based on 16S rRNA gene sequences showed that strain CNURIC011T belongs to the genus Aquimarina in the family Flavobacteriaceae. 16S rRNA gene sequence analysis revealed that the close relatives of the novel strain are Aquimarina latercula ATCC 23177T, Aquimarina marcrocephali JAMB N27T,Aquimarina intermedia KMM 6258T, Aquimarina muelleri KMM 6020T, and Aquimarina brevivitae SMK-19T,with sequence similarities of 97.6, 96.6, 96.0, 95.6, and 94.2%, respectively. DNA-DNA hybridization revealed that the level of relatedness between strain CNURIC011T and Aquimarina latercula ATCC 23177T (=KCTC 2912T) was 4.9%. The DNA G+C content was 35.8 mol% and the major respiratory quinone was MK-6. The major fatty acids were iso-C15:0 (14.9%), C15:0 (13.9%), iso-C17:0 3-OH (12.6%), iso-C15:1 G (7.3%), and iso-C17:1ω9c (7.2%). On the basis of phenotypic, phylogenetic, and genotypic data, strain CNURIC011T represents a novel species within the genus Aquimarina, for which the name Aquimarina litoralis sp. nov. is proposed. The type strain is CNURIC011T (=KCTC 22614T =JCM 15974T).

Gender Related Association between Arterial Stiffness and Aortic Root Geometry

You-Jeong Ki,Hack-Lyoung Kim,Sohee Oh,Won-Kyeong Jeon,Tae-Min Rhee,Woo-Hyun Lim,Jae-Bin Seo,Sang-Hyun Kim,Myung-A Kim,Joo-Hee Zo 한국심초음파학회 2019 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.27 No.1

BACKGROUND The gender-related change in aortic morphology by arterial stiffness has not been well studied. This study was performed to investigate the association between brachial-ankle pulse wave velocity (baPWV) and aortic root size according to gender. METHODS A total of 263 consecutive subjects (63.2 ± 10.6 years, 71.1% men) without overt cardiovascular disease who underwent both baPWV measurement and transthoracic echocardiography on the same day were retrospectively analyzed. The diameters of the aortic annulus (AN), sinus of Valsalva (SV), sinotubular junction (STJ), and ascending aorta (AA) were measured using 2-dimensional echocardiography. RESULTS The body surface area (BSA)-corrected diameters of AN, SV, STJ, and AA were significantly higher in women than in men. Univariable analyses showed that baPWV was significantly correlated with SV/BSA and STJ/BSA in men, and with SV/BSA, STJ/BSA, and AA/BSA in women (p < 0.05 for each). In men, however, these associations disappeared in multiple linear regression models after controlling for potential confounders (p > 0.05 for each). In women, the associations of baPWV with diameters of STJ/BSA (β = 0.407, p < 0.001) and AA/BSA (β = 0.391, p = 0.005) remained significant in the same multivariate models. Women-specific correlation between aortic root size and baPWV was also similarly demonstrated in age-matched analyses (n = 61 in each gender). CONCLUSIONS Among Korean adult without overt cardiovascular disease, the association between increased arterial stiffness and aortic root dilatation is stronger in women than in men.

Physicochemical Property and Effect of the Antioxidant Activity From Citrus and Carrot Mixed Beverage

You-Sung Oh,Joon-Ho Hwang,Hyun-Joeng Oh,Sang-Bin Lim 한국식품영양과학회 2011 한국식품영양과학회 학술대회발표집 Vol.2011 No.10

우리나라 천식 환자의 삶의 질 평가도구 개발

임미경,유빈,문희범,조유숙 대한알레르기학회 1999 천식 및 알레르기 Vol.19 No.5

Background and objective : The outcome of asthma treatment has traditionally been assessed by measuring the conventional clinical parameters such as symptoms, expiratory flow rates and needs for medications. But none of them tells us whether the patients are actually able to function properly in their lives. Only assessment of the quality of life (QOL) can reflect the parts of patients lives affected by the disease. However, there is no measure to assess the quality of life of patients with any chronic diseases in Korea yet. We developed the QOL Questionnaire for Korean Asthmatics and evaluated its measurement properties. Method: The questionnaire was composed of 18 items in four domains : i.e. activity limitation (6 items), symptoms (5 items), emotional function (3 items) and environmental stimuli (4 items). At our out-patient clinic, 32 adults with moderate to severe persistent bronchial asthma were enrolled. The study design consisted of 4 week unblinded single cohort with visits at 0 and 4 weeks, and the patients were asked to answer the questionnaire by self administration method at the two separate visits. Forced expiratory volume for 1 second (FEV1) and peak expiratory flow rate (PEFR) were recorded at each visit. According to the patients and physicians global assessment, the patients were divided into two groups, i.e. stable and changed (improved). The responsiveness, reproducibility and validity of the questionnaire were evaluated. Results : The total QOL scores at the second visit in the changed group were significantly higher than those at the first visit. The score differences between the two visits in the changed group were higher than in the stable group. In the stable group, the responses to the questionnaire were reproducible. The QOL scores showed good longitudinal correlation with the expiratory flow rates, whereas FEV1 did not correlate with the QOL in cross-sectional analysis. Conclusion : The questionnaire proved to be reproducible, responsive and valid in the subjects. It could be recommended for the outcome evaluation of Korean asthmatics.