現代 企業文化에서 디자인 感性經營에 關한 硏究

안종문,박기남 홍익대학교 산업디자인연구소 2003 미술디자인 논문집 Vol.- No.8

새로운 아이디어는 늘 기업경영의 틀 속에 존재한다. 내부에 있을 수도 있고, 외부에 있을 수도 있다. 무엇보다 중요한 원천은 바로 고객이고, 다음은 내부 종사자(구성원)들의 태도에 있다. MIT대학의 연구에 의하며, 산업재의 경우 혁신 아이디어의 60%는 고객에 의해 나오고 나머지 40%는 기업 구성원에 의한다는 것이다. 신상품을 개발하고자 할 때, 표적 집단을 대상으로 하는 정량적인 측정: 분석도중요하지만, FGI 나 Creator Group Interview, Depth Interview등을 통해 전혀 예상치 못한 좋은 아이디어를 신상품 개발에 활용, 표적 집단에 가장 효율적인 마케팅 믹스를 개발 할 수 있다. 디자인 경영은 양적 게임(Volume game)이 아니고 질적 게임(Volume game)에서 진가를 발휘한다. 고객에게 감동을 줄 수 있는 상품과 서비스는 기업의 신뢰와 이미지를 아름답게 가꾸는 동력이다. 매출이 성장하고 이익을 보이는 기업을 Good Company라고 한다면 한 걸음 더 나아가 사회와 소비자에게 존경받는 기업이 되어야 한다. 올바른 가치와 사회적 기여를 통해 국내의 많은 기업들이 Great Company가 되어 소비자, 생산자 모두에게 존경받는 기업이 되어야 한다. 디자인 경영은 최고 경영자(CEO)의 책임이다. 따라서 기업 문화에서 디자인 감성경영은 CEO의 디자인 철학과 디자인 리더십에 달려 있으며, 디자인 개발환경을 사내외에 얼마만큼의 인프라를 구축하여 시장과 고객정보 분석을 토대로 디자인을 통한 디자인 목표에 도달했는가가 핵심이 된다. 분야 별로 국내의 삼성 애니콜, 풀무원의 찬마루, 유한 킴벌리와 국외의 일렉트로룩스(스웨덴), 코카콜라(미국), 이낙스(일본)은 구조와 과정과 조직과 디자인 감성 경영에서 전형을 만들어 왔다. 디자인 감성경영은 올바르게 수행하기 위해서는 먼저 첫째기능은 기업의 감성 경영 전략과 같은 맥락에서 디자인 전략을 수립 시행하되 일관성, 정체성을 확립하는 것이다. 두 번째 기능은 바람직한 이미지를 형성하는 요소개발과 갖고 싶은 구매충동을 일으키는 상품의 매력을 창출하는 일이다. 세 번째 기능은 디자이너와 사내 종사자들이 자사를 위해 창의적인 분위기, 디자인 업무환경을 조성해주는 것이다. 끝으로 디자인 감성 경영환경은 좋은 디자인을 창출 할 수 있는 원동력 즉, 구성원의 복지와 드림(Dream)을 생산하는 사람중시 경영의 조타수가 되는 일이다.

鼻閉塞환자에서 수술전후 Rhinomanometry에 의한 총 비저항치의 변화

김용기,문문만,최봉남 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

For over 100 years, the interest has been shown in evaluation of the nasal airway. As a nasal obstruction can be a subjective complaint, there is wide variation in the interpretation of the nasal symptoms. Rhinomanometry is objective, reliable, easily quantitated and a reproducible method to evaluate the nasal obstruction. 51 patients with nasal obstruction were evaluated with the active anterior rhinomanometry before and after nasal surgery and 60 patients with nomal rhinoscopic findings were evaluated with same methods as a control group. The results were as follows. 1) The mean total nasal resistance was : 1.386CmH_(2)O/LPS in control group. 2.523CmH_(2)O/LPS in patient group(p<0.05). 2) The preoperative total nasal resistance by rhinomanometry was highly correlated with subjective assessment of nasal obstruction, especially for the patient with moderate to severe symptoms of nasal obstruction. 3) In the comparison of preoperative with postoperative total nasal resistance during inspiration according to the different surgical procedure, the total nasal resistance after polypectomy was significantly decreased and the obstructive symptoms were more improved in patients who have recieved polypectomy. 4) The total nasal resistance after nasal surgery was significantly decreased from the preoperative 2.523CmH_(2)O/LPS down to the postoperative 1.512CmH_(2)O/LPS(p<0.05). 5) Therefore rhinomanometry is objectively reliable in evaluation of the nasal obstruction and the effect of nasal surgery.

