http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
중금속 이온과 질소-황을 포함하는 포단드와의 착물형성에 관한 연구
정징운,이선하,최규성,강동현 慶南大學校 附設 基礎科學硏究所 1997 硏究論文集 Vol.10 No.-
The stability constant, enthalpy, and etropy changes of complexation of heavy metal ions (Zn²*, Cd²*) with podands containing nitrogen-sulfur donors such as tri(phenylthio-2-ethyl)amine (Podand Ⅰ), tri(benzylmercapto-2-ethyl)amine(Podand Ⅱ), and tetra(phenylthio-2-ethyl)ethylenediamine (Podand Ⅲ) have been determined by using potentiometric titration in 95% MeOH at various temperature. We observed the Podand Ⅲ ligand showed the largest protonation constant. The values of protonation constant and stability constant for Zn(Ⅱ), and Cd(Ⅱ) ions among three different ligands were increased as following order, Podand Ⅰ< Podand Ⅱ< Podand Ⅲ. In addition, thermodynamic parameters ΔH and TΔS of Zn(Ⅱ), Cd(Ⅱ) complexes have studied.
흰쥐에서 심정지후 Pentoxifylline이 뇌의 허혈-재관류 손상에 미치는 효과
정시경,김영민,오동렬,최경호,박승현,이운정,박규남,유은영,이원재,김세경 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2
Background: Two major events occurring in the cerebral hemodynamics after successful resuscitation from cardiac arrest are reactive hyperemia and postischemic hypoperfusion. In this study, we examined the effect of Pentoxifylline(PTX) on the rat brain following cardiac arrest. Methods: Fourteen rats were anesthetized and artificially ventilated. Cardiac arrest was produced by chest compression and clamping of tracheal tube for 3 minutes in ketamine anesthetized rats. Circulation was restored by standard cardiopulmonary resuscitation methods. In 7 rats, PTX 10mg/kg was infused at 10min after cardiac arrest(PTX group). In the other 7 rats, same amount of normal saline was infused(control group). Results: In both groups, hemodynamic variables, neurologic deficit(ND) score and histopathologic findings of hippocampal CA1 neurons were observed. Hemodynamic variables and ND score were not significantly different between two groups. Delayed ischemic neurons of hippocampal CA1 were decreased in PTX group(2.2±2.4%) compared with control group(9.1±1.2%). Conclusions: We conclude that PTX prevented development of delayed ischemic neurons in hippocampal CA1 after cardiac arrest. PTX may be useful in emergency situations following cardiac arrest.
정규현,하안례,이용환 고신대학교 보건과학연구소 2002 보건과학연구소보 Vol.12 No.-
Formaldehyde irritiates mucous membranes in the eyes, nose, and upper respiratory tract, and it is a potential carcinogen. The purpose of this study was to assess the time-weighted average (TWA) and short-term exposure limit (STEL) concentration to formaldehyde exposure and to suggest proper improvement strategy to minimize exposure. This study was conducted at 3 histopathology laboratories in the hospitals located in Busan from January 20 to March 10, 2002. Formaldehyde and organic solvents (ethanol and xylene) were sampled by personal air sampler and analyzed by gas chromatography. The obtained results were as follows. 1. TWA concentrations of formaldehyde ranged from 0.28 to 10.64 ppm and those of two laboratories out of 3 were exceeded the threshold limit value (TLV). 2. In one laboratory, STEL concentrations was exceeded threshold limit value (TLV), as 2.39 ppm. 3. TWA concentrations of ethanol and xylene were under the TLVs. It is necessary to improve the local ventilation systems and other facilities to prevent the personnels in the laboratories from the diseases due to formaldehyde exposure.
MTT비색법에 의한 결핵균 30-kDa항원이 임파구 증식에 미치는 영향
백태현,김민경,박정규,김화중,조은경,최대경 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.1
The cell mediated immune response appears to result from the specific recognition of an antigen. by T lymphocytes. It has been well recognized that T cell play an important roles in the induction of tuberculin hypersensitivity and immunity to tuberculosis. In order to evaluate effect on T lymphocyte proliferative response to purified 30-kDa antigen from Mycobacterium tuberculosis, stimulation effects of peripheral blood lymphocytes with 30-kDa antigen, crude antigen and PHA were measured by MTT colorimetric assay. Three groups of healthy subjects, representing PPD(+), PPD() and PPD(-) persons, were investigated. The proliferative response to 30-kDa antigen were elicited the plateau at concentration of 20 to 0.1㎍/ml, crude antigen showed rapid reduction as decreasing the concentration of antigen, for the PPD(+) person. Both antigens, at concentration of <1㎍/ml, failed to stimulate lymphocytes of the PPD(-) person. Therefore the concentration of 30-kDa antigen to induce optimal stimulation was 1㎍/ml. The lymphocyte proliferation to 30-kDa antigen and crude antigen were significantly increased in PPD(+) group when compared to those in PPD(-) group, but PHA response was no significant difference. These results suggest that 30-kDa antigen could stimulate lymphocyte from PPD(+) population and MTT colorimetric assay could be applied to assess proliferative response of lymphocyte.
Vitamin D_(3)가 RAW 세포에 감염된 Mycobacterium marinum의 증식억제에 미치는 기전 연구
박정규,정샛별,이길수,김수영,송창화,박종호,조현구,조은경,김화중 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1
The natural resistance-associated macrophage protein 1(Nramp1) has been proposed to directly regulate bactericidal or bacteriostatic activity of the macrophage toward pathogens or participate in macrophage activation that lead to microbial elimination in the host. The relationship between Nramp1 and nitric oxide(NO) as an antimicrobial factor has not been precisely defined to date. To devise an in vitro assay for Nramp1 function, this study introduced a wild type Nramp1^(G169) cDKA transfected RAW264.7 macrophages(A8) which bear a homozygous mutant Nramp1^(D169) allele and are permissive to replication of specific intracellular parasites. RAW264.7 and A8 macrophages did not produce NO, but vitamin D_(3)-activated-Mycobacterium marinum-infected RAW264.7 and A8 macrophages pretreated with vitamin D_(3) leaded to the increase of NO production and growth inhibition of M. marinum. Inhibition of NO production by a NO inhibitor, L-NAME, abolished the above effects. The mRNA expression of iNOS in infected macrophages with costimulated vitamin D_(3) was increased. IFN-γ activated macrophages also showed the same results with vitamin D_(3) activated macrophages. These results suggest that bactericidal or bacteriostatic activity in RAW264.7 and A8 macrophages correlated with the production of NO, although NO might not be the only factor responsible for controlling M. marinum infection. The Nrampl gene is considered to be a cofactor in the controlling the replication of M. marinum infection.