관동맥 재개통 후 QTc간격분산의 감소 : 정량적으로 측정한 심근 허혈의 호전 정도와의 연관성 Relationships with the Quantitative Degree of Improvement in Myocardial Ischemia

박상선,최기준,남기병,이철환,홍멸기,박성욱,박승정,신중우,문대혁,김유호 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

관절염 환자의 실태와 관련요인에 대한 분석적 연구

정승기,남철현,신두만,양숙희,김기열,이미경,문기내 대한보건협회 2002 대한보건연구 Vol.28 No.3

This study was conducted to examine the condition of patients with arthritis and its related factors. Data were collected from 100 people who suffered from arthritis in Seoul. Busan, Daegu, Daejun, Junjoo, and pohang from April 2, 2000 to July 31, 2000. The results of this study are summarized as follows : 1. 6L0% of the subjects were female. The incidence rate of arthritis was higher in the higher age group, lower educated group, and thinner group. In case of male, the incidence rate was higher in the groups of single, residents in big cities, and technicians. In case of female, it was higher in the groups of the married, residents in towns or villages, and housewives. 2. According to the parts of arthritis, knee joint covered 67.4% and backspine joint covered 9.0%. The incidence rate of arthritis was higher in the groups of forties, housewives, single, irreligious people, residents in towns and villages, primary school graduates, thin people, and walk exercisers. 3. The arthritis patients felt pain most when they stood up (31.5%). According to the time when they felt pain most, the time when they were active during daytime was 31.5% and nighttime was 29.8%. When they got up in the morning was 22.4%, while 10.9% felt pain all cay long. 4. they had arthralgia knees and cramp in crook of the knees (21.8%). Their knees ticked when they moved (21.1%). The had to rest hands on anyplace when they stood up (18.7%) and they could not completely unfold their knees. 5. The medical institutions which diagnosed them showed significant difference in the variables of sex, age, marital status, religion, place in residence, education level, economic status, obesity level, exercise, parts of arthritis, and posture of feeling pain. from above results, it can be concluded that it is necessary to develop appropriate medical treatment on the basis of the respondents' socio-democraphic characteristics, pain parts, period of having a pain, satisfaction level with treatment and its related factors. Therefore, related professionals and organizations must develop education program for prevention of arthritis in order to educate them.

우리나라 일부 석면사업장의 석면폐 유병률

백도명,백남원,최정근,손미아,임정기,이원진,문영한,박정선,최병순 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.1

Asbestos industry has been in operation over 60 years in Korea. However, the prevalence of asbestosis has not been yet reported. With rapid turn-over of workers, previous cross-sectional studies of current workers on the job could not find cases with exposures long enough for the development of asbestosis. This study was done to evaluate asbestosis prevalence of those worksites with operation history of more than 20 years. In total, 139 workers from 5 worksites were examined. Asbestos industries covered in the study include 2 asbestos textile, 1 brake lining, and 2 ship repairing worksites. Chest x-ray was taken from all workers and read by two experts familiar with pneumoconiosis classification according to 1980 ILO guidelines. Those with findings compatible with asbestosis were further ckecked with high resolution computerized tomography (HRCT). Pulmonary function tests were done according to ATS guidelines, and occupational and previous medical history was taken through a standardized interview. Air-borne asbestos was measured according to NIOSH method 7400. The air-borne asbestos concentrations ranged from 0.2-1.3 f/cc for asbestos textile, from 0.7-1.0 f/cc for brake lining, and from 6.3-7.8 f/cc during asbestos removal at ship repairing worksite. Of the 139 workers 25 had abnormal chest radiographic findings, and 10 of them had findings compatible with pneumoconiosis. When work history and current asbestos measurements were accounted, 9 workers who had more than 10 years of asbestos exposure history showed chest radiographic findings of pneumoconiosis with Finally, 4 workers showed finding of pulmonary fibrosis and/or pleural thickening at HRCT, and 2 of them had restrictive lung function changes. The study results showed that, among 139 subjects, there were 4(3%) definite asbestosis cases confirmed with HRCT. The prevalence of probable asbestosis was 7% for 10-14 years of exposure, 13% for 15-19 years of exposure, and 23% for 20 or more years of exposure. The prevalence of compensable asbestosis with abnormal lung function was 4-6% for those with 15 or more years of exposure.

연약점토층 위에서 선행하중의 제거-재압축에 따른 점토지반의 거동

정성교,이남기,조기영,김문규 동아대학교 건설기술연구소 1997 硏究報告 Vol.21 No.2

Little has been known about the characteristics of short-term and long-term resettlements on soft clay, such as elastic behaviour and secondary compression due to partial removal of preloading. In this study, different types of oedometer tests on a natural soft clay were peformed for examining such characteristics. As the results of the experiments, the characteristics of short-term and long-term resettlements such as rebound ratio, resettlement point and rate of secondary compression depends on the overconsolidation ratio(OCR) and preloading time. It is showed that resettlement point increased with increasing preloading, but such is not for rebound ratio and rate of secondary compression. This reason would be due to rearrangement of clay particles. And rebound ratio and resettlement point increased with increasing the OCR, but such is not for rate of secondary compression. The correlations between them is showed all the linear relations in a semi-logarithem or log-log plots, and then can be used for settlement prediction in field, as well its results can be compared with those of conventional method. from the comparative results of settlement prediction, it is found as follows : The amount of rebound due to partial removal of preloading and resettlement due to reloading are similar for both methods. But the amount of secondary compression due to partial removal of preloading by this correlation is rather overestimated than that of conventional method, because it would be underestimated the duration of primary consolidation. And for different loading histories, the compression is affected by strain rate(ε_(v)), that is, the compression increases with decreasing strain rate.

Nucleotide sequence and genomic organization of a newly identified member of the genus Carmovirus, soybean yellow mottle mosaic virus, from soybean

Nam, Moon,Kim, Sang Mok,Domier, Leslie L.,Koh, Serry,Moon, Jung Kyung,Choi, Hong Soo,Kim, Hong Gi,Moon, Jae Sun,Lee, Su-Heon Springer-Verlag 2009 Archives of virology Vol.154 No.10

Arabidopsis TTR1 causes LRR-dependent lethal systemic necrosis, rather than systemic acquired resistance, to Tobacco ringspot virus

Nam, Moon,Koh, Serry,Kim, Sung Uk,Domier, Leslie L.,Jeon, Jae Heung,Kim, Hong Gi,Lee, Su-Heon,Bent, Andrew F.,Moon, Jae Sun Springer-Verlag 2011 Molecules and cells Vol.32 No.5

Cationic Liposome-Mediated p53 Gene Therapy in Liver Cancers: Result of Basic and Clinical Study

Moon,Young Ho,Kim,Byung Koo,Shim,Hyung Jin,Uhm,Tae Han,Cha,Sung Jae,Moon,Chul So,Moon,Woo-Chul,Kwak,Byung Kook,Gi,Young Jin,Lim,Hyun Mook,Yoo,Nam Sook,Lee,Chang Joon 가톨릭중앙의료원 가톨릭암센터 1998 암심포지움 Vol.- No.2

p53 is a prototype tumor suppressor gene, which plays key roles in regulation of cell cycle progression, apoptosis, DNA repair and maintenance of genomic stability. Experimental stydy study on p53 gene therapy for cancer have been widely tried and Success of adenovirus or retrovirus-mediated p53 gene therapy have been reported in patients with lung cancer and cancer of the head and neck. However, viral vector-mediated gene therapy may have demerits to be widely applied in human cancers. We herein have designed a cationic liposome-mediated p53 gene therapy and have studied its antitumor efficacy and safety in vitro, in vivo and in human patients with advanced liver cancers. We constructed and prepared a complex of plamid vector carrying cDNA of human wild type(WT) p53, cationic liposome (HECH : DOPE) and cationic polymer (polylysine) in sterile and endotoxin-free condition depending on the guideline of FDA and used this complex for in vitro and in vivo transfer oi WT p53 gene. In vitro administration of p53 gene to a variety of human cancer cells with point mutation or deletion of p53 in DNA dose of 1㎍ per ?? cells induced high level expression of WT p53 and p21/WAF1 as demonstrated by RT-PCR-Southern blot and Western blot, apoptosis as demonstrated by DNA electrophoresis, and significant decrease of viable cell numbers by 70.4 to 98.5%, whereas, administration of p53 gene in same condition to human cancer cells with WT p53 didn't induce either apoptosis or significant decrease of viable cell numbers. In vivo antitumor efficacy of p53 gene transfer was initially analyzed in sc,ip, subrenal capsular and intrahepatic xenograft model of human cancers with deletion of p53. Local, ip, or iv administration of p53 gene in DNA dose of 100㎍ daily for 5 to 10 days induced expression of WT p53 and p21 in tumor tissues, significant decrease of tumor volume (by 62.0 to 99.5%)and/or incidence of tumors, and complete suppression of metastasis. Intravenous administration of p53 gene in DNA dose of up to 12 mg/kg to rats didn't induce significant acute or sub-acute toxicity as demonstrated by survival body weight, laboratory studies, and histologic analysis of vital organs. Trans-hepatic arterial administration of p53 in DNA dose of 0.5 to 5 mg per kg induced expression of human WT p53 in rabbits liver and/or lung and didn't induce significant hepatic toxicity or systemic toxicity. Trans-hepatic arterial administration of p53 gene in DNA dose of 1 mg per kg induced significant decrease of tumor incidence (to 40%) and volume (to 0.4% of control) and suppression of metastasis of rabbits liver VX2 carcinoma which carry point mutation of p53. These results suggested that our cationic polyliposome-mediated p53 gene trasfer might be a promising treatment modality for human cancers which carry mutation of p53. Based on the results of basic research, we carried out a pilot study to investigate antitumor efficacy and safety of cationic liposome-mediated p53 gene therapy in patients with liver cancer. Patients whth advanced, primary (N=12) or metastatic (N=4) liver cancer who had failed conventional therapy underwent p53 gene therapy, of whom 12 showed mutation of p53. Patients with advanced liver cirrhosis or metastasis were also included in the study. Fifteen patients with advanced liver cancer who underwent hepatic angiography alone served as control. p53 gene was administered in complex with HECH : DOPE : PLL into common hepatic artery in DNA dose of 10 to 30 mg every 3 to 4 weeks for 2 to 8 times (mean 4 times). Of 16 patients who underwent p53 gene therapy, 6 showed partial response, 4 minimal response and 3 stable disease. High level expression of WT p53 or p21 were found in tumor tissues of hepatovectin1 administered patients. After p53 gene therapy, 11 of 16 patients developed transient fever and chill, but none developed transient fever and chill, but none developed grade 4 toxicity or deterioration of liver function. Of 16 patients who underwent p53 gene therapy, 7 were alive on 1 year follow up and 9 died from metastatic cancer or liver cirrhosis-related complications. in contrast, none of control group survived for 1 year. These results suggest that cationic liposome-mediated p53 gene trasfer via hepatic artery may become a promising therapeutic modality for advanced liver cancer which carry mutation of p53 gene. Our studies strongly suggest that our cationic liposome-mediated p53 gene therapy may be a promising treatment modality for human cancers which carry mutation of p53 gene and failed by conventional therapies. Further stydies are necessary on the actual benefit of this experimental study and effective systemic delivery method of p53 gene.

멀티미디어 처리 : 멀티미디어 콘텐츠 응시와 이해도 기반 분석 서비스 플랫폼 기술

고기남 ( Gi Nam Ko ),문남미 ( Nam Mee Moon ) 한국정보처리학회 2015 정보처리학회논문지. 소프트웨어 및 데이터 공학 Vol.4 No.8

본 연구의 목적은 시선 관심 객체 기반 양방향 서비스를 효율적으로 하기 위해, 멀티미디어 콘텐츠를 시청하는 소비자의 응시 행위를 개별 객체 중심으로 실시간 모니터링하고, 콘텐츠 소비 시점의 맥락적 소비자 이해도를 인지하여 콘텐츠 제공의도에 맞는 소비행태 분석을 제공하는 플랫폼 기술을 제공하는 데 있다. 이를 위해 미디어 콘텐츠 내 개별 객체 표현 구조를 연구하고, 미디어 제공자의 의도와 비교하여 제공자가 의도한 계획에 맞춰 소비되고 있는지를 파악할 수 있도록 한다. 소비자의 소비행태 분석은 응시 분석(Gaze Profile Analysis)과 콘텐츠 제공자에 의해 제공된 의도 흐름(Intention Flow)과 가중치(Intention Weight)를 분석한 정보를 사용하여 이루어진다. 이와 같은 기술은 교육, 광고 등에 효과적으로 사용될 수 있을 것으로 기대된다. The purposed of this research is to develop multimedia content usage analysis service platform. In the proposed platform, the content gazing behaviors of the users are monitored and profiled in real-time and a set of quantifiable metrics is provided. These metrics are used to determine the closeness of the users`` behavior from the intent set by the provider. Based on the evaluation, it is possible to assess the effectiveness of the contents themselves as well. The content usage assessment is accomplished by utilizing the intention flow and the intent weight, which are embedded into the content by the content provider. Proposed methodology can be effectively applied and used in various application domains such as in education and in commercial advertisements.